The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats

International Journal of Pharmaceutics

Volumn 394, Issue 1-2, 2010, Pages 147-153

  Zhang, Zhiwen ^a   Bu, Huihui ^a   Gao, Zhiwei ^a   Huang, Yan ^a   Gao, Fang ^a,b   Li, Yaping ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Bioavailability; Intestinal absorption; Lipid nanoparticles; Simvastatin; Simvastatin acid

Indexed keywords

CLATHRIN; CYTOCHROME P450 3A; DRUG METABOLITE; SIMVASTATIN; SIMVASTATIN ACID; SOLID LIPID NANOPARTICLE; UNCLASSIFIED DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; NANOPARTICLE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG HALF LIFE; DRUG METABOLISM; DRUG SOLUBILITY; ENDOCYTOSIS; INTESTINE CELL; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NANOENCAPSULATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; SPRAGUE DAWLEY RAT; TIME TO MAXIMUM PLASMA CONCENTRATION; UPPER GASTROINTESTINAL TRACT; ANALOGS AND DERIVATIVES; ANIMAL; BIOAVAILABILITY; BLOOD; CHEMISTRY; COMPARATIVE STUDY; INSTITUTE FOR CANCER RESEARCH MOUSE; ORAL DRUG ADMINISTRATION; SOLUBILITY; TANDEM MASS SPECTROMETRY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, LIQUID; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIPIDS; MALE; MICE; MICE, INBRED ICR; NANOPARTICLES; PARTICLE SIZE; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; SOLUBILITY; TANDEM MASS SPECTROMETRY;

EID: 77953696686     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.04.039     Document Type: Article

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