Impaired synaptic plasticity in a rat model of tuberous sclerosis

European Journal of Neuroscience

Volumn 23, Issue 3, 2006, Pages 686-692

  Von Der Brelie, Christian ^a   Waltereit, Robert ^b   Zhang, Lian ^a   Beck, Heinz ^a   Kirschstein, Timo ^c  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b CENTRAL INSTITUTE OF MENTAL HEALTH   (Germany)

^c UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; BICUCULLINE; TUBERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CONTROLLED STUDY; DISEASE MODEL; DISEASE SEVERITY; GENE MUTATION; GERM LINE; HETEROZYGOTE; HIPPOCAMPUS; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MALE; MENTAL DEFICIENCY; MOLECULAR BIOLOGY; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; RAT; STIMULATION; SYNAPSE; SYNAPTIC TRANSMISSION; TUBEROUS SCLEROSIS; WILD TYPE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; BICUCULLINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; GABA ANTAGONISTS; MALE; MEMBRANE POTENTIALS; NEURONAL PLASTICITY; NEURONS; PATCH-CLAMP TECHNIQUES; RATS; RATS, LONG-EVANS; SYNAPSES; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS;

EID: 33644953843     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2006.04594.x     Document Type: Article

References (56)

1. Auerbach JM. Segal M. 1997 Peroxide modulation of slow onset potentiation in rat hippocampus JNeurosci 17 8695 8701
2. Baybis M. Yu J. Lee A. Golden JA. Weiner H. McKhann G2nd Aronica E. Crino PB. 2004 mTOR cascade activation distinguishes tubers from focal cortical dysplasia AnnNeurol 56 478 487
3. Bear MF. Huber KM. Warren ST. 2004 The mGluR theory of fragile X mental retardation Trends Neurosci 27 370 377
4. Beck H. Goussakov IV. Lie A. Helmstaedter C. Elger CE. 2000 Synaptic plasticity in the human dentate gyrus JNeurosci 20 7080 7086
5. Cammalleri M. Lutjens R. Berton F. King AR. Simpson C. Francesconi W. Sanna PP. 2003 Time-restricted role for dendritic activation of the mTOR-p70S6K pathway in the induction of late-phase long-term potentiation in the CA1 ProcNatlAcadSciUSA 100 14368 14373
6. Coogan AN. O'Leary DM. O'Connor JJ. 1999 P42/44 MAP kinase inhibitor PD98059 attenuates multiple forms of synaptic plasticity in rat dentate gyrus in vitro JNeurophysiol 81 103 110
7. Costa RM. Federov NB. Kogan JH. Murphy GG. Stern J. Ohno M. Kucherlapati R. Jacks T. Silva AJ. 2002 Mechanism for the learning deficits in a mouse model of neurofibromatosis type 1 Nature 415 526 530
8. Costa RM. Yang T. Huynh DP. Pulst SM. Viskochil DH. Silva AJ. Brannan CI. 2001 Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1 NatGenet 27 399 405
9. Crino PB. Trojanowski JQ. Dichter MA. Eberwine J. 1996 Embryonic neuronal markers in tuberous sclerosis: single-cell molecular pathology ProcNatlAcadSciUSA 93 14152 14157
10. Curatolo P. 2003 Tuberous Sclerosis Complex: From Basic Science to Clinical Phenotypes MacKeith Press Cambridge
11. Dabora SL. Jozwiak S. Franz DN. Roberts PS. Nieto A. Chung J. Choy YS. Reeve MP. Thiele E. Egelhoff JC. Kasprzyk-Obara J. Domanska-Pakiela D. Kwiatkowski DJ. 2001 Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs AmJHumGenet 68 64 80
12. Eker R. Mossige J. 1961 A dominant gene for renal adenomas in the rat Nature 189 858 859
13. El-Hashemite N. Zhang H. Henske EP. Kwiatkowski DJ. 2003 Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma Lancet 361 1348 1349
14. English JD. Sweatt JD. 1997 A requirement for the mitogen-activated protein kinase cascade in hippocampal long term potentiation JBiolChem 272 19103 19106
15. Gao X. Zhang Y. Arrazola P. Hino O. Kobayashi T. Yeung RS. Ru B. Pan D. 2002 Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling NatCellBiol 4 699 704
16. Godfraind JM. Reyniers E. De Boulle K. D'Hooge R. De Deyn PP. Bakker CE. Oostra BA. Kooy RF. Willems PJ. 1996 Long-term potentiation in the hippocampus of fragile X knockout mice AmJMedGenet 64 246 251
17. Goussakov IV. Fink K. Elger CE. Beck H. 2000 Metaplasticity of mossy fiber synaptic transmission involves altered release probability JNeurosci 20 3434 3441
18. Hino O. Kobayashi E. Hirayama Y. Kobayashi T. Kubo Y. Tsuchiya H. Kikuchi Y. Mitani H. 1995 Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2) MolCarcinog 14 23 27
19. Ingram DA. Hiatt K. King AJ. Fisher L. Shivakumar R. Derstine C. Wenning MJ. Diaz B. Travers JB. Hood A. Marshall M. Williams DA. Clapp DW. 2001 Hyperactivation of p21 (ras) and the hematopoietic-specific Rho GTPase, Rac2, cooperate to alter the proliferation of neurofibromin-deficient mast cells in vivo and in vitro JExpMed 194 57 69
20. Inoki K. Li Y. Zhu T. Wu J. Guan KL. 2002 TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling NatCell Biol 4 648 657
21. Jiang YH. Armstrong D. Albrecht U. Atkins CM. Noebels JL. Eichele G. Sweatt JD. Beaudet AL. 1998 Mutation of the Angelman ubiquitin ligase in mice causes increased cytoplasmic p53 and deficits of contextual learning and long-term potentiation Neuron 21 799 811
22. Johnson MW. Emelin JK. Park SH. Vinters HV. 1999 Co-localization of TSC1 and TSC2 gene products in tubers of patients with tuberous sclerosis Brain Pathol 9 45 54
23. Jones AC. Daniells CE. Snell RG. Tachataki M. Idziaszczyk SA. Krawczak M. Sampson JR. Cheadle JP. 1997 Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis HumMolGenet 6 2155 2161
24. Jones AC. Shyamsundar MM. Thomas MW. Maynard J. Idziaszczyk S. Tomkins S. Sampson JR. Cheadle JP. 1999 Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis AmJHumGenet 64 1305 1315
25. Kandt RS. 2003 Tuberous sclerosis complex and neurofibromatosis type 1: the two most common neurocutaneous diseases NeurolClin 21 983 1004
26. Kanterewicz BI. Urban NN. McMahon DB. Norman ED. Giffen LJ. Favata MF. Scherle PA. Trzskos JM. Barrionuevo G. Klann E. 2000 The extracellular signal-regulated kinase cascade is required for NMDA receptor-independent LTP in area CA1 but not area CA3 of the hippocampus JNeurosci 20 3057 3066
27. Kelleher RJ3rd Govindarajan A. Jung HY. Kang H. Tonegawa S. 2004 Translational control by MAPK signaling in long-term synaptic plasticity and memory Cell 116 467 479
28. Kenerson HL. Aicher LD. True LD. Yeung RS. 2002 Activated mammalian target of rapamycin pathway in the pathogenesis of tuberous sclerosis complex renal tumors Cancer Res 62 5645 5650
29. Kirschstein T. Beck H. 2004 Status epilepticus-induced impairment of LTP in the rat lateral perforant path is rescued by d -serine Pflügers ArchSuppl 447 S80
30. Kobayashi T. Hirayama Y. Kobayashi E. Kubo Y. Hino O. 1995 A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer NatGenet 9 70 74
31. Manning BD. Cantley LC. 2003 Rheb fills a GAP between TSC and TOR Trends BiochemSci 28 573 576
32. Menchine M. Emelin JK. Mischel PS. Haag TA. Norman MG. Pepkowitz SH. Welsh CT. Townsend JJ. Vinters HV. 1996 Tissue and cell-type specific expression of the tuberous sclerosis gene, TSC2, in human tissues ModPathol 9 1071 1080
33. Morozov A. Muzzio IA. Bourtchouladze R. Van-Strien N. Lapidus K. Yin D. Winder DG. Adams JP. Sweatt JD. Kandel ER. 2003 Rap1 couples cAMP signaling to a distinct pool of p42/44MAPK regulating excitability, synaptic plasticity, learning, and memory Neuron 39 309 325
34. Nalbantoglu J. Tirado-Santiago G. Lahsaini A. Poirier J. Goncalves O. Verge G. Momoli F. Welner SA. Massicotte G. Julien JP. Shapiro ML. 1997 Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein Nature 387 500 505
35. Nellist M. van Slegtenhorst MA. Goedbloed M. van den Ouweland AM. Halley DJ. van der Sluijs P. 1999 Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin JBiolChem 274 35647 35652
36. Oddo S. Caccamo A. Shepherd JD. Murphy MP. Golde TE. Kayed R. Metherate R. Mattson MP. Akbari Y. LaFerla FM. 2003 Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction Neuron 39 409 421
37. Rennebeck G. Kleymenova EV. Anderson R. Yeung RS. Artzt K. Walker CL. 1998 Loss of function of the tuberous sclerosis 2 tumor suppressor gene results in embryonic lethality characterized by disrupted neuroepithelial growth and development ProcNatlAcadSciUSA 95 15629 15634
38. Roach ES. Gomez MR. Northrup H. 1998 Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria JChildNeurol 13 624 628
39. Sweatt JD. 2004 Mitogen-activated protein kinases in synaptic plasticity and memory CurrOpinNeurobiol 14 311 317
40. Takahashi DK. Dinday MT. Barbaro NM. Baraban SC. 2004 Abnormal cortical cells and astrocytomas in the Eker rat model of tuberous sclerosis complex Epilepsia 45 1525 1530
41. Tang SJ. Reis G. Kang H. Gingras AC. Sonenberg N. Schuman EM. 2002 A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus ProcNatlAcadSciUSA 99 467 472
42. Van Slegtenhorst M. Nellist M. Nagelkerken B. Cheadle J. Snell R. van den Ouweland A. Reuser A. Sampson J. Halley D. van der Sluijs P. 1998 Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products HumMolGenet 7 1053 1057
43. Vinters HV. Park SH. Johnson MW. Mischel PS. Catania M. Kerfoot C. 1999 Cortical dysplasia, genetic abnormalities and neurocutaneous syndromes DevNeurosci 21 248 259
44. 2+ and cAMP requires protein kinase A and mitogen-activated protein kinase/extracellular regulated kinase activation JNeurosci 21 5484 5493
45. Waltereit R. von der Brelie C. Welzl H. Zhang L. Dichgans J. Schmidt WJ. Beck H. Weller M. 2004 Altered episodic-like memory, increased susceptibility to kindling, increased p42-MAPK induction and impaired synaptic plasticity in a rat model of tuberous sclerosis SocNeurosciAbstr, Program no 974.6
46. Weeber EJ. Jiang YH. Elgersma Y. Varga AW. Carrasquillo Y. Brown SE. Christian JM. Mirnikjoo B. Silva A. Beaudet AL. Sweatt JD. 2003 Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome JNeurosci 23 2634 2644
47. Wenzel HJ. Patel LS. Robbins CA. Emmi A. Yeung RS. Schwartzkroin PA. 2004 Morphology of cerebral lesions in the Eker rat model of tuberous sclerosis Acta Neuropathol(Berl) 108 97 108
48. Wienecke R. Konig A. DeClue JE. 1995 Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity JBiolChem 270 16409 16414
49. Xiao GH. Jin F. Yeung RS. 1995 Germ-line Tsc2 mutation in a dominantly inherited cancer model defines a novel family of rat intracisternal-A particle elements Oncogene 11 81 87
50. Xiao GH. Shoarinejad F. Jin F. Golemis EA. Yeung RS. 1997 The tuberous sclerosis 2 gene product, tuberin, functions as a Rab5 GTPase activating protein (GAP) in modulating endocytosis JBiolChem 272 6097 6100
51. Yeung RS. Katsetos CD. Klein-Szanto A. 1997 Subependymal astrocytic hamartomas in the Eker rat model of tuberous sclerosis AmJPathol 151 1477 1486
52. Yeung RS. Xiao GH. Everitt JI. Jin F. Walker CL. 1995 Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat MolCarcinog 14 28 36
53. Yeung RS. Xiao GH. Jin F. Lee WC. Testa JR. Knudson AG. 1994 Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene ProcNatlAcadSciUSA 91 11413 11416
54. Yoon HS. Ramachandiran S. Chacko MA. Monks TJ. Lau SS. 2004 Tuberous sclerosis-2 tumor suppressor modulates ERK and B-Raf activity in transformed renal epithelial cells AmJPhysiolRenalPhysiol 286 F417 F424
55. Zhang Y. Gao X. Saucedo LJ. Ru B. Edgar BA. Pan D. 2003 Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins NatCellBiol 5 578 581
56. Zhu JJ. Qin Y. Zhao M. Van Aelst L. Malinow R. 2002 Ras and Rap control AMPA receptor trafficking during synaptic plasticity Cell 110 443 455