A circuitry and biochemical basis for tuberous sclerosis symptoms: From epilepsy to neurocognitive deficits

International Journal of Developmental Neuroscience

Volumn 31, Issue 7, 2013, Pages 667-678

  Feliciano, David M ^a   Lin, Tiffany V ^a   Hartman, Nathaniel W ^a   Bartley, Christopher M ^a   Kubera, Cathryn ^a   Hsieh, Lawrence ^a   Lafourcade, Carlos ^a   O'Keefe, Rachel A ^a   Bordey, Angelique ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autism; Dendrite; Differentiation; Epilepsy; FMRP; Mental retardation; Migration; MTOR; Neurogenesis; Progenitor cell; SEGA; Seizures; Spine; Stem cell; Tuber; Tuberous sclerosis complex

Indexed keywords

EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; RAPAMYCIN; TUBERIN;

BRAIN DISEASE; BRAIN MALFORMATION; COGNITIVE DEFECT; CORTICAL TUBER; DENDRITE; DENDRITIC SPINE; DISEASE MODEL; DRUG SELECTIVITY; ELECTROPORATION; EPILEPSY; GENE MUTATION; HAMARTOMA; HETEROZYGOSITY LOSS; HUMAN; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NERVE FIBER; NEUROPATHOLOGY; NONHUMAN; OLFACTORY HAMARTOMA; PERINATAL DEVELOPMENT; PRIORITY JOURNAL; REVIEW; SEIZURE; SIGNAL TRANSDUCTION; SUBEPENDYMAL GIANT CELL ASTROCYTOMA; SUBEPENDYMAL NODULE; TUBEROUS SCLEROSIS; UNSPECIFIED SIDE EFFECT;

MAMMALIA;

4E-BP1; AUTISM; CENTRAL NERVOUS SYSTEM; CEREBRAL SPINAL FLUID; CNS; CREERT2; CSF; DENDRITE; DIFFERENTIATION; E; EEG; EIF4E-BINDING PROTEIN 1; ELECTROENCEPHALOGRAPHY; EMBRYONIC DAY; EPILEPSY; FCDS; FL; FLOXED; FLOXED AND MUTANT TSC1 ALLELES; FLOXED TSC1 ALLELES (TRANSGENIC MICE); FMR1; FMRP; FMRP GENE; FOCAL CORTICAL DYSPLASIAS; FRAGILE X MENTAL RETARDATION PROTEIN; FRAGILE X SYNDROME; FXS; GAP; GFAP; GLIAL FIBRILLARY ACIDIC PROTEIN; GTPASE ACTIVATING PROTEIN; HGFAP; HUMAN GFAP; IN UTERO ELECTROPORATION; INDUCIBLE CRE; IUE; LATERAL VENTRICLE; LOH; LONG-TERM DEPRESSION; LONG-TERM POTENTIATION; LOSS OF HETEROZYGOSITY; LTD; LTP; LV; MAGNETIC RESONANCE IMAGING; MAMMALIAN TARGET OF RAPAMYCIN; MENTAL RETARDATION; METABOTROPIC GLUTAMATE RECEPTOR CLASS I LONG TERM DEPRESSION; MGFAP; MGLUR-LTD; MIGRATION; MOUSE GFAP; MRI; MTOR; MTOR COMPLEX 1 OR 2; MTORC1 OR MTORC2; NEUROGENESIS; P; P70 S6 KINASE 1; POSTNATAL DAY; PP2A; PROGENITOR CELL; PROTEIN PHOSPHATASE 2A; RAS HOMOLOG ENRICHED IN BRAIN; RETINAL GANGLION CELLS; RGCS; RHEB; S6K1; SEGA; SEIZURES; SEN; SEZ; SPINE; STEM CELL; SUBEPENDYMAL GIANT CELL ASTROCYTOMA; SUBEPENDYMAL NODULES; SUBEPENDYMAL ZONE; SYNAPSIN I PROMOTER-DRIVEN CRE; SYNI-CRE; TSC; TSC GENE 1 OR GENE 2; TSC1 OR TSC2; TSC1(FL/FL); TSC1(FL/MUT); TSC1(WT/MUT); TUBER; TUBEROUS SCLEROSIS COMPLEX; WILDTYPE AND MUTANT TSC1 ALLELES;

ANIMALS; CENTRAL NERVOUS SYSTEM; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; EPILEPSY; HUMANS; MICE; TOR SERINE-THREONINE KINASES; TUBEROUS SCLEROSIS;

EID: 84887607964     PISSN: 07365748     EISSN: 1873474X     Source Type: Journal    
DOI: 10.1016/j.ijdevneu.2013.02.008     Document Type: Review

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