Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 47, 2012, Pages 19504-19509

  Michener, Joshua K ^a,d   Nielsen, Jens ^b   Smolke, Christina D ^c  

^a California Institute of Technology   (United States)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c Stanford University   (United States)

^d HARVARD UNIVERSITY   (United States)

Author keywords

CYP102A1; Cytochrome P450; Systems biology; Yeast

Indexed keywords

CYTOCHROME P450; ENZYME VARIANT; HEME;

ARTICLE; BIOSYNTHESIS; CELL MEMBRANE; CELL STRESS; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME LOCALIZATION; GENE OVEREXPRESSION; HETEROLOGOUS EXPRESSION; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

CYTOCHROME P-450 ENZYME SYSTEM; CYTOSOL; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION, FUNGAL; HEME; INTRACELLULAR SPACE; METABOLIC NETWORKS AND PATHWAYS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHYLOGENY; PROTEASOME ENDOPEPTIDASE COMPLEX; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; STRESS, PHYSIOLOGICAL; SYSTEMS BIOLOGY; THEOPHYLLINE;

SACCHAROMYCES CEREVISIAE;

EID: 84869744652     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1212287109     Document Type: Article

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