Structural basis for molecular recognition of folic acid by folate receptors

Nature

Volumn 500, Issue 7463, 2013, Pages 486-489

  Chen, Chen ^a,b   Ke, Jiyuan ^a   Edward Zhou, X ^a   Yi, Wei ^c   Brunzelle, Joseph S ^d   Li, Jun ^e   Yong, Eu Leong ^e   Xu, H Eric ^a,c   Melcher, Karsten ^a  

^a VAN ANDEL RESEARCH INSTITUTE   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^d NORTHWESTERN UNIVERSITY   (United States)

^e NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPTERIN; FOLATE RECEPTOR; FOLATE RECEPTOR 1; FOLATE RECEPTOR 2; FOLIC ACID; METHOTREXATE; REDUCED FOLATE CARRIER;

CELL ORGANELLE; CRYSTAL STRUCTURE; LIGAND; PROTEIN; TUMOR;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISULFIDE BOND; EMBRYO DEVELOPMENT; HUMAN; HYDROGEN BOND; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; PURIFICATION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; FOLATE RECEPTOR 1; FOLIC ACID; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84882818980     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature12327     Document Type: Article

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