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Volumn 24, Issue 6, 2013, Pages 1151-1158

Meta-omic characterization of prokaryotic gene clusters for natural product biosynthesis

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATIC TOOLS; BIOSYNTHETIC ENZYMES; BIOSYNTHETIC GENE CLUSTER; DIRECT SEQUENCING; METAGENOMIC LIBRARIES; MICROBIAL COMMUNITIES; NATURAL PRODUCTS; SECONDARY METABOLITES;

EID: 84887622208     PISSN: 09581669     EISSN: 18790429     Source Type: Journal    
DOI: 10.1016/j.copbio.2013.05.001     Document Type: Review
Times cited : (25)

References (70)
  • 1
    • 34247109045 scopus 로고    scopus 로고
    • Natural products as sources of new drugs over the last 25 years
    • Newman D.J., Cragg G.M. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007, 70:461-477.
    • (2007) J Nat Prod , vol.70 , pp. 461-477
    • Newman, D.J.1    Cragg, G.M.2
  • 2
    • 84860510662 scopus 로고    scopus 로고
    • Role of natural products in drug discovery
    • John Wiley & Sons, Inc. Z. Rankovic, R. Morphy (Eds.)
    • Lachance H., Wetzel S., Waldmann H. Role of natural products in drug discovery. Lead Generation Approaches in Drug Discovery 2010, 187-229. John Wiley & Sons, Inc. Z. Rankovic, R. Morphy (Eds.).
    • (2010) Lead Generation Approaches in Drug Discovery , pp. 187-229
    • Lachance, H.1    Wetzel, S.2    Waldmann, H.3
  • 4
    • 80053243567 scopus 로고    scopus 로고
    • Approaches to capturing and designing biologically active small molecules produced by uncultured microbes
    • Piel J. Approaches to capturing and designing biologically active small molecules produced by uncultured microbes. Annu Rev Microbiol 2011, 65:431-453.
    • (2011) Annu Rev Microbiol , vol.65 , pp. 431-453
    • Piel, J.1
  • 7
    • 0005292858 scopus 로고
    • Cosmids: a type of plasmid gene-cloning vector that is packagable in vitro in bacteriophage lambda heads
    • Collins J., Hohn B. Cosmids: a type of plasmid gene-cloning vector that is packagable in vitro in bacteriophage lambda heads. Proc Natl Acad Sci U S A 1978, 75:4242-4246.
    • (1978) Proc Natl Acad Sci U S A , vol.75 , pp. 4242-4246
    • Collins, J.1    Hohn, B.2
  • 8
    • 0026594245 scopus 로고
    • Stable propagation of cosmid sized human DNA inserts in an F factor based vector
    • Kim U.J., Shizuya H., de Jong P.J., Birren B., Simon M.I. Stable propagation of cosmid sized human DNA inserts in an F factor based vector. Nucleic Acids Res 1992, 20:1083-1085.
    • (1992) Nucleic Acids Res , vol.20 , pp. 1083-1085
    • Kim, U.J.1    Shizuya, H.2    de Jong, P.J.3    Birren, B.4    Simon, M.I.5
  • 9
    • 84866063474 scopus 로고    scopus 로고
    • Artificial chromosomes to explore and to exploit biosynthetic capabilities of actinomycetes
    • Alduina R., Gallo G. Artificial chromosomes to explore and to exploit biosynthetic capabilities of actinomycetes. J Biomed Biotechnol 2012, 2012:462049.
    • (2012) J Biomed Biotechnol , vol.2012 , pp. 462049
    • Alduina, R.1    Gallo, G.2
  • 10
    • 0026703169 scopus 로고
    • Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector
    • Shizuya H., Birren B., Kim U.J., Mancino V., Slepak T., Tachiiri Y., Simon M. Cloning and stable maintenance of 300-kilobase-pair fragments of human DNA in Escherichia coli using an F-factor-based vector. Proc Natl Acad Sci U S A 1992, 89:8794-8797.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 8794-8797
    • Shizuya, H.1    Birren, B.2    Kim, U.J.3    Mancino, V.4    Slepak, T.5    Tachiiri, Y.6    Simon, M.7
  • 12
    • 84855263216 scopus 로고    scopus 로고
    • Cloning and heterologous expression of the vibrioferrin biosynthetic gene cluster from a marine metagenomic library
    • Fujita M.J., Kimura N., Sakai A., Ichikawa Y., Hanyu T., Otsuka M. Cloning and heterologous expression of the vibrioferrin biosynthetic gene cluster from a marine metagenomic library. Biosci Biotechnol Biochem 2011, 75:2283-2287.
    • (2011) Biosci Biotechnol Biochem , vol.75 , pp. 2283-2287
    • Fujita, M.J.1    Kimura, N.2    Sakai, A.3    Ichikawa, Y.4    Hanyu, T.5    Otsuka, M.6
  • 13
    • 77649206077 scopus 로고    scopus 로고
    • Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria
    • Craig J.W., Chang F.Y., Kim J.H., Obiajulu S.C., Brady S.F. Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria. Appl Environ Microbiol 2010, 76:1633-1641.
    • (2010) Appl Environ Microbiol , vol.76 , pp. 1633-1641
    • Craig, J.W.1    Chang, F.Y.2    Kim, J.H.3    Obiajulu, S.C.4    Brady, S.F.5
  • 14
    • 84861137576 scopus 로고    scopus 로고
    • Metagenomic analysis of Streptomyces lividans reveals host-dependent functional expression
    • McMahon M.D., Guan C., Handelsman J., Thomas M.G. Metagenomic analysis of Streptomyces lividans reveals host-dependent functional expression. Appl Environ Microbiol 2012, 78:3622-3629.
    • (2012) Appl Environ Microbiol , vol.78 , pp. 3622-3629
    • McMahon, M.D.1    Guan, C.2    Handelsman, J.3    Thomas, M.G.4
  • 15
    • 84858984727 scopus 로고    scopus 로고
    • Heterologous expression and genetic engineering of the tubulysin biosynthetic gene cluster using Red/ET recombineering and inactivation mutagenesis
    • Chai Y., Shan S., Weissman K.J., Hu S., Zhang Y., Müller R. Heterologous expression and genetic engineering of the tubulysin biosynthetic gene cluster using Red/ET recombineering and inactivation mutagenesis. Chem Biol 2012, 19:361-371.
    • (2012) Chem Biol , vol.19 , pp. 361-371
    • Chai, Y.1    Shan, S.2    Weissman, K.J.3    Hu, S.4    Zhang, Y.5    Müller, R.6
  • 16
    • 84869861429 scopus 로고    scopus 로고
    • Genome-based bioprospecting of microbes for new therapeutics
    • Zotchev S.B., Sekurova O.N., Katz L. Genome-based bioprospecting of microbes for new therapeutics. Curr Opin Biotechnol 2012, 23:941-947.
    • (2012) Curr Opin Biotechnol , vol.23 , pp. 941-947
    • Zotchev, S.B.1    Sekurova, O.N.2    Katz, L.3
  • 17
    • 64049106903 scopus 로고    scopus 로고
    • Heterologous production of polyketides in bacteria
    • Rodriguez E., Menzella H.G., Gramajo H. Heterologous production of polyketides in bacteria. Methods Enzymol 2009, 459:339-365.
    • (2009) Methods Enzymol , vol.459 , pp. 339-365
    • Rodriguez, E.1    Menzella, H.G.2    Gramajo, H.3
  • 18
    • 27844461167 scopus 로고    scopus 로고
    • Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways
    • Wenzel S.C., Müller R. Recent developments towards the heterologous expression of complex bacterial natural product biosynthetic pathways. Curr Opin Biotechnol 2005, 16:594-606.
    • (2005) Curr Opin Biotechnol , vol.16 , pp. 594-606
    • Wenzel, S.C.1    Müller, R.2
  • 19
    • 78649391538 scopus 로고    scopus 로고
    • Methods and options for the heterologous production of complex natural products
    • Zhang H., Boghigian B.A., Armando J., Pfeifer B.A. Methods and options for the heterologous production of complex natural products. Nat Prod Rep 2011, 28:125-151.
    • (2011) Nat Prod Rep , vol.28 , pp. 125-151
    • Zhang, H.1    Boghigian, B.A.2    Armando, J.3    Pfeifer, B.A.4
  • 20
    • 79957977760 scopus 로고    scopus 로고
    • The art and design of functional metagenomic screens
    • Taupp M., Mewis K., Hallam S.J. The art and design of functional metagenomic screens. Curr Opin Biotechnol 2011, 22:465-472.
    • (2011) Curr Opin Biotechnol , vol.22 , pp. 465-472
    • Taupp, M.1    Mewis, K.2    Hallam, S.J.3
  • 21
    • 70350230400 scopus 로고    scopus 로고
    • Metagenomic approaches to natural products from free-living and symbiotic organisms
    • Brady S.F., Simmons L., Kim J.H., Schmidt E.W. Metagenomic approaches to natural products from free-living and symbiotic organisms. Nat Prod Rep 2009, 26:1488-1503.
    • (2009) Nat Prod Rep , vol.26 , pp. 1488-1503
    • Brady, S.F.1    Simmons, L.2    Kim, J.H.3    Schmidt, E.W.4
  • 22
    • 84856403295 scopus 로고    scopus 로고
    • The great screen anomaly - a new frontier in product discovery through functional metagenomics
    • Ekkers D.M., Cretoiu M.S., Kielak A.M., Elsas J.D. The great screen anomaly - a new frontier in product discovery through functional metagenomics. Appl Microbiol Biotechnol 2012, 93:1005-1020.
    • (2012) Appl Microbiol Biotechnol , vol.93 , pp. 1005-1020
    • Ekkers, D.M.1    Cretoiu, M.S.2    Kielak, A.M.3    Elsas, J.D.4
  • 23
    • 84859988527 scopus 로고    scopus 로고
    • A functional screen for recovery of 4'-phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries
    • Owen J.G., Robins K.J., Parachin N.S., Ackerley D.F. A functional screen for recovery of 4'-phosphopantetheinyl transferase and associated natural product biosynthesis genes from metagenome libraries. Environ Microbiol 2012, 14:1198-1209.
    • (2012) Environ Microbiol , vol.14 , pp. 1198-1209
    • Owen, J.G.1    Robins, K.J.2    Parachin, N.S.3    Ackerley, D.F.4
  • 24
    • 79961225518 scopus 로고    scopus 로고
    • Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites
    • Feng Z., Kallifidas D., Brady S.F. Functional analysis of environmental DNA-derived type II polyketide synthases reveals structurally diverse secondary metabolites. Proc Natl Acad Sci U S A 2011, 108:12629-12634.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 12629-12634
    • Feng, Z.1    Kallifidas, D.2    Brady, S.F.3
  • 27
    • 84856770811 scopus 로고    scopus 로고
    • Direct comparisons of Illumina vs, Roche 454 sequencing technologies on the same microbial community DNA sample
    • Luo C., Tsementzi D., Kyrpides N., Read T., Konstantinidis K.T. Direct comparisons of Illumina vs, Roche 454 sequencing technologies on the same microbial community DNA sample. PLoS ONE 2012, 7:e30087.
    • (2012) PLoS ONE , vol.7
    • Luo, C.1    Tsementzi, D.2    Kyrpides, N.3    Read, T.4    Konstantinidis, K.T.5
  • 28
    • 84866174523 scopus 로고    scopus 로고
    • Genomic approaches to studying the human microbiota
    • Weinstock G.M. Genomic approaches to studying the human microbiota. Nature 2012, 489:250-256.
    • (2012) Nature , vol.489 , pp. 250-256
    • Weinstock, G.M.1
  • 32
    • 79952937941 scopus 로고    scopus 로고
    • Variation in tropical reef symbiont metagenomes defined by secondary metabolism
    • Donia M.S., Fricke W.F., Ravel J., Schmidt E.W. Variation in tropical reef symbiont metagenomes defined by secondary metabolism. PLoS ONE 2011, 6:e17897.
    • (2011) PLoS ONE , vol.6
    • Donia, M.S.1    Fricke, W.F.2    Ravel, J.3    Schmidt, E.W.4
  • 35
    • 81555208983 scopus 로고    scopus 로고
    • Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743
    • Rath C.M., Janto B., Earl J., Ahmed A., Hu F.Z., Hiller L., Dahlgren M., Kreft R., Yu F., Wolff J.J., et al. Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chem Biol 2011, 6:1244-1256.
    • (2011) ACS Chem Biol , vol.6 , pp. 1244-1256
    • Rath, C.M.1    Janto, B.2    Earl, J.3    Ahmed, A.4    Hu, F.Z.5    Hiller, L.6    Dahlgren, M.7    Kreft, R.8    Yu, F.9    Wolff, J.J.10
  • 36
    • 84864394611 scopus 로고    scopus 로고
    • Genomic sequencing of uncultured microorganisms from single cells
    • Lasken R.S. Genomic sequencing of uncultured microorganisms from single cells. Nat Rev Microbiol 2012, 10:631-640.
    • (2012) Nat Rev Microbiol , vol.10 , pp. 631-640
    • Lasken, R.S.1
  • 37
    • 78649723307 scopus 로고    scopus 로고
    • PKS and NRPS gene clusters from microbial symbiont cells of marine sponges by whole genome amplification
    • Siegl A., Hentschel U. PKS and NRPS gene clusters from microbial symbiont cells of marine sponges by whole genome amplification. Environ Microbiol Rep 2009, 2:507-513.
    • (2009) Environ Microbiol Rep , vol.2 , pp. 507-513
    • Siegl, A.1    Hentschel, U.2
  • 38
    • 78650591665 scopus 로고    scopus 로고
    • Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges
    • Siegl A., Kamke J., Hochmuth T., Piel J., Richter M., Liang C., Dandekar T., Hentschel U. Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges. ISME J 2011, 5:61-70.
    • (2011) ISME J , vol.5 , pp. 61-70
    • Siegl, A.1    Kamke, J.2    Hochmuth, T.3    Piel, J.4    Richter, M.5    Liang, C.6    Dandekar, T.7    Hentschel, U.8
  • 40
    • 84860714868 scopus 로고    scopus 로고
    • Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites
    • Engene N., Rottacker E.C., Kaštovský J., Byrum T., Choi H., Ellisman M.H., Komárek J., Gerwick W.H. Moorea producens gen. nov., sp. nov. and Moorea bouillonii comb. nov., tropical marine cyanobacteria rich in bioactive secondary metabolites. Int J Syst Evol Microbiol 2012, 62:1171-1178.
    • (2012) Int J Syst Evol Microbiol , vol.62 , pp. 1171-1178
    • Engene, N.1    Rottacker, E.C.2    Kaštovský, J.3    Byrum, T.4    Choi, H.5    Ellisman, M.H.6    Komárek, J.7    Gerwick, W.H.8
  • 42
    • 84869998312 scopus 로고    scopus 로고
    • Current opportunities and challenges in microbial metagenome analysis - a bioinformatic perspective
    • Teeling H., Glöckner F.O. Current opportunities and challenges in microbial metagenome analysis - a bioinformatic perspective. Brief Bioinform 2012, 13:728-742.
    • (2012) Brief Bioinform , vol.13 , pp. 728-742
    • Teeling, H.1    Glöckner, F.O.2
  • 43
    • 84856496549 scopus 로고    scopus 로고
    • Next generation sequencing and bioinformatic bottlenecks: the current state of metagenomic data analysis
    • Scholz M.B., Lo C.C., Chain P.S. Next generation sequencing and bioinformatic bottlenecks: the current state of metagenomic data analysis. Curr Opin Biotechnol 2012, 23:9-15.
    • (2012) Curr Opin Biotechnol , vol.23 , pp. 9-15
    • Scholz, M.B.1    Lo, C.C.2    Chain, P.S.3
  • 45
    • 79959983606 scopus 로고    scopus 로고
    • Kernel based machine learning algorithm for the efficient prediction of type III polyketide synthase family of proteins
    • Mallika V., Sivakumar K.C., Jaichand S., Soniya E.V. Kernel based machine learning algorithm for the efficient prediction of type III polyketide synthase family of proteins. J Integr Bioinform 2010, 7:143.
    • (2010) J Integr Bioinform , vol.7 , pp. 143
    • Mallika, V.1    Sivakumar, K.C.2    Jaichand, S.3    Soniya, E.V.4
  • 47
    • 84859078407 scopus 로고    scopus 로고
    • The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity
    • Ziemert N., Podell S., Penn K., Badger J.H., Allen E., Jensen P.R. The natural product domain seeker NaPDoS: a phylogeny based bioinformatic tool to classify secondary metabolite gene diversity. PLoS ONE 2012, 7:e34064.
    • (2012) PLoS ONE , vol.7
    • Ziemert, N.1    Podell, S.2    Penn, K.3    Badger, J.H.4    Allen, E.5    Jensen, P.R.6
  • 48
    • 84856406381 scopus 로고    scopus 로고
    • Lessons from the past and charting the future of marine natural products drug discovery and chemical biology
    • Gerwick W.H., Moore B.S. Lessons from the past and charting the future of marine natural products drug discovery and chemical biology. Chem Biol 2012, 19:85-98.
    • (2012) Chem Biol , vol.19 , pp. 85-98
    • Gerwick, W.H.1    Moore, B.S.2
  • 49
    • 85047689741 scopus 로고    scopus 로고
    • Bacterial symbionts: prospects for the sustainable production of invertebrate-derived pharmaceuticals
    • Piel J. Bacterial symbionts: prospects for the sustainable production of invertebrate-derived pharmaceuticals. Curr Med Chem 2006, 13:39-50.
    • (2006) Curr Med Chem , vol.13 , pp. 39-50
    • Piel, J.1
  • 51
    • 79851512980 scopus 로고    scopus 로고
    • Proteomic analysis of polyketide and nonribosomal peptide biosynthesis
    • Meier J.L., Burkart M.D. Proteomic analysis of polyketide and nonribosomal peptide biosynthesis. Curr Opin Chem Biol 2011, 15:48-56.
    • (2011) Curr Opin Chem Biol , vol.15 , pp. 48-56
    • Meier, J.L.1    Burkart, M.D.2
  • 52
    • 79851515868 scopus 로고    scopus 로고
    • Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms
    • Chiang Y.M., Chang S.L., Oakley B.R., Wang C.C. Recent advances in awakening silent biosynthetic gene clusters and linking orphan clusters to natural products in microorganisms. Curr Opin Chem Biol 2011, 15:137-143.
    • (2011) Curr Opin Chem Biol , vol.15 , pp. 137-143
    • Chiang, Y.M.1    Chang, S.L.2    Oakley, B.R.3    Wang, C.C.4
  • 53
    • 73449131845 scopus 로고    scopus 로고
    • An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis
    • Meier J.L., Niessen S., Hoover H.S., Foley T.L., Cravatt B.F., Burkart M.D. An orthogonal active site identification system (OASIS) for proteomic profiling of natural product biosynthesis. ACS Chem Biol 2009, 4:948-957.
    • (2009) ACS Chem Biol , vol.4 , pp. 948-957
    • Meier, J.L.1    Niessen, S.2    Hoover, H.S.3    Foley, T.L.4    Cravatt, B.F.5    Burkart, M.D.6
  • 54
    • 70349959824 scopus 로고    scopus 로고
    • A proteomics approach to discovering natural products and their biosynthetic pathways
    • Bumpus S.B., Evans B.S., Thomas P.M., Ntai I., Kelleher N.L. A proteomics approach to discovering natural products and their biosynthetic pathways. Nat Biotechnol 2009, 27:951-956.
    • (2009) Nat Biotechnol , vol.27 , pp. 951-956
    • Bumpus, S.B.1    Evans, B.S.2    Thomas, P.M.3    Ntai, I.4    Kelleher, N.L.5
  • 56
    • 42949128785 scopus 로고    scopus 로고
    • Fluorescent profiling of modular biosynthetic enzymes by complementary metabolic and activity based probes
    • Meier J.L., Mercer A.C., Burkart M.D. Fluorescent profiling of modular biosynthetic enzymes by complementary metabolic and activity based probes. J Am Chem Soc 2008, 130:5443-5445.
    • (2008) J Am Chem Soc , vol.130 , pp. 5443-5445
    • Meier, J.L.1    Mercer, A.C.2    Burkart, M.D.3
  • 57
    • 65549114937 scopus 로고    scopus 로고
    • In vivo modification of native carrier protein domains
    • Mercer A.C., Meier J.L., Torpey J.W., Burkart M.D. In vivo modification of native carrier protein domains. Chembiochem 2009, 10:1091-1100.
    • (2009) Chembiochem , vol.10 , pp. 1091-1100
    • Mercer, A.C.1    Meier, J.L.2    Torpey, J.W.3    Burkart, M.D.4
  • 58
    • 79955924618 scopus 로고    scopus 로고
    • Proteomics-based discovery of koranimine, a cyclic imine natural product
    • Evans B.S., Ntai I., Chen Y., Robinson S.J., Kelleher N.L. Proteomics-based discovery of koranimine, a cyclic imine natural product. J Am Chem Soc 2011, 133:7316-7319.
    • (2011) J Am Chem Soc , vol.133 , pp. 7316-7319
    • Evans, B.S.1    Ntai, I.2    Chen, Y.3    Robinson, S.J.4    Kelleher, N.L.5
  • 59
    • 84861582277 scopus 로고    scopus 로고
    • NMR in metabolomics and natural products research: two sides of the same coin
    • Robinette S.L., Brushweiler R., Schroeder F.C., Edison A.S. NMR in metabolomics and natural products research: two sides of the same coin. Acc Chem Res 2012, 45:288-297.
    • (2012) Acc Chem Res , vol.45 , pp. 288-297
    • Robinette, S.L.1    Brushweiler, R.2    Schroeder, F.C.3    Edison, A.S.4
  • 60
    • 79851516184 scopus 로고    scopus 로고
    • NMR-spectroscopic analysis of mixtures: from structure to function
    • Forseth R.R., Schroeder F.C. NMR-spectroscopic analysis of mixtures: from structure to function. Curr Opin Chem Biol 2011, 15:38-47.
    • (2011) Curr Opin Chem Biol , vol.15 , pp. 38-47
    • Forseth, R.R.1    Schroeder, F.C.2
  • 61
    • 84861179772 scopus 로고    scopus 로고
    • Microbial strain prioritization using metabolomics tools for the discovery of natural products
    • Hou Y., Braun D.R., Michel C.R., Klassen J.L., Adnani N., Wyche T.P., Bugni T.S. Microbial strain prioritization using metabolomics tools for the discovery of natural products. Anal Chem 2012, 84:4277-4283.
    • (2012) Anal Chem , vol.84 , pp. 4277-4283
    • Hou, Y.1    Braun, D.R.2    Michel, C.R.3    Klassen, J.L.4    Adnani, N.5    Wyche, T.P.6    Bugni, T.S.7
  • 62
    • 84855805908 scopus 로고    scopus 로고
    • Myxoprincomide: a natural product from Myxococcus xanthus discovered by comprehensive analysis of the secondary metabolome
    • Cortina N.S., Krug D., Plaza A., Revermann O., Müller R. Myxoprincomide: a natural product from Myxococcus xanthus discovered by comprehensive analysis of the secondary metabolome. Angew Chem Int Ed Engl 2012, 51:811-816.
    • (2012) Angew Chem Int Ed Engl , vol.51 , pp. 811-816
    • Cortina, N.S.1    Krug, D.2    Plaza, A.3    Revermann, O.4    Müller, R.5
  • 63
    • 79959498224 scopus 로고    scopus 로고
    • Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis
    • Forseth R.R., Fox E.M., Chung D., Howlett B.J., Keller N.P., Schroeder F.C. Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis. J Am Chem Soc 2011, 133:9678-9681.
    • (2011) J Am Chem Soc , vol.133 , pp. 9678-9681
    • Forseth, R.R.1    Fox, E.M.2    Chung, D.3    Howlett, B.J.4    Keller, N.P.5    Schroeder, F.C.6
  • 64
    • 84934434481 scopus 로고    scopus 로고
    • Correlating secondary metabolite production with genetic changes using differential analysis of 2D NMR spectra
    • Forseth R.R., Schroeder F.C. Correlating secondary metabolite production with genetic changes using differential analysis of 2D NMR spectra. Methods Mol Biol 2012, 944:207-219.
    • (2012) Methods Mol Biol , vol.944 , pp. 207-219
    • Forseth, R.R.1    Schroeder, F.C.2
  • 65
    • 84859945291 scopus 로고    scopus 로고
    • Metatranscriptomics of the marine sponge Geodia barretti: tackling phylogeny and function of its microbial community
    • Radax R., Rattei T., Lanzen A., Bayer C., Rapp H.T., Urich T., Schleper C. Metatranscriptomics of the marine sponge Geodia barretti: tackling phylogeny and function of its microbial community. Environ Microbiol 2012, 14:1308-1324.
    • (2012) Environ Microbiol , vol.14 , pp. 1308-1324
    • Radax, R.1    Rattei, T.2    Lanzen, A.3    Bayer, C.4    Rapp, H.T.5    Urich, T.6    Schleper, C.7
  • 66
    • 84856373733 scopus 로고    scopus 로고
    • Culture-independent methods for studying environmental microorganisms: methods, application, and perspective
    • Su C., Lei L., Duan Y., Zhang K.Q., Yang J. Culture-independent methods for studying environmental microorganisms: methods, application, and perspective. Appl Microbiol Biotechnol 2012, 93:993-1003.
    • (2012) Appl Microbiol Biotechnol , vol.93 , pp. 993-1003
    • Su, C.1    Lei, L.2    Duan, Y.3    Zhang, K.Q.4    Yang, J.5
  • 67
    • 84858444651 scopus 로고    scopus 로고
    • Metatranscriptomic analysis of sulfur oxidation genes in the endosymbiont of solemya velum
    • Stewart F.J., Dmytrenko O., Delong E.F., Cavanaugh C.M. Metatranscriptomic analysis of sulfur oxidation genes in the endosymbiont of solemya velum. Front Microbiol 2011, 2:134.
    • (2011) Front Microbiol , vol.2 , pp. 134
    • Stewart, F.J.1    Dmytrenko, O.2    Delong, E.F.3    Cavanaugh, C.M.4
  • 68
    • 84865161156 scopus 로고    scopus 로고
    • Cultivation of unculturable soil bacteria
    • Pham V.H., Kim J. Cultivation of unculturable soil bacteria. Trends Biotechnol 2012, 30:475-484.
    • (2012) Trends Biotechnol , vol.30 , pp. 475-484
    • Pham, V.H.1    Kim, J.2
  • 69
    • 84866332775 scopus 로고    scopus 로고
    • Growing unculturable bacteria
    • Stewart E.J. Growing unculturable bacteria. J Bacteriol 2012, 194:4151-4160.
    • (2012) J Bacteriol , vol.194 , pp. 4151-4160
    • Stewart, E.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.