-
1
-
-
0034702405
-
The Nobel chronicles. 1998 Robert Francis Furchgott (b 1911), Louis J Ignarro (b 1941), and Ferid Murad (b 1936)
-
Raju TN. The Nobel chronicles. 1998: Robert Francis Furchgott (b 1911), Louis J Ignarro (b 1941), and Ferid Murad (b 1936). Lancet. 2000; 356: 346.
-
(2000)
Lancet
, vol.356
, pp. 346
-
-
Raju, T.N.1
-
2
-
-
0030154874
-
Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
-
Boolell BM, Allen MJ, Ballard SA, Gepi-Attee S, Muirhead GJ, Naylor AM, et al. Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res. 1996; 8 (2): 47-52.
-
(1996)
Int J Impot Res
, vol.8
, Issue.2
, pp. 47-52
-
-
Boolell, B.M.1
Allen, M.J.2
Ballard, S.A.3
Gepi-Attee, S.4
Muirhead, G.J.5
Naylor, A.M.6
-
3
-
-
0030572496
-
Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
-
Terrett NK. Sildenafil (Viagra), a potent and selective inhibitor of Type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction. Bioorg Med Chem Lett. 1996; 6 (15): 1819-24.
-
(1996)
Bioorg Med Chem Lett
, vol.6
, Issue.15
, pp. 1819-1824
-
-
Terrett, N.K.1
-
4
-
-
79956140184
-
Getting pharmaceutical R& D back on target
-
Bunnage ME. Getting pharmaceutical R& D back on target. Nat Chem Biol. 2011; 7: 335-9.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 335-339
-
-
Bunnage, M.E.1
-
5
-
-
77649234756
-
How to improve R & D productivity: the pharmaceutical industry's grand challenge
-
Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, Lindborg SR, et al. How to improve R & D productivity: the pharmaceutical industry ' s grand challenge. Nat Rev Drug Discov. 2010; 9: 203-14.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
Persinger, C.C.4
Munos, B.H.5
Lindborg, S.R.6
-
7
-
-
80054116787
-
To market, to market
-
Bronson J, Dhar M, Ewing W, Lonberg N. To market, to market. Annu Rep Med Chem. 2011; 46: 433.
-
(2011)
Annu Rep Med Chem
, vol.46
, pp. 433
-
-
Bronson, J.1
Dhar, M.2
Ewing, W.3
Lonberg, N.4
-
10
-
-
77953405077
-
The emerging academic drug-discovery sector
-
Wyatt PG. The emerging academic drug-discovery sector. Future Med Chem. 2009; 1 (6): 1013-7.
-
(2009)
Future Med Chem
, vol.1
, Issue.6
, pp. 1013-1017
-
-
Wyatt, P.G.1
-
12
-
-
46949102456
-
Current and future status of beta-blockers in the treatment of hypertension
-
Chrysant SG, Chyrsant GS, Dimas B. Current and future status of beta-blockers in the treatment of hypertension. Clin Cardiol. 2008; 31: 249-52.
-
(2008)
Clin Cardiol
, vol.31
, pp. 249-252
-
-
Chrysant, S.G.1
Chyrsant, G.S.2
Dimas, B.3
-
15
-
-
20744456789
-
Solid phase peptide synthesis I. The synthesis of a tetrapeptide
-
Merrifield RB. Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J Am Chem Soc. 1963; 85: 2149-54.
-
(1963)
J Am Chem Soc
, vol.85
, pp. 2149-2154
-
-
Merrifield, R.B.1
-
16
-
-
84868119463
-
Parallel chemistry in the 21st century
-
doi: 10.1002/0471141755.ph0916s58. Chapter 9:Unit9. 16. 2012 Sep
-
Long A. Parallel chemistry in the 21st century. Curr Protoc Pharmacol. 2012. 2012 Sep;Chapter 9:Unit9.16. doi: 10.1002/0471141755.ph0916s58.
-
(2012)
Curr Protoc Pharmacol
-
-
Long, A.1
-
17
-
-
0000951677
-
Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
-
Geysen HM, Meloen RH, Berteling SJ. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc Natl Acad Sci U S A. 1984; 81: 3998-4002.
-
(1984)
Proc Natl Acad Sci U S A
, vol.81
, pp. 3998-4002
-
-
Geysen, H.M.1
Meloen, R.H.2
Berteling, S.J.3
-
18
-
-
0000478940
-
General method for the rapid solidphase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids (simultaneous multiple-peptide synthesis)
-
Houghten RA. General method for the rapid solidphase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids (simultaneous multiple-peptide synthesis). Proc Natl Acad Sci U S A. 1985; 82: 5131-5.
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, pp. 5131-5135
-
-
Houghten, R.A.1
-
19
-
-
0025893762
-
General method for rapid synthesis of multicomponent peptide mixtures
-
Furka A, Sebestyen F, Asgedom M, Dibo G. General method for rapid synthesis of multicomponent peptide mixtures. Int J Pept Protein Res. 1991; 37: 487-93.
-
(1991)
Int J Pept Protein Res
, vol.37
, pp. 487-493
-
-
Furka, A.1
Sebestyen, F.2
Asgedom, M.3
Dibo, G.4
-
20
-
-
0028845834
-
History of combinatorial chemistry
-
Furka A. History of combinatorial chemistry. Drug Dev Res. 1995; 36: 1-12.
-
(1995)
Drug Dev Res
, vol.36
, pp. 1-12
-
-
Furka, A.1
-
21
-
-
0026419328
-
A new type of synthetic peptide library for identifying ligand-binding activity
-
Lam KS, Salmon SE, Hersh EM, Hruby VJ, Kazmierski WM, Knapp RJ. A new type of synthetic peptide library for identifying ligand-binding activity. Nature. 1991; 354: 82-4.
-
(1991)
Nature
, vol.354
, pp. 82-84
-
-
Lam, K.S.1
Salmon, S.E.2
Hersh, E.M.3
Hruby, V.J.4
Kazmierski, W.M.5
Knapp, R.J.6
-
22
-
-
0027362628
-
Complex synthetic chemical libraries indexed with molecular tags
-
Ohlmeyer MHJ, Swanson RN, Dillard LW, Reader JC, Asouline G, Kobayashi R, et al. Complex synthetic chemical libraries indexed with molecular tags. Proc Natl Acad Sci U S A. 1993; 90: 10922-6.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 10922-10926
-
-
Ohlmeyer, M.H.J.1
Swanson, R.N.2
Dillard, L.W.3
Reader, J.C.4
Asouline, G.5
Kobayashi, R.6
-
23
-
-
84868141481
-
Introduction to combinatorial chemistry
-
Nicolaou KC, Hanko R, Hartwig W, editors. Weinheim: Wiley
-
Coffen DL, Luithle JEA. Introduction to combinatorial chemistry. In: Nicolaou KC, Hanko R, Hartwig W, editors. Handbook of combinatorial chemistry: drugs, catalysts, materials. Vol. 1. Weinheim: Wiley; 2002. pp. 10-23.
-
(2002)
Handbook of combinatorial chemistry: drugs, catalysts, materials
, vol.1
, pp. 10-23
-
-
Coffen, D.L.1
Luithle, J.E.A.2
-
24
-
-
33644839988
-
Diversity-oriented synthesis: exploring the intersections between chemistry and biology
-
Tan D. Diversity-oriented synthesis: exploring the intersections between chemistry and biology. Nat Chem Biol. 2005; 1: 74-84.
-
(2005)
Nat Chem Biol
, vol.1
, pp. 74-84
-
-
Tan, D.1
-
25
-
-
0037208308
-
Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry
-
Feher M, Schmidt JM. Property distributions: differences between drugs, natural products, and molecules from combinatorial chemistry. J Chem Inf Comput Sci. 2003; 43: 218-27.
-
(2003)
J Chem Inf Comput Sci
, vol.43
, pp. 218-227
-
-
Feher, M.1
Schmidt, J.M.2
-
26
-
-
33749238553
-
Discovery and development of sorafenib: a multikinase inhibitor for treating cancer
-
Wilhelm S, Carter C, Lynch M, Lowinger T, Dumas J, Smith RA, et al. Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov. 2007; 5: 835-44.
-
(2007)
Nat Rev Drug Discov
, vol.5
, pp. 835-844
-
-
Wilhelm, S.1
Carter, C.2
Lynch, M.3
Lowinger, T.4
Dumas, J.5
Smith, R.A.6
-
27
-
-
0027068161
-
A general and expedient method for the solid-phase synthesis of 1 4-benzodiazepine derivatives
-
Bunin BA, Ellman JA. A general and expedient method for the solid-phase synthesis of 1,4-benzodiazepine derivatives. J Am Chem Soc. 1992; 114: 10997-8.
-
(1992)
J Am Chem Soc
, vol.114
, pp. 10997-10998
-
-
Bunin, B.A.1
Ellman, J.A.2
-
28
-
-
79959907066
-
Multicomponent reaction design in the quest for molecular complexity and diversity
-
Ruijter E, Scheffelaar R, Orru RVA. Multicomponent reaction design in the quest for molecular complexity and diversity. Angew Chem Int Ed. 2011; 50: 6234-46.
-
(2011)
Angew Chem Int Ed
, vol.50
, pp. 6234-6246
-
-
Ruijter, E.1
Scheffelaar, R.2
Orru, R.V.A.3
-
29
-
-
0034678033
-
Target-oriented and diversity-oriented organic synthesis in drug discovery
-
Schreiber SL. Target-oriented and diversity-oriented organic synthesis in drug discovery. Science. 2000; 287: 1964-9.
-
(2000)
Science
, vol.287
, pp. 1964-1969
-
-
Schreiber, S.L.1
-
30
-
-
33746298355
-
Solution -phase mixture synthesis with fluorous tagging en route: total synthesis of an eight-member stereoisomer library of passifloricins
-
Curran DP, Moura-Letts G, Pohlman M. Solution -phase mixture synthesis with fluorous tagging en route: total synthesis of an eight-member stereoisomer library of passifloricins. Angew Chem Int Ed. 2006; 45: 2423-6.
-
(2006)
Angew Chem Int Ed
, vol.45
, pp. 2423-2426
-
-
Curran, D.P.1
Moura-Letts, G.2
Pohlman, M.3
-
31
-
-
33746382280
-
Total synthesis of a 28-member stereoisomer library of murisolins
-
Curran DP, Zhang Q, Richard C, Lu H, Gudipati V, Wilcox CS. Total synthesis of a 28-member stereoisomer library of murisolins. J Am Chem Soc. 2006; 128: 9561-73.
-
(2006)
J Am Chem Soc
, vol.128
, pp. 9561-9573
-
-
Curran, D.P.1
Zhang, Q.2
Richard, C.3
Lu, H.4
Gudipati, V.5
Wilcox, C.S.6
-
32
-
-
11144325118
-
Controlled microwave heating in modern organic synthesis
-
Kappe CO. Controlled microwave heating in modern organic synthesis. Angew Chem Int Ed. 2004; 43: 6250-84.
-
(2004)
Angew Chem Int Ed
, vol.43
, pp. 6250-6284
-
-
Kappe, C.O.1
-
33
-
-
84887254188
-
Learning to relate structural space to property space
-
Selzer PM, editor. Weinheim: Wiley
-
Berger M, Cramer J, Hinz M, Mertens C, Miculka C, Newton T, et al. Learning to relate structural space to property space. In: Selzer PM, editor. Antiparasitic and antibacterial drug discovery: from molecular targets to drug candidates. Weinheim: Wiley; 2009. p. 135-8.
-
(2009)
Antiparasitic and antibacterial drug discovery: from molecular targets to drug candidates
, pp. 135-138
-
-
Berger, M.1
Cramer, J.2
Hinz, M.3
Mertens, C.4
Miculka, C.5
Newton, T.6
-
34
-
-
0031024171
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev. 1997; 23: 3-25.
-
(1997)
Adv Drug Deliv Rev
, vol.23
, pp. 3-25
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
35
-
-
11144320699
-
Navigating chemical space for biology and medicine
-
Lipinski C, Hopkins A. Navigating chemical space for biology and medicine. Nature. 2004; 432: 855-61.
-
(2004)
Nature
, vol.432
, pp. 855-861
-
-
Lipinski, C.1
Hopkins, A.2
-
36
-
-
81555228214
-
A small nonrule of 3 compatible fragment library provides high hit rate of endothiapepsin crystal structures with various fragment chemotypes
-
Köster H, Craan T, Brass S, Herhaus C, Zentgraf M, Neumann L, et al. A small nonrule of 3 compatible fragment library provides high hit rate of endothiapepsin crystal structures with various fragment chemotypes. J Med Chem. 2011; 54 (22): 7784-96.
-
(2011)
J Med Chem
, vol.54
, Issue.22
, pp. 7784-7796
-
-
Köster, H.1
Craan, T.2
Brass, S.3
Herhaus, C.4
Zentgraf, M.5
Neumann, L.6
-
38
-
-
77954724107
-
Ligand specificity in fragment-based drug design
-
Barelier S, Pons J, Gehring K, et al. Ligand specificity in fragment-based drug design. J Med Chem. 2010; 53 (14): 5256-66.
-
(2010)
J Med Chem
, vol.53
, Issue.14
, pp. 5256-5266
-
-
Barelier, S.1
Pons, J.2
Gehring, K.3
-
39
-
-
67650999672
-
Lessons for fragment library design: analysis of output from multiple screening campaigns
-
Chen IJ, Hubbard RE. Lessons for fragment library design: analysis of output from multiple screening campaigns. J Comput Aided Mol Des. 2009; 23 (8): 603-20.
-
(2009)
J Comput Aided Mol Des
, vol.23
, Issue.8
, pp. 603-620
-
-
Chen, I.J.1
Hubbard, R.E.2
-
40
-
-
84856935181
-
Introduction to fragment-based drug discovery
-
Davies TG, Hyvönen M, editors. Topics in current chemistry 317. Berlin Heidelberg: Springer-Verlag
-
Erlanson DA. Introduction to fragment-based drug discovery. In: Davies TG, Hyvönen M, editors. Fragment-based drug discovery and X-ray crystallography. Topics in current chemistry 317. Berlin Heidelberg: Springer-Verlag; 2012. pp. 1-32.
-
(2012)
Fragment-based drug discovery and X-ray crystallography
, pp. 1-32
-
-
Erlanson, D.A.1
-
41
-
-
0034823890
-
Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor
-
Mayer M, Meyer B. Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor. J Am Chem Soc. 2001; 123: 6108-17.
-
(2001)
J Am Chem Soc
, vol.123
, pp. 6108-6117
-
-
Mayer, M.1
Meyer, B.2
-
42
-
-
0035692794
-
WaterLOGSY as a method for primary NMR screening: practical aspects and range of applicability
-
Dalvit C, Fogliatto G, Stewart A, Veronesi M, Stockman B. WaterLOGSY as a method for primary NMR screening: practical aspects and range of applicability. J Biomol NMR. 2001; 21: 349-59.
-
(2001)
J Biomol NMR
, vol.21
, pp. 349-359
-
-
Dalvit, C.1
Fogliatto, G.2
Stewart, A.3
Veronesi, M.4
Stockman, B.5
-
43
-
-
0029836953
-
Discovering high-affinity ligands for proteins: SAR by NMR
-
Shuker SB, Hajduk PJ, Meadows RP, Fesik SW. Discovering high-affinity ligands for proteins: SAR by NMR. Science. 1996; 274 (5292): 1531-4.
-
(1996)
Science
, vol.274
, Issue.5292
, pp. 1531-1534
-
-
Shuker, S.B.1
Hajduk, P.J.2
Meadows, R.P.3
Fesik, S.W.4
-
44
-
-
84863052839
-
Fragment based drug discovery: practical implementation based on 19F NMR spectroscopy
-
Jordan JB, Poppe L, Xia X, Cheng AC, Sun Y, Michelsen K, et al. Fragment based drug discovery: practical implementation based on 19F NMR spectroscopy. J Med Chem. 2012; 55 (2): 678-87.
-
(2012)
J Med Chem
, vol.55
, Issue.2
, pp. 678-687
-
-
Jordan, J.B.1
Poppe, L.2
Xia, X.3
Cheng, A.C.4
Sun, Y.5
Michelsen, K.6
-
45
-
-
70349124638
-
Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine
-
Vulpetti A, Hommel U, Landrum G, et al. Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine. J Am Chem Soc. 2009; 131 (36): 12949-59.
-
(2009)
J Am Chem Soc
, vol.131
, Issue.36
, pp. 12949-12959
-
-
Vulpetti, A.1
Hommel, U.2
Landrum, G.3
-
46
-
-
84863242691
-
Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE -1 inhibitors
-
Davies TG, Hyvönen M, editors. Topics in current chemistry 317. Berlin Heidelberg: Springer-Verlag
-
Wyss DF, Wang Y-S, Eaton HL, et al. Combining NMR and X-ray crystallography in fragment-based drug discovery: discovery of highly potent and selective BACE -1 inhibitors. In: Davies TG, Hyvönen M, editors. Fragment-based drug discovery and X-ray crystallography. Topics in current chemistry 317. Berlin Heidelberg: Springer-Verlag; 2012. pp. 83-114.
-
(2012)
Fragment-based drug discovery and X-ray crystallography
, pp. 83-114
-
-
Wyss, D.F.1
Wang, Y.-S.2
Eaton, H.L.3
-
47
-
-
0024509701
-
Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome
-
Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989; 244: 359-62.
-
(1989)
Science
, vol.244
, pp. 359-362
-
-
Choo, Q.L.1
Kuo, G.2
Weiner, A.J.3
Overby, L.R.4
Bradley, D.W.5
Houghton, M.6
-
48
-
-
84887234352
-
-
World Health Organization. Hepatitis C fact sheet No 164 (accessed 5 November 2012)
-
World Health Organization. 2012. Hepatitis C fact sheet No 164. Available from: http://www.who.int/ mediacentre/factsheets/fs164/en/index.html (accessed 5 November 2012).
-
(2012)
-
-
-
49
-
-
0028905430
-
Variability of hepatitis C virus
-
Simmonds P. Variability of hepatitis C virus. Hepatology. 1995; 21: 570-83.
-
(1995)
Hepatology
, vol.21
, pp. 570-583
-
-
Simmonds, P.1
-
50
-
-
0034120427
-
Clinical significance of hepatitis C virus genotypes
-
Zein NN. Clinical significance of hepatitis C virus genotypes. Clin Microbiol Rev. 2000; 13: 223-35.
-
(2000)
Clin Microbiol Rev
, vol.13
, pp. 223-235
-
-
Zein, N.N.1
-
51
-
-
23944476834
-
Unraveling hepatitis C virus replication from genome to function
-
Lindenbach BD, Rice CM. Unraveling hepatitis C virus replication from genome to function. Nature. 2005; 436: 933-8.
-
(2005)
Nature
, vol.436
, pp. 933-938
-
-
Lindenbach, B.D.1
Rice, C.M.2
-
52
-
-
77954551369
-
A new insight into hepatitis C vaccine development
-
Yu CI, Chiang BL. A new insight into hepatitis C vaccine development. J Biomed Biotechnol. 2010; 2012: 548280.
-
(2010)
J Biomed Biotechnol
, vol.2012
, pp. 548280
-
-
Yu, C.I.1
Chiang, B.L.2
-
53
-
-
23944462641
-
Mechanism of action of interferon and ribavirin in treatment of hepatitis C
-
Feld JJ, Hoofnagle JH. Mechanism of action of interferon and ribavirin in treatment of hepatitis C. Nature. 2005; 436: 967-72.
-
(2005)
Nature
, vol.436
, pp. 967-972
-
-
Feld, J.J.1
Hoofnagle, J.H.2
-
54
-
-
33749241866
-
Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2 3-dioxopropyl]-3-[2(S)-[[[(1,1-dimethylethyl)amino] carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6 -dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection
-
Venkatraman S, Bogen SL, Arasappan A, et al. Discovery of (1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-[2(S)-[[[(1,1 -dimethylethyl)amino] carbonyl]amino]-3,3-dimethyl-1-oxobutyl]-6,6 -dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (SCH 503034), a selective, potent, orally bioavailable hepatitis C virus NS3 protease inhibitor: a potential therapeutic agent for the treatment of hepatitis C infection. J Med Chem. 2006; 49: 6074-86.
-
(2006)
J Med Chem
, vol.49
, pp. 6074-6086
-
-
Venkatraman, S.1
Bogen, S.L.2
Arasappan, A.3
-
55
-
-
84887245267
-
-
Process and intermediates for the preparation of (1R,2S,5S) -N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl] -3-[(2S)-2-[[[[1,1-dimethylethyl]amino]carbonyl] amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3 -azabicyclo[3.1.0]hexane-2-carboxamide. WO2004113294 A1 (Patent)
-
Sudhakar A, Dahanukar V, Zavialov IA, et al. Process and intermediates for the preparation of (1R,2S,5S) -N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl] -3-[(2S)-2-[[[[1,1-dimethylethyl]amino]carbonyl] amino]-3,3-dimethyl-1-oxobutyl]-6,6-dimethyl-3 -azabicyclo[3.1.0]hexane-2-carboxamide. WO2004113294 A1 (Patent) 2004.
-
(2004)
-
-
Sudhakar, A.1
Dahanukar, V.2
Zavialov, I.A.3
-
56
-
-
84887254996
-
-
Whitehouse Station: Merck & Co(accessed 5 No -vember 2012)
-
Whitehouse Station: Merck & Co.; 2011. Highlights of prescribing information for Vitrelis (boceprevir). Available from: http://www.merck.com/product/usa/ pi_circulars/v/victrelis/victrelis_pi.pdf (accessed 5 No -vember 2012).
-
(2011)
Highlights of prescribing information for Vitrelis (boceprevir)
-
-
-
58
-
-
84887253292
-
-
Cambridge: Vertex Pharmaceuticals Inc (accessed 5 November 2012)
-
Cambridge: Vertex Pharmaceuticals Inc.. 2011. Highlights of prescribing information for Incivek (telaprevir). Available from: http://pi.vrtx.com/files/uspi_ telaprevir.pdf (accessed 5 November 2012).
-
(2011)
Highlights of prescribing information for Incivek (telaprevir)
-
-
-
59
-
-
0027250808
-
How does HIV cause AIDS?
-
Weiss RA. How does HIV cause AIDS? Science. 1993; 260: 1273-9.
-
(1993)
Science
, vol.260
, pp. 1273-1279
-
-
Weiss, R.A.1
-
60
-
-
84887255481
-
-
Atlanta: Centers for Disease Control and Prevention;. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults (accessed 5 November)
-
Atlanta: Centers for Disease Control and Prevention; 1992. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Available from: http://www.cdc.gov/mmwr/preview/mmwrhtml/ 00018871.htm (accessed 5 November).
-
(1992)
-
-
-
61
-
-
84887249635
-
-
UNAIDS Joint United Nations Programme on HIV/ AIDS, Geneva; Global facts and figures 09 (accessed 5 November 2012)
-
UNAIDS Joint United Nations Programme on HIV/ AIDS, Geneva; 2009. Global facts and figures 09. Available from: http://data.unaids.org/pub/FactSheet/2009/ 20091124_FS_global_en.pdf (accessed 5 November 2012).
-
(2009)
-
-
-
62
-
-
0036268538
-
Human immunodeficiency virus type 2
-
Reeves JD, Doms RW. Human immunodeficiency virus type 2. J Gen Virol. 2002; 83: 1253-65.
-
(2002)
J Gen Virol
, vol.83
, pp. 1253-1265
-
-
Reeves, J.D.1
Doms, R.W.2
-
63
-
-
84887253610
-
Chapter 20 AIDS and other immunodeficiencies
-
Kindt TJ, Goldsby RA, Osborne BA editors. New York: WH Freeman and Company
-
Kindt TJ, Goldsby RA, Osborne BA. Chapter 20: AIDS and other immunodeficiencies. In Kindt TJ, Goldsby RA, Osborne BA editors. Kuby immunology, 6th edn. New York: WH Freeman and Company; 2007. pp. 493-524.
-
(2007)
Kuby immunology, 6th edn
, pp. 493-524
-
-
Kindt, T.J.1
Goldsby, R.A.2
Osborne, B.A.3
-
64
-
-
77649215009
-
-
US Food and Drug Administration, Silver Spring (accessed 5 November 2012)
-
US Food and Drug Administration, Silver Spring. 2011. Antiretroviral drugs used in the treatment of HIV infection. Available from: http://www.fda.gov/ForConsumers/ByAudience/ForPatientAdvocates/HIVandAID SActivities/ucm118915.htm (accessed 5 November 2012).
-
(2011)
Antiretroviral drugs used in the treatment of HIV infection
-
-
-
65
-
-
37549062916
-
Chapter 50 antiretroviral agents and treatment of HIV infection
-
Goodman LS, Gilman A, editors. New York: McGraw Hill
-
Flexner C. Chapter 50: antiretroviral agents and treatment of HIV infection. In: Goodman LS, Gilman A, editors. Goodman & Gilman ' s the pharmacological basis of therapeutics, 11th edn. New York: McGraw Hill; 2006. pp. 1273-314.
-
(2006)
Goodman & Gilman's the pharmacological basis of therapeutics, 11th edn
, pp. 1273-1314
-
-
Flexner, C.1
-
66
-
-
17944374798
-
Evolution of anti-HIV drug candidates Part 3 diarylpyrimidine (DAPY) analogues
-
Ludovici DW, De Corte BL, Kukla MJ, Ye H, Ho CY, Lichtenstein MA, et al. Evolution of anti-HIV drug candidates. Part 3: diarylpyrimidine (DAPY) analogues. Bioorg Med Chem Lett. 2001; 11: 2235-9.
-
(2001)
Bioorg Med Chem Lett
, vol.11
, pp. 2235-2239
-
-
Ludovici, D.W.1
De Corte, B.L.2
Kukla, M.J.3
Ye, H.4
Ho, C.Y.5
Lichtenstein, M.A.6
-
70
-
-
84887237522
-
-
Raritan: Tibotec Therapeutics (accessed 5 November 2012)
-
Raritan: Tibotec Therapeutics. 2008. Highlights of prescribing information for Intelence (etravirine) Available from: http://www.intelence-info.com/sites/ default/files/pdf/INTELENCE_Booklet_Package_ Insert_hcp.pdf (accessed 5 November 2012).
-
(2008)
Highlights of prescribing information for Intelence (etravirine)
-
-
-
71
-
-
20144366006
-
Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1
-
Guillemont J, Pasquier E, Palandjian P, Vernier D, Gaurrand S, Lewi PJ, et al. Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1. J Med Chem. 2005; 48: 2072-9.
-
(2005)
J Med Chem
, vol.48
, pp. 2072-2079
-
-
Guillemont, J.1
Pasquier, E.2
Palandjian, P.3
Vernier, D.4
Gaurrand, S.5
Lewi, P.J.6
-
74
-
-
74249111385
-
The mechanism of action of glatiramer acetate treatment in multiple sclerosis
-
Racke MK, Lovett-Racke AE, Karandikar NJ. The mechanism of action of glatiramer acetate treatment in multiple sclerosis. Neurology. 2010; 74 (Suppl. 1): S25-30.
-
(2010)
Neurology
, vol.74
, Issue.SUPPL. 1
-
-
Racke, M.K.1
Lovett-Racke, A.E.2
Karandikar, N.J.3
-
75
-
-
79953890862
-
Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanism of action
-
Lalive PH, Neuhaus O, Benkhoucha M, Burger D, Hohlfeld R, Zamvil SS, et al. Glatiramer acetate in the treatment of multiple sclerosis: emerging concepts regarding its mechanism of action. CNS Drugs. 2011; 25: 401.
-
(2011)
CNS Drugs
, vol.25
, pp. 401
-
-
Lalive, P.H.1
Neuhaus, O.2
Benkhoucha, M.3
Burger, D.4
Hohlfeld, R.5
Zamvil, S.S.6
-
76
-
-
84887237675
-
-
TEVA Pharmaceuticals USA. Full prescribing information (package insert) for Copaxone NDA no. 020622 at Drugs@FDA
-
TEVA Pharmaceuticals USA. Full prescribing information (package insert) for Copaxone NDA no. 020622 at Drugs@FDA. 2009.
-
(2009)
-
-
-
77
-
-
12344297545
-
The use of 4-aminopyridine (fampridine) in demyelinating disorders
-
Hayes KC. The use of 4-aminopyridine (fampridine) in demyelinating disorders. CNS Drug Rev. 2004; 10: 295-316.
-
(2004)
CNS Drug Rev
, vol.10
, pp. 295-316
-
-
Hayes, K.C.1
-
78
-
-
0037077308
-
The immune modulator FTY720 targets sphingosine 1-phosphate receptors
-
Brinkman V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, et al. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. J Biol Chem. 2002; 277: 21453.
-
(2002)
J Biol Chem
, vol.277
, pp. 21453
-
-
Brinkman, V.1
Davis, M.D.2
Heise, C.E.3
Albert, R.4
Cottens, S.5
Hof, R.6
-
79
-
-
0037066466
-
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists
-
Mandala S, Hajdu R, Bergstrom J, Quackenbush E, Xie J, Milligan J, et al. Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists. Science. 2002; 296: 346.
-
(2002)
Science
, vol.296
, pp. 346
-
-
Mandala, S.1
Hajdu, R.2
Bergstrom, J.3
Quackenbush, E.4
Xie, J.5
Milligan, J.6
-
80
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
Kappos L, Radue EW, O'Connor P, Polman C, Hohlfeld R, Calabresi P, et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis. N Engl J Med. 2010; 362: 387-401.
-
(2010)
N Engl J Med
, vol.362
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O'Connor, P.3
Polman, C.4
Hohlfeld, R.5
Calabresi, P.6
-
81
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
Cohen JA, Barkhof F, Comi G, Hartung HP, Khatru BO, Montalban X, et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis. N Engl J Med. 2010; 362: 402-15.
-
(2010)
N Engl J Med
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
Hartung, H.P.4
Khatru, B.O.5
Montalban, X.6
-
82
-
-
81555202418
-
Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo -controlled, multicentre trial
-
Kappos L, Li D, Calabresi PA, O'Connor P, Bar-Or A, Barkhof F, et al. Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo -controlled, multicentre trial. Lancet. 2011; 378: 1179-87.
-
(2011)
Lancet
, vol.378
, pp. 1179-1187
-
-
Kappos, L.1
Li, D.2
Calabresi, P.A.3
O'Connor, P.4
Bar-Or, A.5
Barkhof, F.6
-
83
-
-
47749113295
-
Alzheimer's disease: practical management of cognitive symptoms
-
Sucher BJ, Mehlhorn AJ. Alzheimer's disease: practical management of cognitive symptoms. US Pharm. 2007; 32 (6): 45-53.
-
(2007)
US Pharm
, vol.32
, Issue.6
, pp. 45-53
-
-
Sucher, B.J.1
Mehlhorn, A.J.2
-
84
-
-
79551548500
-
Alzheimer' s disease: increasing numbers, but no cure
-
DeSimone EM II, Viereck L. Alzheimer' s disease: increasing numbers, but no cure. US Pharm. 2011; 36 (1): 26-42.
-
(2011)
US Pharm
, vol.36
, Issue.1
, pp. 26-42
-
-
DeSimone II, E.M.1
Viereck, L.2
-
85
-
-
84887259786
-
Efficacy of dementia drugs and guidelines for use
-
Cupp M. Efficacy of dementia drugs and guidelines for use. Pharm Lett. 2008; 24: 240510.
-
(2008)
Pharm Lett
, vol.24
, pp. 240510
-
-
Cupp, M.1
-
86
-
-
77957794366
-
NIH translational programs for assisting pre-clinical drug discovery and development
-
Misra RN. NIH translational programs for assisting pre-clinical drug discovery and development. Annu Rep Med Chem. 2010; 45: 361-77.
-
(2010)
Annu Rep Med Chem
, vol.45
, pp. 361-377
-
-
Misra, R.N.1
-
87
-
-
37249004109
-
Drugs that target muscarinic cholinergic receptors
-
Buccafusco JJ, editor. Basel: Birkhäuser Verlag
-
Messer WS Jr. Drugs that target muscarinic cholinergic receptors. In: Buccafusco JJ, editor. Cognitive enhancing drugs. Basel: Birkhäuser Verlag; 2004. pp. 37-45.
-
(2004)
Cognitive enhancing drugs
, pp. 37-45
-
-
Messer Jr., W.S.1
-
88
-
-
33747708099
-
Glycogen Synthase Kinase-3 (GSK-3): a kinase with exceptional therapeutic potential
-
Benbow JW, Helal CJ, Kung DW, Wager TT. Glycogen Synthase Kinase-3 (GSK-3): a kinase with exceptional therapeutic potential. Annu Rep Med Chem. 2005; 40: 135-47.
-
(2005)
Annu Rep Med Chem
, vol.40
, pp. 135-147
-
-
Benbow, J.W.1
Helal, C.J.2
Kung, D.W.3
Wager, T.T.4
-
89
-
-
78650376641
-
Recent advances in the discovery of GSK-3 inhibitors and a perspective on their utility for the treatment of Alzheimer's disease
-
Gentles RG, Hu S, Dubowchik GM. Recent advances in the discovery of GSK-3 inhibitors and a perspective on their utility for the treatment of Alzheimer ' s disease. Annu Rep Med Chem. 2009; 44: 3-26.
-
(2009)
Annu Rep Med Chem
, vol.44
, pp. 3-26
-
-
Gentles, R.G.1
Hu, S.2
Dubowchik, G.M.3
-
90
-
-
54449099066
-
AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome
-
Lashinger Erin SR, Steiginga Matthew S, Hieble JP, Leon Lisa A, Gardner Scott D, Nagilla R, et al. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Am J Physiol Renal Physiol. 2008; 295: F803-10.
-
(2008)
Am J Physiol Renal Physiol
, vol.295
-
-
Lashinger Erin, S.R.1
Steiginga Matthew, S.2
Hieble, J.P.3
Leon Lisa, A.4
Gardner Scott, D.5
Nagilla, R.6
-
92
-
-
68949209704
-
Antiarrhythmic drugs for atrial fibrillation: focus on dronedarone
-
Krishnamoorthy S, Lip GY. Antiarrhythmic drugs for atrial fibrillation: focus on dronedarone. Expert Rev Cardiovasc Ther. 2009; 7: 473-81.
-
(2009)
Expert Rev Cardiovasc Ther
, vol.7
, pp. 473-481
-
-
Krishnamoorthy, S.1
Lip, G.Y.2
-
93
-
-
80054116787
-
To market, to market-2010
-
Bronson J, Dhar M, Ewing W, Lonberg N. To market, to market-2010. Annu Rep Med Chem. 2011; 46: 491-2.
-
(2011)
Annu Rep Med Chem
, vol.46
, pp. 491-492
-
-
Bronson, J.1
Dhar, M.2
Ewing, W.3
Lonberg, N.4
-
94
-
-
77956239586
-
a mixed sodium and potassium ion channel antagonist that blocks K(v)1.5 channels, for the potential treatment of atrial fibrillation
-
Billman GE. Vernakalant, a mixed sodium and potassium ion channel antagonist that blocks K(v)1.5 channels, for the potential treatment of atrial fibrillation. Curr Opin Investig Drugs. 2010; 11: 1048.
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 1048
-
-
Vernakalant, B.G.E.1
-
96
-
-
57149105884
-
Efficacy and safety of ABT-335 (fenofibric acid) in combination with simvastatin in patients with mixed dyslipidemia: a phase 3, randomized, controlled study
-
Mohiuddin SM, Pepine CJ, Kelly MT, Buttler SM, Setze CM, Sleep DJ, Stolzenbach JC. Efficacy and safety of ABT-335 (fenofibric acid) in combination with simvastatin in patients with mixed dyslipidemia: a phase 3, randomized, controlled study. Am Heart J. 2009; 157: 195.
-
(2009)
Am Heart J
, vol.157
, pp. 195
-
-
Mohiuddin, S.M.1
Pepine, C.J.2
Kelly, M.T.3
Buttler, S.M.4
Setze, C.M.5
Sleep, D.J.6
Stolzenbach, J.C.7
-
100
-
-
38949211561
-
Treatment of acute severe hypertension: current and newer agents
-
Varon J. Treatment of acute severe hypertension: current and newer agents. Drugs. 2008; 68: 283.
-
(2008)
Drugs
, vol.68
, pp. 283
-
-
Varon, J.1
-
101
-
-
80054116787
-
To market, to market-2010
-
Bronson J, Dhar M, Ewing W, Lonberg N. To market, to market-2010. Annu Rep Med Chem. 2011; 46: 464-5.
-
(2011)
Annu Rep Med Chem
, vol.46
, pp. 464-465
-
-
Bronson, J.1
Dhar, M.2
Ewing, W.3
Lonberg, N.4
-
102
-
-
77954577914
-
Ecallantide. In acute hereditary angioedema
-
Garnock-Jones KP. Ecallantide. In acute hereditary angioedema. Drugs. 2010; 70: 1423.
-
(2010)
Drugs
, vol.70
, pp. 1423
-
-
Garnock-Jones, K.P.1
-
108
-
-
70349339368
-
Role of prasugrel, a novel P2Y12 receptor antagonist, in the management of acute coronary syndromes
-
Baker WL, White CM. Role of prasugrel, a novel P2Y12 receptor antagonist, in the management of acute coronary syndromes. Am J Cardiovasc Drugs. 2009; 9: 213.
-
(2009)
Am J Cardiovasc Drugs
, vol.9
, pp. 213
-
-
Baker, W.L.1
White, C.M.2
-
109
-
-
80054116787
-
To market, to market-2010
-
Bronson J, Dhar M, Ewing W, Lonberg N. To market, to market-2010. Annu Rep Med Chem. 2011; 46: 488-91.
-
(2011)
Annu Rep Med Chem
, vol.46
, pp. 488-491
-
-
Bronson, J.1
Dhar, M.2
Ewing, W.3
Lonberg, N.4
-
110
-
-
79851507635
-
Economic burden of illness of acute coronary syndromes: medical and productivity costs
-
Zhao Z, Winget M. Economic burden of illness of acute coronary syndromes: medical and productivity costs. BMC Health Serv Res. 2011; 11: 35.
-
(2011)
BMC Health Serv Res
, vol.11
, pp. 35
-
-
Zhao, Z.1
Winget, M.2
-
111
-
-
80054116787
-
To market, to market-2010
-
Macor JE, editor. Oxford, UK: Elsevier
-
Bronson J, Dhar M, Ewing W, et al. To market, to market-2010. In: Macor JE, editor. Annual reports in medincinal chemistry. Vol. 46. Oxford, UK: Elsevier; 2011. pp. 480-2.
-
(2011)
Annual reports in medincinal chemistry
, vol.46
, pp. 480-482
-
-
Bronson, J.1
Dhar, M.2
Ewing, W.3
-
112
-
-
4344675455
-
Pathophysiology of airflow limitation in chronic obstructive pulmonary disease
-
Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet. 2004; 364: 709-21.
-
(2004)
Lancet
, vol.364
, pp. 709-721
-
-
Hogg, J.C.1
-
113
-
-
34548660457
-
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease GOLD executive summary
-
Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. GOLD executive summary. Am J Respir Crit Care Med. 2007; 176: 532-55.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 532-555
-
-
Rabe, K.F.1
Hurd, S.2
Anzueto, A.3
-
114
-
-
33845338724
-
Projections of global mortality and burden of disease from 2002 to 2030
-
Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 2006; 3: e442.
-
(2006)
PLoS Med
, vol.3
-
-
Mathers, C.D.1
Loncar, D.2
-
115
-
-
0023772701
-
High dose inhaled albuterol in severe chronic airflow limitation
-
Vathenen AS, Britton JR, Ebden P, et al. High dose inhaled albuterol in severe chronic airflow limitation. Am Rev Respir Dis. 1988; 138: 850-5.
-
(1988)
Am Rev Respir Dis
, vol.138
, pp. 850-855
-
-
Vathenen, A.S.1
Britton, J.R.2
Ebden, P.3
-
116
-
-
0024400242
-
Dose response to ipratropium as a nebulized solution in patients with chronic obstructive pulmonary disease: a three-center study
-
Gross NJ, Petty TL, Friedman M, et al. Dose response to ipratropium as a nebulized solution in patients with chronic obstructive pulmonary disease: a three-center study. Am Rev Respir Dis. 1989; 139: 1188-91.
-
(1989)
Am Rev Respir Dis
, vol.139
, pp. 1188-1191
-
-
Gross, N.J.1
Petty, T.L.2
Friedman, M.3
-
117
-
-
0024211843
-
Dose response relation to oral theophylline in severe chronic obstructive airways disease
-
Chrystyn H, Mulley BA, Peake MD. Dose response relation to oral theophylline in severe chronic obstructive airways disease. BMJ. 1988; 297: 1506-10.
-
(1988)
BMJ
, vol.297
, pp. 1506-1510
-
-
Chrystyn, H.1
Mulley, B.A.2
Peake, M.D.3
-
118
-
-
0025777746
-
Effect of salbutamol and ipratropium bromide on airway calibre and bronchial reactivity in asthma and chronic bronchitis
-
Higgins BG, Powell RM, Cooper S, et al. Effect of salbutamol and ipratropium bromide on airway calibre and bronchial reactivity in asthma and chronic bronchitis. Eur Respir J. 1991; 4: 415-20.
-
(1991)
Eur Respir J
, vol.4
, pp. 415-420
-
-
Higgins, B.G.1
Powell, R.M.2
Cooper, S.3
-
119
-
-
0037108632
-
Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease
-
Mahler DA, Wire P, Horstman D, et al. Effectiveness of fluticasone propionate and salmeterol combination delivered via the Diskus device in the treatment of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2002; 166: 1084-91.
-
(2002)
Am J Respir Crit Care Med
, vol.166
, pp. 1084-1091
-
-
Mahler, D.A.1
Wire, P.2
Horstman, D.3
-
120
-
-
0037246565
-
Disease severity and the effect of fluticasone propionate on chronic obstructive pulmonary disease exacerbations
-
Jones PW, Willits LR, Burge PS, et al. Disease severity and the effect of fluticasone propionate on chronic obstructive pulmonary disease exacerbations. Eur Respir J. 2003; 21: 68-73.
-
(2003)
Eur Respir J
, vol.21
, pp. 68-73
-
-
Jones, P.W.1
Willits, L.R.2
Burge, P.S.3
-
121
-
-
0037425745
-
Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomized controlled trial
-
Calverley P, Pauwels R, Vestbo J, et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomized controlled trial. Lancet. 2003; 361: 449-56.
-
(2003)
Lancet
, vol.361
, pp. 449-456
-
-
Calverley, P.1
Pauwels, R.2
Vestbo, J.3
-
122
-
-
0037246566
-
Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease
-
Szafranski W, Cukier A, Ramirez A, et al. Efficacy and safety of budesonide/formoterol in the management of chronic obstructive pulmonary disease. Eur Respir J. 2003; 21: 74-81.
-
(2003)
Eur Respir J
, vol.21
, pp. 74-81
-
-
Szafranski, W.1
Cukier, A.2
Ramirez, A.3
-
123
-
-
0029924786
-
Functional and histologic picture of steroid-induced myopathy in chronic obstructive pulmonary disease
-
Decramer M, de Bock V, Dom R. Functional and histologic picture of steroid-induced myopathy in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1996; 153: 1958-64.
-
(1996)
Am J Respir Crit Care Med
, vol.153
, pp. 1958-1964
-
-
Decramer, M.1
de Bock, V.2
Dom, R.3
-
124
-
-
0028237807
-
Corticosteroids contribute to muscle weakness in chronic airflow obstruction
-
Decramer M, Lacquet LM, Fagard R, et al. Corticosteroids contribute to muscle weakness in chronic airflow obstruction. Am J Respir Crit Care Med. 1994; 150: 11-6.
-
(1994)
Am J Respir Crit Care Med
, vol.150
, pp. 11-16
-
-
Decramer, M.1
Lacquet, L.M.2
Fagard, R.3
-
125
-
-
0026808393
-
Corticosteroid-induced myopathy involving respiratory muscles in patients with chronic obstructive pulmonary disease or asthma
-
Decramer M, Stas KJ. Corticosteroid-induced myopathy involving respiratory muscles in patients with chronic obstructive pulmonary disease or asthma. Am Rev Respir Dis. 1992; 146: 800-2.
-
(1992)
Am Rev Respir Dis
, vol.146
, pp. 800-802
-
-
Decramer, M.1
Stas, K.J.2
-
126
-
-
77957765835
-
To market, to market-2009
-
Macor JE, editor. Oxford, UK: Elsevier
-
Hegde S, Schmidt M. To market, to market-2009. In: Macor JE, editor. Annual reports in medicinal chemistry. Vol. 45. Oxford, UK: Elsevier; 2010. p. 505-7.
-
(2010)
Annual reports in medicinal chemistry
, vol.45
, pp. 505-507
-
-
Hegde, S.1
Schmidt, M.2
-
127
-
-
33645125785
-
Indacaterol. Asthma therapy, Treatment of COPD, β 2-Adrenoceptor agonist
-
Davies SL, Castaner J. Indacaterol. Asthma therapy, Treatment of COPD, β 2-Adrenoceptor agonist. Drugs Future. 2005; 30: 1219-24.
-
(2005)
Drugs Future
, vol.30
, pp. 1219-1224
-
-
Davies, S.L.1
Castaner, J.2
-
128
-
-
84887240455
-
-
US Food and Drug Administration. FDA approves Arcapta Neohaler to treat chronic obstructive pulmonary disease (Press release). 2011 (accessed 9 November 2012)
-
US Food and Drug Administration. 2011. FDA approves Arcapta Neohaler to treat chronic obstructive pulmonary disease (Press release). 2011. Available from: http://www.fda.gov/NewsEvents/Newsroom/ PressAnnouncements/ucm261649.htm (accessed 9 November 2012).
-
(2011)
-
-
-
129
-
-
33646924049
-
Are phosphodiesterase 4 inhibitors just more theophylline?
-
Boswell-Smith V, Cazzola M, Page C. Are phosphodiesterase 4 inhibitors just more theophylline? J Allergy Clin Immunol. 2006; 117: 1237-43.
-
(2006)
J Allergy Clin Immunol
, vol.117
, pp. 1237-1243
-
-
Boswell-Smith, V.1
Cazzola, M.2
Page, C.3
-
130
-
-
79851471591
-
Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD
-
Giembycz MA, Field SK. Roflumilast: first phosphodiesterase 4 inhibitor approved for treatment of COPD. Drug Des Devel Ther. 2010; 4: 147-58.
-
(2010)
Drug Des Devel Ther
, vol.4
, pp. 147-158
-
-
Giembycz, M.A.1
Field, S.K.2
-
131
-
-
77952192978
-
Is PDE4 too difficult a drug target?
-
Higgs G. Is PDE4 too difficult a drug target? Curr Opin Investig Drugs. 2010; 11: 495-8.
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 495-498
-
-
Higgs, G.1
-
132
-
-
77955498534
-
Roflumilast: in chronic obstructive pulmonary disease
-
Sanford M. Roflumilast: in chronic obstructive pulmonary disease. Drugs. 2010; 70: 1615-27.
-
(2010)
Drugs
, vol.70
, pp. 1615-1627
-
-
Sanford, M.1
-
133
-
-
84887233698
-
-
EMA. CHMP assessment report. 22 April 2010 EMA/ 464905/2010
-
EMA. CHMP assessment report. 22 April 2010 EMA/ 464905/2010.
-
-
-
-
135
-
-
0027636624
-
Rewriting medical history: charles best and the banting and best myth
-
Bliss M. Rewriting medical history: charles best and the banting and best myth. J Hist Med. 1993; 48: 254.
-
(1993)
J Hist Med
, vol.48
, pp. 254
-
-
Bliss, M.1
-
136
-
-
49649095014
-
Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled Type 2 diabetes on sulfonylurea-based therapy
-
Fonseca VA, Rosenstock J, Wang AC, Truitt KE, Jones MR. Colesevelam HCl improves glycemic control and reduces LDL cholesterol in patients with inadequately controlled Type 2 diabetes on sulfonylurea-based therapy. Diabetes Care. 2008; 31: 1479-84.
-
(2008)
Diabetes Care
, vol.31
, pp. 1479-1484
-
-
Fonseca, V.A.1
Rosenstock, J.2
Wang, A.C.3
Truitt, K.E.4
Jones, M.R.5
-
137
-
-
0033861067
-
Bromocriptine: a novel approach to the treatment of Type 2 diabetes
-
Pijl H, Ohashi S, Matsuda M, et al. Bromocriptine: a novel approach to the treatment of Type 2 diabetes. Diabetes Care. 2000; 23: 1154-61.
-
(2000)
Diabetes Care
, vol.23
, pp. 1154-1161
-
-
Pijl, H.1
Ohashi, S.2
Matsuda, M.3
-
138
-
-
0034880691
-
Determinants of the effectiveness of glucagon-like peptide-1 in Type 2 diabetes
-
Toft-Nielsen M, Madsbad S, Holst J. Determinants of the effectiveness of glucagon-like peptide-1 in Type 2 diabetes. J Clin Endocrinol Metab. 2001; 86: 3853-60.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 3853-3860
-
-
Toft-Nielsen, M.1
Madsbad, S.2
Holst, J.3
-
139
-
-
79955777481
-
Liraglutide: once-daily GLP-1 agonist for the treatment of Type 2 diabetes
-
Ryan GJ, Hardy Y. Liraglutide: once-daily GLP-1 agonist for the treatment of Type 2 diabetes. J Clin Pharm Ther. 2011; 36: 260-74.
-
(2011)
J Clin Pharm Ther
, vol.36
, pp. 260-274
-
-
Ryan, G.J.1
Hardy, Y.2
-
140
-
-
42449084168
-
Dipeptidyl peptidase-IV inhibitors: pharmacological profile and clinical use
-
White J. Dipeptidyl peptidase-IV inhibitors: pharmacological profile and clinical use. Clin Diabetes. 2008; 26: 53-7.
-
(2008)
Clin Diabetes
, vol.26
, pp. 53-57
-
-
White, J.1
-
141
-
-
33947685466
-
11 years of cyanopyrrolidines as DPP-IV inhibitors
-
Peters JU. 11 years of cyanopyrrolidines as DPP-IV inhibitors. Curr Top Med Chem. 2007; 7: 579-95.
-
(2007)
Curr Top Med Chem
, vol.7
, pp. 579-595
-
-
Peters, J.U.1
-
143
-
-
34548660457
-
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease GOLD executive summary
-
Rabe KF, Hurd S, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. GOLD executive summary. Am J Respir Crit Care Med. 2007; 176: 532-55.
-
(2007)
Am J Respir Crit Care Med
, vol.176
, pp. 532-555
-
-
Rabe, K.F.1
Hurd, S.2
Anzueto, A.3
-
144
-
-
0027962628
-
Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1 The Lung Health Study
-
Anthonisen NR, Connett JE, Kiley JP, et al. Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1. The Lung Health Study. JAMA. 1994; 272: 1497-505.
-
(1994)
JAMA
, vol.272
, pp. 1497-1505
-
-
Anthonisen, N.R.1
Connett, J.E.2
Kiley, J.P.3
-
145
-
-
0345188819
-
Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking European Respiratory Society Study on Chronic Obstructive Pulmonary Disease
-
Pauwels RA, Lofdahl CG, Laitinen LA, et al. Long-term treatment with inhaled budesonide in persons with mild chronic obstructive pulmonary disease who continue smoking. European Respiratory Society Study on Chronic Obstructive Pulmonary Disease. N Engl J Med. 1999; 340: 1948-53.
-
(1999)
N Engl J Med
, vol.340
, pp. 1948-1953
-
-
Pauwels, R.A.1
Lofdahl, C.G.2
Laitinen, L.A.3
-
146
-
-
0033614639
-
Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial
-
Vestbo J, Sorensen T, Lange P, et al. Long-term effect of inhaled budesonide in mild and moderate chronic obstructive pulmonary disease: a randomised controlled trial. Lancet. 1999; 353: 1819-23.
-
(1999)
Lancet
, vol.353
, pp. 1819-1823
-
-
Vestbo, J.1
Sorensen, T.2
Lange, P.3
-
147
-
-
0034643610
-
Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial
-
Burge PS, Calverley PM, Jones PW, et al. Randomised, double blind, placebo controlled study of fluticasone propionate in patients with moderate to severe chronic obstructive pulmonary disease: the ISOLDE trial. BMJ. 2000; 320: 1297-303.
-
(2000)
BMJ
, vol.320
, pp. 1297-1303
-
-
Burge, P.S.1
Calverley, P.M.2
Jones, P.W.3
-
148
-
-
84887221826
-
-
National Osteoporosis Foundation. (accessed 5 November 2012)
-
National Osteoporosis Foundation. Available from: www.NFO.org (accessed 5 November 2012).
-
-
-
-
149
-
-
84863633404
-
Osteoblastogenesis regulation signals in bone remodeling
-
Zuo C, Huang Y, Bajis R, et al. Osteoblastogenesis regulation signals in bone remodeling. Osteoporos Int. 2012; 23: 1653-63.
-
(2012)
Osteoporos Int
, vol.23
, pp. 1653-1663
-
-
Zuo, C.1
Huang, Y.2
Bajis, R.3
-
150
-
-
84857440651
-
Individualizing osteoporosis therapy
-
Silvernam S, Christiansen C. Individualizing osteoporosis therapy. Osteoporos Int. 2012; 23: 797-809.
-
(2012)
Osteoporos Int
, vol.23
, pp. 797-809
-
-
Silvernam, S.1
Christiansen, C.2
-
151
-
-
84873737216
-
Lack of response to teriparatide therapy for bisphosphonate -associated osteonecrosis of the jaw
-
(Epub ahead of publication doi: 10.1007/s00198-012-1918-9)
-
Narváez J, Narváez JA, Gómez-Vaquero C, et al. Lack of response to teriparatide therapy for bisphosphonate -associated osteonecrosis of the jaw. Osteoporos Int. 2012 (Epub ahead of publication. doi: 10.1007/ s00198-012-1918-9).
-
(2012)
Osteoporos Int
-
-
Narváez, J.1
Narváez, J.A.2
Gómez-Vaquero, C.3
-
152
-
-
84872072934
-
Incidence of fractures of the femur, including subchanteric, up to 8 years since initiation of oral bisphosphonate therapy; a register-based cohort study using the US MarketScan claims database
-
(Epub ahead of publication doi: 10.1007/s00198-012-1952-7)
-
Pazianas M, Abrahamsen B, Wang Y, Russell RG. Incidence of fractures of the femur, including subchanteric, up to 8 years since initiation of oral bisphosphonate therapy; a register-based cohort study using the US MarketScan claims database. Osteoporos Int. 2012 (Epub ahead of publication. doi: 10.1007/ s00198-012-1952-7).
-
(2012)
Osteoporos Int
-
-
Pazianas, M.1
Abrahamsen, B.2
Wang, Y.3
Russell, R.G.4
-
153
-
-
84857368424
-
Use of bisphosphonate and risk of atrial fibrillation in older women with osteoporosis
-
Rhee CW, Lee J, Oh S, et al. Use of bisphosphonate and risk of atrial fibrillation in older women with osteoporosis. Osteoporos Int. 2012; 23: 247-54.
-
(2012)
Osteoporos Int
, vol.23
, pp. 247-254
-
-
Rhee, C.W.1
Lee, J.2
Oh, S.3
-
154
-
-
0022648104
-
Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors
-
Bertolini DR, Nedwin GE, Timothy SB, et al. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors. Nature. 1986; 319: 516-8.
-
(1986)
Nature
, vol.319
, pp. 516-518
-
-
Bertolini, D.R.1
Nedwin, G.E.2
Timothy, S.B.3
-
155
-
-
77958097353
-
Denosumab for the treatment of osteoporosis
-
Iqbal J, Sun L, Zaidi M. Denosumab for the treatment of osteoporosis. Curr Osteoporos Rep. 2010; 8: 163-7.
-
(2010)
Curr Osteoporos Rep
, vol.8
, pp. 163-167
-
-
Iqbal, J.1
Sun, L.2
Zaidi, M.3
-
157
-
-
0032976315
-
Updated guidelines for the diagnosis and treatment of gastroesopheal reflux disease The practice parameters committee of the American College of Gastroenterology
-
DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesopheal reflux disease. The practice parameters committee of the American College of Gastroenterology. Am J Gastroenterol. 1999; 94: 1431-2.
-
(1999)
Am J Gastroenterol
, vol.94
, pp. 1431-1432
-
-
DeVault, K.R.1
Castell, D.O.2
-
159
-
-
13744261420
-
Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease
-
DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 2005; 100: 190-200.
-
(2005)
Am J Gastroenterol
, vol.100
, pp. 190-200
-
-
DeVault, K.R.1
Castell, D.O.2
-
160
-
-
63849151475
-
Review article: dual delayed release formulation of dexlansoprazole MR, a novel approach to overcome the limitations of conventional single release proton pump inhibitor therapy
-
Metz DC, Vakily M, Dixit T, Mulford D. Review article: dual delayed release formulation of dexlansoprazole MR, a novel approach to overcome the limitations of conventional single release proton pump inhibitor therapy. Aliment Pharmacol Ther. 2009; 29: 928-37.
-
(2009)
Aliment Pharmacol Ther
, vol.29
, pp. 928-937
-
-
Metz, D.C.1
Vakily, M.2
Dixit, T.3
Mulford, D.4
-
161
-
-
34248136340
-
Inflammatory bowel disease: clinical aspects and established and evolving therapies
-
Baumgart DC, Sandborn WJ. Inflammatory bowel disease: clinical aspects and established and evolving therapies. Lancet. 2007; 369: 1641-57.
-
(2007)
Lancet
, vol.369
, pp. 1641-1657
-
-
Baumgart, D.C.1
Sandborn, W.J.2
-
162
-
-
84887229220
-
-
Business Wire. 2008. APRISO granted marketing approval for maintenance of remission of ulcerative colitis (accessed 5 November 2012)
-
Business Wire. 2008. APRISO granted marketing approval for maintenance of remission of ulcerative colitis. Available from: http://www.businesswire.com/ news/home/20081031005860/en/APRISO-TM-Granted-FDA-Marketing-Approval-Mai ntenance (accessed 5 November 2012).
-
-
-
-
163
-
-
0035074301
-
Management of Crohn's disease in adults
-
Hanauer SB, Sandborn W. Management of Crohn ' s disease in adults. Am J Gastroenterol. 2001; 96: 635-43.
-
(2001)
Am J Gastroenterol
, vol.96
, pp. 635-643
-
-
Hanauer, S.B.1
Sandborn, W.2
-
164
-
-
7044264854
-
A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab
-
Scheinfeld N. A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab. J Dermatolog Treat. 2004; 15: 280-94.
-
(2004)
J Dermatolog Treat
, vol.15
, pp. 280-294
-
-
Scheinfeld, N.1
-
165
-
-
77953660821
-
Certolizumab pegol
-
Goel N, Stephens S. Certolizumab pegol. MAbs. 2010; 2: 137-47.
-
(2010)
MAbs
, vol.2
, pp. 137-147
-
-
Goel, N.1
Stephens, S.2
-
166
-
-
0037264969
-
Therapeutic antibodies for human diseases at the dawn of the twenty-first century
-
Brekke OH, Sandlie I. Therapeutic antibodies for human diseases at the dawn of the twenty-first century. Nat Rev Drug Discov. 2003; 2: 52-62.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 52-62
-
-
Brekke, O.H.1
Sandlie, I.2
-
167
-
-
84887227193
-
-
Medical News Today. 2007. HUMIRA ((Adalimumab) receives FDA approval for treatment of Crohn's disease (accessed 5 November 2012)
-
Medical News Today. 2007. HUMIRA ® (Adalimumab) receives FDA approval for treatment of Crohn ' s disease. Available from: http://www.medicalnewstoday.com/ releases/64063.php (accessed 5 November 2012).
-
-
-
-
168
-
-
0041582974
-
Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide
-
Zamecnik PC, Stephenson ML. Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide. Proc Natl Acad Sci U S A. 1978; 75: 280-4.
-
(1978)
Proc Natl Acad Sci U S A
, vol.75
, pp. 280-284
-
-
Zamecnik, P.C.1
Stephenson, M.L.2
-
169
-
-
0032545933
-
Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
-
Fire A, Xu S, Montgomery MK, et al. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998; 391: 806-11.
-
(1998)
Nature
, vol.391
, pp. 806-811
-
-
Fire, A.1
Xu, S.2
Montgomery, M.K.3
-
170
-
-
0035942736
-
Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
-
Elabashir SM, Harborth J, Lendeckel W, et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature. 2001; 411: 494-8.
-
(2001)
Nature
, vol.411
, pp. 494-498
-
-
Elabashir, S.M.1
Harborth, J.2
Lendeckel, W.3
-
171
-
-
0001508918
-
Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5
-
Smith CC, Aurelian L, Reddy MP, et al. Antiviral effect of an oligo(nucleoside methylphosphonate) complementary to the splice junction of herpes simplex virus type 1 immediate early pre-mRNAs 4 and 5. Proc Natl Acad Sci U S A. 1986; 83: 2787-91.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 2787-2791
-
-
Smith, C.C.1
Aurelian, L.2
Reddy, M.P.3
-
172
-
-
0024382446
-
Uncharged stereoregular nucleic acid analogs: 2 Morpholino nucleoside oligomers with carbamate internucleoside linkages
-
Stirchak EP, Summerton JE, Weller DD. Uncharged stereoregular nucleic acid analogs: 2. Morpholino nucleoside oligomers with carbamate internucleoside linkages. Nucleic Acids Res. 1989; 17: 6129-41.
-
(1989)
Nucleic Acids Res
, vol.17
, pp. 6129-6141
-
-
Stirchak, E.P.1
Summerton, J.E.2
Weller, D.D.3
-
173
-
-
79954580272
-
Current prospects for RNA interference-based therapies
-
Davidson BL, McCray PB Jr. Current prospects for RNA interference-based therapies. Nat Rev Genet. 2011; 12: 329-40.
-
(2011)
Nat Rev Genet
, vol.12
, pp. 329-340
-
-
Davidson, B.L.1
McCray Jr., P.B.2
-
174
-
-
79960965295
-
Therapeutic oligonucleotides
-
Goodchild J. Therapeutic oligonucleotides. Methods Mol Biol. 2011; 764: 1-15.
-
(2011)
Methods Mol Biol
, vol.764
, pp. 1-15
-
-
Goodchild, J.1
-
175
-
-
84856431819
-
RNA therapeutics: beyond RNA interference and antisense oligonucleotides
-
Kole R, Krainer AR, Altman S. RNA therapeutics: beyond RNA interference and antisense oligonucleotides. Nat Rev Drug Discov. 2012; 11: 125-40.
-
(2012)
Nat Rev Drug Discov
, vol.11
, pp. 125-140
-
-
Kole, R.1
Krainer, A.R.2
Altman, S.3
-
176
-
-
0025074907
-
In vitro selection of RNA molecules that bind specific ligands
-
Ellington AD, Szostak JW. In vitro selection of RNA molecules that bind specific ligands. Nature. 1990; 346: 818-22.
-
(1990)
Nature
, vol.346
, pp. 818-822
-
-
Ellington, A.D.1
Szostak, J.W.2
-
177
-
-
0025194307
-
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
-
Tuerk C, Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science. 1990; 249: 505-10.
-
(1990)
Science
, vol.249
, pp. 505-510
-
-
Tuerk, C.1
Gold, L.2
-
178
-
-
80052228547
-
Nucleic acid aptamers: clinical applications and promising new horizons
-
Ni X, Castanares M, Mukherjee A, Lupold SE. Nucleic acid aptamers: clinical applications and promising new horizons. Curr Med Chem. 2011; 18: 4206-14.
-
(2011)
Curr Med Chem
, vol.18
, pp. 4206-4214
-
-
Ni, X.1
Castanares, M.2
Mukherjee, A.3
Lupold, S.E.4
-
180
-
-
1642633533
-
Toxicological evaluation of oligonucleotide therapeutics
-
Marquis JK, Grindel JM. Toxicological evaluation of oligonucleotide therapeutics. Curr Opin Mol Ther. 2000; 2: 258-63.
-
(2000)
Curr Opin Mol Ther
, vol.2
, pp. 258-263
-
-
Marquis, J.K.1
Grindel, J.M.2
-
181
-
-
74049148749
-
Orphan products: an emerging trend in drug approvals
-
Cote T, Kelkar A, Xu K, Braun MM, Phillips MI. Orphan products: an emerging trend in drug approvals. Nat Rev Drug Discov. 2010; 9: 84.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 84
-
-
Cote, T.1
Kelkar, A.2
Xu, K.3
Braun, M.M.4
Phillips, M.I.5
-
182
-
-
84929529694
-
-
US Food and Drug Administration (accessed 5 November 2012)
-
US Food and Drug Administration. Developing products for rare diseases and conditions. 2012. Available from: http://www.fda.gov/orphan (accessed 5 November 2012).
-
(2012)
Developing products for rare diseases and conditions
-
-
-
183
-
-
77954243603
-
Emergence of orphan drugs in the United States: a quantitative assessment of the first 25 years
-
Braun MM, Farag-El-Massah S, Xu K, Cote TR. Emergence of orphan drugs in the United States: a quantitative assessment of the first 25 years. Nat Rev Drug Discov. 2010; 9 (7): 519-22.
-
(2010)
Nat Rev Drug Discov
, vol.9
, Issue.7
, pp. 519-522
-
-
Braun, M.M.1
Farag-El-Massah, S.2
Xu, K.3
Cote, T.R.4
-
184
-
-
79955580019
-
European regulation on orphan medicinal products: 10 years of experience and future perspectives
-
Scientific Secretariat of The Committee for Orphan Medicinal Products, the European Medicines Agency
-
Scientific Secretariat of The Committee for Orphan Medicinal Products, the European Medicines Agency. European regulation on orphan medicinal products: 10 years of experience and future perspectives. Nat Rev Drug Discov. 2011; 10: 341-9.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 341-349
-
-
-
185
-
-
77953405077
-
The emerging academic drug-discovery sector
-
Wyatt PG. The emerging academic drug-discovery sector. Future Med Chem. 2009; 1 (6): 1013-7.
-
(2009)
Future Med Chem
, vol.1
, Issue.6
, pp. 1013-1017
-
-
Wyatt, P.G.1
-
186
-
-
77954977329
-
Integration of small -molecule discovery in academic biomedical research
-
Ohlmeyer M, Zhou M-M. Integration of small -molecule discovery in academic biomedical research. Mt Sinai J Med. 2010; 77: 350-7.
-
(2010)
Mt Sinai J Med
, vol.77
, pp. 350-357
-
-
Ohlmeyer, M.1
Zhou, M.-M.2
-
187
-
-
84887232637
-
-
National Institutes of Health Center for Translational Therapeutics (accessed 5 November 2012)
-
National Institutes of Health Center for Translational Therapeutics. Therapeutics for rare and neglected diseases. Available from: http://nctt.nih.gov/trnd/ (accessed 5 November 2012).
-
Therapeutics for rare and neglected diseases
-
-
-
188
-
-
62549153611
-
Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist
-
Erickson-Miller CL, Delorme E, Tian S-S, Hopson CB, Landis AJ, Valoret EI, et al. Preclinical activity of eltrombopag (SB-497115), an oral, nonpeptide thrombopoietin receptor agonist. Stem Cells. 2009; 27: 424-30.
-
(2009)
Stem Cells
, vol.27
, pp. 424-430
-
-
Erickson-Miller, C.L.1
Delorme, E.2
Tian, S.-S.3
Hopson, C.B.4
Landis, A.J.5
Valoret, E.I.6
-
189
-
-
79952031932
-
Eltrombopag-a novel approach for the treatment of chronic immune thrombocytopenic purpura: review and safety considerations
-
Cook L, Cooper N. Eltrombopag-a novel approach for the treatment of chronic immune thrombocytopenic purpura: review and safety considerations. Drug Des Devel Ther. 2010; 4: 139-45.
-
(2010)
Drug Des Devel Ther
, vol.4
, pp. 139-145
-
-
Cook, L.1
Cooper, N.2
-
190
-
-
77249150559
-
The incidence of immune thrombocytopenic purpura in children and adults: a critical review of published reports
-
Terrell DR, Beebe LA, Vesely SK, Neas BR, Segal JB, George JN. The incidence of immune thrombocytopenic purpura in children and adults: a critical review of published reports. Am J Hematol. 2010; 85: 174-80.
-
(2010)
Am J Hematol
, vol.85
, pp. 174-180
-
-
Terrell, D.R.1
Beebe, L.A.2
Vesely, S.K.3
Neas, B.R.4
Segal, J.B.5
George, J.N.6
-
191
-
-
77954096636
-
Treatment options for chronic refractory idiopathic thrombocytopenic purpura in adults: focus on romiplostim and eltrombopag
-
Chouhan JD, Herrington JD. Treatment options for chronic refractory idiopathic thrombocytopenic purpura in adults: focus on romiplostim and eltrombopag. Pharmacotherapy. 2010; 30: 666-83.
-
(2010)
Pharmacotherapy
, vol.30
, pp. 666-683
-
-
Chouhan, J.D.1
Herrington, J.D.2
-
192
-
-
84887250121
-
-
Department of Health and Human Services (accessed 5 November 2012)
-
Department of Health and Human Services. 2008. Eltrombopag olamine. Available from: http://www. accessdata.fda.gov/drugsatfda_docs/appletter/2008/ 022291s000ltr.pdf (accessed 5 November 2012).
-
(2008)
Eltrombopag olamine
-
-
-
193
-
-
80052368128
-
The European Medicines Agency review of eltrombopag (Revolade) for the treatment of adult chronic immune (idiopathic) thrombocytopenic purpura: summary of the scientific assessment of the Committee for Medicinal Products for Human Use
-
Nieto M, Calvo G, Hudson I, Feldschreiber P, Brown D, Lee CC, et al. The European Medicines Agency review of eltrombopag (Revolade) for the treatment of adult chronic immune (idiopathic) thrombocytopenic purpura: summary of the scientific assessment of the Committee for Medicinal Products for Human Use. Haematologica. 2011; 96: e33-40.
-
(2011)
Haematologica
, vol.96
-
-
Nieto, M.1
Calvo, G.2
Hudson, I.3
Feldschreiber, P.4
Brown, D.5
Lee, C.C.6
-
194
-
-
36549047972
-
Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C
-
McHutchison JG, Dusheiko G, Shiffman ML, Rodriguez-Torres M, Sigal S, Bourliere M, et al. Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med. 2007; 357: 2227-36.
-
(2007)
N Engl J Med
, vol.357
, pp. 2227-2236
-
-
McHutchison, J.G.1
Dusheiko, G.2
Shiffman, M.L.3
Rodriguez-Torres, M.4
Sigal, S.5
Bourliere, M.6
-
195
-
-
84887260502
-
-
World Health Organization. Accelerating work to overcome the global impact of neglected tropical diseases: a roadmap for implementation
-
World Health Organization. Accelerating work to overcome the global impact of neglected tropical diseases: a roadmap for implementation. 2010.
-
(2010)
-
-
-
196
-
-
0037157590
-
Drug development for neglected diseases: a deficient market and a public-health policy failure
-
Trouiller P, Olliaro P, Torreele E, et al. Drug development for neglected diseases: a deficient market and a public-health policy failure. Lancet. 2002; 22: 2188-94.
-
(2002)
Lancet
, vol.22
, pp. 2188-2194
-
-
Trouiller, P.1
Olliaro, P.2
Torreele, E.3
-
197
-
-
61449194131
-
Neglected disease research and development: how much are we really spending?
-
Moran M, Guzman J, Ropars AL, et al. Neglected disease research and development: how much are we really spending? PLoS Med. 2009; 6: e30.
-
(2009)
PLoS Med
, vol.6
-
-
Moran, M.1
Guzman, J.2
Ropars, A.L.3
-
198
-
-
77956289287
-
Development of and access to products for neglected diseases
-
Cohen J, Dibner MS, Wilson A. Development of and access to products for neglected diseases. PLoS ONE. 2010; 5: e10610.
-
(2010)
PLoS ONE
, vol.5
-
-
Cohen, J.1
Dibner, M.S.2
Wilson, A.3
-
200
-
-
84887227149
-
-
BIO Ventures for Global Health. Developing new drugs and vaccines for neglected diseases of the poor
-
BIO Ventures for Global Health. Developing new drugs and vaccines for neglected diseases of the poor, 2012.
-
(2012)
-
-
-
201
-
-
84887252230
-
Malaria: new medicines for its control and eradication
-
Palmer M, Wells TNC, editors. Cambridge: RSC Publishing
-
Wells TNC, Gutteridge WE. Malaria: new medicines for its control and eradication. In: Palmer M, Wells TNC, editors. Neglected diseases and drug discovery. Cambridge: RSC Publishing; 2011. p. 1-32.
-
(2011)
Neglected diseases and drug discovery
, pp. 1-32
-
-
Wells, T.N.C.1
Gutteridge, W.E.2
-
202
-
-
79951601844
-
A research agenda to underpin malaria eradication
-
Alonso PL, Brown G, Arevalo-Herrera M, et al. A research agenda to underpin malaria eradication. PLoS Med. 2011; 8: e1000406.
-
(2011)
PLoS Med
, vol.8
-
-
Alonso, P.L.1
Brown, G.2
Arevalo-Herrera, M.3
-
203
-
-
84860295215
-
Tuberculosis: the drug development pipeline at a glance
-
Villemagne B, Crauste C, Flipo M, et al. Tuberculosis: the drug development pipeline at a glance. Eur J Med Chem. 2012; 51: 1-16.
-
(2012)
Eur J Med Chem
, vol.51
, pp. 1-16
-
-
Villemagne, B.1
Crauste, C.2
Flipo, M.3
-
204
-
-
77954978118
-
NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness
-
Yun O, Priotto G, Tong J, et al. NECT is next: implementing the new drug combination therapy for Trypanosoma brucei gambiense sleeping sickness. PLoS Negl Trop Dis. 2010; 4: e720.
-
(2010)
PLoS Negl Trop Dis
, vol.4
-
-
Yun, O.1
Priotto, G.2
Tong, J.3
-
205
-
-
79959787951
-
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human african trypanosomiasis
-
Jacobs RT, Nare B, Wring SA, et al. SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human african trypanosomiasis. PLoS NTD. 2011; 5: e1151.
-
(2011)
PLoS NTD
, vol.5
-
-
Jacobs, R.T.1
Nare, B.2
Wring, S.A.3
-
206
-
-
78650682602
-
Fexinidazole-a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness
-
Torreele E, Bourdin Trunz B, Tweats D, et al. Fexinidazole-a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS NTD. 2010; 4: e923.
-
(2010)
PLoS NTD
, vol.4
-
-
Torreele, E.1
Bourdin Trunz, B.2
Tweats, D.3
-
207
-
-
79953031840
-
Visceral leishmaniasis: elimination with existing interventions
-
Matlashewski G, Arana B, Kroeger A, et al. Visceral leishmaniasis: elimination with existing interventions. Lancet Infect Dis. 2011; 4: 322-5.
-
(2011)
Lancet Infect Dis
, vol.4
, pp. 322-325
-
-
Matlashewski, G.1
Arana, B.2
Kroeger, A.3
-
208
-
-
84858308226
-
Natural Products as sources of new drugs over the 30 years from 1981 to 2010
-
Newman DJ, Cragg GM. Natural Products as sources of new drugs over the 30 years from 1981 to 2010. J Nat Prod. 2012; 75: 311-55.
-
(2012)
J Nat Prod
, vol.75
, pp. 311-355
-
-
Newman, D.J.1
Cragg, G.M.2
-
209
-
-
14944383798
-
The evolving role of natural products in drug discovery
-
Koehn FE, Carter GT. The evolving role of natural products in drug discovery. Nat Rev Drug Discov. 2005; 4: 206-20.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 206-220
-
-
Koehn, F.E.1
Carter, G.T.2
-
210
-
-
84859032176
-
Natural products and traditional medicine: turning on a paradigm
-
Cordell GA, Colvard MD. Natural products and traditional medicine: turning on a paradigm. J Nat Prod. 2012; 75: 514-25.
-
(2012)
J Nat Prod
, vol.75
, pp. 514-525
-
-
Cordell, G.A.1
Colvard, M.D.2
-
211
-
-
84858232647
-
Natural products in drug discovery: clinical evaluations and investigations
-
Tiwari VK, Mishra BB, editors. Research Signpost
-
Mishra BB, Tiwari VK. Natural products in drug discovery: clinical evaluations and investigations. In: Tiwari VK, Mishra BB, editors. Opportunity, challenge and scope of natural products in medicinal chemistry. Research Signpost. pp. 1-62.
-
Opportunity, challenge and scope of natural products in medicinal chemistry
, pp. 1-62
-
-
Mishra, B.B.1
Tiwari, V.K.2
-
212
-
-
4344668661
-
Drug repositioning: identifying and developing new uses for existing drugs
-
Ashburn TT, Thor KB. Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004; 3: 673-83.
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 673-683
-
-
Ashburn, T.T.1
Thor, K.B.2
-
213
-
-
65649114787
-
Drug repositioning summit: finding new routes to success
-
Campas C. Drug repositioning summit: finding new routes to success. Drug News Perspect. 2009; 22: 126-8.
-
(2009)
Drug News Perspect
, vol.22
, pp. 126-128
-
-
Campas, C.1
-
214
-
-
65649112521
-
The value of drug repositioning in the current pharmaceutical market
-
Tobinick EL. The value of drug repositioning in the current pharmaceutical market. Drug News Perspect. 2009; 22 (2): 119-25.
-
(2009)
Drug News Perspect
, vol.22
, Issue.2
, pp. 119-125
-
-
Tobinick, E.L.1
-
216
-
-
84878013705
-
-
US Food and Drug Administration. (accessed 5 No -vember 2012)
-
US Food and Drug Administration. 2008. Living with fibromyalgia, drugs, approved to manage pain. Available from: http://www.fda.gov/ForConsumers/ ConsumerUpdates/ucm107802.htm (accessed 5 No -vember 2012).
-
(2008)
Living with fibromyalgia, drugs, approved to manage pain
-
-
-
217
-
-
84887252468
-
-
US Food and Drug Administration (accessed 5 November 2012)
-
US Food and Drug Administration2010. News Re -lease: FDA clears Cymbalta to treat musculoskeletal pain. Available from: http://www.fda.gov/NewsEvents/ Newsroom/PressAnnouncements/ucm232708.htm (accessed 5 November 2012).
-
(2010)
News Re -lease: FDA clears Cymbalta to treat musculoskeletal pain
-
-
-
218
-
-
84887239159
-
-
Eli Lilly annual report, (accessed 5 November 2012)
-
Eli Lilly annual report. 2012. Available from: https:// investor.lilly.com (accessed 5 November 2012).
-
(2012)
-
-
-
219
-
-
77954813961
-
Repurposing strategies for therapeutics
-
Sleigh SH, Barton CL. Repurposing strategies for therapeutics. Pharm Med. 2010; 24: 151-9.
-
(2010)
Pharm Med
, vol.24
, pp. 151-159
-
-
Sleigh, S.H.1
Barton, C.L.2
-
220
-
-
0034905737
-
Doxepin in the treatment of primary insomnia: a placebo -controlled, double-blind, polysomnographic study
-
Hajak G, Rodenbeck A, Voderholzer U et al. Doxepin in the treatment of primary insomnia: a placebo -controlled, double-blind, polysomnographic study. J Clin Psychiatry. 2001; 62: 453-63.
-
(2001)
J Clin Psychiatry
, vol.62
, pp. 453-463
-
-
Hajak, G.1
Rodenbeck, A.2
Voderholzer, U.3
-
222
-
-
80054121749
-
The future of drug repositioning: old drugs, new opportunities
-
Doan TL, Pollastri M, Walters MA, Georg GI. The future of drug repositioning: old drugs, new opportunities. Annu Rep Med Chem. 2011; 46: 385-401.
-
(2011)
Annu Rep Med Chem
, vol.46
, pp. 385-401
-
-
Doan, T.L.1
Pollastri, M.2
Walters, M.A.3
Georg, G.I.4
-
224
-
-
79957880949
-
Mining for therapeutic gold
-
Collins FS. Mining for therapeutic gold. Nat Rev Drug Discov. 2011; 10: 397.
-
(2011)
Nat Rev Drug Discov
, vol.10
, pp. 397
-
-
Collins, F.S.1
-
225
-
-
79960830371
-
Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases
-
Xu K, Cote TR. Database identifies FDA-approved drugs with potential to be repurposed for treatment of orphan diseases. Brief Bioinform. 2011; 12: 341-5.
-
(2011)
Brief Bioinform
, vol.12
, pp. 341-345
-
-
Xu, K.1
Cote, T.R.2
-
226
-
-
79955428497
-
The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics
-
ps16
-
Huang R, Southall N, Wang Y, Yasgar A, Shinn P, Jadhav A, et al. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Sci Transl Med. 2011; 3: 80ps16.
-
(2011)
Sci Transl Med
, vol.3
, pp. 80
-
-
Huang, R.1
Southall, N.2
Wang, Y.3
Yasgar, A.4
Shinn, P.5
Jadhav, A.6
-
227
-
-
84859267174
-
Repositioned drugs: integrating intellectual property and regulatory strategies
-
Smith RB. Repositioned drugs: integrating intellectual property and regulatory strategies. Drug Discov Today Ther Strateg. 2011; 8 (3-4): 131-7.
-
(2011)
Drug Discov Today Ther Strateg
, vol.8
, Issue.3-4
, pp. 131-137
-
-
Smith, R.B.1
-
229
-
-
84887255262
-
-
SLAS Electronic laboratory neighborhood (accessed 5 November 2012)
-
SLAS Electronic laboratory neighborhood. Molecular Libraries Program review. 2012. Available from: http://www.eln.slas.org/story/1/52-the-nihs-molecular -libraries-program-whats-next (accessed 5 November 2012).
-
(2012)
Molecular Libraries Program review
-
-
-
232
-
-
84887214150
-
-
World Pharma News (accessed 5 November 2012)
-
World Pharma News. 2011. Lilly launches open innovation drug discovery platform. Available from: http:// www.worldpharmanews.com/lilly/1809-lilly-launches -open-innovation-drug-discovery-platform (accessed 5 November 2012).
-
(2011)
Lilly launches open innovation drug discovery platform
-
-
|