Novel oxysterols have pro-osteogenic and anti-adipogenic effects in vitro and induce spinal fusion in vivo

Journal of Cellular Biochemistry

Volumn 112, Issue 6, 2011, Pages 1673-1684

  Johnson, Jared S ^a   Meliton, Vicente ^a   Kim, Woo Kyun ^a   Lee, Kwang Bok ^a   Wang, Jeffrey C ^a   Nguyen, Khanhlinh ^b   Yoo, Dongwon ^b   Jung, Michael E ^b   Atti, Elisa ^b   Tetradis, Sotirios ^b   Pereira, Renata C ^b   Magyar, Clara ^b   Nargizyan, Taya ^a   Hahn, Theodore J ^c   Farouz, Francine ^d   Thies, Scott ^d   Parhami, Farhad ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^d Fate Therapeutics   (United States)

Author keywords

adipogenesis; BMP2; osteogenesis; oxysterols; spinal fusion

Indexed keywords

ALKALINE PHOSPHATASE; BONE SIALOPROTEIN; CHOLESTAN 3BETA,6ALPHA,20 TRIOL; COLLAGEN IMPLANT; FATTY ACID BINDING PROTEIN 4; HYDROXYCHOLESTEROL; LIPOPROTEIN LIPASE; OSTEOCALCIN; OXYSTEROL; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TROGLITAZONE; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BONE DEVELOPMENT; BONE MINERALIZATION; CELL DIFFERENTIATION; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVITY; MALE; MOUSE; NONHUMAN; OSSIFICATION; PRIORITY JOURNAL; RAT; SPINE FUSION;

ADIPOGENESIS; ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINE; HYDROXYCHOLESTEROLS; MALE; MICE; OSTEOGENESIS; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SPINAL FUSION; SPINE; STROMAL CELLS;

ERINACEIDAE; RATTUS;

EID: 79954544086     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23082     Document Type: Article

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