-
1
-
-
0035876043
-
LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli
-
Altincicek B., Kollas A., Eberl M., Wiesner J., Sanderbrand S., Hintz M., Beck E., and Jomaa H. LytB, a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway of isoprenoid biosynthesis in Escherichia coli. FEBS Lett. 499 (2001) 37-40
-
(2001)
FEBS Lett.
, vol.499
, pp. 37-40
-
-
Altincicek, B.1
Kollas, A.2
Eberl, M.3
Wiesner, J.4
Sanderbrand, S.5
Hintz, M.6
Beck, E.7
Jomaa, H.8
-
2
-
-
0033977834
-
The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin
-
Bate N., Butler A.R., Smith I.P., and Cundliffe E. The mycarose-biosynthetic genes of Streptomyces fradiae, producer of tylosin. Microbiology 146 Pt 1 (2000) 139-146
-
(2000)
Microbiology
, vol.146
, Issue.PART 1
, pp. 139-146
-
-
Bate, N.1
Butler, A.R.2
Smith, I.P.3
Cundliffe, E.4
-
3
-
-
0029161160
-
Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2)
-
Bedford D.J., Schweizer E., Hopwood D.A., and Khosla C. Expression of a functional fungal polyketide synthase in the bacterium Streptomyces coelicolor A3(2). J. Bacteriol. 177 (1995) 4544-4548
-
(1995)
J. Bacteriol.
, vol.177
, pp. 4544-4548
-
-
Bedford, D.J.1
Schweizer, E.2
Hopwood, D.A.3
Khosla, C.4
-
4
-
-
0037046560
-
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
-
Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L., Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D., Bateman A., Brown S., et al. Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417 (2002) 141-147
-
(2002)
Nature
, vol.417
, pp. 141-147
-
-
Bentley, S.D.1
Chater, K.F.2
Cerdeno-Tarraga, A.M.3
Challis, G.L.4
Thomson, N.R.5
James, K.D.6
Harris, D.E.7
Quail, M.A.8
Kieser, H.9
Harper, D.10
Bateman, A.11
Brown, S.12
-
5
-
-
0026645203
-
Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp
-
Bierman M., Logan R., O'Brien K., Seno E.T., Rao R.N., and Schoner B.E. Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp. Gene 116 (1992) 43-49
-
(1992)
Gene
, vol.116
, pp. 43-49
-
-
Bierman, M.1
Logan, R.2
O'Brien, K.3
Seno, E.T.4
Rao, R.N.5
Schoner, B.E.6
-
6
-
-
27544456830
-
The impact of bacterial genomics on natural product research
-
Bode H.B., and Muller R. The impact of bacterial genomics on natural product research. Angew. Chem. Int. Ed. Engl. 44 (2005) 6828-6846
-
(2005)
Angew. Chem. Int. Ed. Engl.
, vol.44
, pp. 6828-6846
-
-
Bode, H.B.1
Muller, R.2
-
7
-
-
11144311139
-
Lessons from natural molecules
-
Clardy J., and Walsh C. Lessons from natural molecules. Nature 432 (2004) 829-837
-
(2004)
Nature
, vol.432
, pp. 829-837
-
-
Clardy, J.1
Walsh, C.2
-
8
-
-
0029027352
-
Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage
-
Cortes J., Wiesmann K.E., Roberts G.A., Brown M.J., Staunton J., and Leadlay P.F. Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage. Science 268 (1995) 1487-1489
-
(1995)
Science
, vol.268
, pp. 1487-1489
-
-
Cortes, J.1
Wiesmann, K.E.2
Roberts, G.A.3
Brown, M.J.4
Staunton, J.5
Leadlay, P.F.6
-
9
-
-
0035152567
-
The tylosin-biosynthetic genes of Streptomyces fradiae
-
Cundliffe E., Bate N., Butler A., Fish S., Gandecha A., and Merson-Davies L. The tylosin-biosynthetic genes of Streptomyces fradiae. Antonie Van Leeuwenhoek 79 (2001) 229-234
-
(2001)
Antonie Van Leeuwenhoek
, vol.79
, pp. 229-234
-
-
Cundliffe, E.1
Bate, N.2
Butler, A.3
Fish, S.4
Gandecha, A.5
Merson-Davies, L.6
-
10
-
-
49649123572
-
A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea
-
Chng C., Lum A.M., Vroom J.A., and Kao C.M. A key developmental regulator controls the synthesis of the antibiotic erythromycin in Saccharopolyspora erythraea. Proc. Natl. Acad. Sci. USA 105 (2008) 11346-11351
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 11346-11351
-
-
Chng, C.1
Lum, A.M.2
Vroom, J.A.3
Kao, C.M.4
-
11
-
-
0037163047
-
Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2)
-
Diacovich L., Peiru S., Kurth D., Rodriguez E., Podesta F., Khosla C., and Gramajo H. Kinetic and structural analysis of a new group of Acyl-CoA carboxylases found in Streptomyces coelicolor A3(2). J. Biol. Chem. 277 (2002) 31228-31236
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 31228-31236
-
-
Diacovich, L.1
Peiru, S.2
Kurth, D.3
Rodriguez, E.4
Podesta, F.5
Khosla, C.6
Gramajo, H.7
-
12
-
-
0141736926
-
Strategies for combinatorial biosynthesis with modular polyketide synthases
-
Donadio S., and Sosio M. Strategies for combinatorial biosynthesis with modular polyketide synthases. Comb. Chem. High Throughput Screen 6 (2003) 489-500
-
(2003)
Comb. Chem. High Throughput Screen
, vol.6
, pp. 489-500
-
-
Donadio, S.1
Sosio, M.2
-
13
-
-
9244234513
-
Biosynthesis of nonribosomal peptides1
-
Finking R., and Marahiel M.A. Biosynthesis of nonribosomal peptides1. Annu. Rev. Microbiol. 58 (2004) 453-488
-
(2004)
Annu. Rev. Microbiol.
, vol.58
, pp. 453-488
-
-
Finking, R.1
Marahiel, M.A.2
-
14
-
-
0348087044
-
Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa
-
Finking R., Solsbacher J., Konz D., Schobert M., Schafer A., Jahn D., and Marahiel M.A. Characterization of a new type of phosphopantetheinyl transferase for fatty acid and siderophore synthesis in Pseudomonas aeruginosa. J. Biol. Chem. 277 (2002) 50293-50302
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50293-50302
-
-
Finking, R.1
Solsbacher, J.2
Konz, D.3
Schobert, M.4
Schafer, A.5
Jahn, D.6
Marahiel, M.A.7
-
15
-
-
0031572413
-
High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes
-
Flett F., Mersinias V., and Smith C.P. High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes. FEMS Microbiol. Lett. 155 (1997) 223-229
-
(1997)
FEMS Microbiol. Lett.
, vol.155
, pp. 223-229
-
-
Flett, F.1
Mersinias, V.2
Smith, C.P.3
-
16
-
-
20444443559
-
Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products
-
Fortman J.L., and Sherman D.H. Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products. ChemBioChem 6 (2005) 960-978
-
(2005)
ChemBioChem
, vol.6
, pp. 960-978
-
-
Fortman, J.L.1
Sherman, D.H.2
-
17
-
-
0028242645
-
Engineered biosynthesis of novel polyketides: Dissection of the catalytic specificity of the act ketoreductase
-
Fu H., Ebert-Khosla S., Hopwood D.A., and Khosla C. Engineered biosynthesis of novel polyketides: Dissection of the catalytic specificity of the act ketoreductase. J. Am. Chem. Soc. 116 (1994) 4166-4170
-
(1994)
J. Am. Chem. Soc.
, vol.116
, pp. 4166-4170
-
-
Fu, H.1
Ebert-Khosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
18
-
-
0031013034
-
Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome
-
Gandecha A.R., Large S.L., and Cundliffe E. Analysis of four tylosin biosynthetic genes from the tylLM region of the Streptomyces fradiae genome. Gene 184 (1997) 197-203
-
(1997)
Gene
, vol.184
, pp. 197-203
-
-
Gandecha, A.R.1
Large, S.L.2
Cundliffe, E.3
-
19
-
-
0031952729
-
Cloning and heterologous expression of genes from the kinamycin biosynthetic pathway of Streptomyces murayamaensis
-
Gould S.J., Hong S.T., and Carney J.R. Cloning and heterologous expression of genes from the kinamycin biosynthetic pathway of Streptomyces murayamaensis. J. Antibiot. (Tokyo) 51 (1998) 50-57
-
(1998)
J. Antibiot. (Tokyo)
, vol.51
, pp. 50-57
-
-
Gould, S.J.1
Hong, S.T.2
Carney, J.R.3
-
20
-
-
0027483415
-
Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated
-
Gramajo H.C., Takano E., and Bibb M.J. Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated. Mol. Microbiol. 7 (1993) 837-845
-
(1993)
Mol. Microbiol.
, vol.7
, pp. 837-845
-
-
Gramajo, H.C.1
Takano, E.2
Bibb, M.J.3
-
21
-
-
15744376560
-
Posttranslational modification of myxobacterial carrier protein domains in Pseudomonas sp. by an intrinsic phosphopantetheinyl transferase
-
Gross F., Gottschalk D., and Muller R. Posttranslational modification of myxobacterial carrier protein domains in Pseudomonas sp. by an intrinsic phosphopantetheinyl transferase. Appl. Microbiol. Biotechnol. 68 (2005) 66-74
-
(2005)
Appl. Microbiol. Biotechnol.
, vol.68
, pp. 66-74
-
-
Gross, F.1
Gottschalk, D.2
Muller, R.3
-
22
-
-
33644552441
-
Bacterial type III polyketide synthases: Phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads
-
Gross F., Luniak N., Perlova O., Gaitatzis N., Jenke-Kodama H., Gerth K., Gottschalk D., Dittmann E., and Muller R. Bacterial type III polyketide synthases: Phylogenetic analysis and potential for the production of novel secondary metabolites by heterologous expression in pseudomonads. Arch. Microbiol. 185 (2006) 28-38
-
(2006)
Arch. Microbiol.
, vol.185
, pp. 28-38
-
-
Gross, F.1
Luniak, N.2
Perlova, O.3
Gaitatzis, N.4
Jenke-Kodama, H.5
Gerth, K.6
Gottschalk, D.7
Dittmann, E.8
Muller, R.9
-
23
-
-
0031014024
-
Cloning and heterologous expression of the entire gene clusters for PD 116740 from Streptomyces strain WP 4669 and tetrangulol and tetrangomycin from Streptomyces rimosus NRRL 3016
-
Hong S.T., Carney J.R., and Gould S.J. Cloning and heterologous expression of the entire gene clusters for PD 116740 from Streptomyces strain WP 4669 and tetrangulol and tetrangomycin from Streptomyces rimosus NRRL 3016. J. Bacteriol. 179 (1997) 470-476
-
(1997)
J. Bacteriol.
, vol.179
, pp. 470-476
-
-
Hong, S.T.1
Carney, J.R.2
Gould, S.J.3
-
24
-
-
0027024882
-
Genes for polyketide secondary metabolic pathways in microorganisms and plants
-
discussion 106-112
-
Hopwood D.A., and Khosla C. Genes for polyketide secondary metabolic pathways in microorganisms and plants. Ciba Found. Symp. 171 (1992) 88-106 discussion 106-112
-
(1992)
Ciba Found. Symp.
, vol.171
, pp. 88-106
-
-
Hopwood, D.A.1
Khosla, C.2
-
25
-
-
0037906344
-
Approaches to stabilization of inter-domain recombination in polyketide synthase gene expression plasmids
-
Hu Z., Desai R.P., Volchegursky Y., Leaf T., Woo E., Licari P., Santi D.V., Hutchinson C.R., and McDaniel R. Approaches to stabilization of inter-domain recombination in polyketide synthase gene expression plasmids. J. Ind. Microbiol. Biotechnol. 30 (2003) 161-167
-
(2003)
J. Ind. Microbiol. Biotechnol.
, vol.30
, pp. 161-167
-
-
Hu, Z.1
Desai, R.P.2
Volchegursky, Y.3
Leaf, T.4
Woo, E.5
Licari, P.6
Santi, D.V.7
Hutchinson, C.R.8
McDaniel, R.9
-
26
-
-
0042601765
-
Enhanced heterologous polyketide production in Streptomyces by exploiting plasmid co-integration
-
Hu Z., Hopwood D.A., and Hutchinson C.R. Enhanced heterologous polyketide production in Streptomyces by exploiting plasmid co-integration. J. Ind. Microbiol. Biotechnol. 30 (2003) 516-522
-
(2003)
J. Ind. Microbiol. Biotechnol.
, vol.30
, pp. 516-522
-
-
Hu, Z.1
Hopwood, D.A.2
Hutchinson, C.R.3
-
27
-
-
0038148677
-
Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: Towards comparative analysis of the benzoisochromanequinone gene clusters
-
Ichinose K., Ozawa M., Itou K., Kunieda K., and Ebizuka Y. Cloning, sequencing and heterologous expression of the medermycin biosynthetic gene cluster of Streptomyces sp. AM-7161: Towards comparative analysis of the benzoisochromanequinone gene clusters. Microbiology 149 (2003) 1633-1645
-
(2003)
Microbiology
, vol.149
, pp. 1633-1645
-
-
Ichinose, K.1
Ozawa, M.2
Itou, K.3
Kunieda, K.4
Ebizuka, Y.5
-
28
-
-
0030875774
-
Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase
-
Jacobsen J.R., Hutchinson C.R., Cane D.E., and Khosla C. Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase. Science 277 (1997) 367-369
-
(1997)
Science
, vol.277
, pp. 367-369
-
-
Jacobsen, J.R.1
Hutchinson, C.R.2
Cane, D.E.3
Khosla, C.4
-
29
-
-
0036716940
-
Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus
-
Julien B., and Shah S. Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus. Antimicrob. Agents Chemother. 46 (2002) 2772-2778
-
(2002)
Antimicrob. Agents Chemother.
, vol.46
, pp. 2772-2778
-
-
Julien, B.1
Shah, S.2
-
30
-
-
4344715857
-
Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase
-
Kalaitzis J.A., and Moore B.S. Heterologous biosynthesis of truncated hexaketides derived from the actinorhodin polyketide synthase. J. Nat. Prod. 67 (2004) 1419-1422
-
(2004)
J. Nat. Prod.
, vol.67
, pp. 1419-1422
-
-
Kalaitzis, J.A.1
Moore, B.S.2
-
31
-
-
0027932534
-
Engineered biosynthesis of a complete macrolactone in a heterologous host
-
Kao C.M., Katz L., and Khosla C. Engineered biosynthesis of a complete macrolactone in a heterologous host. Science 265 (1994) 509-512
-
(1994)
Science
, vol.265
, pp. 509-512
-
-
Kao, C.M.1
Katz, L.2
Khosla, C.3
-
32
-
-
0028857296
-
Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase
-
Kao C.M., Luo G., Katz L., Cane D.E., and Khosla C. Manipulation of macrolide ring size by directed mutagenesis of a modular polyketide synthase. J. Am. Chem. Soc. 117 (1995) 9105-9106
-
(1995)
J. Am. Chem. Soc.
, vol.117
, pp. 9105-9106
-
-
Kao, C.M.1
Luo, G.2
Katz, L.3
Cane, D.E.4
Khosla, C.5
-
33
-
-
0037094002
-
Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B
-
Kato Y., Bai L., Xue Q., Revill W.P., Yu T.W., and Floss H.G. Functional expression of genes involved in the biosynthesis of the novel polyketide chain extension unit, methoxymalonyl-acyl carrier protein, and engineered biosynthesis of 2-desmethyl-2-methoxy-6-deoxyerythronolide B. J. Am. Chem. Soc. 124 (2002) 5268-5269
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 5268-5269
-
-
Kato, Y.1
Bai, L.2
Xue, Q.3
Revill, W.P.4
Yu, T.W.5
Floss, H.G.6
-
34
-
-
0031968766
-
Developmental regulation of transcription of whiE, a locus specifying the polyketide spore pigment in Streptomyces coelicolor A3 (2)
-
Kelemen G.H., Brian P., Flardh K., Chamberlin L., Chater K.F., and Buttner M.J. Developmental regulation of transcription of whiE, a locus specifying the polyketide spore pigment in Streptomyces coelicolor A3 (2). J. Bacteriol. 180 (1998) 2515-2521
-
(1998)
J. Bacteriol.
, vol.180
, pp. 2515-2521
-
-
Kelemen, G.H.1
Brian, P.2
Flardh, K.3
Chamberlin, L.4
Chater, K.F.5
Buttner, M.J.6
-
35
-
-
4244059507
-
Harnessing the biosynthetic potential of modular polyketide synthases
-
Khosla C. Harnessing the biosynthetic potential of modular polyketide synthases. Chem. Rev. 97 (1997) 2577-2590
-
(1997)
Chem. Rev.
, vol.97
, pp. 2577-2590
-
-
Khosla, C.1
-
36
-
-
0026539625
-
Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: Role for the acyl carrier protein
-
Khosla C., Ebert-Khosla S., and Hopwood D.A. Targeted gene replacements in a Streptomyces polyketide synthase gene cluster: Role for the acyl carrier protein. Mol. Microbiol. 6 (1992) 3237-3249
-
(1992)
Mol. Microbiol.
, vol.6
, pp. 3237-3249
-
-
Khosla, C.1
Ebert-Khosla, S.2
Hopwood, D.A.3
-
37
-
-
0003869903
-
-
The John Innes Foundation, Norwich, UK
-
Kieser T., Bibb M.J., Buttner M.J., Chater K.F., and Hopwood D.A. Practical Streptomyces genetics. (2000), The John Innes Foundation, Norwich, UK
-
(2000)
Practical Streptomyces genetics.
-
-
Kieser, T.1
Bibb, M.J.2
Buttner, M.J.3
Chater, K.F.4
Hopwood, D.A.5
-
38
-
-
0028935276
-
Heterologous expression of an engineered biosynthetic pathway: Functional dissection of type II polyketide synthase components in Streptomyces species
-
Kim E.S., Cramer K.D., Shreve A.L., and Sherman D.H. Heterologous expression of an engineered biosynthetic pathway: Functional dissection of type II polyketide synthase components in Streptomyces species. J. Bacteriol. 177 (1995) 1202-1207
-
(1995)
J. Bacteriol.
, vol.177
, pp. 1202-1207
-
-
Kim, E.S.1
Cramer, K.D.2
Shreve, A.L.3
Sherman, D.H.4
-
39
-
-
8144226497
-
Total synthesis of long DNA sequences: Synthesis of a contiguous 32-kb polyketide synthase gene cluster
-
Kodumal S.J., Patel K.G., Reid R., Menzella H.G., Welch M., and Santi D.V. Total synthesis of long DNA sequences: Synthesis of a contiguous 32-kb polyketide synthase gene cluster. Proc. Natl. Acad. Sci. USA 101 (2004) 15573-15578
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 15573-15578
-
-
Kodumal, S.J.1
Patel, K.G.2
Reid, R.3
Menzella, H.G.4
Welch, M.5
Santi, D.V.6
-
40
-
-
1842791547
-
MeaB is a component of the methylmalonyl-CoA mutase complex required for protection of the enzyme from inactivation
-
Korotkova N., and Lidstrom M.E. MeaB is a component of the methylmalonyl-CoA mutase complex required for protection of the enzyme from inactivation. J. Biol. Chem. 279 (2004) 13652-13658
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 13652-13658
-
-
Korotkova, N.1
Lidstrom, M.E.2
-
41
-
-
0028882690
-
Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase
-
Lambalot R.H., and Walsh C.T. Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase. J. Biol. Chem. 270 (1995) 24658-24661
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 24658-24661
-
-
Lambalot, R.H.1
Walsh, C.T.2
-
42
-
-
0034877862
-
Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering
-
Lombo F., Pfeifer B., Leaf T., Ou S., Kim Y.S., Cane D.E., Licari P., and Khosla C. Enhancing the atom economy of polyketide biosynthetic processes through metabolic engineering. Biotechnol. Prog. 17 (2001) 612-617
-
(2001)
Biotechnol. Prog.
, vol.17
, pp. 612-617
-
-
Lombo, F.1
Pfeifer, B.2
Leaf, T.3
Ou, S.4
Kim, Y.S.5
Cane, D.E.6
Licari, P.7
Khosla, C.8
-
43
-
-
3242727731
-
Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays
-
Lum A.M., Huang J., Hutchinson C.R., and Kao C.M. Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. Metab. Eng. 6 (2004) 186-196
-
(2004)
Metab. Eng.
, vol.6
, pp. 186-196
-
-
Lum, A.M.1
Huang, J.2
Hutchinson, C.R.3
Kao, C.M.4
-
44
-
-
13944259584
-
Genetically modified bacterial strains and novel bacterial artificial chromosome shuttle vectors for constructing environmental libraries and detecting heterologous natural products in multiple expression hosts
-
Martinez A., Kolvek S.J., Yip C.L., Hopke J., Brown K.A., MacNeil I.A., and Osburne M.S. Genetically modified bacterial strains and novel bacterial artificial chromosome shuttle vectors for constructing environmental libraries and detecting heterologous natural products in multiple expression hosts. Appl. Environ. Microbiol. 70 (2004) 2452-2463
-
(2004)
Appl. Environ. Microbiol.
, vol.70
, pp. 2452-2463
-
-
Martinez, A.1
Kolvek, S.J.2
Yip, C.L.3
Hopke, J.4
Brown, K.A.5
MacNeil, I.A.6
Osburne, M.S.7
-
46
-
-
0027746346
-
Engineered biosynthesis of novel polyketides: Manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities
-
McDaniel R., Ebert-Khosla S., Hopwood D.A., and Khosla C. Engineered biosynthesis of novel polyketides: Manipulation and analysis of an aromatic polyketide synthase with unproven catalytic specificities. J. Am. Chem. Soc. 115 (1993) 11671-11675
-
(1993)
J. Am. Chem. Soc.
, vol.115
, pp. 11671-11675
-
-
McDaniel, R.1
Ebert-Khosla, S.2
Hopwood, D.A.3
Khosla, C.4
-
47
-
-
0033515090
-
Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products
-
McDaniel R., Thamchaipenet A., Gustafsson C., Fu H., Betlach M., and Ashley G. Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. Proc. Natl. Acad. Sci. USA 96 (1999) 1846-1851
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 1846-1851
-
-
McDaniel, R.1
Thamchaipenet, A.2
Gustafsson, C.3
Fu, H.4
Betlach, M.5
Ashley, G.6
-
48
-
-
34250704344
-
Combinatorial biosynthesis for drug development
-
Menzella H.G., and Reeves C.D. Combinatorial biosynthesis for drug development. Curr. Opin. Microbiol. 10 (2007) 238-245
-
(2007)
Curr. Opin. Microbiol.
, vol.10
, pp. 238-245
-
-
Menzella, H.G.1
Reeves, C.D.2
-
49
-
-
0028236752
-
Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome
-
Merson-Davies L.A., and Cundliffe E. Analysis of five tylosin biosynthetic genes from the tyllBA region of the Streptomyces fradiae genome. Mol. Microbiol. 13 (1994) 349-355
-
(1994)
Mol. Microbiol.
, vol.13
, pp. 349-355
-
-
Merson-Davies, L.A.1
Cundliffe, E.2
-
50
-
-
0042100690
-
Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production
-
Murli S., Kennedy J., Dayem L.C., Carney J.R., and Kealey J.T. Metabolic engineering of Escherichia coli for improved 6-deoxyerythronolide B production. J. Ind. Microbiol. Biotechnol. 30 (2003) 500-509
-
(2003)
J. Ind. Microbiol. Biotechnol.
, vol.30
, pp. 500-509
-
-
Murli, S.1
Kennedy, J.2
Dayem, L.C.3
Carney, J.R.4
Kealey, J.T.5
-
51
-
-
31544449418
-
Heterologous production of epothilone C and D in Escherichia coli
-
Mutka S.C., Carney J.R., Liu Y., and Kennedy J. Heterologous production of epothilone C and D in Escherichia coli. Biochemistry 45 (2006) 1321-1330
-
(2006)
Biochemistry
, vol.45
, pp. 1321-1330
-
-
Mutka, S.C.1
Carney, J.R.2
Liu, Y.3
Kennedy, J.4
-
54
-
-
18444395871
-
Production of the potent antibacterial polyketide erythromycin C in Escherichia coli
-
Peiru S., Menzella H.G., Rodriguez E., Carney J., and Gramajo H. Production of the potent antibacterial polyketide erythromycin C in Escherichia coli. Appl. Environ. Microbiol. 71 (2005) 2539-2547
-
(2005)
Appl. Environ. Microbiol.
, vol.71
, pp. 2539-2547
-
-
Peiru, S.1
Menzella, H.G.2
Rodriguez, E.3
Carney, J.4
Gramajo, H.5
-
55
-
-
64049100642
-
Metabolically engineered Escherichia coli for efficient production of glycosylated natural products
-
Peiru S., Rodriguez E., Menzella H.G., Carney J., and Gramajo H. Metabolically engineered Escherichia coli for efficient production of glycosylated natural products. Microbial. Biotechnol. 1 (2008) 476-486
-
(2008)
Microbial. Biotechnol.
, vol.1
, pp. 476-486
-
-
Peiru, S.1
Rodriguez, E.2
Menzella, H.G.3
Carney, J.4
Gramajo, H.5
-
56
-
-
30844464361
-
Heterologous production of daptomycin in Streptomyces lividans
-
Penn J., Li X., Whiting A., Latif M., Gibson T., Silva C.J., Brian P., Davies J., Miao V., Wrigley S.K., and Baltz R.H. Heterologous production of daptomycin in Streptomyces lividans. J. Ind. Microbiol. Biotechnol. 33 (2006) 121-128
-
(2006)
J. Ind. Microbiol. Biotechnol.
, vol.33
, pp. 121-128
-
-
Penn, J.1
Li, X.2
Whiting, A.3
Latif, M.4
Gibson, T.5
Silva, C.J.6
Brian, P.7
Davies, J.8
Miao, V.9
Wrigley, S.K.10
Baltz, R.H.11
-
57
-
-
0035793858
-
Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli
-
Pfeifer B.A., Admiraal S.J., Gramajo H., Cane D.E., and Khosla C. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science 291 (2001) 1790-1792
-
(2001)
Science
, vol.291
, pp. 1790-1792
-
-
Pfeifer, B.A.1
Admiraal, S.J.2
Gramajo, H.3
Cane, D.E.4
Khosla, C.5
-
58
-
-
0242405686
-
Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host
-
Pfeifer B.A., Wang C.C., Walsh C.T., and Khosla C. Biosynthesis of Yersiniabactin, a complex polyketide-nonribosomal peptide, using Escherichia coli as a heterologous host. Appl. Environ. Microbiol. 69 (2003) 6698-6702
-
(2003)
Appl. Environ. Microbiol.
, vol.69
, pp. 6698-6702
-
-
Pfeifer, B.A.1
Wang, C.C.2
Walsh, C.T.3
Khosla, C.4
-
59
-
-
33745036968
-
Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea
-
Reeves A.R., Brikun I.A., Cernota W.H., Leach B.I., Gonzalez M.C., and Weber J.M. Effects of methylmalonyl-CoA mutase gene knockouts on erythromycin production in carbohydrate-based and oil-based fermentations of Saccharopolyspora erythraea. J. Ind. Microbiol. Biotechnol. 33 (2006) 600-609
-
(2006)
J. Ind. Microbiol. Biotechnol.
, vol.33
, pp. 600-609
-
-
Reeves, A.R.1
Brikun, I.A.2
Cernota, W.H.3
Leach, B.I.4
Gonzalez, M.C.5
Weber, J.M.6
-
60
-
-
34249301015
-
Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production
-
Reeves A.R., Brikun I.A., Cernota W.H., Leach B.I., Gonzalez M.C., and Weber J.M. Engineering of the methylmalonyl-CoA metabolite node of Saccharopolyspora erythraea for increased erythromycin production. Metab. Eng. 9 (2007) 293-303
-
(2007)
Metab. Eng.
, vol.9
, pp. 293-303
-
-
Reeves, A.R.1
Brikun, I.A.2
Cernota, W.H.3
Leach, B.I.4
Gonzalez, M.C.5
Weber, J.M.6
-
61
-
-
5444219634
-
Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts
-
Reeves C.D., Ward S.L., Revill W.P., Suzuki H., Marcus M., Petrakovsky O.V., Marquez S., Fu H., Dong S.D., and Katz L. Production of hybrid 16-membered macrolides by expressing combinations of polyketide synthase genes in engineered Streptomyces fradiae hosts. Chem. Biol. 11 (2004) 1465-1472
-
(2004)
Chem. Biol.
, vol.11
, pp. 1465-1472
-
-
Reeves, C.D.1
Ward, S.L.2
Revill, W.P.3
Suzuki, H.4
Marcus, M.5
Petrakovsky, O.V.6
Marquez, S.7
Fu, H.8
Dong, S.D.9
Katz, L.10
-
62
-
-
0035458437
-
Role of an essential acyl coenzyme A carboxylase in the primary and secondary metabolism of Streptomyces coelicolor A3(2)
-
Rodriguez E., Banchio C., Diacovich L., Bibb M.J., and Gramajo H. Role of an essential acyl coenzyme A carboxylase in the primary and secondary metabolism of Streptomyces coelicolor A3(2). Appl. Environ. Microbiol. 67 (2001) 4166-4176
-
(2001)
Appl. Environ. Microbiol.
, vol.67
, pp. 4166-4176
-
-
Rodriguez, E.1
Banchio, C.2
Diacovich, L.3
Bibb, M.J.4
Gramajo, H.5
-
63
-
-
0032746921
-
Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2)
-
Rodriguez E., and Gramajo H. Genetic and biochemical characterization of the alpha and beta components of a propionyl-CoA carboxylase complex of Streptomyces coelicolor A3(2). Microbiology 145 Pt 11 (1999) 3109-3119
-
(1999)
Microbiology
, vol.145
, Issue.PART 11
, pp. 3109-3119
-
-
Rodriguez, E.1
Gramajo, H.2
-
64
-
-
0038364969
-
Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains
-
Rodriguez E., Hu Z., Ou S., Volchegursky Y., Hutchinson C.R., and McDaniel R. Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains. J. Ind. Microbiol. Biotechnol. 30 (2003) 480-488
-
(2003)
J. Ind. Microbiol. Biotechnol.
, vol.30
, pp. 480-488
-
-
Rodriguez, E.1
Hu, Z.2
Ou, S.3
Volchegursky, Y.4
Hutchinson, C.R.5
McDaniel, R.6
-
65
-
-
0034788156
-
Combinatorial biosynthesis of antimicrobials and other natural products
-
Rodriguez E., and McDaniel R. Combinatorial biosynthesis of antimicrobials and other natural products. Curr. Opin. Microbiol. 4 (2001) 526-534
-
(2001)
Curr. Opin. Microbiol.
, vol.4
, pp. 526-534
-
-
Rodriguez, E.1
McDaniel, R.2
-
66
-
-
5444268703
-
Engineered biosynthesis of 16-membered macrolides that require methoxymalonyl-ACP precursors in Streptomyces fradiae
-
Rodriguez E., Ward S., Fu H., Revill W.P., McDaniel R., and Katz L. Engineered biosynthesis of 16-membered macrolides that require methoxymalonyl-ACP precursors in Streptomyces fradiae. Appl. Microbiol. Biotechnol. 66 (2004) 85-91
-
(2004)
Appl. Microbiol. Biotechnol.
, vol.66
, pp. 85-91
-
-
Rodriguez, E.1
Ward, S.2
Fu, H.3
Revill, W.P.4
McDaniel, R.5
Katz, L.6
-
67
-
-
0032541316
-
Construction of new vectors for high-level expression in actinomycetes
-
Rowe C.J., Cortes J., Gaisser S., Staunton J., and Leadlay P.F. Construction of new vectors for high-level expression in actinomycetes. Gene 216 (1998) 215-223
-
(1998)
Gene
, vol.216
, pp. 215-223
-
-
Rowe, C.J.1
Cortes, J.2
Gaisser, S.3
Staunton, J.4
Leadlay, P.F.5
-
68
-
-
33750969392
-
Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor
-
Ryu Y.G., Butler M.J., Chater K.F., and Lee K.J. Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor. Appl. Environ. Microbiol. 72 (2006) 7132-7139
-
(2006)
Appl. Environ. Microbiol.
, vol.72
, pp. 7132-7139
-
-
Ryu, Y.G.1
Butler, M.J.2
Chater, K.F.3
Lee, K.J.4
-
69
-
-
0028831760
-
Improved high-level expression system for eukaryotic genes in Escherichia coli using T7 RNA polymerase and rare ArgtRNAs
-
-198200
-
Schenk P.M., Baumann S., Mattes R., and Steinbiss H.H. Improved high-level expression system for eukaryotic genes in Escherichia coli using T7 RNA polymerase and rare ArgtRNAs. Biotechniques 19 (1995) 196 -198200
-
(1995)
Biotechniques
, vol.19
, pp. 196
-
-
Schenk, P.M.1
Baumann, S.2
Mattes, R.3
Steinbiss, H.H.4
-
70
-
-
33845212858
-
Type III polyketide synthase-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining
-
Song L., Barona-Gomez F., Corre C., Xiang L., Udwary D.W., Austin M.B., Noel J.P., Moore B.S., and Challis G.L. Type III polyketide synthase-ketoacyl-ACP starter unit and ethylmalonyl-CoA extender unit selectivity discovered by Streptomyces coelicolor genome mining. J. Am. Chem. Soc. 128 (2006) 14754-14755
-
(2006)
J. Am. Chem. Soc.
, vol.128
, pp. 14754-14755
-
-
Song, L.1
Barona-Gomez, F.2
Corre, C.3
Xiang, L.4
Udwary, D.W.5
Austin, M.B.6
Noel, J.P.7
Moore, B.S.8
Challis, G.L.9
-
71
-
-
13144249211
-
Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering
-
Stassi D.L., Kakavas S.J., Reynolds K.A., Gunawardana G., Swanson S., Zeidner D., Jackson M., Liu H., Buko A., and Katz L. Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering. Proc. Natl. Acad. Sci. USA 95 (1998) 7305-7309
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7305-7309
-
-
Stassi, D.L.1
Kakavas, S.J.2
Reynolds, K.A.3
Gunawardana, G.4
Swanson, S.5
Zeidner, D.6
Jackson, M.7
Liu, H.8
Buko, A.9
Katz, L.10
-
72
-
-
0034887171
-
Polyketide biosynthesis: A millennium review
-
Staunton J., and Weissman K.J. Polyketide biosynthesis: A millennium review. Nat. Prod. Rep. 18 (2001) 380-416
-
(2001)
Nat. Prod. Rep.
, vol.18
, pp. 380-416
-
-
Staunton, J.1
Weissman, K.J.2
-
73
-
-
4644354371
-
Metagenomics-the key to the uncultured microbes
-
Streit W.R., and Schmitz R.A. Metagenomics-the key to the uncultured microbes. Curr. Opin. Microbiol. 7 (2004) 492-498
-
(2004)
Curr. Opin. Microbiol.
, vol.7
, pp. 492-498
-
-
Streit, W.R.1
Schmitz, R.A.2
-
74
-
-
0034141564
-
Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases
-
Tang L., Fu H., and McDaniel R. Formation of functional heterologous complexes using subunits from the picromycin, erythromycin and oleandomycin polyketide synthases. Chem. Biol. 7 (2000) 77-84
-
(2000)
Chem. Biol.
, vol.7
, pp. 77-84
-
-
Tang, L.1
Fu, H.2
McDaniel, R.3
-
75
-
-
0347753488
-
Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene
-
von Mulert U., Luzhetskyy A., Hofmann C., Mayer A., and Bechthold A. Expression of the landomycin biosynthetic gene cluster in a PKS mutant of Streptomyces fradiae is dependent on the coexpression of a putative transcriptional activator gene. FEMS Microbiol. Lett. 230 (2004) 91-97
-
(2004)
FEMS Microbiol. Lett.
, vol.230
, pp. 91-97
-
-
von Mulert, U.1
Luzhetskyy, A.2
Hofmann, C.3
Mayer, A.4
Bechthold, A.5
-
76
-
-
0032882588
-
Insertional inactivation of methylmalonyl coenzyme A (CoA). mutase and isobutyryl-CoA mutase genes in Streptomyces cinnamonensis: Influence on polyketide antibiotic biosynthesis
-
Vrijbloed J.W., Zerbe-Burkhardt K., Ratnatilleke A., Grubelnik-Leiser A., and Robinson J.A. Insertional inactivation of methylmalonyl coenzyme A (CoA). mutase and isobutyryl-CoA mutase genes in Streptomyces cinnamonensis: Influence on polyketide antibiotic biosynthesis. J. Bacteriol. 181 (1999) 5600-5605
-
(1999)
J. Bacteriol.
, vol.181
, pp. 5600-5605
-
-
Vrijbloed, J.W.1
Zerbe-Burkhardt, K.2
Ratnatilleke, A.3
Grubelnik-Leiser, A.4
Robinson, J.A.5
-
77
-
-
1642304143
-
Polyketide and nonribosomal peptide antibiotics: Modularity and versatility
-
Walsh C.T. Polyketide and nonribosomal peptide antibiotics: Modularity and versatility. Science 303 (2004) 1805-1810
-
(2004)
Science
, vol.303
, pp. 1805-1810
-
-
Walsh, C.T.1
-
78
-
-
5444249226
-
Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: Novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae
-
Ward S.L., Hu Z., Schirmer A., Reid R., Revill W.P., Reeves C.D., Petrakovsky O.V., Dong S.D., and Katz L. Chalcomycin biosynthesis gene cluster from Streptomyces bikiniensis: Novel features of an unusual ketolide produced through expression of the chm polyketide synthase in Streptomyces fradiae. Antimicrob. Agents Chemother. 48 (2004) 4703-4712
-
(2004)
Antimicrob. Agents Chemother.
, vol.48
, pp. 4703-4712
-
-
Ward, S.L.1
Hu, Z.2
Schirmer, A.3
Reid, R.4
Revill, W.P.5
Reeves, C.D.6
Petrakovsky, O.V.7
Dong, S.D.8
Katz, L.9
-
79
-
-
33746354671
-
Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli
-
Watanabe K., Hotta K., Praseuth A.P., Koketsu K., Migita A., Boddy C.N., Wang C.C., Oguri H., and Oikawa H. Total biosynthesis of antitumor nonribosomal peptides in Escherichia coli. Nat. Chem. Biol. 2 (2006) 423-428
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 423-428
-
-
Watanabe, K.1
Hotta, K.2
Praseuth, A.P.3
Koketsu, K.4
Migita, A.5
Boddy, C.N.6
Wang, C.C.7
Oguri, H.8
Oikawa, H.9
-
80
-
-
0345550239
-
Exploiting the genetic potential of polyketide producing streptomycetes
-
Weber T., Welzel K., Pelzer S., Vente A., and Wohlleben W. Exploiting the genetic potential of polyketide producing streptomycetes. J. Biotechnol. 106 (2003) 221-232
-
(2003)
J. Biotechnol.
, vol.106
, pp. 221-232
-
-
Weber, T.1
Welzel, K.2
Pelzer, S.3
Vente, A.4
Wohlleben, W.5
-
81
-
-
30544434619
-
Combinatorial biosynthesis of reduced polyketides
-
Weissman K.J., and Leadlay P.F. Combinatorial biosynthesis of reduced polyketides. Nat. Rev. Microbiol. 3 (2005) 925-936
-
(2005)
Nat. Rev. Microbiol.
, vol.3
, pp. 925-936
-
-
Weissman, K.J.1
Leadlay, P.F.2
-
82
-
-
15744370033
-
Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering
-
Wenzel S.C., Gross F., Zhang Y., Fu J., Stewart A.F., and Muller R. Heterologous expression of a myxobacterial natural products assembly line in pseudomonads via red/ET recombineering. Chem. Biol. 12 (2005) 349-356
-
(2005)
Chem. Biol.
, vol.12
, pp. 349-356
-
-
Wenzel, S.C.1
Gross, F.2
Zhang, Y.3
Fu, J.4
Stewart, A.F.5
Muller, R.6
-
83
-
-
0035988290
-
Increasing the efficiency of heterologous promoters in actinomycetes
-
Wilkinson C.J., Hughes-Thomas Z.A., Martin C.J., Bohm I., Mironenko T., Deacon M., Wheatcroft M., Wirtz G., Staunton J., and Leadlay P.F. Increasing the efficiency of heterologous promoters in actinomycetes. J. Mol. Microbiol. Biotechnol. 4 (2002) 417-426
-
(2002)
J. Mol. Microbiol. Biotechnol.
, vol.4
, pp. 417-426
-
-
Wilkinson, C.J.1
Hughes-Thomas, Z.A.2
Martin, C.J.3
Bohm, I.4
Mironenko, T.5
Deacon, M.6
Wheatcroft, M.7
Wirtz, G.8
Staunton, J.9
Leadlay, P.F.10
-
84
-
-
0034643859
-
The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units
-
Wu K., Chung L., Revill W.P., Katz L., and Reeves C.D. The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units. Gene 251 (2000) 81-90
-
(2000)
Gene
, vol.251
, pp. 81-90
-
-
Wu, K.1
Chung, L.2
Revill, W.P.3
Katz, L.4
Reeves, C.D.5
-
86
-
-
0028883635
-
Ectopic expression of the Streptomyces coelicolor whiE genes for polyketide spore pigment synthesis and their interaction with the act genes for actinorhodin biosynthesis
-
Yu T.W., and Hopwood D.A. Ectopic expression of the Streptomyces coelicolor whiE genes for polyketide spore pigment synthesis and their interaction with the act genes for actinorhodin biosynthesis. Microbiology 141 Pt 11 (1995) 2779-2791
-
(1995)
Microbiology
, vol.141
, Issue.PART 11
, pp. 2779-2791
-
-
Yu, T.W.1
Hopwood, D.A.2
-
87
-
-
0034050427
-
A two-vector system for the production of recombinant polyketides in Streptomyces
-
Ziermann R., and Betlach M. A two-vector system for the production of recombinant polyketides in Streptomyces. J. Ind. Microbiol. Biotechnol. 24 (2000) 46-50
-
(2000)
J. Ind. Microbiol. Biotechnol.
, vol.24
, pp. 46-50
-
-
Ziermann, R.1
Betlach, M.2
-
88
-
-
0032921036
-
Recombinant polyketide synthesis in Streptomyces: Engineering of improved host strains
-
Ziermann R., and Betlach M.C. Recombinant polyketide synthesis in Streptomyces: Engineering of improved host strains. Biotechniques 26 (1999) 106-110
-
(1999)
Biotechniques
, vol.26
, pp. 106-110
-
-
Ziermann, R.1
Betlach, M.C.2
|