Denosumab for the treatment of osteoporosis

Current Osteoporosis Reports

Volumn 8, Issue 4, 2010, Pages 163-167

  Iqbal, Jameel ^a   Sun, Li ^a   Zaidi, Mone ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Denosumab; Osteoclast; Osteoporosis; RANKL

Indexed keywords

BISPHOSPHONIC ACID DERIVATIVE; DENOSUMAB; INSULIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PLACEBO; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TUMOR NECROSIS FACTOR;

BONE DENSITY; BONE MASS; BONE REMODELING; BONE TURNOVER; CELL SURVIVAL; CELLULITIS; CLINICAL TRIAL; CYTOKINE RELEASE; DRUG EFFICACY; DRUG TARGETING; FRACTURE; FRAGILITY FRACTURE; HIP FRACTURE; HUMAN; HYPOCALCEMIA; INSULIN RELEASE; LANGERHANS CELL; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; PATHOGENESIS; REVIEW; RISK REDUCTION; VERTEBRA FRACTURE;

ANTIBODIES, MONOCLONAL; BONE DENSITY; BONE REMODELING; CLINICAL TRIALS AS TOPIC; HUMANS; LANGERHANS CELLS; OSTEOBLASTS; OSTEOPOROSIS; RANK LIGAND;

EID: 77958097353     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-010-0034-z     Document Type: Review

References (20)

1. DR Bertolini GE Nedwin TS Bringman, et al. 1986 Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necrosis factors Nature 319 516 518 1:CAS:528:DyaL28XhtVOlu70%3D 10.1038/319516a0 3511389 (Pubitemid 16212936)
2. WS Simonet DL Lacey CR Dunstan, et al. 1997 Osteoprotegerin: a novel secreted protein involved in the regulation of bone density Cell 89 309 319 1:CAS:528:DyaK2sXislCgtLc%3D 10.1016/S0092-8674(00)80209-3 9108485
3. DL Lacey E Timms HL Tan, et al. 1998 Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation Cell 93 165 176 1:CAS:528:DyaK1cXivVyhtrg%3D 10.1016/S0092-8674(00)81569-X 9568710 (Pubitemid 28180851)
4. JF Randolph Jr M Sowers IV Bondarenko, et al. 2004 Change in estradiol and follicle-stimulating hormone across the early menopausal transition: effects of ethnicity and age J Clin Endocrinol Metab 89 1555 1561 1:CAS:528: DC%2BD2cXjt1els7g%3D 10.1210/jc.2003-031183 15070912 (Pubitemid 38507902)
5. MR Sowers M Jannausch D McConnell, et al. 2006 Hormone predictors of bone mineral density changes during the menopausal transition J Clin Endocrinol Metab 91 1261 1267 1:CAS:528:DC%2BD28XjvFOks7k%3D 10.1210/jc.2005-1836 16403818
6. J Iqbal L Sun TR Kumar, et al. 2006 Follicle-stimulating hormone stimulates TNF production from immune cells to enhance osteoblast and osteoclast formation Proc Natl Acad Sci U S A 103 14925 14930 1:CAS:528:DC%2BD28XhtVygsrjJ 10.1073/pnas.0606805103 17003115 (Pubitemid 44527830)
7. L Sun Y Peng AC Sharrow, et al. 2006 FSH directly regulates bone mass Cell 125 247 260 1:CAS:528:DC%2BD28Xkt1Oqtbs%3D 10.1016/j.cell.2006.01.051 16630814
8. SR Cummings J San Martin MR McClung, et al. 2009 Denosumab for prevention of fractures in postmenopausal women with osteoporosis N Engl J Med 361 756 765 1:CAS:528:DC%2BD1MXhtVWls7nF 10.1056/NEJMoa0809493 19671655
9. HK Genant K Engelke DA Hanley, et al. 2010 Denosumab improves density and strength parameters as measured by QCT of the radius in postmenopausal women with low bone mineral density Bone 47 131 139 1:CAS:528:DC%2BC3cXntVCrtLo%3D 10.1016/j.bone.2010.04.594 20399288
10. J Iqbal M Zaidi 2009 Understanding estrogen action during menopause Endocrinology 150 3443 3445 1:CAS:528:DC%2BD1MXpsV2rt78%3D 10.1210/en.2009-0449 19622779
11. JE Fata YY Kong J Li, et al. 2000 The osteoclast differentiation factor osteoprotegerin-ligand is essential for mammary gland development Cell 103 41 50 1:CAS:528:DC%2BD3cXnt1yqtbw%3D 10.1016/S0092-8674(00)00103-3 11051546
12. LE Theill WJ Boyle JM Penninger 2002 RANK-L and RANK: T cells, bone loss, and mammalian evolution Annu Rev Immunol 20 795 823 1:CAS:528: DC%2BD38XjtlWgtbo%3D 10.1146/annurev.immunol.20.100301.064753 11861618 (Pubitemid 34293440)
13. A Leibbrandt JM Penninger 2010 Novel functions of RANK(L) signaling in the immune system Adv Exp Med Biol 658 77 94 10.1007/978-1-4419-1050-9-9 19950018
14. A Leibbrandt JM Penninger 2008 RANK/RANKL: regulators of immune responses and bone physiology Ann N Y Acad Sci 1143 123 150 1:CAS:528: DC%2BD1MXpvFKqsg%3D%3D 10.1196/annals.1443.016 19076348
15. JB Barbaroux M Beleut C Brisken, et al. 2008 Epidermal receptor activator of NF-kappaB ligand controls Langerhans cells numbers and proliferation J Immunol 181 1103 1108 1:CAS:528:DC%2BD1cXotF2rsLw%3D 18606662
16. M Ferron J Wei T Yoshizawa, et al. 2010 Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism Cell 142 296 308 1:CAS:528:DC%2BC3cXpsVahsr4%3D 10.1016/j.cell.2010.06.003 20655470
17. M Hirao J Hashimoto W Ando, et al. 2008 Response of serum carboxylated and undercarboxylated osteocalcin to alendronate monotherapy and combined therapy with vitamin K2 in postmenopausal women J Bone Miner Metab 26 260 264 1:CAS:528:DC%2BD1cXls1Kntr4%3D 10.1007/s00774-007-0823-3 18470667 (Pubitemid 351677843)
18. R Hanada A Leibbrandt T Hanada, et al. 2009 Central control of fever and female body temperature by RANKL/RANK Nature 462 505 509 1:CAS:528: DC%2BD1MXhsVylsLzK 10.1038/nature08596 19940926
19. J Iqbal L Sun M Zaidi 2009 Coupling bone degradation to formation Nat Med 15 729 731 1:CAS:528:DC%2BD1MXotlSntL8%3D 10.1038/nm0709-729 19584858
20. Y Tang X Wu W Lei, et al. 2009 TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation Nat Med 15 757 765 1:CAS:528:DC%2BD1MXotlSnsr0%3D 10.1038/nm.1979 19584867