To Market, To Market-2010

Annual Reports in Medicinal Chemistry

Volumn 46, Issue , 2011, Pages 433-502

  Bronson, Joanne ^a   Dhar, Murali ^a   Ewing, William ^a   Lonberg, Nils ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b Research and Development Oncology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80054116787     PISSN: 00657743     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-386009-5.00002-3     Document Type: Chapter

References (176)

1. The collection of new therapeutic entities first launched in 2010 originated from the following sources: Prous Integrity Database; Thomson-Reuters Pipeline Database; The Pink Sheet; Drugs@FDA Website; FDA News Releases; IMS R&D Focus; Adis Business Intelligence R&D Insight; Pharmaprojects; (b) A. Mullard. Nat. Rev. Drug Discov. 2011, 10:82.
2. Origlieri C., Bielory L. Expert Opin. Emerg. Drugs 2009, 14:523.
3. Ono S.J., Lane K. Drug Des. Dev. Ther. 2011, 5:77.
4. Bohets H., McGowan C., Mannens G., Schroeder N., Edwards-Swanson K., Shapiro A. J. Ocul. Pharm. Ther. 2011, 27:187.
5. Greiner J.V., Edwards-Swanson K., Ingerman A. Clin. Ophthalmol. 2011, 5:87.
6. Torkildsen G., Shedden A. Curr. Med. Res. Opin. 2011, 27:623.
7. Gallwitz B., Haering H.U. Diabetes Obes. Metab. 2010, 12:1.
8. Neumiller J.J., Wood L., Campbell R.K. Pharmacotherapy 2010, 30:463.
9. Gerich J. Diabetes Res. Clin. Pract. 2010, 90:131.
10. Zettl H., Schubert-Zsilavecz M., Steinhilber D. ChemMedChem 2010, 5:179.
11. Feng J., Zhang Z., Wallace M.B., Stafford J.A., Kaldor S.W., Kassel D.B., Navre M., Shi L., Skene R.J., Asakawa T., Takeuchi K., Xu R., Webb D.R., Gwaltney S.L. J. Med. Chem. 2007, 50:2297.
12. Lee B., Shi L., Kassel D.B., Asakawa T., Takeuchi K., Christopher R.J. Eur. J. Pharmacol. 2008, 589:306.
13. Christopher R., Karim A. Expert Rev. Clin. Pharmacol. 2009, 2:589.
14. Scott L., Lesley J. Drugs 2010, 70:2051.
15. Pratley R.E. Expert Opin. Pharmacother. 2009, 10:503.
16. del Cuvillo A., Sastre J., Montoro J., Jauregui I., Davila I., Ferrer M., Bartra J., Mullol J., Valero A., Invest J. Allergol. Clin. Immunol. 2009, 19(Suppl. 1):11.
17. Corcostegui R., Labeaga L., Innerarity A., Berisa A., Orjales A. Drugs Res. Dev. 2005, 6:371.
18. Corcostegui R., Labeaga L., Innerarity A., Berisa A., Orjales A. Drugs Res. Dev. 2006, 7:219.
19. Jauregizar N., de la Fuente L., Lucero M.L., Sologuren A., Leal N., Rodriguez M. Clin. Pharmacokinet. 2009, 48:543.
20. Garcia-Gea C., Martinez-Colomer J., Antonijoan R.M., Valiente R., Barbanoj M.-J. J. Clin. Psychopharmacol. 2008, 28:675.
21. A. V. Orjales and V. Rubio-Royo, ES2048109, 1994.
22. Collier S.J., Wu X., Poh Z., Rajkumar G.A., Yet L. Syn. Commun. 2011, 41:1394.
23. Ferrer E., Pandian R., Bolos J., Castaner R. Drugs Future 2010, 35:98.
24. Didier E., Oddon G., Pauze D., Leon P., Riguet D. Patent Application WO9925704 1999.
25. Vrignaud P., Lejeune P., Lavelle F., Chaplin D., Bissery M.C. Proc. Am. Assoc. Cancer Res. 2000, 41. Abstract 1365.
26. Bissery M.C., Bouchard H., Riou H. Proc. Am. Assoc. Cancer Res. 2000, 41. Abstract 1364.
27. Mita A.C., Denis L.J., Rowinsky E.K., DeBono J.S., Goetz A.D., Ochoa L., Forouzesh B., Beeram M., Patnaik A., Molpus K., Semiond D., Besenval M., Tolcher A.W. Clin. Cancer Res. 2009, 15:723.
28. DeBono J.S., Oudard S., Ozguroglu M., Hansen S., Machiels J.H., Shen L., Matthews P., Sartor A.O. J. Clin. Oncol. 2010, 28(Suppl. 15). Abstract 4508.
29. Galsky M.D., Dritselis A., Kirkpatrick P., Oh W.K. Nat. Rev. Drug Dis. 2010, 9:677.
30. Bouchet B.P., Galmarini C.M. Drugs Today 2010, 46:735.
31. Biek D., Critchley I.A., Riccobene T.A., Thyne D.A. Antimicrob. Chemother. 2010, 65(Suppl. 4):9.
32. Zhanel G.G., Sniezek G., Schwiezer F., Zelenitsky S., Lagace-Wiens P.R.S., Rubenstein E., Gin A.S., Hoban D.J., Karlowsky J.A. Drugs 2009, 69:809.
33. Steed M.E., Rybak M.J. Pharmacotherapy 2010, 30:375.
34. Klevens R.M., Morrison M.A., Nadle J., Petit S., Gershman K., Ray S., Harrison L.H., Lynfield R., Dumyati G., Townes J.M., Craig A.S., Zell E.R., Fosheim G.E., McDougal L.K., Carey R.B., Fridkin S.K. J. Am. Med. Assoc. 2007, 298:1763.
35. Köck R., Becker K., Cookson B., van Gemert-Pijnen J.E., Harbarth S., Kluytmans J., Mielke M., Peters G., Skov R.L., Struelens M.J., Tacconelli E., Navarro Torné A., Witte W., Friedrich A.W. Eur. Surveill. 2010, 15:19688.
36. Villegas-Estrada A., Lee M., Hesek D., Vakulenko S.B., Mobashery S. J. Am. Chem. Soc. 2008, 130:9212.
37. Ishikawa T., Matsunaga N., Tawada H., Kuroda N., Nakayama Y., Ishibashi Y., Tomimoto M., Ikeda Y., Tagawa Y., Iizawa Y., Okonogi K., Hashiguchi S., Miyake A. Bioorg. Med. Chem. 2003, 11:2427.
38. Wang Y., Mealy N., Serradell N., Rosa E., Bolos J. Drugs Future 2008, 33:302.
39. Boivin J., Bunting L., Collins J.A., Nygren K.G. Hum. Reprod. 2007, 22:1506.
40. Verbost P., Sloot W.N., Rose U.M., de Leeuw R., Hanssen R.G.J.M., Verheijden G.F.M. Eur. J. Pharmacol. 2011, 651:227.
41. Loutradis D., Drakakis P., Vlismas A., Antsaklis A. Curr. Opin. Invest. Drugs (BioMed Cent.) 2009, 10:372.
42. van Schanke A., van de Wetering-Krebbers S.F.M., Bos E., Sloot W.N. Pharmacology 2010, 85:77.
43. Fauser B.C.J.M., Mannaerts B.M.J.L., Devroey P., Leader A., Boime I., Baird D.T. Hum. Reprod. Update 2009, 15:309.
44. http://www.nationalmssociety.org/about-multiple-sclerosis.
45. Hayes K.C. CNS Drug Rev. 2004, 10:295.
46. Burton J.M., Bell C.M., Walker S.E., O'Connor P.W. Neurology 2008, 71:1833.
47. Smith W., Swan S., Marbury T., Henney H. J. Clin. Pharmacol. 2010, 50:151.
48. Goodman A.D., Brown T.R., Krupp L.B., Schapiro R.T., Schwid S.R., Cohen R., Marinucci L.N., Blight A.R. Lancet 2009, 373:732.
49. Goodman A.D., Schwid S.R., Brown T.R. Multiple Sclerosis 2008, 14(Suppl. 1):S298.
50. Goodman A.D., Hyland M. Drugs Today 2010, 46:635.
51. Boyce B.F., Xing L. Arthritis Res. Ther. 2007, 9(Suppl. 1):S1.
52. Green L., Hardy M.C., Maynard-Currie C.E., Tsuda H., Louie D.M., Mendez M.J., Abderrahim H., Noguchi M., Smith D.H., Zeng Y., David N.E., Sasai H., Garza D., Brenner D.G., Hales J.F., McGuinness R.P., Capon D.J., Klapholz S., Jakobovits A. Nat. Genet. 1994, 7:13.
53. Kostenuik P.J., Nguyen H.Q., McCabe J., Warmington K.S., Kurahara C., Sun N., Chen C., Li L., Cattley R.C., Van G., Scully S., Elliott R., Grisanti M., Morony S., Tan H.L., Asuncion F., Li X., Ominsky M.S., Stolina M., Dwyer D., Dougall W.C., Hawkins N., Boyle W.J., Simonet W.S., Sullivan J.K. J. Bone Miner. Res. 2009, 24:182.
54. Cummings S.R., San Martin J., McClung M.R., Siris E.S., Eastell R., Reid I.R., Delmas P., Zoog H.B., Austin M., Wang A., Kutilek S., Adami S., Zanchetta J., Libanati C., Siddhanti S., Christiansen C. N. Engl. J. Med. 2009, 361:756. Erratum in: N. Engl. J. Med., 2009, 361, 1914.
55. Kendler D.L., Roux C., Benhamou C.L., Brown J.P., Lillestol M., Siddhanti S., Man H.S., San Martin J., Bone H.G. J. Bone Miner. Res. 2010, 25:72.
56. Brown J.P., Prince R.L., Deal C., Recker R.R., Kiel D.P., de Gregorio L.H., Hadji P., Hofbauer L.C., Alvaro-Gracia J.M., Wang H., Austin M., Wagman R.B., Newmark R., Libanati C., San Martin J., Bone H.G. J. Bone Miner. Res. 2009, 24:153.
57. Stopeck A.T., Lipton A., Body J.J., Steger G.G., Tonkin K., de Boer R.H., Lichinitser M., Fujiwara Y., Yardley D.A., Viniegra M., Fan M., Jiang Q., Dansey R., Jun S., Braun A. J. Clin. Oncol. 2010, 28:5132.
58. Henry D.H., Costa L., Goldwasser F., Hirsh V., Hungria V., Prausova J., Scagliotti G.V., Sleeboom H., Spencer A., Vadhan-Raj S., von Moos R., Willenbacher W., Woll P.J., Wang J., Jiang Q., Jun S., Dansey R., Yeh H. J. Clin. Oncol. 2011, 29:1125.
59. Fizazi K., Carducci M., Smith M., Damião R., Brown J., Karsh L., Milecki P., Shore N., Rader M., Wang H., Jiang Q., Tadros S., Dansey R., Goessl C. Lancet 2011, 377:813.
60. Santen Pharmaceuticals and Inspire Pharmaceuticals Press Release, April 2010.
61. Peral A., Dominguez-Godinez C.O., Carracedo G., Pintor J. Drug News Perspect. 2008, 21:166.
62. Nichols K.K., Yerxa B., Kellerman D.J. Expert Opin. Invest. Drugs 2004, 13:47.
63. Fischbarg J. Curr. Opin. Invest. Drugs 2003, 4:1377.
64. Pendergast W., Yerxa B.R., Douglass J.G., Shaver S.R. Bioorg. Med. Chem. Lett. 2001, 11:157.
65. Yerxa B.R., Brown E.G. US Patent 7528119 2009.
66. FDA Dermatologic and Ophthalmic Drugs Advisory Committee Meeting Briefing Document, June 2009.
67. Thomson Reuters Report for Diquafosol, updated March 14, 2011.
68. Banerji A. Allergy Asthma Proc. 2010, 31:398.
69. Bernstein J.A., Qazi M. Expert Rev. Clin. Immunol. 2010, 6:29.
70. Garnock-Jones K.P. Drugs 2010, 70:1423.
71. US FDA. Center for Drug Evaluation and Research application number 125277: ecallantide summary review [online]. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/125277s000SumR.pdf.
72. Ecallantide (Kalbitor) Advisory Committee Briefing Document. http://www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials/drugs/pulmonary-allergydrugsadvisorycommittee/ucm170334.pdf.
73. Towle M.J., Salvato K.A., Budrow J., Wels B.F., Kuznetsov G., Aalfs K.K., Welsh S., Zheng W., Seletsky B.M., Palme M.H., Habgood G.J., Singer L.A., Dipietro L.V., Wang Y., Chen J.J., Quincy D.A., Davis A., Yoshimatsu K., Kishi Y., Yu M.J., Littlefield B.A. Cancer Res. 2001, 61:1013.
74. Smith J.A., Wilson L., Azarenko O., Zhu X., Lewis B.M., Littlefield B.A., Jordan M.A. Biochemistry 2010, 49:1331.
75. Dong C.-G., Henderson J.A., Kaburagi Y., Sasaki T., Kim D.-S., Kim J.T., Urabe D., Guo H., Kishi Y. J. Am. Chem. Soc. 2009, 131:15642.
76. Yang Y.-R., Kim D.-S., Kishi Y. Org. Lett. 2009, 11:4516.
77. Wang Y., Serradell N., Bolos J., Rosa E. Drugs Future 2007, 32:681.
78. Twelves C., Loesch D., Blum J.L., Vahdat L.T., Petrakova K., Chollet P.J., Akerele C.E., Seegobin S., Wanders J., Cortes J. Proc. Am. Soc. Clin. Oncol. 2010, 28:18s.
79. Morris P.G. Anti-Cancer Drugs 2010, 21:885.
80. Adachi K., Kohara T., Nakao N., Arita M., Chiba K., Mishina T., Sasaki S., Fujita T. Bioorg. Med. Chem. Lett. 1995, 5:853.
81. Brinkmann V., Davis M.D., Heise C.E., Albert R., Cottens S., Hof R., Bruns C., Prieschl E., Baumruker T., Hiestand P., Foster C.A., Zollinger M., Lynch K.R. J. Biol. Chem. 2002, 277:21453.
82. Mandala S., Hajdu R., Bergstrom J., Quackenbush El, Xie J., Milligan J., Thornton R., Shei G.J., Card D., Keohane C., Rosenbach M., Hale J., Lynch C.L., Rupprecht K., Parsons W., Rosen H. Science 2002, 296:346.
83. Kiuchi M., Adachi K., Kohara T., Minoguchi M., Hanano T., Aoki Y., Mishina T., Arita M., Nakao N., Ohtsuki M., Hoshino Y., Teshima K., Chiba K., Sasaki S., Fujita T. J. Med. Chem. 2000, 43:2946.
84. (b). M. Tadashi, O. Toshiyuki and A. Kunitomo, JP 1999310556;.
85. Sugiyama S., Araj S., Kiriyama M., Ishi K. Chem. Pharm. Bull 2005, 53:100.
86. Kappos L., Radue E.W., O'Connor P., Polman C., Hohlfeld R., Calabresi P., Selmaj K., Agoropoulou C., Leyk M., Zheng-Auberson L., Burtin P. N. Engl. J. Med. 2010, 362:387.
87. Cohen J.A., Barkhof F., Comi G., Hartung H.P., Khatri B.O., Montalban X., Pelletier J., Capra R., Gallo P., Izquierdo G., Tiel-Wilck K., de Vera A., Jin J., Stites T., Wu S., Aradhye S., Kappos L. N. Engl. J. Med. 2010, 362:402.
88. Brinkmann V., Billich A., Baumruker T., Heining P., Schmouder R., Francis G., Aradhye S., Burtin P. Nat. Rev. Drug Discov. 2010, 9:883.
89. Sobieraj D.M. Formulary 2010, 45:245.
90. Reviriego C. Drugs Future 2010, 35:537.
91. Yamashita M. Antiviral Chem. Chemother. 2010, 21:71.
92. Boltz D.A., Aldridge J.R., Webster R.G., Govorkova E.A. Drugs 2010, 70:1349.
93. Gubareva L.V., Trujillo A.A., Okomo-Adhiambo M., Mishin V.P., Deyde V.M., Sleeman K., Nguyen H.T., Sheu T.G., Garten R.J., Shaw M.W., Fry A.M., Klimov A.I. Antiviral Ther. 2010, 15:1151.
94. Honda T., Kubo S., Masuda T., Asai M., Kobayashi Y., Yamashita M. Bioorg. Med. Chem. Lett. 2009, 19:2938.
95. Yamashita M., Tomozawa T., Kakuta M., Tokumitsu A., Nasu H., Kubo S. Antimicrob. Agents Chemother. 2009, 53:186.
96. Kiso M., Kubo S., Ozawa M., Le Q.M., Nidom C.A., Yamashita M., Kawaoka Y. PloS Pathog. 2010, 6:e10000786.
97. Ishizuka H., Yoshiba S., Okabe H., Yoshihara K. J. Clin. Pharmacol. 2010, 50:1319.
98. Watanabe A., Chang S.C., Kim M.J., Chu D.W., Osashi Y. Clin Infect. Dis. 2010, 51:1167.
99. Sugaya N., Ohashi Y. Antimicrob. Agents Chemother. 2010, 54:2575.
100. Hopkins C.R. ACS Chem. Neurosci. 2011, 2:58.
101. Citrome L. Int. J. Clin. Pract. 2011, 65:189.
102. Ishibashi T., Horisawa T., Tokuda K., Ishiyama T., Ogasa M., Tagashira R., Matsumoto K., Nishikawa H., Ueda Y., Toma S., Oki H., Tanno N., Saji I., Ito A., Ohno Y., Nakamura M. J. Pharmacol. Exp. Ther. 2010, 334:171.
103. Ishiyama T., Tokuda K., Ishibashi K., Ito A., Toma S., Ohno Y. Eur. J. Pharmacol. 2007, 572:160.
104. Enomoto T., Ishibashi T., Tokuda K., Ishiyama T., Toma S., Ito A. Behav. Brain Res. 2008, 186:197.
105. Cole P., Serradell N., Rosa E., Bolos J. Drugs Future 2008, 33:316.
106. Meyer J.M., Loebel A.D., Schweizer E. Expert Opin. Invest. Drugs 2009, 18:1715.
107. Fogler W.E., Fidler I.J. Int. J. Immunopharmacol. 1987, 9:141.
108. Asano T., McWatters A., An T., Matsushima K., Kleinerman E.S. J. Pharmacol. Exp. Ther. 1994, 268:1032.
109. Dieter P., Ambs P., Fitzke E., Hidaka H., Hoffman R., Schwende H. J. Immunol. 1995, 155:2595.
110. Strober W., Murray P.J., Kitani A., Watanabe T. Nat. Rev. Immunol. 2006, 6:9.
111. Prous J.R., Castaner J. Drugs Future 1989, 14:220.
112. Brundish D.E., Wade R. J. Label. Compd. Radiopharm. 1985, 22:29.
113. Meyers P.A., Scwartz C.A., Krailo M.D., Healey J.H., Bernstein M.L., Betcher D., Ferguson W.S., Gebhardt M.C., Goorin A.M., Harris M., Kleinerman E., Link M.P., Nadel H., Nieder M., Siegal G.P., Weiner M.A., Wells R.J., Womer R.B., Grier H.E. J. Clin. Oncol. 2008, 26:633.
114. Ando K., Mori K., Corradini N., Redini F., Heymann D. Expert Opin. Pharmacother. 2011, 12:285.
115. Anderson P.M., Tomaras M., McConnell K. Drugs Today 2010, 46:327.
116. Birnkrant D., Cox E. N. Engl. J. Med. 2009, 361:2204.
117. Mancuso C.E., Gabay M.P., Steinke L.M., VanOsdol S.J. Ann. Pharmacother. 2010, 44:1240.
118. Kohno S., Kida H., Mizuguchi M., Shimada J. Antimicrob. Agents Chemother. 2010, 54:4568.
119. Hayden F. Clin. Infect. Dis. 2009, 48(Suppl. 1):S3.
120. Babu Y.S., Chand P., Bantia S., Kotian P., Dehghani A., El-Kattan Y., Lin T.H., Hutchison T.L., Elliott A.J., Parker C.D., Ananth S.L., Horn L.L., Laver G.W., Montgomery J.A. J. Med. Chem. 2000, 43:3482.
121. Chand P., Kotian P.L., Dehghani A., El-Kattan Y., Lin T.H., Hutchison T.L., Babu Y.S., Bantia S., Elliott A.J., Montgomery J.A. J. Med. Chem. 2001, 44:4379.
122. Chand P. Expert Opin. Ther. Patents 2005, 15:1009.
123. Hernandez J.E., Adiga R., Armstrong R., Bazan J., Bonilla H., Bradley J., Dretler R., Ison M.G., Mangino J.E., Maroushek S., Shetty A.K., Wald A., Ziebold C., Elder J., Hollister A.S., Sheridan W. Clin. Infect. Dis. 2011, 52:695. on behalf of the eIND Peramivir Investigators.
124. Giembycz M.A., Field S.K. Drug Des. Dev. Ther. 2010, 4:147.
125. Sanford M. Drugs 2010, 70:1615.
126. Higgs G. Curr. Opin. Invest. Drugs 2010, 11:495.
127. Hatselmann A., Schudt C. J. Pharmacol. Exp. Ther. 2001, 297:267.
128. Field S.K. Expert Opin. Invest. Drugs 2008, 17:811.
129. Sorbera L.A., Leeson P.A., Castañer J. Drugs Future 2000, 25:1261.
130. Furumai R., Matsuyama A., Kobashi N., Lee K.H., Nishiyama M., Nakajima H., Tanaka A., Komatsu Y., Nishino N., Yoshida M., Horinouchi S. Cancer Res. 2002, 62:4916.
131. For example, see N. H. Vrolijk and G. L. Verdine, Patent Application US20100093610, 2010.
132. Khan W.L., Wu J., Xing W., Simon J.A. J. Am. Chem. Soc. 1996, 118:7237.
133. Greshock T.J., Johns D.M., Noguchi Y., Williams R.M. Org. Lett. 2008, 10:613.
134. Narita K., Kikuchi T., Watanabe K., Takizawa T., Oguchi T., Kudo K., Matsuhara K., Abe H., Yamori T., Yoshida M., Katoh T. Chem. Eur. J. 2009, 15:11174.
135. Sandor V., Bakke S., Robey R.W., Kang M.H., Blagosklonny M.V., Bender J., Brooks R., Piekarz R.L., Tucker E., Figg W.D., Chan K.K., Goldspiel B., Fojo A.T., Balcerzak S.P., Bates S.E. Clin. Cancer Res. 2002, 8:718.
136. Demierre M., Whittaker S., Kim Y., Kim E., Piekarz R., Prince M., Nichols J., Balser J., Prentice A., Bates S. J. Clin. Oncol. 2009, 27(Suppl. 15). Abstract 8546.
137. Piekarz R.L., Frye R., Turner M., Wright J.J., Allen S.L., Kirschbaum M.H., Zain J., Prince H.M., Leonard J.P., Geskin L.J., Reeder C., Joske D., Figg W.D., Gardner E.R., Steinberg S.M., Jaffe E.S., Syevenson M.S., Lade S., Fojo T., Bates S.E. J. Clin. Oncol. 2009, 27:5410.
138. Campas-Moya C. Drugs Today 2009, 45:787.
139. Sheikh N.A., Jones L.A. Cancer Immunol. Immunother. 2008, 57:1381.
140. Sheikh N.A., Wesley J.D., Chadwick E., Perdue N., dela Rosa C.P., Frohlich M.W., Stewart F.P., Urdal D.L. J. Clin. Oncol. 2011, 29(Suppl. 7). Abstract 155.
141. Kantoff P.W., Higano C.S., Shore N.D., Berger E.R., Small E.J., Penson D.F., Redfern C.H., Ferrari A.C., Dreicer R., Sims R.B., Xu Y., Frohlich M.W., Schellhammer P.F. N. Engl. J. Med. 2010, 363:411. the IMPACT Study Investigators.
142. Small E.J., Schellhammer P.F., Higano C.S., Redfern C.H., Nemunaitis J.J., Valone F.H., Verjee S.S., Jones L.A., Hershberg R.M. J. Clin. Oncol. 2006, 24:3089.
143. Higano C.S., Schellhammer P.F., Small E.J., Burch P.A., Nemunaitis J., Yuh L., Provost N., Frohlich M.W. Cancer 2009, 115:3670.
144. Leung V.L., Glesby M.J. Curr. Opin. Infect. Dis. 2011, 24:43.
145. Falutz J., Mamputu J.C., Potvin D., Moyle G., Soulban G., Loughrey H., Marsolais C., Turner R., Grinspoon S. J. Clin. Endocrinol. Metab. 2010, 95:4291.
146. Grunfeld C., Dritselis A., Kirkpatrick P. Nat. Rev. Drug Discov. 2011, 10:95.
147. Wang Y., Tomlinson B. Expert Opin. Invest. Drugs 2009, 18:303.
148. Zhao Z., Winget M. BMC Health Serv. Res. 2011, 11:35.
149. Abergel E., Nikolsky E. Vasc. Health Risk Manage. 2010, 6:963.
150. Wallentin L. Eur. Heart J. 2009, 30:1964.
151. Springthorpe B., Bailey A., Barton P., Birkinshaw T.N., Bonnert R.V., Brown R.C., Chapman D., Dixon J., Guile S.D., Humphries R.G., Hunt S.F., Ince F., Ingall A.H., Kirk I.P., Leeson P.D., Leff P., Lewis R.J., Martin B.P., McGinnity D.F., Mortimore M.P., Paine S.W., Pairaudeau G., Patel A., Rigby A.J., Riley R.J., Teobald B.J., Tomlinson W., Webborn P.J.H., Willis P.A. Bioorg. Med. Chem. Lett. 2007, 17:6013.
152. Teng R., Oliver S., Hayes M.A., Butler K. Drug Metab. Dispos. 2010, 38:1514.
153. Siller-Matula J.M., Jilma B. Future Cardiol. 2010, 6:753.
154. Jennings D.L. Formulary 2010, 45:148.
155. Anderson S.D., Shah N.K., Yim J., Epstein B.J. Ann. Pharmacother. 2010, 44:524.
156. Ehrlich J.R., Nattel S. Drugs 2009, 69:757.
157. Cheng J.W.M., Rybak I. Clin. Med. Ther. 2009, 1:215.
158. Dobrev D., Hamad B., Kirkpatrick P. Nat. Rev. Drug Discov. 2010, 9:915.
159. Billman G.E. Curr. Opin. Invest. Drugs 2010, 11:1048.
160. Ngan V.K., Bellman K., Panda D., Hill B.T., Jordan M.A., Wilson L. Cancer Res. 2000, 60:5045.
161. Jacquesy J.C., Fahy J., Berrier C., Bigg D., Jouannetaud M.P., Zunino F., Kruczynski A., Kiss R. Patent Application WO 95/03312 1995.
162. Fahy J., Duflos A., Ribet J.P., Jacquesy J.C., Berrier C., Jouannetaud M.P., Zunino F. J. Am. Chem. Soc. 1997, 119:8576.
163. Kruczynski A., Colpaert F., Tarayre J.P., Mouillard P., Fahy J., Hill B.T. Cancer Chemother. Pharmacol. 1998, 41:437.
164. Kruczynski A., Hill B.T. Crit. Rev. Oncol. Hematol. 2001, 40:159.
165. Bennouna J., Fumoleau P., Armand J.P., Raymond E., Campone M., Delgado F.M., Puozzo C., Marty M. Ann. Oncol. 2003, 14:630.
166. Bellmunt J., Theodore C., Demkov T., Komyakov B., Sengelov L., Daugaard G., Caty A., Carles J., Jagiello-Gruszfeld A., Karyakin O., Delgado F.M., Hurteloup P., Winquist E., Morsli N., Salhi Y., Culine S., von der Maase H. J. Clin. Oncol. 2009, 27:4454.
167. Frampton J.E., Moen M.D. Drugs 2010, 70:1283.
168. Summary Basis of Decision CIVANEX, Health Canada, 2010.
169. Bernstein J.E. US Patent 5063060 1991.
170. Bernstein J.E. US Patent 7244446 2007.
171. Caterina M.J., Julius D. Annu. Rev. Neurosci. 2001, 24:487.
172. Bley K. Expert Opin. Invest. Drugs 2004, 13:1445.
173. Westaway S.M. J. Med. Chem. 2007, 50:2589.
174. Knotkova H., Pappagallo M., Szallasi A. Clin. J. Pain 2008, 24:142.
175. Hua X.Y., Chen P., Hwang J., Yaksh T.L. Pain 1997, 71:313.
176. Gannett P.M., Nagel D.L., Reilly P.J., Lawson T., Sharpe J., Toth B. J. Org. Chem. 1988, 53:1064.