Synthesis of novel diarylpyrimidine analogues and their antiviral activity against human immunodeficiency virus type 1

Journal of Medicinal Chemistry

Volumn 48, Issue 6, 2005, Pages 2072-2079

  Guillemont, Jerome ^a   Pasquier, Elisabeth ^a   Palandjian, Patrice ^a   Vernier, Daniel ^a   Gaurrand, Sandrine ^a   Lewi, Paul J ^b   Heeres, Jan ^b   De Jonge, Marc R ^b   Koymans, Lucien M H ^b   Daeyaert, Frits F D ^b   Vinkers, Maarten H ^b   Arnold, Eddy ^e   Das, Kalyan ^e   Pauwels, Rudi ^c   Andries, Koen ^c   De Béthune, Marie Pierre ^c   Bettens, Eva ^c   Hertogs, Kurt ^c   Wigerinck, Piet ^c   Timmerman, Philip ^d   Janssen, Paul A J ^b   more..

^a Medicinal Chemistry Department   (France)

^b Center for Molecular Design   (Belgium)

^c Virco BVBA   (Belgium)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^e RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 {4 [2 (4 CYANOPHENYLAMINO)PYRIMIDIN 4 YLAMINO] 3,5 DIMETHYLBENZYLIDENE}SUCCINONITRILE; 4 [4 (4 CYANOMETHYL 2,6 DIMETHYLPHENYLAMINO)PYRIMIDIN 2 YLAMINO]BENZONITRILE; 4 {4 [4 (1 CHLORO 2 CYANOVINYL) 2,6 DIMETHYLPHENYLAMINO]PYRIMIDIN 2 YLAMINO}BENZONITRILE; 4 {4 [4 (2 CYANO 1 METHYLETHYL) 2,6 DIMETHYLPHENYLAMINO]PYRIMIDIN 2 YLAMINO}BENZONITRILE; 4 {4 [4 (2 CYANO 1 METHYLVINYL) 2,6 DIMETHYLPHENYLAMINO]PYRIMIDIN 2 YLAMINO}BENZONITRILE; 4 {4 [4 (2 CYANO 2 METHYLVINYL) 2,6 DIMETHYLPHENYLAMINO]PYRIMIDIN 2 YLAMINO}BENZONITRILE; 4 {4 [4 (2 CYANO ETHYL) 2,6 DIMETHYLPHENYLAMINO]PYRIMIDIN 2 YLAMINO}BENZONITRILE; 4 {4 [4 (2 CYANOETHOXYMETHYL) 2,6 DIMETHYLPHENYLAMINO]PYRIMIDIN 2 YLAMINO}BENZONITRILE; 4 {4 [4 (2 CYANOVINYL) 2,6 DIMETHYLPHENYLAMINO]PYRIMIDIN 2 YLAMINO}BENZONITRILE; 5 {4 [2 (4 CYANOPHENYLAMINO)PYRIMIDIN 4 YLAMINO] 3,5 DIMETHYLPHENYL} FURAN 2 CARBONITRILE; DELAVIRDINE; DIARYLPYRIMIDINE; EFAVIRENZ; NEVIRAPINE; PYRIMIDINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTANT; SYNTHESIS; VIRUS STRAIN;

ANTI-HIV AGENTS; CELL LINE; DRUG RESISTANCE, VIRAL; HIV-1; HIV-1 REVERSE TRANSCRIPTASE; HUMANS; MUTATION; PYRIMIDINES; REVERSE TRANSCRIPTASE INHIBITORS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20144366006     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040838n     Document Type: Article

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