Free-floating amphiphilic picoliter droplet carriers for multiplexed liquid loading in a microfluidic channel

Microfluidics and Nanofluidics

Volumn 13, Issue 3, 2012, Pages 511-518

  Park, Wook ^a   Han, Sangkwon ^b   Lee, Hosuk ^b   Kwon, Sunghoon ^b  

^a Kyung Hee University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Amphiphilic carrier; Encoded droplet carrier; Liquid loading; Microfluidics

Indexed keywords

AMPHIPHILICS; ENCODED DROPLET CARRIER; HIGH-THROUGHPUT; INNER STRUCTURE; LIQUID LOADING; MICRO-FLUIDIC DEVICES; MICROBEADS; MICROCARRIERS; MICROFLUIDIC CHANNEL; MICROFLUIDIC ENVIRONMENT; MICROWELLS; OIL FLOW; OIL PHASE; PICOLITER DROPLETS;

DROPS; FLUIDIC DEVICES; LIQUIDS; MICROFLUIDICS; MULTIPLEXING; SUSPENSIONS (FLUIDS);

LOADING;

EID: 84867231150     PISSN: 16134982     EISSN: 16134990     Source Type: Journal    
DOI: 10.1007/s10404-012-0989-4     Document Type: Article

References (30)

1. Beebe DJ, Moore JS, Bauer JM et al (2000) Functional hydrogel structures for autonomous flow control inside microfluidic channels. Nature 404:588-590
2. Birtwell S, Morgan H (2009) Microparticle encoding technologies for high-throughput multiplexed suspension assays. Integr Biol 1:345-362
3. Bong KW, Chapin SC, Doyle PS (2010) Magnetic barcoded hydrogel microparticles for multiplexed detection. Langmuir 26:8008-8014
4. Braeckmans K, De Smedt S, Leblans M et al (2002) Encoding microcarriers: present and future technologies. Nat Rev Drug Discov 1:447-456
5. Braeckmans K, De Smedt SC, Roelant C et al (2003) Encoding microcarriers by spatial selective photobleaching. Nat Mater 2:169-173
6. Chapin SC, Pregibon DC, Doyle PS (2009) High-throughput flow alignment of barcoded hydrogel microparticles. Lab Chip 9:3100-3109
7. Chung SE, Park W, Park H et al (2007) Optofluidic maskless lithography system for real-time synthesis of photopolymerized microstructures in microfluidic channels. Appl Phys Lett 91: 041106
8. Dendukuri D, Pregibon DC, Collins J, Hatton TA, Doyle PS (2006) Continuous-flow lithography for high-throughput microparticle synthesis. Nat Mater 5:365-369
9. Dittrich PS, Manz A (2006) Lab-on-a-chip: microfluidics in drug discovery. Nat Rev Drug Discov 5:210-218
10. Edd JF, Di Carlo D, Humphry KJ et al (2008) Controlled encapsulation of single-cells into monodisperse picolitre drops. Lab Chip 8:1262-1264
11. Hong J, Edel JB, Demello AJ (2009) Micro-and nanofluidic systems for high-throughput biological screening. Drug Discov Today 14:134-146
12. Hwang DK, Oakey J, Toner M et al (2009) Stop-flow lithography for the production of shape-evolving degradable microgel particles. J Am Chem Soc 131:4499-4504
13. Kim S-H, Shim JW, Yang S-M (2011) Microfluidic multicolor encoding of microspheres with nanoscopic surface complexity for multiplex immunoassays. Angew Chem Int Ed 50:1171-1174
14. Kumacheva E, Garstecki P, Wu H et al (2003) Two-dimensional colloid crystals obtained by coupling of flow and confinement. Phys Rev Lett 91:128301
15. Lee H, Kim J, Kim H et al (2010) Colour barcoded magnetic microparticles for multiplexed bioassays. Nat Mater 9:745-749
16. Lee SA, Chung SE, Park W et al (2009) Three-dimensional fabrication of heterogeneous microstructures using soft membrane deformation and optofluidic maskless lithography. Lab Chip 9:1670-1675
17. Meiring JE, Lee S, Costner EA et al (2009) Pattern recognition of shape-encoded hydrogel biosensor arrays. Opt Eng 48:037201-037214
18. Nam J-M, Thaxton CS, Mirkin CA (2003) Nanoparticle-based bio-bar codes for the ultrasensitive detection of proteins. Science 301:1884-1886
19. Niu X, Gielen F, Edel JB et al (2011) A microdroplet dilutor for highthroughput screening. Nat Chem 3:437-442
20. Panda P, Ali S, Lo E et al (2008) Stop-flow lithography to generate cell-laden microgel particles. Lab Chip 8:1056-1061
21. Park W, Han S, Kwon S (2010) Fabrication of membrane-type microvalves in rectangular microfluidic channels via seal photopolymerization. Lab Chip 10:2814-2817
22. Park W, Lee H, Park H et al (2009) Sorting directionally oriented microstructures using railed microfluidics. Lab Chip 9:2169-2175
23. Pregibon DC, Toner M, Doyle PS (2007) Multifunctional encoded particles for high-throughput biomolecule analysis. Science 315:1393-1396
24. Tan W-H, Takeuchi S (2007) A trap-and-release integrated microfluidic system for dynamic microarray applications. Proc Natl Acad Sci 104:1146-1151
25. Whitesides GM (2006) The origins and the future of microfluidics. Nature 442:368-373
26. Wilson R, Cossins AR, Spiller DG (2006) Encoded microcarriers for high-throughput multiplexed detection. Angew Chem Int Ed 45:6104-6117
27. Wilson R, Spiller DG, Prior IA et al (2007) A simple method for preparing spectrally encoded magnetic beads for multiplexed detection. ACS Nano 1:487-493
28. Wolcke J, Ullmann D (2001) Miniaturized HTS technologies-uHTS. Drug Discov Today 6:637-646
29. Yliperttula M, Chung BG, Navaladi A et al (2008) High-throughput screening of cell responses to biomaterials. Eur J Pharm Sci 35:151-160
30. Zhao Y, Shum HC, Chen H et al (2011) Microfluidic generation of multifunctional quantum dot barcode particles. J Am Chem Soc 133:8790-8793