Single-cell Tsc1 knockout during corticogenesis generates tuber-like lesions and reduces seizure threshold in mice

Journal of Clinical Investigation

Volumn 121, Issue 4, 2011, Pages 1596-1607

  Feliciano, David M ^a   Su, Tiffany ^a   Lopez, Jean ^a   Platel, Jean Claude ^a,b   Bordey, Angélique ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN S6; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN DAMAGE; BRAIN DEVELOPMENT; DENDRITIC CELL; GENE DELETION; GLIA CELL; GLIOSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOLECULAR MECHANICS; MOUSE; NERVE CELL; NERVE EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; SEIZURE; UPREGULATION;

ANIMALS; ASTROCYTES; BASE SEQUENCE; CELL SIZE; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DNA PRIMERS; FEMALE; GENE KNOCKOUT TECHNIQUES; MICE; MICE, 129 STRAIN; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MICE, TRANSGENIC; PREGNANCY; SEIZURES; TOR SERINE-THREONINE KINASES; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 79953296435     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI44909     Document Type: Article

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