Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur

EMBO Journal

Volumn 21, Issue 5, 2002, Pages 1054-1062

  Brown, James ^a   Esnouf, Robert M ^a   Jones, Margaret A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Growth factor receptor; IGF II; Protein crystallography; Tumour suppression

Indexed keywords

CELL SURFACE RECEPTOR; SOMATOMEDIN B; SOMATOMEDIN B RECEPTOR; SULFUR;

ARTICLE; BETA SHEET; BINDING SITE; CANCER INHIBITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DATA BASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; RECEPTOR BINDING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CHICKENS; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; HUMANS; INSULIN-LIKE GROWTH FACTOR II; MAMMALS; MODELS, MOLECULAR; NEOPLASM PROTEINS; POINT MUTATION; POLYMORPHISM, GENETIC; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, IGF TYPE 2; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036499988     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.5.1054     Document Type: Article

References (48)

1. Crystallography and NMR system: A new software suite for macromolecular structure determination
2. Cell survival and proliferation are modified by insulin-like growth factor 2 between days 9 and 10 of mouse gestation
3. Disruption of ligand binding to the insulin-like growth factor II/mannose 6-phosphate receptor by cancer-associated missense mutations
4. Dimerization of the insulin-like growth factor II/mannose 6-phosphate receptor
5. The bovine mannose 6-phosphate/insulin-like growth factor II receptor. The role of arginine residues in mannose 6-phosphate binding
6. Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods
7. Cellular activation of latent transforming growth factor β requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor
8. An insulin-like growth factor II (IGF-II) affinity-enhancing domain localized within extracytoplasmic repeat 13 of the IGF-II/mannose 6-phosphate receptor
9. Altered ligand binding by insulin-like growth factor II/mannose 6-phosphate receptors bearing missense mutations in human cancers
10. Further additions to MolScript version 1.4, including reading and contouring of electron-density maps
11. Genomic imprinting: Implications for human disease
12. Assembly and crystallization of the complex between the human T cell coreceptor CD8α homodimer and HLA-A2
13. Truncated forms of the insulin-like growth factor II (IGF-II)/mannose 6-phosphate receptor encompassing the IGF-II binding site: Characterization of a point mutation that abolishes IGF-II binding
14. A computational procedure for determining energetically favorable binding sites on biologically important macromolecules
15. ESPript: Analysis of multiple sequence alignments in PostScript
16. Insulin-like growth factor II supply modifies growth of intestinal adenoma in Apc(Min/+) mice
17. Structure of the hydrophobic protein crambin determined directly from the anomalous scattering of sulfur
18. PROMOTIF - A program to identify and analyze structural motifs in proteins
19. Genomic imprinting, mammalian evolution, and the mystery of egg-laying mammals
20. Improved methods for building protein models in electron-density maps and the location of errors in these models
21. M6P/IGF2R imprinting evolution in mammals
22. Mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) variants in American and Japanese populations
23. Rapid automated molecular replacement by evolutionary search
24. M6P/IGF2R is mutated in squamous cell carcinoma of the lung
25. Structure and function of the mannose 6-phosphate/insulin-like growth factor II receptors
26. Procheck - A program to check the stereochemical quality of protein structures
27. Real time kinetics of insulin-like growth factor II (IGF-II) interaction with the IGF-II/mannose 6-phosphate receptor: The effects of domain 13 and pH
28. Cloning and sequence analysis of the cation-independent mannose 6-phosphate receptor
29. Raster3D: Photorealistic molecular graphics
30. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis
31. Protein folding and association - Insights from the interfacial and thermodynamic properties of hydrocarbons
32. Structural basis for recognition of phosphorylated high mannose oligosaccharides by the cation-dependent mannose 6-phosphate receptor
33. The human cation-independent mannose 6-phosphate receptor. Cloning and sequence of the full-length cDNA and expression of functional receptor in COS cells
34. Processing of X-ray diffraction data collected in oscillation mode
35. Automated protein model building combined with iterative structure refinement
36. Molecular basis of lysosomal enzyme recognition: Three-dimensional structure of the cation-dependent mannose 6-phosphate receptor
37. Localization of the insulin-like growth factor II binding site to amino acids 1508-1566 in repeat 11 of the mannose 6-phosphate/insulin-like growth factor II receptor
38. Crystal structure of cat muscle pyruvate kinase at a resolution of 2.6 Å
39. Solution structure of human insulin-like growth factor II: Recognition sites for receptors and binding proteins
40. Clustal_W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
41. Involvement of IGF-II in human cancer
42. The design and implementation of SnB version 2.0
43. Hematopoietic receptor complexes
44. The kangaroo cation-independent mannose 6-phosphate receptor binds insulin-like growth factor II with low affinity
45. The rate of internalization of the mannose 6-phosphate/insulin-like growth factor II receptor is enhanced by multivalent ligand binding
46. The interaction of insulin-like growth factor-I with the N-terminal domain of IGFBP-5
47. Cloning and expression of the cDNA of chicken cation-independent mannose-6-phosphate receptor