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Volumn 24, Issue 6, 2013, Pages 1000-1009

Molecular tools for chemical biotechnology

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGICAL PRODUCTION; DE NOVO PATHWAY; DIVERSITY GENERATIONS; HIGH-VALUE CHEMICALS; HOST ORGANISM; METABOLIC CONTROL; MOLECULAR TOOLS; WHOLE CELL;

EID: 84887623613     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2013.03.001     Document Type: Review
Times cited : (10)

References (75)
  • 1
    • 0032750433 scopus 로고    scopus 로고
    • Chemical biotechnology industrial applications and recent advances - invited overview
    • Petersen M. Chemical biotechnology industrial applications and recent advances - invited overview. Curr Opin Biotechnol 1999, 10:593-594.
    • (1999) Curr Opin Biotechnol , vol.10 , pp. 593-594
    • Petersen, M.1
  • 3
    • 79961179947 scopus 로고    scopus 로고
    • Synergies between synthetic biology and metabolic engineering
    • Nielsen J., Keasling J.D. Synergies between synthetic biology and metabolic engineering. Nat Biotechnol 2011, 29:693-695.
    • (2011) Nat Biotechnol , vol.29 , pp. 693-695
    • Nielsen, J.1    Keasling, J.D.2
  • 4
    • 84862817382 scopus 로고    scopus 로고
    • Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae
    • Sun J., Shao Z., Zhao H., Nair N., Wen F., Xu J.H. Cloning and characterization of a panel of constitutive promoters for applications in pathway engineering in Saccharomyces cerevisiae. Biotechnol Bioeng 2012, 109:2082-2092.
    • (2012) Biotechnol Bioeng , vol.109 , pp. 2082-2092
    • Sun, J.1    Shao, Z.2    Zhao, H.3    Nair, N.4    Wen, F.5    Xu, J.H.6
  • 5
    • 64849114915 scopus 로고    scopus 로고
    • Coding-sequence determinants of gene expression in Escherichia coli
    • Kudla G., Murray A.W., Tollervey D., Plotkin J.B. Coding-sequence determinants of gene expression in Escherichia coli. Science 2009, 324:255-258.
    • (2009) Science , vol.324 , pp. 255-258
    • Kudla, G.1    Murray, A.W.2    Tollervey, D.3    Plotkin, J.B.4
  • 7
    • 79951565301 scopus 로고    scopus 로고
    • Design, construction and characterization of a set of insulated bacterial promoters
    • Davis J.H., Rubin A.J., Sauer R.T. Design, construction and characterization of a set of insulated bacterial promoters. Nucleic Acids Res 2011, 39:1131-1141.
    • (2011) Nucleic Acids Res , vol.39 , pp. 1131-1141
    • Davis, J.H.1    Rubin, A.J.2    Sauer, R.T.3
  • 8
    • 84867389802 scopus 로고    scopus 로고
    • RNA processing enables predictable programming of gene expression
    • Qi L., Haurwitz R.E., Shao W., Doudna J.A., Arkin A.P. RNA processing enables predictable programming of gene expression. Nat Biotechnol 2012, 30:1002-1006.
    • (2012) Nat Biotechnol , vol.30 , pp. 1002-1006
    • Qi, L.1    Haurwitz, R.E.2    Shao, W.3    Doudna, J.A.4    Arkin, A.P.5
  • 9
    • 70349964350 scopus 로고    scopus 로고
    • Automated design of synthetic ribosome binding sites to control protein expression
    • Salis H.M., Mirsky E.A., Voigt C.A. Automated design of synthetic ribosome binding sites to control protein expression. Nat Biotechnol 2009, 27:946-950.
    • (2009) Nat Biotechnol , vol.27 , pp. 946-950
    • Salis, H.M.1    Mirsky, E.A.2    Voigt, C.A.3
  • 10
    • 79952348850 scopus 로고    scopus 로고
    • A synthetic library of RNA control modules for predictable tuning of gene expression in yeast
    • Babiskin A.H., Smolke C.D. A synthetic library of RNA control modules for predictable tuning of gene expression in yeast. Mol Syst Biol 2011, 7:471.
    • (2011) Mol Syst Biol , vol.7 , pp. 471
    • Babiskin, A.H.1    Smolke, C.D.2
  • 11
    • 79960697001 scopus 로고    scopus 로고
    • Organization of intracellular reactions with rationally designed RNA assemblies
    • Delebecque C.J., Lindner A.B., Silver P.A., Aldaye F.A. Organization of intracellular reactions with rationally designed RNA assemblies. Science 2011, 333:470-474.
    • (2011) Science , vol.333 , pp. 470-474
    • Delebecque, C.J.1    Lindner, A.B.2    Silver, P.A.3    Aldaye, F.A.4
  • 14
    • 79551478567 scopus 로고    scopus 로고
    • Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes
    • Albertsen L., Chen Y., Bach L.S., Rattleff S., Maury J., Brix S., Nielsen J., Mortensen U.H. Diversion of flux toward sesquiterpene production in Saccharomyces cerevisiae by fusion of host and heterologous enzymes. Appl Environ Microbiol 2011, 77:1033-1040.
    • (2011) Appl Environ Microbiol , vol.77 , pp. 1033-1040
    • Albertsen, L.1    Chen, Y.2    Bach, L.S.3    Rattleff, S.4    Maury, J.5    Brix, S.6    Nielsen, J.7    Mortensen, U.H.8
  • 15
    • 84864080129 scopus 로고    scopus 로고
    • Direct conversion of xylan to ethanol by recombinant Saccharomyces cerevisiae strains displaying an engineered minihemicellulosome
    • Sun J., Wen F., Si T., Xu J.H., Zhao H. Direct conversion of xylan to ethanol by recombinant Saccharomyces cerevisiae strains displaying an engineered minihemicellulosome. Appl Environ Microbiol 2012, 78:3837-3845.
    • (2012) Appl Environ Microbiol , vol.78 , pp. 3837-3845
    • Sun, J.1    Wen, F.2    Si, T.3    Xu, J.H.4    Zhao, H.5
  • 17
    • 59649108349 scopus 로고    scopus 로고
    • DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways
    • Shao Z., Zhao H. DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways. Nucleic Acids Res 2009, 37:e16.
    • (2009) Nucleic Acids Res , vol.37
    • Shao, Z.1    Zhao, H.2
  • 18
    • 80053064386 scopus 로고    scopus 로고
    • Reiterative recombination for the in vivo assembly of libraries of multigene pathways
    • Wingler L.M., Cornish V.W. Reiterative recombination for the in vivo assembly of libraries of multigene pathways. Proc Natl Acad Sci U S A 2011, 108:15135-15140.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 15135-15140
    • Wingler, L.M.1    Cornish, V.W.2
  • 21
    • 84860778298 scopus 로고    scopus 로고
    • Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting
    • Fu J., Bian X., Hu S., Wang H., Huang F., Seibert P.M., Plaza A., Xia L., Muller R., Stewart A.F., et al. Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting. Nat Biotechnol 2012, 30:440-446.
    • (2012) Nat Biotechnol , vol.30 , pp. 440-446
    • Fu, J.1    Bian, X.2    Hu, S.3    Wang, H.4    Huang, F.5    Seibert, P.M.6    Plaza, A.7    Xia, L.8    Muller, R.9    Stewart, A.F.10
  • 23
    • 84555188306 scopus 로고    scopus 로고
    • The KEGG databases and tools facilitating omics analysis: latest developments involving human diseases and pharmaceuticals
    • Kotera M., Hirakawa M., Tokimatsu T., Goto S., Kanehisa M. The KEGG databases and tools facilitating omics analysis: latest developments involving human diseases and pharmaceuticals. Methods Mol Biol 2012, 802:19-39.
    • (2012) Methods Mol Biol , vol.802 , pp. 19-39
    • Kotera, M.1    Hirakawa, M.2    Tokimatsu, T.3    Goto, S.4    Kanehisa, M.5
  • 26
    • 84870256513 scopus 로고    scopus 로고
    • Global probabilistic annotation of metabolic networks enables enzyme discovery
    • Plata G., Fuhrer T., Hsiao T.L., Sauer U., Vitkup D. Global probabilistic annotation of metabolic networks enables enzyme discovery. Nat Chem Biol 2012, 8:848-854.
    • (2012) Nat Chem Biol , vol.8 , pp. 848-854
    • Plata, G.1    Fuhrer, T.2    Hsiao, T.L.3    Sauer, U.4    Vitkup, D.5
  • 28
  • 31
    • 79952910616 scopus 로고    scopus 로고
    • Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways
    • Bond-Watts B.B., Bellerose R.J., Chang M.C. Enzyme mechanism as a kinetic control element for designing synthetic biofuel pathways. Nat Chem Biol 2011, 7:222-227.
    • (2011) Nat Chem Biol , vol.7 , pp. 222-227
    • Bond-Watts, B.B.1    Bellerose, R.J.2    Chang, M.C.3
  • 32
    • 80051941601 scopus 로고    scopus 로고
    • Engineered reversal of the beta-oxidation cycle for the synthesis of fuels and chemicals
    • Dellomonaco C., Clomburg J.M., Miller E.N., Gonzalez R. Engineered reversal of the beta-oxidation cycle for the synthesis of fuels and chemicals. Nature 2011, 476:355-359.
    • (2011) Nature , vol.476 , pp. 355-359
    • Dellomonaco, C.1    Clomburg, J.M.2    Miller, E.N.3    Gonzalez, R.4
  • 36
  • 40
    • 78649649132 scopus 로고    scopus 로고
    • PCRless library mutagenesis via oligonucleotide recombination in yeast
    • Pirakitikulr N., Ostrov N., Peralta-Yahya P., Cornish V.W. PCRless library mutagenesis via oligonucleotide recombination in yeast. Protein Sci 2010, 19:2336-2346.
    • (2010) Protein Sci , vol.19 , pp. 2336-2346
    • Pirakitikulr, N.1    Ostrov, N.2    Peralta-Yahya, P.3    Cornish, V.W.4
  • 41
    • 84871539146 scopus 로고    scopus 로고
    • A heritable recombination system for synthetic Darwinian evolution in yeast
    • Romanini D.W., Peralta-Yahya P., Mondol V., Cornish V.W. A heritable recombination system for synthetic Darwinian evolution in yeast. ACS Synth Biol 2012, 1:602-609.
    • (2012) ACS Synth Biol , vol.1 , pp. 602-609
    • Romanini, D.W.1    Peralta-Yahya, P.2    Mondol, V.3    Cornish, V.W.4
  • 42
    • 79960980943 scopus 로고    scopus 로고
    • A general strategy for the evolution of bond-forming enzymes using yeast display
    • Chen I., Dorr B.M., Liu D.R. A general strategy for the evolution of bond-forming enzymes using yeast display. Proc Natl Acad Sci U S A 2011, 108:11399-11404.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 11399-11404
    • Chen, I.1    Dorr, B.M.2    Liu, D.R.3
  • 43
    • 84862167101 scopus 로고    scopus 로고
    • High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch
    • Michener J.K., Smolke C.D. High-throughput enzyme evolution in Saccharomyces cerevisiae using a synthetic RNA switch. Metab Eng 2012, 14:306-316.
    • (2012) Metab Eng , vol.14 , pp. 306-316
    • Michener, J.K.1    Smolke, C.D.2
  • 44
    • 79955534060 scopus 로고    scopus 로고
    • A system for the continuous directed evolution of biomolecules
    • Esvelt K.M., Carlson J.C., Liu D.R. A system for the continuous directed evolution of biomolecules. Nature 2011, 472:499-503.
    • (2011) Nature , vol.472 , pp. 499-503
    • Esvelt, K.M.1    Carlson, J.C.2    Liu, D.R.3
  • 46
  • 47
    • 27744488443 scopus 로고    scopus 로고
    • Applications of metabolic modeling to drive bioprocess development for the production of value-added chemicals
    • Mahadevan R., Burgard A.P., Famili I., Van Dien S., Schilling C.H. Applications of metabolic modeling to drive bioprocess development for the production of value-added chemicals. Biotechnol Bioproc E 2005, 10:408-417.
    • (2005) Biotechnol Bioproc E , vol.10 , pp. 408-417
    • Mahadevan, R.1    Burgard, A.P.2    Famili, I.3    Van Dien, S.4    Schilling, C.H.5
  • 48
    • 84869744652 scopus 로고    scopus 로고
    • Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases
    • Michener J.K., Nielsen J., Smolke C.D. Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases. Proc Natl Acad Sci U S A 2012, 109:19504-19509.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 19504-19509
    • Michener, J.K.1    Nielsen, J.2    Smolke, C.D.3
  • 49
    • 79961072482 scopus 로고    scopus 로고
    • Unravelling evolutionary strategies of yeast for improving galactose utilization through integrated systems level analysis
    • Hong K.K., Vongsangnak W., Vemuri G.N., Nielsen J. Unravelling evolutionary strategies of yeast for improving galactose utilization through integrated systems level analysis. Proc Natl Acad Sci U S A 2011, 108:12179-12184.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12179-12184
    • Hong, K.K.1    Vongsangnak, W.2    Vemuri, G.N.3    Nielsen, J.4
  • 50
    • 0037069467 scopus 로고    scopus 로고
    • Analysis of optimality in natural and perturbed metabolic networks
    • Segre D., Vitkup D., Church G.M. Analysis of optimality in natural and perturbed metabolic networks. Proc Natl Acad Sci U S A 2002, 99:15112-15117.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15112-15117
    • Segre, D.1    Vitkup, D.2    Church, G.M.3
  • 51
    • 30044437327 scopus 로고    scopus 로고
    • Evolutionary programming as a platform for in silico metabolic engineering
    • Patil K.R., Rocha I., Forster J., Nielsen J. Evolutionary programming as a platform for in silico metabolic engineering. BMC Bioinformatics 2005, 6:308.
    • (2005) BMC Bioinformatics , vol.6 , pp. 308
    • Patil, K.R.1    Rocha, I.2    Forster, J.3    Nielsen, J.4
  • 52
    • 0037313750 scopus 로고    scopus 로고
    • Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network
    • Forster J., Famili I., Fu P., Palsson B.O., Nielsen J. Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network. Genome Res 2003, 13:244-253.
    • (2003) Genome Res , vol.13 , pp. 244-253
    • Forster, J.1    Famili, I.2    Fu, P.3    Palsson, B.O.4    Nielsen, J.5
  • 53
    • 70449592325 scopus 로고    scopus 로고
    • Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering
    • Asadollahi M.A., Maury J., Patil K.R., Schalk M., Clark A., Nielsen J. Enhancing sesquiterpene production in Saccharomyces cerevisiae through in silico driven metabolic engineering. Metab Eng 2009, 11:328-334.
    • (2009) Metab Eng , vol.11 , pp. 328-334
    • Asadollahi, M.A.1    Maury, J.2    Patil, K.R.3    Schalk, M.4    Clark, A.5    Nielsen, J.6
  • 54
    • 73949094856 scopus 로고    scopus 로고
    • Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers
    • Jung Y.K., Kim T.Y., Park S.J., Lee S.Y. Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers. Biotechnol Bioeng 2010, 105:161-171.
    • (2010) Biotechnol Bioeng , vol.105 , pp. 161-171
    • Jung, Y.K.1    Kim, T.Y.2    Park, S.J.3    Lee, S.Y.4
  • 55
    • 0344328817 scopus 로고    scopus 로고
    • An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR)
    • Reed J.L., Vo T.D., Schilling C.H., Palsson B.O. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Genome Biol 2003, 4:R54.
    • (2003) Genome Biol , vol.4
    • Reed, J.L.1    Vo, T.D.2    Schilling, C.H.3    Palsson, B.O.4
  • 56
    • 0242487787 scopus 로고    scopus 로고
    • Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization
    • Burgard A.P., Pharkya P., Maranas C.D. Optknock: a bilevel programming framework for identifying gene knockout strategies for microbial strain optimization. Biotechnol Bioeng 2003, 84:647-657.
    • (2003) Biotechnol Bioeng , vol.84 , pp. 647-657
    • Burgard, A.P.1    Pharkya, P.2    Maranas, C.D.3
  • 59
    • 77955690481 scopus 로고    scopus 로고
    • Considerations for using integral feedback control to construct a perfectly adapting synthetic gene network
    • Ang J., Bagh S., Ingalls B.P., McMillen D.R. Considerations for using integral feedback control to construct a perfectly adapting synthetic gene network. J Theor Biol 2010, 266:723-738.
    • (2010) J Theor Biol , vol.266 , pp. 723-738
    • Ang, J.1    Bagh, S.2    Ingalls, B.P.3    McMillen, D.R.4
  • 60
    • 77955852574 scopus 로고    scopus 로고
    • A model for improving microbial biofuel production using a synthetic feedback loop
    • Dunlop M.J., Keasling J.D., Mukhopadhyay A. A model for improving microbial biofuel production using a synthetic feedback loop. Syst Synth Biol 2010, 4:95-104.
    • (2010) Syst Synth Biol , vol.4 , pp. 95-104
    • Dunlop, M.J.1    Keasling, J.D.2    Mukhopadhyay, A.3
  • 61
    • 84857050180 scopus 로고    scopus 로고
    • Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways
    • Michener J.K., Thodey K., Liang J.C., Smolke C.D. Applications of genetically-encoded biosensors for the construction and control of biosynthetic pathways. Metab Eng 2012, 14:212-222.
    • (2012) Metab Eng , vol.14 , pp. 212-222
    • Michener, J.K.1    Thodey, K.2    Liang, J.C.3    Smolke, C.D.4
  • 62
    • 79959913313 scopus 로고    scopus 로고
    • Biosensors and their applications in microbial metabolic engineering
    • Zhang F., Keasling J. Biosensors and their applications in microbial metabolic engineering. Trends Microbiol 2011, 19:323-329.
    • (2011) Trends Microbiol , vol.19 , pp. 323-329
    • Zhang, F.1    Keasling, J.2
  • 63
    • 84455174703 scopus 로고    scopus 로고
    • Model-driven engineering of RNA devices to quantitatively program gene expression
    • Carothers J.M., Goler J.A., Juminaga D., Keasling J.D. Model-driven engineering of RNA devices to quantitatively program gene expression. Science 2011, 334:1716-1719.
    • (2011) Science , vol.334 , pp. 1716-1719
    • Carothers, J.M.1    Goler, J.A.2    Juminaga, D.3    Keasling, J.D.4
  • 64
    • 84862827747 scopus 로고    scopus 로고
    • Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene alpha-santalene in a fed-batch mode
    • Scalcinati G., Knuf C., Partow S., Chen Y., Maury J., Schalk M., Daviet L., Nielsen J., Siewers V. Dynamic control of gene expression in Saccharomyces cerevisiae engineered for the production of plant sesquitepene alpha-santalene in a fed-batch mode. Metab Eng 2012, 14:91-103.
    • (2012) Metab Eng , vol.14 , pp. 91-103
    • Scalcinati, G.1    Knuf, C.2    Partow, S.3    Chen, Y.4    Maury, J.5    Schalk, M.6    Daviet, L.7    Nielsen, J.8    Siewers, V.9
  • 65
    • 77950858848 scopus 로고    scopus 로고
    • Autonomous induction of recombinant proteins by minimally rewiring native quorum sensing regulon of E. coli
    • Tsao C.Y., Hooshangi S., Wu H.C., Valdes J.J., Bentley W.E. Autonomous induction of recombinant proteins by minimally rewiring native quorum sensing regulon of E. coli. Metab Eng 2010, 12:291-297.
    • (2010) Metab Eng , vol.12 , pp. 291-297
    • Tsao, C.Y.1    Hooshangi, S.2    Wu, H.C.3    Valdes, J.J.4    Bentley, W.E.5
  • 66
    • 0034024497 scopus 로고    scopus 로고
    • Improving lycopene production in Escherichia coli by engineering metabolic control
    • Farmer W.R., Liao J.C. Improving lycopene production in Escherichia coli by engineering metabolic control. Nat Biotechnol 2000, 18:533-537.
    • (2000) Nat Biotechnol , vol.18 , pp. 533-537
    • Farmer, W.R.1    Liao, J.C.2
  • 67
    • 84859633048 scopus 로고    scopus 로고
    • Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids
    • Zhang F., Carothers J.M., Keasling J.D. Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids. Nat Biotechnol 2012, 30:354-359.
    • (2012) Nat Biotechnol , vol.30 , pp. 354-359
    • Zhang, F.1    Carothers, J.M.2    Keasling, J.D.3
  • 68
    • 77950863739 scopus 로고    scopus 로고
    • Use of modular, synthetic scaffolds for improved production of glucaric acid in engineered E. coli
    • Moon T.S., Dueber J.E., Shiue E., Prather K.L. Use of modular, synthetic scaffolds for improved production of glucaric acid in engineered E. coli. Metab Eng 2010, 12:298-305.
    • (2010) Metab Eng , vol.12 , pp. 298-305
    • Moon, T.S.1    Dueber, J.E.2    Shiue, E.3    Prather, K.L.4
  • 69
    • 84855229099 scopus 로고    scopus 로고
    • Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells
    • Wang Y.C., Yu O. Synthetic scaffolds increased resveratrol biosynthesis in engineered yeast cells. J Biotechnol 2012, 157:258-260.
    • (2012) J Biotechnol , vol.157 , pp. 258-260
    • Wang, Y.C.1    Yu, O.2
  • 73
    • 84866280237 scopus 로고    scopus 로고
    • Interactions between the termini of lumen enzymes and shell proteins mediate enzyme encapsulation into bacterial microcompartments
    • Fan C.G., Cheng S.Q., Sinha S., Bobik T.A. Interactions between the termini of lumen enzymes and shell proteins mediate enzyme encapsulation into bacterial microcompartments. Proc Natl Acad Sci U S A 2012, 109:14995-15000.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 14995-15000
    • Fan, C.G.1    Cheng, S.Q.2    Sinha, S.3    Bobik, T.A.4
  • 74
    • 73349139923 scopus 로고    scopus 로고
    • Synthesis of DNA fragments in yeast by one-step assembly of overlapping oligonucleotides
    • Gibson D.G. Synthesis of DNA fragments in yeast by one-step assembly of overlapping oligonucleotides. Nucleic Acids Res 2009, 37:6984-6990.
    • (2009) Nucleic Acids Res , vol.37 , pp. 6984-6990
    • Gibson, D.G.1
  • 75
    • 84865611750 scopus 로고    scopus 로고
    • Harnessing recombination to speed adaptive evolution in Escherichia coli
    • Winkler J., Kao K.C. Harnessing recombination to speed adaptive evolution in Escherichia coli. Metab Eng 2012, 14:487-495.
    • (2012) Metab Eng , vol.14 , pp. 487-495
    • Winkler, J.1    Kao, K.C.2


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