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Journal of the American Chemical Society

Volumn 131, Issue 36, 2009, Pages 12949-12959

Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine

(5) Vulpetti, Anna a Hommel, Ulrich a Landrum, Gregory a Lewis, Richard a Dalvit, Claudio a,b

a NOVARTIS PHARMA AG (Switzerland)

b ISTITUTO ITALIANO DI TECNOLOGIA (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AFFINITY LIGANDS; CHEMICAL FRAGMENTS; DESCRIPTORS; DRUG DISCOVERY; LOCAL ENVIRONMENTS; MULTIPLE LIGANDS; NOVEL STRATEGIES; OPTIMIZATION PROCESS; SCREENING EXPERIMENTS; THEORETICAL SIMULATION;

FLUORINE; NUCLEAR MAGNETIC RESONANCE;

LIGANDS;

AMINO ACID; FLUORINE; LIGAND; LYSOZYME; PROTEIN; TRYPSIN;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG SCREENING; FLUORINATION; FLUORINE NUCLEAR MAGNETIC RESONANCE; FRAGMENT BASED DRUG DISCOVERY; LIGAND BINDING; MOLECULE;

DRUG DISCOVERY; FLUORINE; LIGANDS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 70349124638 PISSN: 00027863 EISSN: None Source Type: Journal
DOI: 10.1021/ja905207t Document Type: Article

Times cited : (108)

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