Novel crystalline solid dispersion of tranilast with high photostability and improved oral bioavailability

European Journal of Pharmaceutical Sciences

Volumn 39, Issue 4, 2010, Pages 256-262

  Kawabata, Yohei ^a   Yamamoto, Kiyoshi ^a   Debari, Kazuhiro ^b   Onoue, Satomi ^a   Yamada, Shizuo ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b SHOWA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Absorption; Dissolution; Photostability; Solid dispersion; Tranilast

Indexed keywords

TRANILAST;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EXPOSURE; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; FREEZE DRYING; LASER DIFFRACTION; LIGHT SCATTERING; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PHOTOCHEMICAL EFFICIENCY; PHOTODEGRADATION; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TIME TO MAXIMUM PLASMA CONCENTRATION; ULTRAVIOLET IRRADIATION; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; ANTHRANILIC ACIDS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG STABILITY; SOLUBILITY; ULTRAVIOLET RAYS;

EID: 75449106350     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2009.12.009     Document Type: Article

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