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Volumn 19, Issue 9, 2004, Pages 716-725

Molecular pathogenesis of tuber formation in tuberous sclerosis complex

Author keywords

[No Author keywords available]

Indexed keywords

HAMARTIN; RIBOSOME PROTEIN; S6 KINASE; TARGET OF RAPAMYCIN KINASE; TUBERIN;

EID: 8844224854     PISSN: 08830738     EISSN: None     Source Type: Journal    
DOI: 10.1177/08830738040190091301     Document Type: Review
Times cited : (79)

References (57)
  • 1
    • 0030879277 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
    • van Slegtenhorst M, de Hoogt R, Hermans C, et al: Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 1997;277:805-808.
    • (1997) Science , vol.277 , pp. 805-808
    • van Slegtenhorst, M.1    de Hoogt, R.2    Hermans, C.3
  • 2
    • 0027770784 scopus 로고
    • Identification and characterization of the tuberous sclerosis gene on chromosome 16
    • Consortium ECTS
    • Consortium ECTS: Identification and characterization of the tuberous sclerosis gene on chromosome 16. Cell 1993;75:1305-1315.
    • (1993) Cell , vol.75 , pp. 1305-1315
  • 4
    • 0036263937 scopus 로고    scopus 로고
    • Neuro-epileptic determinants of autism spectrum disorders in tuberous sclerosis complex
    • Bolton PF, Park RJ, Higgins JN, et al: Neuro-epileptic determinants of autism spectrum disorders in tuberous sclerosis complex. Brain 2002;125:1247-1255.
    • (2002) Brain , vol.125 , pp. 1247-1255
    • Bolton, P.F.1    Park, R.J.2    Higgins, J.N.3
  • 5
    • 0033821259 scopus 로고    scopus 로고
    • Epilepsy surgery in children with tuberous sclerosis complex: Presurgical evaluation and outcome
    • Koh S, Jayakar P, Dunoyer C, et al: Epilepsy surgery in children with tuberous sclerosis complex: Presurgical evaluation and outcome. Epilepsia 2000;41:1206-1213.
    • (2000) Epilepsia , vol.41 , pp. 1206-1213
    • Koh, S.1    Jayakar, P.2    Dunoyer, C.3
  • 6
    • 0025861531 scopus 로고
    • Pathology of tuberous sclerosis
    • Richardson EP: Pathology of tuberous sclerosis. Ann N Y Acad Sci 1991;615:128-139.
    • (1991) Ann. N. Y. Acad. Sci. , vol.615 , pp. 128-139
    • Richardson, E.P.1
  • 7
    • 0030742270 scopus 로고    scopus 로고
    • Tuberous sclerosis in a 20-week gestation fetus: Immunohistochemical study
    • Park SH, Pepkowitz SH, Kerfoot C, et al: Tuberous sclerosis in a 20-week gestation fetus: Immunohistochemical study. Acta Neuropathol (Berl) 1997;94:180-186.
    • (1997) Acta Neuropathol (Berl.) , vol.94 , pp. 180-186
    • Park, S.H.1    Pepkowitz, S.H.2    Kerfoot, C.3
  • 8
    • 0019363996 scopus 로고
    • Ultrastructure of tuberous sclerosis: Cortical tuber and subependymal tumor
    • Trombley IK, Mirra SS: Ultrastructure of tuberous sclerosis: Cortical tuber and subependymal tumor. Ann Neurol 1981;9:174-181.
    • (1981) Ann. Neurol. , vol.9 , pp. 174-181
    • Trombley, I.K.1    Mirra, S.S.2
  • 9
    • 0030954850 scopus 로고    scopus 로고
    • Evidence of abnormal differentiation in giant cells of tuberous sclerosis
    • Yamanouchi H, Jay V, Rutka JT, et al: Evidence of abnormal differentiation in giant cells of tuberous sclerosis. Pediatr Neurol 1997;17:49-53.
    • (1997) Pediatr. Neurol. , vol.17 , pp. 49-53
    • Yamanouchi, H.1    Jay, V.2    Rutka, J.T.3
  • 10
    • 0021743111 scopus 로고
    • Fine structure of cortical tubers in tuberous sclerosis
    • Huttenlocher PR, Heydemann PT: Fine structure of cortical tubers in tuberous sclerosis. Ann Neurol 1984;16:595-602.
    • (1984) Ann. Neurol. , vol.16 , pp. 595-602
    • Huttenlocher, P.R.1    Heydemann, P.T.2
  • 11
    • 0029098454 scopus 로고
    • Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: An immunohistochemical. ultrastructural, and immunoelectron microscopic study
    • Hirose Y, Scheithauer BW, Lopes MBS, et al: Tuber and subependymal giant cell astrocytoma associated with tuberous sclerosis: An immunohistochemical. ultrastructural, and immunoelectron microscopic study. Acta Neuropathol 1995;90:387-399.
    • (1995) Acta Neuropathol. , vol.90 , pp. 387-399
    • Hirose, Y.1    Scheithauer, B.W.2    Lopes, M.B.S.3
  • 12
    • 0029932720 scopus 로고    scopus 로고
    • Immunohistochemical characterization of subependymal giant cell astrocytomas
    • Lopes MBS, Altermatt HJ, Scheitauer BW, et al: Immunohistochemical characterization of subependymal giant cell astrocytomas. Acta Neuropathol 1996;91:368-375.
    • (1996) Acta Neuropathol. , vol.91 , pp. 368-375
    • Lopes, M.B.S.1    Altermatt, H.J.2    Scheitauer, B.W.3
  • 15
    • 0035115120 scopus 로고    scopus 로고
    • Differential transcription of neurotransmitter receptor subunits and uptake sites in giant cells and dysplastic neurons in cortical tubers
    • White R, Hua Y, Lynch DR, et al: Differential transcription of neurotransmitter receptor subunits and uptake sites in giant cells and dysplastic neurons in cortical tubers. Ann Neurol 2001;49:67-78.
    • (2001) Ann. Neurol. , vol.49 , pp. 67-78
    • White, R.1    Hua, Y.2    Lynch, D.R.3
  • 16
    • 0038754165 scopus 로고    scopus 로고
    • Markers of cellular proliferation are expressed in cortical tubers
    • Lee A, Maldonado M, Baybis MS, et al: Markers of cellular proliferation are expressed in cortical tubers. Ann Neurol 2003; 53: 668-673.
    • (2003) Ann. Neurol. , vol.53 , pp. 668-673
    • Lee, A.1    Maldonado, M.2    Baybis, M.S.3
  • 17
    • 0034794788 scopus 로고    scopus 로고
    • Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex
    • Kyin R, Hua Y, Baybis M, et al: Differential cellular expression of neurotrophins in cortical tubers of the tuberous sclerosis complex. Am J Pathol 2001;159:1541-1554.
    • (2001) Am. J. Pathol. , vol.159 , pp. 1541-1554
    • Kyin, R.1    Hua, Y.2    Baybis, M.3
  • 18
    • 0031798268 scopus 로고    scopus 로고
    • Surgical treatment of epilepsy in tuberous sclerosis: Strategies and results in 18 patients
    • Guerreiro MM, Andermann F, Andermann E, et al: Surgical treatment of epilepsy in tuberous sclerosis: Strategies and results in 18 patients. Neurology 1998;51:1263-1269.
    • (1998) Neurology , vol.51 , pp. 1263-1269
    • Guerreiro, M.M.1    Andermann, F.2    Andermann, E.3
  • 19
    • 0030639826 scopus 로고    scopus 로고
    • Tuberous sclerosis-like lesions in epileptogenic human neocortex lack allelic loss at the TSC1 and TSC2 regions
    • Wolf HK, Normann S, Green AJ, et al: Tuberous sclerosis-like lesions in epileptogenic human neocortex lack allelic loss at the TSC1 and TSC2 regions. Acta Neuropathol (Berl) 1997; 93:93-96.
    • (1997) Acta Neuropathol. (Berl) , vol.93 , pp. 93-96
    • Wolf, H.K.1    Normann, S.2    Green, A.J.3
  • 20
    • 0027520835 scopus 로고
    • Cortical tubers demonstrate reduced immunoreactivity for synapsin I
    • Lippa CF, Pearson D, Smith TW. Cortical tubers demonstrate reduced immunoreactivity for synapsin I. Acta Neuropathol 1993; 85:449-451.
    • (1993) Acta Neuropathol. , vol.85 , pp. 449-451
    • Lippa, C.F.1    Pearson, D.2    Smith, T.W.3
  • 21
    • 0032213545 scopus 로고    scopus 로고
    • Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles
    • Plank TL, Yeung RS, Henske EP: Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles. Cancer Res 1998;58:4766-4770.
    • (1998) Cancer Res. , vol.58 , pp. 4766-4770
    • Plank, T.L.1    Yeung, R.S.2    Henske, E.P.3
  • 22
    • 0033775869 scopus 로고    scopus 로고
    • The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
    • Lamb RF, Roy C, Diefenbach TJ, et al: The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat Cell Biol 2000;2:281-287.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 281-287
    • Lamb, R.F.1    Roy, C.2    Diefenbach, T.J.3
  • 23
    • 0028838709 scopus 로고
    • The tuberous sclerosis 2 gene is expressed at high levels in the cerebellum and developing spinal cord
    • Geist RT, Gutmann DH: The tuberous sclerosis 2 gene is expressed at high levels in the cerebellum and developing spinal cord. Cell Growth Differ 1995;6:1477-1483.
    • (1995) Cell Growth Differ. , vol.6 , pp. 1477-1483
    • Geist, R.T.1    Gutmann, D.H.2
  • 24
    • 0030130431 scopus 로고    scopus 로고
    • Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues
    • Geist RT, Reddy AJ, Zhang J, Gutmann DH: Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues. Neurobiol Dis 1996;3:11-120.
    • (1996) Neurobiol. Dis. , vol.3 , pp. 11-120
    • Geist, R.T.1    Reddy, A.J.2    Zhang, J.3    Gutmann, D.H.4
  • 25
    • 0029859607 scopus 로고    scopus 로고
    • Localization of tuberous sclerosis 2 mRNA and its protein product tuberin in normal human brain and in cerebral lesion of patients with tuberous sclerosis
    • Kerfoot C, Wienecke R, Menchine M, et al. Localization of tuberous sclerosis 2 mRNA and its protein product tuberin in normal human brain and in cerebral lesion of patients with tuberous sclerosis. Brain Pathol 1996;6:367-377.
    • (1996) Brain Pathol. , vol.6 , pp. 367-377
    • Kerfoot, C.1    Wienecke, R.2    Menchine, M.3
  • 26
    • 0030853223 scopus 로고    scopus 로고
    • Tuberin immunohistochemistry in brain, kidneys and heart with or without tuberous sclerosis
    • Mizuguchi M, Kato M, Yamanouchi H, et al: Tuberin immunohistochemistry in brain, kidneys and heart with or without tuberous sclerosis. Acta Neuropathol (Berl) 1997;94:525-531.
    • (1997) Acta Neuropathol. (Berl.) , vol.94 , pp. 525-531
    • Mizuguchi, M.1    Kato, M.2    Yamanouchi, H.3
  • 27
    • 0031033220 scopus 로고    scopus 로고
    • Expression of the TSC2 product tuberin and its target Rap1 in non-nal human tissues
    • Wienecke R, Maize J, Reed J, et al: Expression of the TSC2 product tuberin and its target Rap1 in non-nal human tissues. Am J Pathol 1997;150:43-50.
    • (1997) Am. J. Pathol. , vol.150 , pp. 43-50
    • Wienecke, R.1    Maize, J.2    Reed, J.3
  • 28
    • 1842337009 scopus 로고    scopus 로고
    • Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus
    • Wienecke R, Maize J, Shoarinejad F, et al: Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus. Oncogene 1996;13:913-923.
    • (1996) Oncogene , vol.13 , pp. 913-923
    • Wienecke, R.1    Maize, J.2    Shoarinejad, F.3
  • 29
    • 0030663735 scopus 로고    scopus 로고
    • Role of the tuberous sclerosis gene-2 product in cell cycle control
    • Soucek T, Pusch O, Wienecke R, et al: Role of the tuberous sclerosis gene-2 product in cell cycle control. J Biol Chem 1997;272:29301-293082.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29301-293082
    • Soucek, T.1    Pusch, O.2    Wienecke, R.3
  • 30
    • 0032580368 scopus 로고    scopus 로고
    • A role of the tuberous sclerosis gene-2 product during neuronal differentiation
    • Soucek T, Holzl G, Bernaschek G, Hengstschlager M: A role of the tuberous sclerosis gene-2 product during neuronal differentiation. Oncogene 1998;16:2197-2204.
    • (1998) Oncogene , vol.16 , pp. 2197-2204
    • Soucek, T.1    Holzl, G.2    Bernaschek, G.3    Hengstschlager, M.4
  • 31
    • 0034936816 scopus 로고    scopus 로고
    • Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B
    • Catania MG, Mischel PS, Vinters HV: Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B. J Neuropathol Exp Neurol 2001;60:711-723.
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 711-723
    • Catania, M.G.1    Mischel, P.S.2    Vinters, H.V.3
  • 32
    • 0032693614 scopus 로고    scopus 로고
    • New developments in the neurobiology of the tuberous sclerosis complex
    • Crino PB, Henske EP: New developments in the neurobiology of the tuberous sclerosis complex. Neurology 1999;53:1384-1391.
    • (1999) Neurology , vol.53 , pp. 1384-1391
    • Crino, P.B.1    Henske, E.P.2
  • 33
    • 0035805162 scopus 로고    scopus 로고
    • Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size
    • Potter CJ, Huang H, Xu T. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 2001;105:357-368.
    • (2001) Cell , vol.105 , pp. 357-368
    • Potter, C.J.1    Huang, H.2    Xu, T.3
  • 34
    • 0034982971 scopus 로고    scopus 로고
    • TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
    • Gao X, Pan D: TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev 2001;15:1383-1392.
    • (2001) Genes Dev. , vol.15 , pp. 1383-1392
    • Gao, X.1    Pan, D.2
  • 35
    • 7144255533 scopus 로고    scopus 로고
    • Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products
    • van Slegtenhorst M, Nellist M, Nagelkerken B, et al: Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products. Hum Mol Genet 1998;7:1053-1057.
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 1053-1057
    • van Slegtenhorst, M.1    Nellist, M.2    Nagelkerken, B.3
  • 36
    • 0036712905 scopus 로고    scopus 로고
    • Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
    • Arrazola P, Hino O, Kobayashi T, et al: Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol 2002;4:699-704.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 699-704
    • Arrazola, P.1    Hino, O.2    Kobayashi, T.3
  • 37
    • 0037108682 scopus 로고    scopus 로고
    • Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors
    • Kenerson HL, Aicher LD, True L, et al: Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors. Cancer Res 2002;62:5645-5650.
    • (2002) Cancer Res. , vol.62 , pp. 5645-5650
    • Kenerson, H.L.1    Aicher, L.D.2    True, L.3
  • 38
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle T, Hall MN, et al: TOR, a central controller of cell growth. Cell 2000;103:253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 39
    • 0036712741 scopus 로고    scopus 로고
    • TSC1-TSC2: A complex tale of PKB-mediated S6K regulation
    • McManus EJ, Alessi DR: TSC1-TSC2: A complex tale of PKB-mediated S6K regulation. Nat Cell Biol 2002;4:E214-E216.
    • (2002) Nat. Cell Biol. , vol.4
    • McManus, E.J.1    Alessi, D.R.2
  • 40
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • Tee AR, Fingar DC, Manning BD, et al: Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A 2002;99:13571-13576.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3
  • 41
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, et al: TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002; 4:648-657.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3
  • 42
    • 0036943576 scopus 로고    scopus 로고
    • Tsc2 null murine neuronal epithelial cells are a model for human tuber giant cells and show activation of an mTOR pathway
    • Onda H, Crino PB, Zhang H, et al: Tsc2 null murine neuronal epithelial cells are a model for human tuber giant cells and show activation of an mTOR pathway. Mol Cell Neurosci 2002;21: 561-574.
    • (2002) Mol. Cell Neurosci. , vol.21 , pp. 561-574
    • Onda, H.1    Crino, P.B.2    Zhang, H.3
  • 43
    • 0037454409 scopus 로고    scopus 로고
    • Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma
    • El-Hashemite N, Zhang H, Henske EP, Kwiatkowski DJ: Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma. Lancet 2003;361: 1348-1349.
    • (2003) Lancet , vol.361 , pp. 1348-1349
    • El-Hashemite, N.1    Zhang, H.2    Henske, E.P.3    Kwiatkowski, D.J.4
  • 44
    • 0028289473 scopus 로고
    • Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients
    • Green AJ, Smith M, Yates JR: Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nat Genet 1994;6:193-196.
    • (1994) Nat. Genet. , vol.6 , pp. 193-196
    • Green, A.J.1    Smith, M.2    Yates, J.R.3
  • 45
    • 0029831886 scopus 로고    scopus 로고
    • Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions
    • Henske E, Scheithauer B, Short M, et al: Allelic loss is frequent in tuberous sclerosis kidney lesions but rare in brain lesions. Am J Hum Genet 1996;59:400-406.
    • (1996) Am. J. Hum. Genet. , vol.59 , pp. 400-406
    • Henske, E.1    Scheithauer, B.2    Short, M.3
  • 46
    • 0030725540 scopus 로고    scopus 로고
    • Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors
    • Henske E, Wessner L, Golden J, et al: Loss of tuberin in both subependymal giant cell astrocytomas and angiomyolipomas supports a two-hit model for the pathogenesis of tuberous sclerosis tumors. Am J Pathol 1997;151:1639-1647.
    • (1997) Am. J. Pathol. , vol.151 , pp. 1639-1647
    • Henske, E.1    Wessner, L.2    Golden, J.3
  • 47
    • 0034887907 scopus 로고    scopus 로고
    • Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions
    • Niida Y, Stemmer-Rachamimov AO, Logrip M, et al: Survey of somatic mutations in tuberous sclerosis complex (TSC) hamartomas suggests different genetic mechanisms for pathogenesis of TSC lesions. Am J Hum Genet 2001;69:493-503.
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 493-503
    • Niida, Y.1    Stemmer-Rachamimov, A.O.2    Logrip, M.3
  • 48
    • 0032957003 scopus 로고    scopus 로고
    • Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis
    • Johnson MW, Emelin JK, Park SH: Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis. Brain Pathol 1999;9:45-54.
    • (1999) Brain Pathol. , vol.9 , pp. 45-54
    • Johnson, M.W.1    Emelin, J.K.2    Park, S.H.3
  • 49
    • 0029859607 scopus 로고    scopus 로고
    • Localization of tuberous sclerosis 2 mRNA and its protein product tuberin in normal human brain and in cerebral lesion of patients with tuberous sclerosis
    • Kerfoot C, Wienecke R, Menchine M, et al: Localization of tuberous sclerosis 2 mRNA and its protein product tuberin in normal human brain and in cerebral lesion of patients with tuberous sclerosis. Brain Pathol 1996;6:367-377.
    • (1996) Brain Pathol. , vol.6 , pp. 367-377
    • Kerfoot, C.1    Wienecke, R.2    Menchine, M.3
  • 50
    • 0030853223 scopus 로고    scopus 로고
    • Tuberin immunohistochemistry in brain, kidneys and heart with or without tuberous sclerosis
    • Mizuguchi M, Kato M, Yamanouchi H, et al: Tuberin immunohistochemistry in brain, kidneys and heart with or without tuberous sclerosis. Acta Neuropathol (Berl) 1997;94:525-531.
    • (1997) Acta Neuropathol. (Berl) , vol.94 , pp. 525-531
    • Mizuguchi, M.1    Kato, M.2    Yamanouchi, H.3
  • 51
    • 0842325813 scopus 로고    scopus 로고
    • Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions
    • Han S, Santos TM, Puga A, et al: Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions. Cancer Res 2004;64: 812-816.
    • (2004) Cancer Res. , vol.64 , pp. 812-816
    • Han, S.1    Santos, T.M.2    Puga, A.3
  • 52
    • 0035167932 scopus 로고    scopus 로고
    • Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs
    • Dabora SL, Jozwiak S, Franz DN, et al: Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet 2001;68:64-80.
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 64-80
    • Dabora, S.L.1    Jozwiak, S.2    Franz, D.N.3
  • 53
    • 0032438210 scopus 로고    scopus 로고
    • Tuberous sclerosis complex consensus conference: Revised clinical diagnostic criteria
    • Roach ES, Gomez MR, Northrup H: Tuberous sclerosis complex consensus conference: Revised clinical diagnostic criteria. J Child Neurol 1998;13:624-628.
    • (1998) J. Child Neurol. , vol.13 , pp. 624-628
    • Roach, E.S.1    Gomez, M.R.2    Northrup, H.3
  • 54
    • 0037092415 scopus 로고    scopus 로고
    • Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway
    • Parent JM, Valentin VV, Lowenstein DH, et al: Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone-olfactory bulb pathway. J Neurosci 2002;22:3174-3188.
    • (2002) J. Neurosci. , vol.22 , pp. 3174-3188
    • Parent, J.M.1    Valentin, V.V.2    Lowenstein, D.H.3
  • 55
    • 0032159190 scopus 로고    scopus 로고
    • White matter abnormalities in tuberous sclerosis complex
    • Griffiths PD, Bolton P, Verity C: White matter abnormalities in tuberous sclerosis complex. Acta Radiol 1998;39:482-486.
    • (1998) Acta Radiol. , vol.39 , pp. 482-486
    • Griffiths, P.D.1    Bolton, P.2    Verity, C.3
  • 56
    • 0032725180 scopus 로고    scopus 로고
    • MR imaging of tuberous sclerosis in neonates and young infants
    • Baron Y, Barkovich AJ: MR imaging of tuberous sclerosis in neonates and young infants. AJNR Am J Neuroradiol 1999;20: 907-916.
    • (1999) AJNR Am. J. Neuroradiol. , vol.20 , pp. 907-916
    • Baron, Y.1    Barkovich, A.J.2
  • 57
    • 0142157634 scopus 로고    scopus 로고
    • Expression of ICAM-1 TNF-alpha, NFkappaB, and MAP kinase in tubers of the tuberous sclerosis complex
    • Maldonado M, Baybis M, Newman D, et al: Expression of ICAM-1 TNF-alpha, NFkappaB, and MAP kinase in tubers of the tuberous sclerosis complex. Neurobiol Dis 2003;14:279-290.
    • (2003) Neurobiol. Dis. , vol.14 , pp. 279-290
    • Maldonado, M.1    Baybis, M.2    Newman, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.