메뉴 건너뛰기




Volumn 65, Issue , 2011, Pages 431-453

Approaches to capturing and designing biologically active small molecules produced by uncultured microbes

Author keywords

Biosynthesis; Community; Metagenomics; Single cell analysis; Symbiotic bacteria; Uncultivated bacteria

Indexed keywords

BACTERIAL DNA; BRYOSTATIN; INDIRUBIN; NATURAL PRODUCT; RHIZOXIN; ULITHIACYCLAMIDE;

EID: 80053243567     PISSN: 00664227     EISSN: 15453251     Source Type: Book Series    
DOI: 10.1146/annurev-micro-090110-102805     Document Type: Review
Times cited : (90)

References (144)
  • 1
    • 0028946084 scopus 로고
    • Phylogenetic identification and in-situ detection of individual microbial cells without cultivation
    • Amann RI, LudwigW,SchleiferKH. 1995. Phylogenetic identification and in-situ detection of individual microbial cells without cultivation. Microbiol. Rev. 59:143-69
    • (1995) Microbiol. Rev. , vol.59 , pp. 143-69
    • Amann, R.I.1    Ludwig, W.2    Schleifer, K.H.3
  • 3
    • 67349209853 scopus 로고    scopus 로고
    • Next-generation DNA sequencing techniques
    • AnsorgeWJ. 2009. Next-generation DNA sequencing techniques. New Biotechnol. 25:195-203
    • (2009) New Biotechnol. , vol.25 , pp. 195-203
    • Ansorge, W.J.1
  • 4
    • 56249128990 scopus 로고    scopus 로고
    • Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary
    • Banik JJ, Brady SF. 2008. Cloning and characterization of new glycopeptide gene clusters found in an environmental DNA megalibrary. Proc. Natl. Acad. Sci. USA 105:17273-77
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 17273-77
    • Banik, J.J.1    Brady, S.F.2
  • 5
    • 77952997484 scopus 로고    scopus 로고
    • Utahmycins A and B, azaquinones produced by an environmental DNA clone
    • Bauer JD, King RW, Brady SF. 2010. Utahmycins A and B, azaquinones produced by an environmental DNA clone. J. Nat. Prod. 73:976-79
    • (2010) J. Nat. Prod. , vol.73 , pp. 976-79
    • Bauer, J.D.1    King, R.W.2    Brady, S.F.3
  • 6
    • 0029794187 scopus 로고    scopus 로고
    • Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts
    • Bewley CA, Holland ND, Faulkner DJ. 1996. Two classes of metabolites from Theonella swinhoei are localized in distinct populations of bacterial symbionts. Experientia 52:716-22 (Pubitemid 26318633)
    • (1996) Experientia , vol.52 , Issue.7 , pp. 716-722
    • Bewley, C.A.1    Holland, N.D.2    Faulkner, D.J.3
  • 7
    • 40249095175 scopus 로고    scopus 로고
    • Something from (almost) nothing: The impact of multiple displacement amplification on microbial ecology
    • DOI 10.1038/ismej.2008.10, PII ISMEJ200810
    • Binga EK, Lasken RS, Neufeld JD. 2008. Something from (almost) nothing: the impact of multiple displacement amplification on microbial ecology. ISME J. 2:233-41 (Pubitemid 351334272)
    • (2008) ISME Journal , vol.2 , Issue.3 , pp. 233-241
    • Binga, E.K.1    Lasken, R.S.2    Neufeld, J.D.3
  • 9
    • 34250220631 scopus 로고    scopus 로고
    • Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules
    • DOI 10.1038/nprot.2007.195, PII NPROT.2007.195
    • Brady SF. 2007. Construction of soil environmental DNA cosmid libraries and screening for clones that produce biologically active small molecules. Nat. Prot. 2:1297-305 (Pubitemid 46901307)
    • (2007) Nature Protocols , vol.2 , Issue.5 , pp. 1297-1305
    • Brady, S.F.1
  • 10
    • 35048880555 scopus 로고    scopus 로고
    • Natural products from isnA-containing biosynthetic gene clusters recovered from the genomes of cultured and uncultured bacteria
    • DOI 10.1021/ja075492v
    • Brady SF, Bauer JD, Clarke-Pearson MF, Daniels R. 2007. Natural products from isnA-containing biosynthetic gene clusters recovered from the genomes of cultured and uncultured bacteria. J. Am. Chem. Soc. 129:12102-3 (Pubitemid 47556840)
    • (2007) Journal of the American Chemical Society , vol.129 , Issue.40 , pp. 12102-12103
    • Brady, S.F.1    Bauer, J.D.2    Clarke-Pearson, M.F.3    Daniels, R.4
  • 11
    • 0037189889 scopus 로고    scopus 로고
    • New natural product families from an environmental DNA (eDNA) gene cluster
    • DOI 10.1021/ja0268985
    • Brady SF, Chao CJ, Clardy J. 2002. New natural product families from an environmental DNA (eDNA) gene cluster. J. Am. Chem. Soc. 124:9968-69 (Pubitemid 34919716)
    • (2002) Journal of the American Chemical Society , vol.124 , Issue.34 , pp. 9968-9969
    • Brady, S.F.1    Chao, C.J.2    Clardy, J.3
  • 12
    • 8744289725 scopus 로고    scopus 로고
    • Long-chain N-acyltyrosine synthases from environmental DNA
    • DOI 10.1128/AEM.70.11.6865-6870.2004
    • Brady SF, Chao CJ, Clardy J. 2004. Long-chain N-acyltyrosine synthases from environmental DNA. Appl. Environ. Microbiol. 70:6865-70 (Pubitemid 39518599)
    • (2004) Applied and Environmental Microbiology , vol.70 , Issue.11 , pp. 6865-6870
    • Brady, S.F.1    Chao, C.J.2    Clardy, J.3
  • 13
    • 0035963668 scopus 로고    scopus 로고
    • Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA
    • Brady SF, Chao CJ, Handelsman J, Clardy J. 2001. Cloning and heterologous expression of a natural product biosynthetic gene cluster from eDNA. Org. Lett. 3:1981-84
    • (2001) Org. Lett. , vol.3 , pp. 1981-84
    • Brady, S.F.1    Chao, C.J.2    Handelsman, J.3    Clardy, J.4
  • 14
    • 4344625255 scopus 로고    scopus 로고
    • Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water
    • DOI 10.1021/np0499766
    • Brady SF, Clardy J. 2004. Palmitoylputrescine, an antibiotic isolated from the heterologous expression of DNA extracted from bromeliad tank water. J. Nat. Prod. 67:1283-86 (Pubitemid 39145630)
    • (2004) Journal of Natural Products , vol.67 , Issue.8 , pp. 1283-1286
    • Brady, S.F.1    Clardy, J.2
  • 15
    • 27744453364 scopus 로고    scopus 로고
    • Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA
    • DOI 10.1002/anie.200501941
    • Brady SF, Clardy J. 2005. Cloning and heterologous expression of isocyanide biosynthetic genes from environmental DNA. Angew. Chem. Int. Ed. 44:7063-65 (Pubitemid 41587572)
    • (2005) Angewandte Chemie - International Edition , vol.44 , Issue.43 , pp. 7063-7065
    • Brady, S.F.1    Clardy, J.2
  • 16
    • 27744497479 scopus 로고    scopus 로고
    • Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom
    • DOI 10.1002/anie.200501942
    • Brady SF, Clardy J. 2005. Systematic investigation of the Escherichia coli metabolome for the biosynthetic origin of an isocyanide carbon atom. Angew. Chem. Int. Ed. 44:7045-48 (Pubitemid 41587570)
    • (2005) Angewandte Chemie - International Edition , vol.44 , Issue.43 , pp. 7045-7048
    • Brady, S.F.1    Clardy, J.2
  • 17
    • 70350230400 scopus 로고    scopus 로고
    • Metagenomic approaches to natural products from free-living and symbiotic organisms
    • Brady SF, Simmons L, Kim JH, Schmidt EW. 2009. Metagenomic approaches to natural products from free-living and symbiotic organisms. Nat. Prod. Rep. 26:1488-503
    • (2009) Nat. Prod. Rep. , vol.26 , pp. 1488-503
    • Brady, S.F.1    Simmons, L.2    Kim, J.H.3    Schmidt, E.W.4
  • 18
    • 80053249217 scopus 로고
    • Bis-(3-indolyl)-3H-indolylide methane, dye formed by Saccharomyces cerevisiae
    • Budzikie H, Eckau H, Ehrenber M. 1972. Bis-(3-indolyl)-3H-indolylide methane, dye formed by Saccharomyces cerevisiae. Tetrahedron Lett. 36:3807-10
    • (1972) Tetrahedron Lett. , vol.36 , pp. 3807-10
    • Budzikie, H.1    Eckau, H.2    Ehrenber, M.3
  • 19
    • 0034711399 scopus 로고    scopus 로고
    • Dissecting the chain length specificity in bacterial aromatic polyketide synthases using chimeric genes
    • Burson KK, Khosla C. 2000. Dissecting the chain length specificity in bacterial aromatic polyketide synthases using chimeric genes. Tetrahedron 56:9401-8
    • (2000) Tetrahedron , vol.56 , pp. 9401-8
    • Burson, K.K.1    Khosla, C.2
  • 20
    • 0033485280 scopus 로고    scopus 로고
    • The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases
    • Cane DE, Walsh CT. 1999. The parallel and convergent universes of polyketide synthases and nonribosomal peptide synthetases. Chem. Biol. 6:R319-25
    • (1999) Chem. Biol. , vol.6
    • Cane, D.E.1    Walsh, C.T.2
  • 21
    • 0037151788 scopus 로고    scopus 로고
    • The barbamide biosynthetic gene cluster: A novel marine cyanobacterial system of mixed polyketide synthase (PKS)-non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit
    • DOI 10.1016/S0378-1119(02)00860-0, PII S0378111902008600
    • Chang ZX, Flatt P, Gerwick WH, Nguyen VA,Willis CL, Sherman DH. 2002. The barbamide biosynthetic gene cluster: a novel marine cyanobacterial system of mixed polyketide synthase (PKS)-nonribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene 296:235-47 (Pubitemid 35287342)
    • (2002) Gene , vol.296 , Issue.1-2 , pp. 235-247
    • Chang, Z.1    Flatt, P.2    Gerwick, W.H.3    Nguyen, V.-A.4    Willis, C.L.5    Sherman, D.H.6
  • 22
    • 38949193318 scopus 로고    scopus 로고
    • Forest soil metagenome gene cluster involved in antifungal activity expression in Escherichia coli
    • Chung EJ, LimHK, Kim JC, Choi GJ, Park EJ, et al. 2008. Forest soil metagenome gene cluster involved in antifungal activity expression in Escherichia coli. Appl. Environ. Microbiol. 74:723-30
    • (2008) Appl. Environ. Microbiol. , vol.74 , pp. 723-30
    • Chung, E.J.1    Limhk Kim, J.C.2    Choi, G.J.3    Park, E.J.4
  • 23
    • 34548512495 scopus 로고    scopus 로고
    • Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured β-proteobacterium
    • DOI 10.1128/JB.00457-07
    • Clardy J, Brady SF. 2007. Cyclic AMP directly activates NasP, an N-acyl amino acid antibiotic biosynthetic enzyme cloned from an uncultured beta-proteobacterium. J. Bacteriol. 189:6487-89 (Pubitemid 47378659)
    • (2007) Journal of Bacteriology , vol.189 , Issue.17 , pp. 6487-6489
    • Clardy, J.1    Brady, S.F.2
  • 26
    • 60749097148 scopus 로고    scopus 로고
    • Natural products from environmental DNA hosted in Ralstonia metallidurans
    • Craig JW, Chang FY, Brady SF. 2009. Natural products from environmental DNA hosted in Ralstonia metallidurans. ACS Chem. Biol. 4:23-28
    • (2009) ACS Chem. Biol. , vol.4 , pp. 23-28
    • Craig, J.W.1    Chang, F.Y.2    Brady, S.F.3
  • 27
    • 77649206077 scopus 로고    scopus 로고
    • Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria
    • Craig JW, Chang FY, Kim JH, Obiajulu SC, Brady SF. 2010. Expanding small-molecule functional metagenomics through parallel screening of broad-host-range cosmid environmental DNA libraries in diverse proteobacteria. Appl. Environ. Microbiol. 76:1633-41
    • (2010) Appl. Environ. Microbiol. , vol.76 , pp. 1633-41
    • Craig, J.W.1    Chang, F.Y.2    Kim, J.H.3    Obiajulu, S.C.4    Brady, S.F.5
  • 28
    • 0033594414 scopus 로고    scopus 로고
    • Fungus-growing ants use antibiotic-producing bacteria to control garden parasites
    • DOI 10.1038/19519
    • Currie CR, Scott JA, Summerbell RC, Malloch D. 1999. Fungus-growing ants use antibiotic-producing bacteria to control garden parasites. Nature 398:701-4 (Pubitemid 29197647)
    • (1999) Nature , vol.398 , Issue.6729 , pp. 701-704
    • Currie, C.R.1    Scottt, J.A.2    Summerbell, R.C.3    Malloch, D.4
  • 29
    • 45849097581 scopus 로고    scopus 로고
    • Use of flow cytometric methods for single-cell analysis in environmental microbiology
    • Czechowska K, Johnson DR, van der Meer JR. 2008. Use of flow cytometric methods for single-cell analysis in environmental microbiology. Curr. Opin. Microbiol. 11:205-12
    • (2008) Curr. Opin. Microbiol. , vol.11 , pp. 205-12
    • Czechowska, K.1    Johnson, D.R.2    Van Der Meer, J.R.3
  • 30
    • 19144366982 scopus 로고    scopus 로고
    • The metagenomics of soil
    • DOI 10.1038/nrmicro1160
    • Daniel R. 2005. The metagenomics of soil. Nat. Rev. Microbiol. 3:470-78 (Pubitemid 40716173)
    • (2005) Nature Reviews Microbiology , vol.3 , Issue.6 , pp. 470-478
    • Daniel, R.1
  • 32
    • 0035487279 scopus 로고    scopus 로고
    • Evidence for the Biosynthesis of Bryostatins by the Bacterial Symbiont "Candidatus Endobugula sertula" of the Bryozoan Bugula neritina
    • DOI 10.1128/AEM.67.10.4531-4537.2001
    • Davidson SK, Allen SW, Lim GE, Anderson CM, Haygood MG. 2001. Evidence for the biosynthesis of bryostatins by the bacterial symbiont 'Candidatus Endobugula sertula' of the bryozoan Bugula neritina. Appl. Environ. Microbiol. 67:4531-37 (Pubitemid 33646081)
    • (2001) Applied and Environmental Microbiology , vol.67 , Issue.10 , pp. 4531-4537
    • Davidson, S.K.1    Allen, S.W.2    Lim, G.E.3    Anderson, C.M.4    Haygood, M.G.5
  • 33
    • 0034305155 scopus 로고    scopus 로고
    • Small bugs, big business: The economic power of themicrobe
    • Demain AL. 2000. Small bugs, big business: the economic power of themicrobe. Biotechnol. Adv. 18:499-514
    • (2000) Biotechnol. Adv. , vol.18 , pp. 499-514
    • Demain, A.L.1
  • 34
    • 0036865981 scopus 로고    scopus 로고
    • Teredinibacter turnerae gen. nov., sp. nov., a dinitrogen-fixing, cellulolytic, endosymbiotic γ-proteobacterium isolated from the gills of wood-boring molluscs (Bivalvia: Teredinidae)
    • DOI 10.1099/ijs.0.02184-0
    • Distel DL, Morrill W, MacLaren-Toussaint N, Franks D, Waterbury J. 2002. Teredinibacter turnerae gen. nov., sp nov., a dinitrogen-fixing, cellulolytic, endosymbiotic gamma-proteobacterium isolated from the gills of wood-boring molluscs (Bivalvia: Teredinidae). Int. J. Syst. Evol. Microbiol. 52:2261-69 (Pubitemid 36007742)
    • (2002) International Journal of Systematic and Evolutionary Microbiology , vol.52 , Issue.6 , pp. 2261-2269
    • Distel, D.L.1    Morrill, W.2    MacLaren-Toussaint, N.3    Franks, D.4    Waterbury, J.5
  • 37
    • 43749113148 scopus 로고    scopus 로고
    • A global assembly line for cyanobactins
    • DOI 10.1038/nchembio.84, PII NCHEMBIO84
    • Donia MS, Ravel J, Schmidt EW. 2008. A global assembly line for cyanobactins. Nat. Chem. Biol. 4:341-43 (Pubitemid 351693990)
    • (2008) Nature Chemical Biology , vol.4 , Issue.6 , pp. 341-343
    • Donia, M.S.1    Ravel, J.2    Schmidt, E.W.3
  • 38
    • 0034142130 scopus 로고    scopus 로고
    • Highlights of marine natural products chemistry (1972-1999)
    • DOI 10.1039/a909113k
    • Faulkner DJ. 2000. Highlights ofmarine natural products chemistry (1972-1999). Nat. Prod. Rep. 17:1-6 (Pubitemid 30097622)
    • (2000) Natural Product Reports , vol.17 , Issue.1 , pp. 1-6
    • Faulkner, D.J.1
  • 39
    • 68549132517 scopus 로고    scopus 로고
    • Assessment of bias associated with incomplete extraction of microbial DNA from soil
    • Feinstein LM, Sul WJ, Blackwood CB. 2009. Assessment of bias associated with incomplete extraction of microbial DNA from soil. Appl. Environ. Microbiol. 75:5428-33
    • (2009) Appl. Environ. Microbiol. , vol.75 , pp. 5428-33
    • Feinstein, L.M.1    Sul, W.J.2    Blackwood, C.B.3
  • 40
    • 77956075607 scopus 로고    scopus 로고
    • Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster
    • Feng ZY, Kim JH, Brady SF. 2010. Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster. J. Am. Chem. Soc. 132:11902-3
    • (2010) J. Am. Chem. Soc. , vol.132 , pp. 11902-3
    • Feng, Z.Y.1    Kim, J.H.2    Brady, S.F.3
  • 42
    • 2942620063 scopus 로고    scopus 로고
    • Discovery of the novel candidate phylum "Poribacteria" in marine sponges
    • DOI 10.1128/AEM.70.6.3724-3732.2004
    • Fieseler L, Horn M, Wagner M, Hentschel U. 2004. Discovery of the novel candidate phylum 'Poribacteria' in marine sponges. Appl. Environ. Microbiol. 70:3724-32 (Pubitemid 38745923)
    • (2004) Applied and Environmental Microbiology , vol.70 , Issue.6 , pp. 3724-3732
    • Fieseler, L.1    Horn, M.2    Wagner, M.3    Hentschel, U.4
  • 43
    • 67650281479 scopus 로고    scopus 로고
    • Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting
    • Fisch KM, Gurgui C, Heycke N, van der Sar SA, Anderson SA, et al. 2009. Polyketide assembly lines of uncultivated sponge symbionts from structure-based gene targeting. Nat. Chem. Biol. 5:494-501
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 494-501
    • Fisch, K.M.1    Gurgui, C.2    Heycke, N.3    Van Der Sar, S.A.4    Anderson, S.A.5
  • 44
    • 21844468774 scopus 로고    scopus 로고
    • Identification of the cellular site of polychlorinated peptide biosynthesis in the marine sponge Dysidea (Lamellodysidea) herbacea and symbiotic cyanobacterium Oscillatoria spongeliae by CARD-FISH analysis
    • DOI 10.1007/s00227-005-1614-9
    • Flatt P,Gautschi J,Thacker R, Musafija-Girt M, Crews P,GerwickW.2005. Identification of the cellular site of polychlorinated peptide biosynthesis in the marine sponge Dysidea (Lamellodysidea) herbacea and symbiotic cyanobacterium Oscillatoria spongeliae by CARD-FISH analysis. Mar. Biol. 147:761-74 (Pubitemid 40950494)
    • (2005) Marine Biology , vol.147 , Issue.3 , pp. 761-774
    • Flatt, P.M.1    Gautschi, J.T.2    Thacker, R.W.3    Musafija-Girt, M.4    Crews, P.5    Gerwick, W.H.6
  • 45
    • 0031868508 scopus 로고    scopus 로고
    • Cellular origin of chlorinated diketopiperazines in the dictyoceratid sponge Dysidea herbacea (Keller)
    • DOI 10.1007/s004410051089
    • Flowers AE, Garson MJ,Webb RI, Dumdei EJ, Charan RD. 1998. Cellular origin of chlorinated diketopiperazines in the dictyoceratid sponge Dysidea herbacea (Keller). Cell Tissue Res. 292:597-607 (Pubitemid 28282472)
    • (1998) Cell and Tissue Research , vol.292 , Issue.3 , pp. 597-607
    • Flowers, A.E.1    Garson, M.J.2    Webb, R.I.3    Dumdei, E.J.4    Charan, R.D.5
  • 46
    • 70350012294 scopus 로고    scopus 로고
    • Bionectriol A, a polyketide glycoside from the fungus Bionectria sp. associated with the fungus-growing ant, Apterostigma dentigerum
    • Freinkman E, Oh DC, Scott JJ, Currie CR, Clardy J. 2009. Bionectriol A, a polyketide glycoside from the fungus Bionectria sp. associated with the fungus-growing ant, Apterostigma dentigerum. Tetrahedron Lett. 50:6834-37
    • (2009) Tetrahedron Lett. , vol.50 , pp. 6834-37
    • Freinkman, E.1    Oh, D.C.2    Scott, J.J.3    Currie, C.R.4    Clardy, J.5
  • 47
    • 0344299237 scopus 로고    scopus 로고
    • Rapid isolation of single microbial cells from mixed natural and laboratory populations with the aid of a micromanipulator
    • Fröhlich J, König H. 1999. Rapid isolation of single microbial cell from mixed natural and laboratory populations with the aid of a micromanipulator. Syst. Appl. Microbiol. 22:249-57 (Pubitemid 29267505)
    • (1999) Systematic and Applied Microbiology , vol.22 , Issue.2 , pp. 249-257
    • Frohlich, J.1    Konig, H.2
  • 48
    • 0033758599 scopus 로고    scopus 로고
    • New techniques for isolation of single prokaryotic cells
    • Fröhlich J, König H. 2000. New techniques for isolation of single prokaryotic cells. FEMS Microbiol. Rev. 24:567-72
    • (2000) FEMS Microbiol. Rev. , vol.24 , pp. 567-72
    • Fröhlich, J.1    König, H.2
  • 49
    • 55249090459 scopus 로고    scopus 로고
    • Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition
    • Fu J, Wenzel SC, Perlova O, Wang JP, Gross F, et al. 2008. Efficient transfer of two large secondary metabolite pathway gene clusters into heterologous hosts by transposition. Nucleic Acids Res. 36:e113
    • (2008) Nucleic Acids Res. , vol.36
    • Fu, J.1    Wenzel, S.C.2    Perlova, O.3    Wang, J.P.4    Gross, F.5
  • 50
    • 0028229103 scopus 로고
    • The distribution of brominated long-chain fatty acids in sponge and symbiont cell types from the tropical marine sponge Amphimedon terpenensis
    • Garson MJ, Zimmermann MP, Battershill CN, Holden JL, Murphy PT. 1994. The distribution of brominated long-chain fatty acids in sponge and symbiont cell types from the tropical marine sponge Amphimedon terpenensis. Lipids 29:509-16 (Pubitemid 24224296)
    • (1994) Lipids , vol.29 , Issue.7 , pp. 509-516
    • Garson, M.J.1    Zimmermann, M.P.2    Battershill, C.N.3    Holden, J.L.4    Murphy, P.T.5
  • 55
    • 0028261409 scopus 로고
    • Lessons from an evolving ribosomalRNA: 16S and 23S ribosomal RNA structures from a comparative perspective
    • Gutell RR, Larsen N, WoeseCR. 1994. Lessons from an evolving ribosomalRNA:16S and 23S ribosomal RNA structures from a comparative perspective. Microbiol. Rev. 58:10-26
    • (1994) Microbiol. Rev. , vol.58 , pp. 10-26
    • Gutell, R.R.1    Larsen, N.2    Woese, C.R.3
  • 56
    • 63849278056 scopus 로고    scopus 로고
    • Candicidin-producing Streptomyces support leaf-cutting ants to protect their fungus garden against the pathogenic fungus Escovopsis
    • Haeder S, Wirth R, Herz H, Spiteller D. 2009. Candicidin-producing Streptomyces support leaf-cutting ants to protect their fungus garden against the pathogenic fungus Escovopsis. Proc. Natl. Acad. Sci. USA 106:4742-46
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 4742-46
    • Haeder, S.1    Wirth, R.2    Herz, H.3    Spiteller, D.4
  • 57
    • 34249723655 scopus 로고    scopus 로고
    • Advanced sequencing technologies and their wider impact in microbiology
    • DOI 10.1242/jeb.001370
    • Hall N. 2007. Advanced sequencing technologies and their wider impact in microbiology. J. Exp. Biol. 210:1518-25 (Pubitemid 46841957)
    • (2007) Journal of Experimental Biology , vol.210 , Issue.9 , pp. 1518-1525
    • Hall, N.1
  • 58
    • 10344227692 scopus 로고    scopus 로고
    • Metagenomics: Application of genomics to uncultured microorganisms
    • DOI 10.1128/MMBR.68.4.669-685.2004
    • Handelsman J. 2004. Metagenomics: application of genomics to uncultured microorganisms. Microbiol. Mol. Biol. Rev. 68:669-85 (Pubitemid 39628532)
    • (2004) Microbiology and Molecular Biology Reviews , vol.68 , Issue.4 , pp. 669-685
    • Handelsman, J.1
  • 59
    • 0032192790 scopus 로고    scopus 로고
    • Molecular biological access to the chemistry of unknown soil microbes: A new frontier for natural products
    • Handelsman J, Rondon MR, Brady SF, Clardy J, Goodman RM. 1998. Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products. Chem. Biol. 5:R245-49 (Pubitemid 29000111)
    • (1998) Chemistry and Biology , vol.5 , Issue.10
    • Handelsman, J.1    Rondon, M.R.2    Brady, S.F.3    Clardy, J.4    Goodman, R.M.5
  • 60
    • 73349097561 scopus 로고    scopus 로고
    • Identification and characterization of new LuxR/LuxI-type quorum sensing systems from metagenomic libraries
    • Hao YA, Winans SC, Glick BR, Charles TC. 2010. Identification and characterization of new LuxR/LuxI-type quorum sensing systems from metagenomic libraries. Environ. Microbiol. 12:105-17
    • (2010) Environ. Microbiol. , vol.12 , pp. 105-17
    • Hao, Y.A.1    Winans, S.C.2    Glick, B.R.3    Charles, T.C.4
  • 61
    • 0030691919 scopus 로고    scopus 로고
    • Small-subunit rRNA genes and in situ hybridization with oligonucleotides specific for the bacterial symbionts in the larvae of the bryozoan Bugula neritina and proposal of 'Candidatus endobugula sertula'
    • Haygood MG, Davidson SK. 1997. Small-subunit rRNA genes and in situ hybridization with oligonucleotides specific for the bacterial symbionts in the larvae of the bryozoan Bugula neritina and proposal of "Candidatus Endobugula sertula". Appl. Environ. Microbiol. 63:4612-16 (Pubitemid 27485802)
    • (1997) Applied and Environmental Microbiology , vol.63 , Issue.11 , pp. 4612-4616
    • Haygood, M.G.1    Davidson, S.K.2
  • 62
    • 33846923183 scopus 로고    scopus 로고
    • Type II polyketide synthases: Gaining a deeper insight into enzymatic teamwork
    • DOI 10.1039/b507395m
    • Hertweck C, Luzhetskyy A, Rebets Y, Bechthold A. 2007. Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat. Prod. Rep. 24:162-90 (Pubitemid 46238594)
    • (2007) Natural Product Reports , vol.24 , Issue.1 , pp. 162-190
    • Hertweck, C.1    Luzhetskyy, A.2    Rebets, Y.3    Bechthold, A.4
  • 63
    • 8844270242 scopus 로고    scopus 로고
    • BryA: An unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina
    • DOI 10.1016/j.chembiol.2004.08.018, PII S1074552104002674
    • Hildebrand M, Waggoner LE, LiuHB, Sudek S,Allen S, et al. 2004. bryA:An unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chem. Biol. 11:1543-52 (Pubitemid 39533595)
    • (2004) Chemistry and Biology , vol.11 , Issue.11 , pp. 1543-1552
    • Hildebrand, M.1    Waggoner, L.E.2    Liu, H.3    Sudek, S.4    Allen, S.5    Anderson, C.6    Sherman, D.H.7    Haygood, M.8
  • 64
    • 77950595690 scopus 로고    scopus 로고
    • Culture-independentmolecular techniques for soil microbial ecology
    • Hirsch PR,MauchlineTH, Clark IM.2010. Culture-independentmolecular techniques for soil microbial ecology. Soil Biol. Biochem. 42:878-87
    • (2010) Soil Biol. Biochem. , vol.42 , pp. 878-87
    • Hirsch, P.R.1    Mauchline, T.H.2    Clark, I.M.3
  • 65
    • 78650019762 scopus 로고    scopus 로고
    • Linking chemical and microbial diversity in marine sponges: Possible role for Poribacteria as producers of methyl-branched fatty acids
    • Hochmuth T, Niederkr üger H, Gernert C, Siegl A, Taudien S, et al. 2010. Linking chemical and microbial diversity in marine sponges: possible role for Poribacteria as producers of methyl-branched fatty acids. ChemBioChem 11:2572-78
    • (2010) Chem Bio Chem , vol.11 , pp. 2572-78
    • Hochmuth, T.1    Niederkrüger, H.2    Gernert, C.3    Siegl, A.4    Taudien, S.5
  • 66
    • 33846412600 scopus 로고    scopus 로고
    • Rapid isolation of rare clones from highly complex DNA libraries by PCR analysis of liquid gel pools
    • DOI 10.1016/j.mimet.2006.09.009, PII S0167701206002740
    • Hrvatin S, Piel J. 2007. Rapid isolation of rare clones from highly complexDNAlibraries byPCR analysis of liquid gel pools. J. Microbiol. Methods 68:434-36 (Pubitemid 46149946)
    • (2007) Journal of Microbiological Methods , vol.68 , Issue.2 , pp. 434-436
    • Hrvatin, S.1    Piel, J.2
  • 68
    • 77954679917 scopus 로고    scopus 로고
    • The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria
    • Jones AC, Monroe EA, Eisman EB, Gerwick L, Sherman DH, Gerwick WH. 2010. The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Nat. Prod. Rep. 27:1048-65
    • (2010) Nat. Prod. Rep. , vol.27 , pp. 1048-65
    • Jones, A.C.1    Monroe, E.A.2    Eisman, E.B.3    Gerwick, L.4    Sherman, D.H.5    Gerwick, W.H.6
  • 70
    • 0036716940 scopus 로고    scopus 로고
    • Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus
    • Julien B, Shah S. 2002. Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus. Antimicrob. Agents Chemother. 46:2772-78
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 2772-78
    • Julien, B.1    Shah, S.2
  • 71
    • 0037052320 scopus 로고    scopus 로고
    • Isolating "uncultivabte" microorganisms in pure culture in a simulated natural environment
    • DOI 10.1126/science.1070633
    • Kaeberlein T, Lewis K, Epstein SS. 2002. Isolating 'uncultivable' microorganisms in pure culture in a simulated natural environment. Science 296:1127-29 (Pubitemid 34517131)
    • (2002) Science , vol.296 , Issue.5570 , pp. 1127-1129
    • Kaeberlein, T.1    Lewis, K.2    Epstein, S.S.3
  • 72
    • 0036009127 scopus 로고    scopus 로고
    • Molecular identification of an endosymbiotic bacterium associated with pederin biosynthesis in Paederus sabaeus (Coleoptera: Staphylinidae)
    • DOI 10.1016/S0965-1748(01)00115-1, PII S0965174801001151
    • Kellner RLL. 2002. Molecular identification of an endosymbiotic bacterium associated with pederin biosynthesis in Paederus sabaeus (Coleoptera: Staphylinidae). Insect. Biochem. Mol. Biol. 32:389-95 (Pubitemid 34213885)
    • (2002) Insect Biochemistry and Molecular Biology , vol.32 , Issue.4 , pp. 389-395
    • Kellner, R.L.L.1
  • 73
    • 77954630177 scopus 로고    scopus 로고
    • Cloning large natural product gene clusters from the environment: Piecing environmental DNA gene clusters back together with TAR
    • Kim JH, Feng ZY, Bauer JD, Kallifidas D, Calle PY, Brady SF. 2010. Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR. Biopolymers 93:833-44
    • (2010) Biopolymers , vol.93 , pp. 833-44
    • Kim, J.H.1    Feng, Z.Y.2    Bauer, J.D.3    Kallifidas, D.4    Calle, P.Y.5    Brady, S.F.6
  • 74
    • 33745782501 scopus 로고    scopus 로고
    • Diversity of polyketide synthase genes from bacteria associated with the marine sponge Pseudoceratina clavata: Culture-dependent and culture-independent approaches
    • DOI 10.1111/j.1462-2920.2006.01040.x
    • Kim TK, Fuerst JA. 2006. Diversity of polyketide synthase genes from bacteria associated with the marine sponge Pseudoceratina clavata: culture-dependent and culture-independent approaches. Environ. Microbiol. 8:1460-70 (Pubitemid 44025338)
    • (2006) Environmental Microbiology , vol.8 , Issue.8 , pp. 1460-1470
    • Tae, K.K.1    Fuerst, J.A.2
  • 75
    • 0026594245 scopus 로고
    • Stable propagation of cosmid sized human DNA inserts in an F-factor based vector
    • Kim UJ, Shizuya H, Dejong PJ, Birren B, Simon MI. 1992. Stable propagation of cosmid sized human DNA inserts in an F-factor based vector. Nucleic Acids Res. 20:1083-85
    • (1992) Nucleic Acids Res. , vol.20 , pp. 1083-85
    • Kim, U.J.1    Shizuya, H.2    Dejong, P.J.3    Birren, B.4    Simon, M.I.5
  • 76
    • 70349923903 scopus 로고    scopus 로고
    • An environmental DNA-derived type II polyketide biosynthetic pathway encodes the biosynthesis of the pentacyclic polyketide erdacin
    • King RW, Bauer JD, Brady SF. 2009. An environmental DNA-derived type II polyketide biosynthetic pathway encodes the biosynthesis of the pentacyclic polyketide erdacin. Angew. Chem. Int. Ed. 48:6257-61
    • (2009) Angew. Chem. Int. Ed. , vol.48 , pp. 6257-61
    • King, R.W.1    Bauer, J.D.2    Brady, S.F.3
  • 77
    • 33847306942 scopus 로고    scopus 로고
    • Specific single-cell isolation and genomic amplification of uncultured microorganisms
    • Kvist T, Ahring BK, Lasken RS, Westermann P. 2007. Specific single-cell isolation and genomic amplification of uncultured microorganisms. Appl. Microbiol. Biotechnol. 74:926-35
    • (2007) Appl. Microbiol. Biotechnol. , vol.74 , pp. 926-35
    • Kvist, T.1    Ahring, B.K.2    Lasken, R.S.3    Westermann, P.4
  • 80
    • 35748983784 scopus 로고    scopus 로고
    • Single-cell genomic sequencing using Multiple Displacement Amplification
    • DOI 10.1016/j.mib.2007.08.005, PII S1369527407001191, Antimicrobials/Genomics
    • Lasken RS. 2007. Single-cell genomic sequencing using multiple displacement amplification. Curr. Opin. Microbiol. 10:510-16 (Pubitemid 350052686)
    • (2007) Current Opinion in Microbiology , vol.10 , Issue.5 , pp. 510-516
    • Lasken, R.S.1
  • 81
    • 0036753178 scopus 로고    scopus 로고
    • A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A
    • DOI 10.1016/S1074-5521(02)00223-5, PII S1074552102002235
    • Li AY, Piel J. 2002. A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A. Chem. Biol. 9:1017-26 (Pubitemid 35273722)
    • (2002) Chemistry and Biology , vol.9 , Issue.9 , pp. 1017-1026
    • Li, A.1    Piel, J.2
  • 82
    • 77950109576 scopus 로고    scopus 로고
    • Complexity and simplicity in the biosynthesis of enediyne natural products
    • Liang ZX. 2010. Complexity and simplicity in the biosynthesis of enediyne natural products. Nat. Prod. Rep. 27:499-528
    • (2010) Nat. Prod. Rep. , vol.27 , pp. 499-528
    • Liang, Z.X.1
  • 85
    • 26944437043 scopus 로고    scopus 로고
    • Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production
    • DOI 10.1002/cbic.200500210
    • Long PF, Dunlap WC, Battershill CN, Jaspars M. 2005. Shotgun cloning and heterologous expression of the patellamide gene cluster as a strategy to achieving sustained metabolite production. ChemBioChem 6:1760-65 (Pubitemid 41475266)
    • (2005) ChemBioChem , vol.6 , Issue.10 , pp. 1760-1765
    • Long, P.F.1    Dunlap, W.C.2    Battershill, C.N.3    Jaspars, M.4
  • 86
    • 19144366814 scopus 로고    scopus 로고
    • Metagenomics and industrial applications
    • DOI 10.1038/nrmicro1161
    • Lorenz P, Eck J. 2005. Metagenomics and industrial applications. Nat. Rev. Microbiol. 3:510-16 (Pubitemid 40716178)
    • (2005) Nature Reviews Microbiology , vol.3 , Issue.6 , pp. 510-516
    • Lorenz, P.1    Eck, J.2
  • 88
    • 13944259584 scopus 로고    scopus 로고
    • Genetically modified bacterial strains and novel bacterial artificial chromosome shuttle vectors for constructing environmental libraries and detecting heterologous natural products in multiple expression hosts
    • DOI 10.1128/AEM.70.4.2452-2463.2004
    • Martinez A, Kolvek SJ, Yip CLT, Hopke J, Brown KA, et al. 2004. Genetically modified bacterial strains and novel bacterial artificial chromosome shuttle vectors for constructing environmental libraries and detecting heterologous natural products in multiple expression hosts. Appl. Environ. Microbiol. 70:2452-63 (Pubitemid 38500551)
    • (2004) Applied and Environmental Microbiology , vol.70 , Issue.4 , pp. 2452-2463
    • Martinez, A.1    Kolvek, S.J.2    Yip, C.L.T.3    Hopke, J.4    Brown, K.A.5    MacNeil, I.A.6    Osburne, M.S.7
  • 89
    • 0038127226 scopus 로고    scopus 로고
    • Nonribosomal peptides from marine sponges
    • Matsunaga S, Fusetani N. 2003. Nonribosomal peptides from marine sponges. Curr. Org. Chem. 7:945-66 (Pubitemid 36773208)
    • (2003) Current Organic Chemistry , vol.7 , Issue.10 , pp. 945-966
    • Matsunaga, S.1    Fusetani, N.2
  • 90
    • 0027908014 scopus 로고
    • Engineered biosynthesis of novel polyketides
    • McDaniel R, Ebert-Khosla S, Hopwood DA, Khosla C. 1993. Engineered biosynthesis of novel polyketides. Science 262:1546-50 (Pubitemid 24036782)
    • (1993) Science , vol.262 , Issue.5139 , pp. 1546-1550
    • McDaniel, R.1    Ebert-Khosla, S.2    Hopwood, D.A.3    Khosla, C.4
  • 91
    • 4544352632 scopus 로고    scopus 로고
    • Partial activation of a silent angucycline-type gene cluster from a Rubromycin β producing Streptomyces sp. PGA64
    • Metsä-Ketelä M, Ylihonko K, Mäntsälä P. 2004. Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64. J. Antibiot. 57:502-10 (Pubitemid 39255674)
    • (2004) Journal of Antibiotics , vol.57 , Issue.8 , pp. 502-510
    • Metsa-Ketela, M.1    Ylihonko, K.2    Mantsala, P.3
  • 92
    • 77953254182 scopus 로고    scopus 로고
    • Functional single-cell analyses: Flow cytometry and cell sorting of microbial populations and communities
    • Muller S, Nebe-von-Caron G. 2010. Functional single-cell analyses: flow cytometry and cell sorting of microbial populations and communities. FEMS Microbiol. Rev. 34:554-87
    • (2010) FEMS Microbiol. Rev. , vol.34 , pp. 554-87
    • Muller, S.1    Nebe-Von-Caron, G.2
  • 93
    • 0034603783 scopus 로고    scopus 로고
    • PCR-mediated gene replacement in Escherichia coli
    • DOI 10.1016/S0378-1119(00)00071-8, PII S0378111900000718
    • Murphy KC, Campellone KG, Poteete AR. 2000. PCR-mediated gene replacement in Escherichia coli. Gene 246:321-30 (Pubitemid 30190186)
    • (2000) Gene , vol.246 , Issue.1-2 , pp. 321-330
    • Murphy, K.C.1    Campellone, K.G.2    Poteete, A.R.3
  • 94
    • 0034571687 scopus 로고    scopus 로고
    • The pederin family of antitumor agents: Structures, synthesis and biological activity
    • ed. R Mulzer, R Bohlmann Heidelberg, Ger.: Springer-Verlag
    • Narquizian R, Kocienski PJ. 2000. The pederin family of antitumor agents: structures, synthesis and biological activity. In The Role of Natural Products in Drug Discovery, ed. R Mulzer, R Bohlmann, 32:25-30. Heidelberg, Ger.: Springer-Verlag
    • (2000) The Role of Natural Products in Drug Discovery , vol.32 , pp. 25-30
    • Narquizian, R.1    Kocienski, P.J.2
  • 96
    • 67349096399 scopus 로고    scopus 로고
    • Dentigerumycin: A bacterial mediator of an ant-fungus symbiosis
    • Oh DC, Poulsen M, Currie CR, Clardy J. 2009. Dentigerumycin: a bacterial mediator of an ant-fungus symbiosis. Nat. Chem. Biol. 5:391-93
    • (2009) Nat. Chem. Biol. , vol.5 , pp. 391-93
    • Oh, D.C.1    Poulsen, M.2    Currie, C.R.3    Clardy, J.4
  • 97
    • 60849098765 scopus 로고    scopus 로고
    • Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp
    • Oh DC, Scott JJ, Currie CR, Clardy J. 2009. Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp. Org. Lett. 11:633-36
    • (2009) Org. Lett. , vol.11 , pp. 633-36
    • Oh, D.C.1    Scott, J.J.2    Currie, C.R.3    Clardy, J.4
  • 99
    • 33845342557 scopus 로고    scopus 로고
    • Microfluidic digital PCR enables multigene analysis of individual environmental bacteria
    • DOI 10.1126/science.1131370
    • Ottesen EA, Hong JW, Quake SR, Leadbetter JR. 2006. Microfluidic digital PCR enables multigene analysis of individual environmental bacteria. Science 314:1464-67 (Pubitemid 44871954)
    • (2006) Science , vol.314 , Issue.5804 , pp. 1464-1467
    • Ottesen, E.A.1    Jong, W.H.2    Quake, S.R.3    Leadbetter, J.R.4
  • 100
    • 27144465524 scopus 로고    scopus 로고
    • Pathogenic fungus harbours endosymbiotic bacteria for toxin production
    • DOI 10.1038/nature03997, PII N03997
    • Partida-Martinez LP, Hertweck C. 2005. Pathogenic fungus harbours endosymbiotic bacteria for toxin production. Nature 437:884-88 (Pubitemid 41486763)
    • (2005) Nature , vol.437 , Issue.7060 , pp. 884-888
    • Partida-Martinez, L.P.1    Hertweck, C.2
  • 101
    • 33846294808 scopus 로고    scopus 로고
    • A gene cluster encoding rhizoxin biosynthesis in "Burkholderia rhizoxina", the bacterial endosymbiont of the fungus Rhizopus microsporus
    • DOI 10.1002/cbic.200600393
    • Partida-Martinez LP,HertweckC. 2007. A gene cluster encoding rhizoxin biosynthesis in 'Burkholderia rhizoxina', the bacterial endosymbiont of the fungus Rhizopus microsporus. ChemBioChem 8:41-45 (Pubitemid 46121569)
    • (2007) ChemBioChem , vol.8 , Issue.1 , pp. 41-45
    • Partida-Martinez, L.P.1    Hertweck, C.2
  • 102
    • 0036276618 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization and catalyzed reporter deposition for the identification of marine bacteria
    • DOI 10.1128/AEM.68.6.3094-3101.2002
    • Pernthaler A, Pernthaler J, Amann R. 2002. Fluorescence in situ hybridization and catalyzed reporter deposition for the identification of marine bacteria. Appl. Environ. Microbiol. 68:3094-101 (Pubitemid 34602035)
    • (2002) Applied and Environmental Microbiology , vol.68 , Issue.6 , pp. 3094-3101
    • Pernthaler, A.1    Pernthaler, J.2    Amann, R.3
  • 103
    • 0035793858 scopus 로고    scopus 로고
    • Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
    • DOI 10.1126/science.1058092
    • Pfeifer BA, Admiraal SJ, Gramajo H, Cane DE, Khosla C. 2001. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 291:1790-92 (Pubitemid 32198984)
    • (2001) Science , vol.291 , Issue.5509 , pp. 1790-1792
    • Pfeifer, B.A.1    Admiraal, S.J.2    Gramajo, H.3    Cane, D.E.4    Khosla, C.5
  • 104
    • 0037195174 scopus 로고    scopus 로고
    • A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles
    • DOI 10.1073/pnas.222481399
    • Piel J. 2002. A polyketide synthase-peptide synthetase gene cluster from an uncultured bacterial symbiont of Paederus beetles. Proc. Natl. Acad. Sci. USA 99:14002-7 (Pubitemid 35257614)
    • (2002) Proceedings of the National Academy of Sciences of the United States of America , vol.99 , Issue.22 , pp. 14002-14007
    • Piel, J.1
  • 105
    • 4444264936 scopus 로고    scopus 로고
    • Metabolites from symbiotic bacteria
    • DOI 10.1039/b310175b
    • Piel J. 2004. Metabolites from symbiotic bacteria. Nat. Prod. Rep. 21:519-38 (Pubitemid 39182706)
    • (2004) Natural Product Reports , vol.21 , Issue.4 , pp. 519-538
    • Piel, J.1
  • 106
    • 85047689741 scopus 로고    scopus 로고
    • Bacterial symbionts: Prospects for the sustainable production of invertebrate-derived pharmaceuticals
    • Piel J. 2006. Bacterial symbionts: prospects for the sustainable production of invertebrate-derived pharmaceuticals. Curr. Med. Chem. 13:39-50
    • (2006) Curr. Med. Chem. , vol.13 , pp. 39-50
    • Piel, J.1
  • 107
    • 61449113023 scopus 로고    scopus 로고
    • Metabolites from symbiotic bacteria
    • Piel J. 2009. Metabolites from symbiotic bacteria. Nat. Prod. Rep. 26:338-62
    • (2009) Nat. Prod. Rep. , vol.26 , pp. 338-62
    • Piel, J.1
  • 108
    • 77954675603 scopus 로고    scopus 로고
    • Biosynthesis of polyketides by trans-AT polyketide synthases
    • Piel J. 2010. Biosynthesis of polyketides by trans-AT polyketide synthases. Nat. Prod. Rep. 27:996-1047
    • (2010) Nat. Prod. Rep. , vol.27 , pp. 996-1047
    • Piel, J.1
  • 109
    • 10744231115 scopus 로고    scopus 로고
    • Evidence for A Symbiosis Island Involved in Horizontal Acquisition of Pederin Biosynthetic Capabilities by the Bacterial Symbiont of Paederus fuscipes Beetles
    • DOI 10.1128/JB.186.5.1280-1286.2004
    • Piel J, Höfer I, Hui DQ. 2004. Evidence for a symbiosis island involved in horizontal acquisition of pederin biosynthetic capabilities by the bacterial symbiont of Paederus fuscipes beetles. J. Bacteriol. 186:1280-86 (Pubitemid 38248716)
    • (2004) Journal of Bacteriology , vol.186 , Issue.5 , pp. 1280-1286
    • Piel, J.1    Hofer, I.2    Hui, D.3
  • 110
    • 4344675456 scopus 로고    scopus 로고
    • Targeting modular polyketide synthases with iteratively acting acyltransferases from metagenomes of uncultured bacterial consortia
    • DOI 10.1111/j.1462-2920.2004.00531.x
    • Piel J, HuiDQ, Fusetani N, Matsunaga S. 2004. Targetingmodular polyketide synthases with iteratively acting acyltransferases frommetagenomes of uncultured bacterial consortia. Environ.Microbiol. 6:921-27 (Pubitemid 39123246)
    • (2004) Environmental Microbiology , vol.6 , Issue.9 , pp. 921-927
    • Piel, J.1    Hui, D.2    Fusetani, N.3    Matsunaga, S.4
  • 112
    • 0347717826 scopus 로고    scopus 로고
    • Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase
    • DOI 10.1002/cbic.200300782
    • Piel J, Wen GP, Platzer M, Hui DQ. 2004. Unprecedented diversity of catalytic domains in the first four modules of the putative pederin polyketide synthase. ChemBioChem 5:93-98 (Pubitemid 38095026)
    • (2004) ChemBioChem , vol.5 , Issue.1 , pp. 93-98
    • Piel, J.1    Wen, G.2    Platzer, M.3    Hui, D.4
  • 114
    • 0242523909 scopus 로고    scopus 로고
    • The uncultured microbial majority
    • DOI 10.1146/annurev.micro.57.030502.090759
    • Rappé MS, Giovannoni SJ. 2003. The uncultured microbial majority. Annu. Rev. Microbiol. 57:369-94 (Pubitemid 37392948)
    • (2003) Annual Review of Microbiology , vol.57 , pp. 369-394
    • Rappe, M.S.1    Giovannoni, S.J.2
  • 115
    • 58149145729 scopus 로고    scopus 로고
    • Characterization of the microbial community and polyketide biosynthetic potential in the palmerolide-producing tunicate Synoicum adareanum
    • Riesenfeld CS,Murray AE, Baker BJ. 2008. Characterization of the microbial community and polyketide biosynthetic potential in the palmerolide-producing tunicate Synoicum adareanum. J. Nat. Prod. 71:1812-18
    • (2008) J. Nat. Prod. , vol.71 , pp. 1812-18
    • Riesenfeld, C.S.1    Murray, A.E.2    Baker, B.J.3
  • 118
    • 23744472955 scopus 로고    scopus 로고
    • Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta
    • DOI 10.1128/AEM.71.8.4840-4849.2005
    • Schirmer A, GadkariR,Reeves CD, Ibrahim F, Delong EF,HutchinsonCR. 2005. Metagenomic analysis reveals diverse polyketide synthase gene clusters in microorganisms associated with the marine sponge Discodermia dissoluta. Appl. Environ. Microbiol. 71:4840-49 (Pubitemid 41129543)
    • (2005) Applied and Environmental Microbiology , vol.71 , Issue.8 , pp. 4840-4849
    • Schirmer, A.1    Gadkari, R.2    Reeves, C.D.3    Ibrahim, F.4    DeLong, E.F.5    Hutchinson, C.R.6
  • 119
    • 47649093673 scopus 로고    scopus 로고
    • Trading molecules and tracking targets in symbiotic interactions
    • DOI 10.1038/nchembio.101, PII NCHEMBIO101
    • Schmidt EW. 2008. Trading molecules and tracking targets in symbiotic interactions. Nat. Chem. Biol. 4:466-73 (Pubitemid 352019761)
    • (2008) Nature Chemical Biology , vol.4 , Issue.8 , pp. 466-473
    • Schmidt, E.W.1
  • 121
    • 0030690924 scopus 로고    scopus 로고
    • A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: A means to access and use genes from uncultured microorganisms
    • Seow KT, Meurer G, Gerlitz M, Wendt-Pienkowski E, Hutchinson CR, Davies J. 1997. A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: a means to access and use genes from uncultured microorganisms. J. Bacteriol. 179:7360-68 (Pubitemid 27509973)
    • (1997) Journal of Bacteriology , vol.179 , Issue.23 , pp. 7360-7368
    • Seow, K.-T.1    Meurer, G.2    Gerlitz, M.3    Wendt-Pienkowski, E.4    Hutchinson, C.R.5    Davies, J.6
  • 122
    • 36849004408 scopus 로고    scopus 로고
    • Localization of Candidatus Endobugula sertula and the bryostatins throughout the life cycle of the bryozoan Bugula neritina
    • DOI 10.1038/ismej.2007.78, PII ISMEJ200778
    • Sharp KH, Davidson SK, Haygood MG. 2007. Localization of 'Candidatus Endobugula sertula' and the bryostatins throughout the life cycle of the bryozoan Bugula neritina. ISME J. 1:693-702 (Pubitemid 350231338)
    • (2007) ISME Journal , vol.1 , Issue.8 , pp. 693-702
    • Sharp, K.H.1    Davidson, S.K.2    Haygood, M.G.3
  • 123
    • 78649723307 scopus 로고    scopus 로고
    • PKS and NRPS gene clusters from microbial symbiont cells of marine sponges by whole genome amplification. Environ
    • Siegl A, Hentschel U. 2010. PKS and NRPS gene clusters from microbial symbiont cells of marine sponges by whole genome amplification. Environ. Microbiol. Rep. 2:507-13
    • (2010) Microbiol. Rep. , vol.2 , pp. 507-13
    • Siegl, A.1    Hentschel, U.2
  • 124
    • 78650591665 scopus 로고    scopus 로고
    • Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges
    • Siegl A, Kamke J, Hochmuth T, Piel J, Richter M, et al. 2011. Single-cell genomics reveals the lifestyle of Poribacteria, a candidate phylum symbiotically associated with marine sponges. ISME J. 5:61-70
    • (2011) ISME J. , vol.5 , pp. 61-70
    • Siegl, A.1    Kamke, J.2    Hochmuth, T.3    Piel, J.4    Richter, M.5
  • 125
    • 33847029508 scopus 로고    scopus 로고
    • Identification of the putative bryostatin polyketide synthase gene cluster from 'Candidatus Endobugula sertula', the uncultivated microbial symbiont of the marine bryozoan Bugula neritina
    • Sudek S, LopanikNB, Waggoner LE, Hildebrand M, Anderson C, et al. 2007. Identification of the putative bryostatin polyketide synthase gene cluster from 'Candidatus Endobugula sertula', the uncultivated microbial symbiont of the marine bryozoan Bugula neritina. J. Nat. Prod. 70:67-74
    • (2007) J. Nat. Prod. , vol.70 , pp. 67-74
    • Sudek, S.1    Lopanik, N.B.2    Waggoner, L.E.3    Hildebrand, M.4    Anderson, C.5
  • 126
    • 1642496907 scopus 로고    scopus 로고
    • The biosynthesis of glycopeptide antibiotics - A model for complex, non-ribosomally synthesized, peptidic secondary metabolites
    • DOI 10.1007/s00253-003-1443-z
    • Süssmuth RD,WohllebenW. 2004. The biosynthesis of glycopeptide antibiotics-a model for complex, non-ribosomally synthesized, peptidic secondary metabolites. Appl. Microbiol. Biotechnol. 63:344-50 (Pubitemid 38134771)
    • (2004) Applied Microbiology and Biotechnology , vol.63 , Issue.4 , pp. 344-350
    • Sussmuth, R.D.1    Wohlleben, W.2
  • 127
    • 0034723333 scopus 로고    scopus 로고
    • Cloning and heterologous expression of the epothilone gene cluster
    • DOI 10.1126/science.287.5453.640
    • Tang L, Shah S, Chung L, Carney J, Katz L, et al. 2000. Cloning and heterologous expression of the epothilone gene cluster. Science 287:640-42 (Pubitemid 30070909)
    • (2000) Science , vol.287 , Issue.5453 , pp. 640-642
    • Tang, L.1    Shah, S.2    Chung, L.3    Carney, J.4    Katz, L.5    Khosla, C.6    Julien, B.7
  • 128
  • 129
    • 34250733462 scopus 로고    scopus 로고
    • Sponge-associated microorganisms: Evolution, ecology, and biotechnological potential
    • DOI 10.1128/MMBR.00040-06
    • Taylor MW, Radax R, Steger D, Wagner M. 2007. Sponge-associated microorganisms: evolution, ecology, and biotechnological potential. Microbiol. Mol. Biol. Rev. 71:295-347 (Pubitemid 46954308)
    • (2007) Microbiology and Molecular Biology Reviews , vol.71 , Issue.2 , pp. 295-347
    • Taylor, M.W.1    Radax, R.2    Steger, D.3    Wagner, M.4
  • 130
    • 43649083523 scopus 로고    scopus 로고
    • Importance of DNA quality in comparative soil microbial community structure analyses
    • Thakuria D, Schmidt O, Mac Siurtain M, Egan D, Doohan FM. 2008. Importance of DNA quality in comparative soil microbial community structure analyses. Soil Biol. Biochem. 40:1390-403
    • (2008) Soil Biol. Biochem. , vol.40 , pp. 1390-403
    • Thakuria, D.1    Schmidt, O.2    Mac Siurtain, M.3    Egan, D.4    Doohan, F.M.5
  • 132
    • 33748328250 scopus 로고    scopus 로고
    • FeeM, an N-Acyl Amino Acid Synthase from an Uncultured Soil Microbe: Structure, Mechanism, and Acyl Carrier Protein Binding
    • DOI 10.1016/j.str.2006.07.005, PII S0969212606003273
    • Van WagonerRM,Clardy J. 2006. FeeM, anN-acyl amino acid synthase from an uncultured soil microbe: structure, mechanism, and acyl carrier protein binding. Structure 14:1425-35 (Pubitemid 44331617)
    • (2006) Structure , vol.14 , Issue.9 , pp. 1425-1435
    • Van Wagoner, R.M.1    Clardy, J.2
  • 134
    • 77953121190 scopus 로고    scopus 로고
    • Single cell analysis: The new frontier in 'omics'
    • Wang DJ, Bodovitz S. 2010. Single cell analysis: the new frontier in 'omics'. Trends Biotechnol. 28:281-90
    • (2010) Trends Biotechnol. , vol.28 , pp. 281-90
    • Wang, D.J.1    Bodovitz, S.2
  • 135
    • 0034632413 scopus 로고    scopus 로고
    • Novel natural products from soil DNA libraries in a streptomycete host
    • Wang GYS, Graziani E, Waters B, Pan WB, Li X, et al. 2000. Novel natural products from soil DNA libraries in a streptomycete host. Org. Lett. 2:2401-4
    • (2000) Org. Lett. , vol.2 , pp. 2401-4
    • Gys, W.1    Graziani, E.2    Waters, B.3    Pan, W.B.4    Li, X.5
  • 136
    • 0034752042 scopus 로고    scopus 로고
    • How many antibiotics are produced by the genus Streptomyces?
    • DOI 10.1007/s002030100345
    • Watve MG, Tickoo R, Jog MM, Bhole BD. 2001. How many antibiotics are produced by the genus Streptomyces? Arch. Microbiol. 176:386-90 (Pubitemid 33020814)
    • (2001) Archives of Microbiology , vol.176 , Issue.5 , pp. 386-390
    • Watve, M.G.1    Tickoo, R.2    Jog, M.M.3    Bhole, B.D.4
  • 139
    • 15744370033 scopus 로고    scopus 로고
    • Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via Red/ET recombineering
    • DOI 10.1016/j.chembiol.2004.12.012
    • Wenzel SC, Gross F, Zhang YM, Fu J, Stewart AF, Müller R. 2005. Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering. Chem. Biol. 12:349-56 (Pubitemid 40406282)
    • (2005) Chemistry and Biology , vol.12 , Issue.3 , pp. 349-356
    • Wenzel, S.C.1    Gross, F.2    Zhang, Y.3    Fu, J.4    Stewart, A.F.5    Muller, R.6
  • 142
    • 67749097789 scopus 로고    scopus 로고
    • The complete genome of Teredinibacter turnerae T7901: An intracellular endosymbiont of marine wood-boring bivalves (shipworms)
    • Yang JC,Madupu R, Durkin AS, EkborgNA, Pedamallu CS, et al. 2009. The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms). PLoS One 4(7):e6085
    • (2009) PLoS One , vol.4 , Issue.7
    • Yang, J.C.1    Madupu, R.2    Durkin, A.S.3    Ekborg, N.A.4    Pedamallu, C.S.5
  • 143
    • 67650819221 scopus 로고    scopus 로고
    • An improved method for purifying genomic DNA from forest leaf litters and soil suitable for PCR
    • Zhang L, Xu ZH, Patel BKC. 2009. An improved method for purifying genomic DNA from forest leaf litters and soil suitable for PCR. J. Soils Sediments 9:261-66
    • (2009) J. Soils Sediments , vol.9 , pp. 261-66
    • Zhang, L.1    Zh, X.2    Patel, B.K.C.3
  • 144
    • 67749122311 scopus 로고    scopus 로고
    • Pederin-type pathways of uncultivated bacterial symbionts: Analysis of O-methyltransferases and generation of a biosynthetic hybrid
    • Zimmermann K, Engeser M, Blunt JW, Munro MHG, Piel J. 2009. Pederin-type pathways of uncultivated bacterial symbionts: analysis of O-methyltransferases and generation of a biosynthetic hybrid. J. Am. Chem. Soc. 131:2780-81
    • (2009) J. Am. Chem. Soc. , vol.131 , pp. 2780-81
    • Zimmermann, K.1    Engeser, M.2    Blunt, J.W.3    Mhg, M.4    Piel, J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.