-
2
-
-
77953405077
-
The emerging academic drug-discovery sector
-
Wyatt PG. The emerging academic drug-discovery sector. Future Med Chem 2009; 1: 1013-1017.
-
(2009)
Future Med Chem
, vol.1
, pp. 1013-1017
-
-
Wyatt, P.G.1
-
3
-
-
33748286712
-
Why academic drug discovery makes sense [2]
-
Kozikowski AP, Roth B, Tropsha A. Why academic drug discovery makes sense. Science 2006; 313:1235-1236. (Pubitemid 44330930)
-
(2006)
Science
, vol.313
, Issue.5791
, pp. 1235-1236
-
-
Kozikowski, A.P.1
Roth, B.2
Tropsha, A.3
-
5
-
-
0043069489
-
Drug research: Myths, hype and reality
-
Kubinyi H. Drug research: myths, hype and reality. Nat Rev Drug Discov 2003; 2: 665-668. (Pubitemid 37368830)
-
(2003)
Nature Reviews Drug Discovery
, vol.2
, Issue.8
, pp. 665-668
-
-
Kubinyi, H.1
-
6
-
-
0037860938
-
Modulation of protein-protein interactions with small organic molecules
-
DOI 10.1002/anie.200200558
-
Berg T. Modulation of protein-protein interactions with small organic molecules. Angew Chem Int Ed Engl 2003; 42: 2462-2481. (Pubitemid 36753413)
-
(2003)
Angewandte Chemie - International Edition
, vol.42
, Issue.22
, pp. 2462-2481
-
-
Berg, T.1
-
7
-
-
70149105669
-
The role of human bromodomains in chromatin biology and gene transcription
-
Sanchez R, Zhou MM. The role of human bromodomains in chromatin biology and gene transcription. Curr Opin Drug Discov Devel 2009; 12: 659-665.
-
(2009)
Curr Opin Drug Discov Devel
, vol.12
, pp. 659-665
-
-
Sanchez, R.1
Zhou, M.M.2
-
8
-
-
35848961668
-
How chromatin-binding modules interpret histone modifications: Lessons from professional pocket pickers
-
DOI 10.1038/nsmb1338, PII NSMB1338
-
Taverna SD, Li H, Ruthenberg AJ, et al. How chromatinbinding modules interpret histone modifications: lessons from professional pocket pickers. Nat Struct Mol Biol 2007; 14: 1025-1040. (Pubitemid 350060344)
-
(2007)
Nature Structural and Molecular Biology
, vol.14
, Issue.11
, pp. 1025-1040
-
-
Taverna, S.D.1
Li, H.2
Ruthenburg, A.J.3
Allis, C.D.4
Patel, D.J.5
-
9
-
-
0036206045
-
Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain
-
DOI 10.1016/S1097-2765(02)00483-5
-
Mujtaba S, He Y, Zeng L, et al. Structural basis of lysine-acetylated HIV-1 Tat recognition by PCAF bromodomain. Mol Cell 2002; 9: 575-586. (Pubitemid 34273788)
-
(2002)
Molecular Cell
, vol.9
, Issue.3
, pp. 575-586
-
-
Mujtaba, S.1
He, Y.2
Zeng, L.3
Farooq, A.4
Carlson, J.E.5
Ott, M.6
Verdin, E.7
Zhou, M.-M.8
-
10
-
-
10744233648
-
Structural Mechanism of the Bromodomain of the Coactivator CBP in p53 Transcriptional Activation
-
DOI 10.1016/S1097-2765(03)00528-8
-
Mujtaba S, He Y, Zeng L, et al. Structural mechanism of the bromodomain of the coactivator CBP in p53 transcriptional activation. Mol Cell 2004; 13: 251-263. (Pubitemid 38183271)
-
(2004)
Molecular Cell
, vol.13
, Issue.2
, pp. 251-263
-
-
Mujtaba, S.1
He, Y.2
Zeng, L.3
Yan, S.4
Plotnikova, O.5
Sachchidanand6
Sanchez, R.7
Zeleznik-Le, N.J.8
Ronai, Z.9
Zhou, M.-M.10
-
11
-
-
0043127085
-
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains
-
FischleW, Wang Y, Jacobs SA, et al. Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains. Genes Dev 2003; 17: 1870-1881.
-
(2003)
Genes Dev
, vol.17
, pp. 1870-1881
-
-
Fischle, W.1
Wang, Y.2
Jacobs, S.A.3
-
12
-
-
61749088806
-
Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA
-
Huang B, Yang XD, Zhou MM, et al. Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. Mol Cell Biol 2009; 29: 1375-1387.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 1375-1387
-
-
Huang, B.1
Yang, X.D.2
Zhou, M.M.3
-
13
-
-
14744276712
-
Selective small molecules blocking HIV-1 Tat and coactivator PCAF association
-
Zeng L, Li J, Muller M, et al. Selective small molecules blocking HIV-1 Tat and coactivator PCAF association. J Am Chem Soc 2005; 127: 2376-2377.
-
(2005)
J Am Chem Soc
, vol.127
, pp. 2376-2377
-
-
Zeng, L.1
Li, J.2
Muller, M.3
-
14
-
-
30744456492
-
Target structure-based discovery of small molecules that block human p53 and CREB binding protein association
-
Sachchidanand, Resnick-Silverman L, Yan S. Target structure-based discovery of small molecules that block human p53 and CREB binding protein association. Chem Biol 2006; 13: 81-90.
-
(2006)
Chem Biol
, vol.13
, pp. 81-90
-
-
Sachchidanand1
Resnick-Silverman, L.2
Yan, S.3
-
15
-
-
34249027590
-
Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding proteinassociated factor
-
Pan C, Mezei M, Mujtaba S, et al. Structure-guided optimization of small molecules inhibiting human immunodeficiency virus 1 Tat association with the human coactivator p300/CREB binding proteinassociated factor. J Med Chem 2007; 50: 2285-2288.
-
(2007)
J Med Chem
, vol.50
, pp. 2285-2288
-
-
Pan, C.1
Mezei, M.2
Mujtaba, S.3
-
16
-
-
0029836953
-
Discovering high-affinity ligands for proteins: SAR by NMR
-
Shuker SB, Hajduk PJ, Meadows RP, Fesik SW. Discovering high-affinity ligands for proteins: SAR by NMR. Science 1996; 274: 1531-1534.
-
(1996)
Science
, vol.274
, pp. 1531-1534
-
-
Shuker, S.B.1
Hajduk, P.J.2
Meadows, R.P.3
Fesik, S.W.4
-
17
-
-
0030708525
-
Discovering high-affinity ligands for proteins
-
Hajduk PJ, Meadows RP, Fesik SW. Discovering high-affinity ligands for proteins. Science 1997; 278: 497-499.
-
(1997)
Science
, vol.278
, pp. 497-499
-
-
Hajduk, P.J.1
Meadows, R.P.2
Fesik, S.W.3
-
18
-
-
0033168872
-
High-throughput nuclear magnetic resonance-based screening
-
DOI 10.1021/jm9901475
-
Hajduk PJ, Gerfin T, Boehlen JM, et al. High-throughput nuclear magnetic resonance-based screening. J Med Chem 1999; 42: 2315-2317. (Pubitemid 29305164)
-
(1999)
Journal of Medicinal Chemistry
, vol.42
, Issue.13
, pp. 2315-2317
-
-
Hajduk, P.J.1
Gerfin, T.2
Boehlen, J.-M.3
Haberli, M.4
Marek, D.5
Fesik, S.W.6
-
19
-
-
0032900490
-
NMR screening in drug discovery
-
Moore JM. NMR screening in drug discovery. Curr Opin Biotechnol 1999; 10: 54-58.
-
(1999)
Curr Opin Biotechnol
, vol.10
, pp. 54-58
-
-
Moore, J.M.1
-
20
-
-
11144341956
-
Chemical space and biology
-
Dobson CM. Chemical space and biology. Nature 2004; 432: 824-828.
-
(2004)
Nature
, vol.432
, pp. 824-828
-
-
Dobson, C.M.1
-
21
-
-
11144320699
-
Navigating chemical space for biology and medicine
-
DOI 10.1038/nature03193
-
Lipinski C, Hopkins A. Navigating chemical space for biology and medicine. Nature 2004; 432: 855-861. (Pubitemid 40037141)
-
(2004)
Nature
, vol.432
, Issue.7019
, pp. 855-861
-
-
Lipinski, C.1
Hopkins, A.2
-
22
-
-
33846583340
-
Hit and lead identification: Efficient practices for drug discovery
-
Goodnow RA Jr, Gillespie P. Hit and lead identification: efficient practices for drug discovery. Prog Med Chem 2007; 45: 1-61.
-
(2007)
Prog Med Chem
, vol.45
, pp. 1-61
-
-
Goodnow Jr., R.A.1
Gillespie, P.2
-
23
-
-
33745809902
-
Hit discovery and hit-to-lead approaches
-
Keseru GM, Makara GM. Hit discovery and hit-to-lead approaches. Drug Discov Today 2006; 11: 741-748.
-
(2006)
Drug Discov Today
, vol.11
, pp. 741-748
-
-
Keseru, G.M.1
Makara, G.M.2
-
24
-
-
68049117352
-
High-throughput hit finding and compound-profiling technologies for academic drug discovery
-
Gribbon P. High-throughput hit finding and compound-profiling technologies for academic drug discovery. Drug Discov Today Tech 2008; 5: e3-e7.
-
(2008)
Drug Discov Today Tech
, vol.5
-
-
Gribbon, P.1
-
25
-
-
35748934487
-
The influence of drug-like concepts on decision-making in medicinal chemistry
-
DOI 10.1038/nrd2445, PII NRD2445
-
Leeson PD, Springthorpe B. The influence of drug-like concepts on desision-making in medicinal chemistry. Nat Rev Drug Discov 2007; 6: 881-890. (Pubitemid 350042396)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.11
, pp. 881-890
-
-
Leeson, P.D.1
Springthorpe, B.2
-
26
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
DOI 10.1016/S0169-409X(00)00129-0, PII S0169409X00001290
-
Lipinski CA, Lombardo F, Dominy BW, Feeney PJ. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 2001; 46: 3-26. (Pubitemid 33653411)
-
(2000)
Advanced Drug Delivery Reviews
, vol.46
, Issue.1-3
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
27
-
-
0037366605
-
The combinatorial synthesis of bicyclic privileged structures or priveleged substructures
-
Horton DA, Bourne GT, Smythe ML. The combinatorial synthesis of bicyclic privileged structures or priveleged substructures. Chem Rev 2003; 103: 893-930.
-
(2003)
Chem Rev
, vol.103
, pp. 893-930
-
-
Horton, D.A.1
Bourne, G.T.2
Smythe, M.L.3
-
28
-
-
67049134276
-
Advances in solution-and solid-phase synthesis toward the generation of natural product-like libraries
-
Nandy JP, Prakesch M, Khadem S, et al. Advances in solution-and solid-phase synthesis toward the generation of natural product-like libraries. Chem Rev 2009; 109: 1999-2060.
-
(2009)
Chem Rev
, vol.109
, pp. 1999-2060
-
-
Nandy, J.P.1
Prakesch, M.2
Khadem, S.3
-
29
-
-
11644261806
-
Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
-
Morris GM, Goodsell DS, Halliday RS, et al. Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem 1998; 19: 1639-1662.
-
(1998)
J Comput Chem
, vol.19
, pp. 1639-1662
-
-
Morris, G.M.1
Goodsell, D.S.2
Halliday, R.S.3
-
30
-
-
34447538141
-
High-throughput screening assays for the identification of chemical probes
-
DOI 10.1038/nchembio.2007.17
-
Inglese J, Johnson RL, Simeonov A, et al. High-throughput screening assays for the identification of chemical probes. Nat Chem Biol 2007; 3: 466-479. (Pubitemid 47080373)
-
(2007)
Nature Chemical Biology
, vol.3
, Issue.8
, pp. 466-479
-
-
Inglese, J.1
Johnson, R.L.2
Simeonov, A.3
Xia, M.4
Zheng, W.5
Austin, C.P.6
Auld, D.S.7
-
31
-
-
34347212482
-
Building a pharmacological lexicon: Small molecule discovery in academia
-
DOI 10.1124/mol.107.035113
-
Lazo JS, Brady LS, Dingledine R. Building a pharmacological lexicon: small molecule discovery in academia. Mol Pharmacol 2007; 72: 1-7. (Pubitemid 46998519)
-
(2007)
Molecular Pharmacology
, vol.72
, Issue.1
, pp. 1-7
-
-
Lazo, J.S.1
Brady, L.S.2
Dingledine, R.3
-
33
-
-
33947395259
-
High-content siRNA screening
-
Krausz E. High-content siRNA screening. Mol Biosyst 2007; 3: 232-240.
-
(2007)
Mol Biosyst
, vol.3
, pp. 232-240
-
-
Krausz, E.1
-
34
-
-
11144298973
-
Exploring biology with small organic molecules
-
Stockwell BR. Exploring biology with small organic molecules. Nature 2004; 432: 846-854.
-
(2004)
Nature
, vol.432
, pp. 846-854
-
-
Stockwell, B.R.1
-
35
-
-
44849114974
-
Neurobiological applications of small molecule screening
-
DOI 10.1021/cr0782372
-
Bauer A, Stockwell B. Neurobiological applications of small molecule screening. Chem Rev 2008; 108: 1774-1786. (Pubitemid 351796409)
-
(2008)
Chemical Reviews
, vol.108
, Issue.5
, pp. 1774-1786
-
-
Bauer, A.J.1
Stockwell, B.R.2
-
36
-
-
21144440283
-
Chemical genetics to chemical genomics: Small molecules offer big insights
-
Spring DR. Chemical genetics to chemical genomics: small molecules offer big insights. Chem Soc Rev 2005; 34: 472-482.
-
(2005)
Chem Soc Rev
, vol.34
, pp. 472-482
-
-
Spring, D.R.1
-
37
-
-
0033773937
-
Fluoresence polarization and anisotropy in high throughput screening: Perspectives and primer
-
Owicki JC. Fluoresence polarization and anisotropy in high throughput screening: perspectives and primer. J Biomol Screen 2000; 5: 297-306.
-
(2000)
J Biomol Screen
, vol.5
, pp. 297-306
-
-
Owicki, J.C.1
-
38
-
-
33745188660
-
Screening in a spirit haunted world
-
Shoichet BK. Screening in a spirit haunted world. Drug Discov Today 2006; 11: 607-615.
-
(2006)
Drug Discov Today
, vol.11
, pp. 607-615
-
-
Shoichet, B.K.1
-
40
-
-
77949839054
-
Accelerating the drugdiscovery process: New tools and technologies available to medicinal chemists
-
Raveglia LF, Giardina GAM. Accelerating the drugdiscovery process: new tools and technologies available to medicinal chemists. Future Med Chem 2009; 1: 1019-1023.
-
(2009)
Future Med Chem
, vol.1
, pp. 1019-1023
-
-
Raveglia, L.F.1
Giardina, G.A.M.2
-
41
-
-
0035804384
-
Functionalized polymers - Emerging versatile tools for solution-phase chemistry and automated parallel synthesis
-
DOI 10.1002/1521-3773(20010216)40:4<650::AID-ANIE6500>3.0.CO;2-C
-
Kirschning A, Monenschein H, Wittenberg R. Functionalized polymers - emerging versatile tools for solution-phase chemistry and automated parallel synthesis. Angew Chem Int Ed Engl 2001; 40: 650-679. (Pubitemid 32179720)
-
(2001)
Angewandte Chemie - International Edition
, vol.40
, Issue.4
, pp. 650-679
-
-
Kirschning, A.1
Monenschein, H.2
Wittenberg, R.3
-
42
-
-
0036691029
-
New tools and concepts for modern organic synthesis
-
DOI 10.1038/nrd871
-
Ley SV, Baxendale IR. New tools and concepts for modern organic synthesis. Nat Rev Drug Discov 2002; 1: 573-586. (Pubitemid 37361521)
-
(2002)
Nature Reviews Drug Discovery
, vol.1
, Issue.8
, pp. 573-586
-
-
Ley, S.V.1
Baxendale, I.R.2
-
43
-
-
85047683939
-
Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety
-
Wang J, Urban L, Bojanic D. Maximising use of in vitro ADMET tools to predict in vivo bioavailability and safety. Expert Opin Drug Metab Toxicol 2007; 3: 641.
-
(2007)
Expert Opin Drug Metab Toxicol
, vol.3
, pp. 641
-
-
Wang, J.1
Urban, L.2
Bojanic, D.3
-
44
-
-
34547656228
-
The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates
-
Kramer JA, Sagartz JE, Morris DL. The application of discovery toxicology and pathology towards the design of safer pharmaceutical lead candidates. Nat Rev Drug Discov 2007; 6: 636-649.
-
(2007)
Nat Rev Drug Discov
, vol.6
, pp. 636-649
-
-
Kramer, J.A.1
Sagartz, J.E.2
Morris, D.L.3
|