-
1
-
-
85031183837
-
-
The collection of new therapeutic entities first launched in 2008 originated from the following sources: (a) Integrity®, Prous Science database. (b) Iddb, Current Drugs database. (c) IMS R&D Focus. (d) Adis Business Intelligence R&D Insight. (e) Pharmaprojects. (f) Package Inserts of individual NMEs
-
The collection of new therapeutic entities first launched in 2008 originated from the following sources: (a) Integrity®, Prous Science database. (b) Iddb, Current Drugs database. (c) IMS R&D Focus. (d) Adis Business Intelligence R&D Insight. (e) Pharmaprojects. (f) Package Inserts of individual NMEs.
-
-
-
-
2
-
-
62649101241
-
-
A. I. Graul, L. Revel, M. Barrionuevo, E. Cruces, E. Rosa, C. Vergés, B. Lupone, N. Diaz and R. Castaňer, Drug News Perspect., 2009, 22, 7.
-
(2009)
Drug News Perspect
, vol.22
, pp. 7
-
-
Graul, A.I.1
Revel, L.2
Barrionuevo, M.3
Cruces, E.4
Rosa, E.5
Vergés, C.6
Lupone, B.7
Diaz, N.8
Castaňer, R.9
-
4
-
-
53849123343
-
-
M. P. Curran, G. W. Robins, L. J. Scott and C. M. Perry, Drugs, 2008, 68, 2011.
-
(2011)
Drugs
, vol.2008
-
-
Curran, M.P.1
Robins, G.W.2
Scott, L.J.3
Perry, C.M.4
-
5
-
-
51049115787
-
-
C. P. Delaney, U. Yasothan and P. Kirkpatrick, Nat. Rev. Drug Discov., 2008, 7, 727.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 727
-
-
Delaney, C.P.1
Yasothan, U.2
Kirkpatrick, P.3
-
8
-
-
0030023640
-
-
J. A. Werner, L. R. Cerbone, S. A. Frank, J. A. Ward, P. Labib, R. W. Tharp-Taylor and C. W. Ryan, J. Org. Chem., 1996, 61, 587.
-
(1996)
J. Org. Chem.
, vol.61
, pp. 587
-
-
Werner, J.A.1
Cerbone, L.R.2
Frank, S.A.3
Ward, J.A.4
Labib, P.5
Tharp-Taylor, R.W.6
Ryan, C.W.7
-
9
-
-
42449091861
-
-
J. Steffel, F. R. Eberli, T. F. Lüscher and F. C. Tanner, Ann. Med., 2008, 40, 242.
-
(2008)
Ann. Med.
, vol.40
, pp. 242
-
-
Steffel, J.1
Eberli, F.R.2
Lüscher, T.F.3
Tanner, F.C.4
-
10
-
-
53149141718
-
-
S. Windecker, P. W. Serruys, S. Wandel, P. Buszman, S. Trznadel, A. Linke, K. Lenk, T. Ischinger, V. Klauss, F. Eberli, R. Corti, W. Wijns, M. Morice, C. di Mario, S. Davies, R. van Geuns, P. Eerdmans, G. van Es, B. Meier and P. Jüni, Lancet, 2008, 372, 1163.
-
(2008)
Lancet
, vol.372
, pp. 1163
-
-
Windecker, S.1
Serruys, P.W.2
Wandel, S.3
Buszman, P.4
Trznadel, S.5
Linke, A.6
Lenk, K.7
Ischinger, T.8
Klauss, V.9
Eberli, F.10
Corti, R.11
Wijns, W.12
Morice, M.13
di Mario, C.14
Davies, S.15
van Geuns, R.16
Eerdmans, P.17
van Es, G.18
Meier, B.19
Jüni, P.20
more..
-
15
-
-
0027369154
-
-
M. Oka, Y. Noda, Y. Ochi, K. Furukawa, T. Une, S. Kurumiya, K. Hino and T. Karasawa, J. Pharmacol. Exp. Ther., 1993, 264, 158.
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.264
, pp. 158
-
-
Oka, M.1
Noda, Y.2
Ochi, Y.3
Furukawa, K.4
Une, T.5
Kurumiya, S.6
Hino, K.7
Karasawa, T.8
-
16
-
-
0027490962
-
-
Y. Noda, S. Kurumiya, Y. Miura and M. Oka, J. Pharmacol. Exp. Ther., 1993, 265, 745.
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.265
, pp. 745
-
-
Noda, Y.1
Kurumiya, S.2
Miura, Y.3
Oka, M.4
-
18
-
-
14944339476
-
-
L. A. Sorbera, J. Castañer and R. M. Castañer, Drugs Future, 2005, 30, 11.
-
(2005)
Drugs Future
, vol.30
, pp. 11
-
-
Sorbera, L.A.1
Castañer, J.2
Castañer, R.M.3
-
24
-
-
48749132240
-
-
G. Y. Melmed, S. R. Targan, U. Yasothan, D. Hanicq and P. Kirkpatrick, Nat. Rev. Drug Discov., 2008, 7, 641.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 641
-
-
Melmed, G.Y.1
Targan, S.R.2
Yasothan, U.3
Hanicq, D.4
Kirkpatrick, P.5
-
25
-
-
34447523749
-
-
W. J. Sandborn, B. C. Feagan, S. Stoinov, P. J. Honiball, P. Rutgeerts, D. Mason, R. Bloomfield and S. Schreiber, N. Engl. J. Med., 2007, 357, 228.
-
(2007)
N. Engl. J. Med.
, vol.357
, pp. 228
-
-
Sandborn, W.J.1
Feagan, B.C.2
Stoinov, S.3
Honiball, P.J.4
Rutgeerts, P.5
Mason, D.6
Bloomfield, R.7
Schreiber, S.8
-
27
-
-
59049086841
-
-
A. C. Goldberg, H. E. Bays, C. M. Ballantyne, M. T. Kelly, S. M. Buttler, C. M. Setze, D. J. Sleep and J. C. Stolzenbach, Am. J. Cardiol., 2009, 103, 515.
-
(2009)
Am. J. Cardiol.
, vol.103
, pp. 515
-
-
Goldberg, A.C.1
Bays, H.E.2
Ballantyne, C.M.3
Kelly, M.T.4
Buttler, S.M.5
Setze, C.M.6
Sleep, D.J.7
Stolzenbach, J.C.8
-
28
-
-
57149105884
-
-
S. M. Mohiuddin, C. J. Pepine, M. T. Kelly, S. M. Buttler, C. M. Setze, D. J. Sleep and J. C. Stolzenbach, Am. Heart J., 2009, 157, 195.
-
(2009)
Am. Heart J.
, vol.157
, pp. 195
-
-
Mohiuddin, S.M.1
Pepine, C.J.2
Kelly, M.T.3
Buttler, S.M.4
Setze, C.M.5
Sleep, D.J.6
Stolzenbach, J.C.7
-
30
-
-
54349086839
-
-
I. Noviawaty, G. Uzun and A. I. Qureshi, Expert Opin. Pharmacother., 2008, 9, 2519.
-
(2008)
Expert Opin. Pharmacother.
, vol.9
, pp. 2519
-
-
Noviawaty, I.1
Uzun, G.2
Qureshi, A.I.3
-
33
-
-
38949211561
-
-
J. Varon, Drugs, 2008, 68, 283.
-
(2008)
Drugs
, vol.68
, pp. 283
-
-
Varon, J.1
-
35
-
-
30544450381
-
-
L. A. Sorbera, J. Bozzo and J. Castañer, Drugs Future, 2005, 30, 877.
-
(2005)
Drugs Future
, vol.30
, pp. 877
-
-
Sorbera, L.A.1
Bozzo, J.2
Castañer, J.3
-
36
-
-
46449119238
-
-
B. I. Eriksson, H. Smith, U. Yasothan and P. Kirkpatrick, Nat. Rev. Drug Discov., 2008, 7, 557.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 557
-
-
Eriksson, B.I.1
Smith, H.2
Yasothan, U.3
Kirkpatrick, P.4
-
38
-
-
0037171819
-
-
N. H. Hauel, H Nar, H. Priepke, U. Ries, J.-M. Stassen and W. Wienen, J. Med. Chem., 2002, 45, 1757.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1757
-
-
Hauel, N.H.1
Nar, H.2
Priepke, H.3
Ries, U.4
Stassen, J.-M.5
Wienen, W.6
-
39
-
-
33745201885
-
-
L. A. Sorbera, J. Bolos and N. Serradell, Drugs Future, 2006, 31, 304.
-
(2006)
Drugs Future
, vol.31
, pp. 304
-
-
Sorbera, L.A.1
Bolos, J.2
Serradell, N.3
-
40
-
-
51349093458
-
-
B. A. Sproule, M. Hazra and B. G. Pollock, Drugs Today, 2008, 44, 475.
-
(2008)
Drugs Today
, vol.44
, pp. 475
-
-
Sproule, B.A.1
Hazra, M.2
Pollock, B.G.3
-
42
-
-
52949134506
-
-
M. A. Spopko, Jr., M. J. Ehret and M. Grgas, Ann. Pharmacother., 2008, 42, 1439.
-
(2008)
Ann. Pharmacother.
, vol.42
, pp. 1439
-
-
Spopko Jr., M.A.1
Ehret, M.J.2
Grgas, M.3
-
44
-
-
55949123179
-
-
R. Haubrich, S. Gubernick, U. Yasothan and P. Kirkpatrick, Nat. Rev. Drug Discov., 2008, 7, 287.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 287
-
-
Haubrich, R.1
Gubernick, S.2
Yasothan, U.3
Kirkpatrick, P.4
-
47
-
-
22244491993
-
-
S. L. Davies, J. Castañer, J. S. Silvestre and M. Bayés, Drugs Future, 2005, 30, 462.
-
(2005)
Drugs Future
, vol.30
, pp. 462
-
-
Davies, S.L.1
Castañer, J.2
Silvestre, J.S.3
Bayés, M.4
-
48
-
-
40949146616
-
-
B. M. Knoll, S. Vento and Z. Temesgen, Drugs Today, 2008, 44, 23.
-
(2008)
Drugs Today
, vol.44
, pp. 23
-
-
Knoll, B.M.1
Vento, S.2
Temesgen, Z.3
-
50
-
-
0142137273
-
-
L. A. Sorbera, J. Castañer and P. A. Leeson, Drugs Future, 2003, 28, 647.
-
(2003)
Drugs Future
, vol.28
, pp. 647
-
-
Sorbera, L.A.1
Castañer, J.2
Leeson, P.A.3
-
52
-
-
35748930227
-
-
V. W. Nitti, R. Dmochowski, K. P. Sand, H.-T. Forst, C. Haag-Molkenteller, U. Massow, J. Wang, M. Brodsky and T. Bavendam, J. Urol., 2007, 178, 2488.
-
(2007)
J. Urol.
, vol.178
, pp. 2488
-
-
Nitti, V.W.1
Dmochowski, R.2
Sand, K.P.3
Forst, H.-T.4
Haag-Molkenteller, C.5
Massow, U.6
Wang, J.7
Brodsky, M.8
Bavendam, T.9
-
53
-
-
41049092868
-
-
P. Ney, R. K. Pandita, D. T. Newgreen, A. Breidenbach, T. Stöhr and K.-E. Andersson, BJU Int., 2008, 101, 1036.
-
(2008)
BJU Int
, vol.101
, pp. 1036
-
-
Ney, P.1
Pandita, R.K.2
Newgreen, D.T.3
Breidenbach, A.4
Stöhr, T.5
Andersson, K.-E.6
-
54
-
-
53849143605
-
-
C. R. Chapple, P. E. van Kerrebroeck, K.-P. Junemann, J. T. Wang and M. Brodsky, BJU Int., 2008, 102, 1128.
-
(2008)
BJU Int
, vol.102
, pp. 1128
-
-
Chapple, C.R.1
van Kerrebroeck, P.E.2
Junemann, K.-P.3
Wang, J.T.4
Brodsky, M.5
-
57
-
-
0034704822
-
-
J. J. Hale, S. G. Mills, M. MacCoss, C. P. Dorn, P. E. Finke, R. J. Budhu, R. A. Reamer, S.-E. W. Huskey, D. Luffer-Atlas, B. J. Dean, E. M. McGowan, W. P. Feeney, S.-H. Lee Chiu, M. A. Cascieri, G. G. Chicchi, M. M. Kurtz, S. Sadowski, E. Ber, F. D. Tattersall, N. M. J. Rupniak, A. R. Williams, W. Rycroft, R. Hargreaves, J. M. Metzger and D. E. MacIntyre, J. Med. Chem., 2000, 43, 1234.
-
(2000)
J. Med. Chem.
, vol.43
, pp. 1234
-
-
Hale, J.J.1
Mills, S.G.2
MacCoss, M.3
Dorn, C.P.4
Finke, P.E.5
Budhu, R.J.6
Reamer, R.A.7
Huskey, S.-E.8
Luffer-Atlas, D.9
Dean, B.J.10
McGowan, E.M.11
Feeney, W.P.12
Lee Chiu, S.-H.13
Cascieri, M.A.14
Chicchi, G.G.15
Kurtz, M.M.16
Sadowski, S.17
Ber, E.18
Tattersall, F.D.19
Rupniak, N.M.J.20
Williams, A.R.21
Rycroft, W.22
Hargreaves, R.23
Metzger, J.M.24
MacIntyre, D.E.25
more..
-
58
-
-
33646228840
-
-
L. A. Sorbera, D. Fernández-Forner and M. Bayés, Drugs Future, 2008, 31, 101.
-
(2008)
Drugs Future
, vol.31
, pp. 101
-
-
Sorbera, L.A.1
Fernández-Forner, D.2
Bayés, M.3
-
60
-
-
53249154732
-
-
K. Bork, U. Yasothan and P. Kirkpatrick, Nat. Rev. Drug Discov., 2008, 7, 801.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 801
-
-
Bork, K.1
Yasothan, U.2
Kirkpatrick, P.3
-
62
-
-
11144242153
-
-
J. A. McIntyre, J. Castañer and L. Martin, Drugs Future, 2004, 29, 992.
-
(2004)
Drugs Future
, vol.29
, pp. 992
-
-
McIntyre, J.A.1
Castañer, J.2
Martin, L.3
-
63
-
-
57049154843
-
-
E. Perucca, U. Yasothan, G. Clincke and P. Kirkpatrick, Nat. Rev. Drug Discov., 2008, 7, 973.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 973
-
-
Perucca, E.1
Yasothan, U.2
Clincke, G.3
Kirkpatrick, P.4
-
65
-
-
36348956757
-
-
T.-Y. Chen, C. E. Rosow, N. Serradell and J. Bolós, Drugs Future, 2007, 32, 771.
-
(2007)
Drugs Future
, vol.32
, pp. 771
-
-
Chen, T.-Y.1
Rosow, C.E.2
Serradell, N.3
Bolós, J.4
-
66
-
-
44349145194
-
-
J. Thomas, S. Karver, G. A. Cooney, B. H. Chamberlain, C. K. Watt, N. E. Slatkin, N. Stambler, A. B. Kremer and R. J. Israel, N. Engl. J. Med., 2008, 358, 2332.
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 2332
-
-
Thomas, J.1
Karver, S.2
Cooney, G.A.3
Chamberlain, B.H.4
Watt, C.K.5
Slatkin, N.E.6
Stambler, N.7
Kremer, A.B.8
Israel, R.J.9
-
67
-
-
4344639878
-
-
V. J. Thannickal, K. R. Flaherty, F. J. Martinez and J. P. Lynch, Expert Opin. Pharmacother., 2004, 5, 1671.
-
(2004)
Expert Opin. Pharmacother.
, vol.5
, pp. 1671
-
-
Thannickal, V.J.1
Flaherty, K.R.2
Martinez, F.J.3
Lynch, J.P.4
-
69
-
-
27944433446
-
-
V. J. Thannickal, K. R. Flaherty, R. C. Hyzy and J. P. Lynch, 3rd, Expert Opin. Emerg. Drugs, 2005, 10, 707.
-
(2005)
Expert Opin. Emerg. Drugs
, vol.10
, pp. 707
-
-
Thannickal, V.J.1
Flaherty, K.R.2
Hyzy, R.C.3
Lynch III, J.P.4
-
70
-
-
34648816354
-
-
S. Shi, J. Wu, H. Chen, H. Chen, J. Wu and F. Zeng, J. Clin. Pharmacol., 2007, 47, 1268.
-
(2007)
J. Clin. Pharmacol.
, vol.47
, pp. 1268
-
-
Shi, S.1
Wu, J.2
Chen, H.3
Chen, H.4
Wu, J.5
Zeng, F.6
-
71
-
-
49449094892
-
-
R. Goldbach-Mansky, S. D. Shroff, M. Wilson, C. Snyder, S. Plehn, B. Barham, T.-H. Pham, F. Pucino, R. A. Wesley, J. H. Papadopoulos, S. P. Weinsein, S. J. Mellis and D. L. Kastner, Arthritis Rheum., 2008, 58, 2432.
-
(2008)
Arthritis Rheum
, vol.58
, pp. 2432
-
-
Goldbach-Mansky, R.1
Shroff, S.D.2
Wilson, M.3
Snyder, C.4
Plehn, S.5
Barham, B.6
Pham, T.-H.7
Pucino, F.8
Wesley, R.A.9
Papadopoulos, J.H.10
Weinsein, S.P.11
Mellis, S.J.12
Kastner, D.L.13
-
72
-
-
34547760901
-
-
L. A. Sorbera, J. Bozzo and M. Bayés, Drugs Future, 2007, 32, 411.
-
(2007)
Drugs Future
, vol.32
, pp. 411
-
-
Sorbera, L.A.1
Bozzo, J.2
Bayés, M.3
-
73
-
-
42949139787
-
-
H. M. Hoffman, U. Yasothan and P. Kirkpatrick, Nat. Rev. Drug Discov., 2008, 7, 385.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 385
-
-
Hoffman, H.M.1
Yasothan, U.2
Kirkpatrick, P.3
-
74
-
-
33748764407
-
-
G. Escolar, J. Villalta, F. Casals, J. Bozzo, N. Serradell and J. Bolós, Drugs Future, 2006, 31, 484.
-
(2006)
Drugs Future
, vol.31
, pp. 484
-
-
Escolar, G.1
Villalta, J.2
Casals, F.3
Bozzo, J.4
Serradell, N.5
Bolós, J.6
-
75
-
-
34247494229
-
-
P. Kakar, T. Watson and G. Y. H. Lip, Drugs Today, 2007, 43, 129.
-
(2007)
Drugs Today
, vol.43
, pp. 129
-
-
Kakar, P.1
Watson, T.2
Lip, G.Y.H.3
-
76
-
-
55349124018
-
-
D. B. Cines, U. Yasothan and P. Kirkpatrick, Nat. Rev. Drug Discov., 2008, 7, 887.
-
(2008)
Nat. Rev. Drug Discov.
, vol.7
, pp. 887
-
-
Cines, D.B.1
Yasothan, U.2
Kirkpatrick, P.3
-
77
-
-
43249099099
-
-
R. Stasi, M. L Evangelista and S. Amadori, Drugs, 2008, 68, 901.
-
(2008)
Drugs
, vol.68
, pp. 901
-
-
Stasi, R.1
Evangelista, M.L.2
Amadori, S.3
-
79
-
-
33745115029
-
-
M. Biava, G. C. Porretta, D. Deidda and R. Pompei, Infect. Disorders, 2006, 6, 159.
-
(2006)
Infect. Disorders
, vol.6
, pp. 159
-
-
Biava, M.1
Porretta, G.C.2
Deidda, D.3
Pompei, R.4
-
82
-
-
0026773203
-
-
O. Tamura, M. Hashimoto, Y. Kobayashi, T. Katoh, K. Nakatani, M. Kamada, I. Hayakawa, T. Akiba and S. Terashima, Tet. Lett., 1992, 24, 3487.
-
(1992)
Tet. Lett.
, vol.24
, pp. 3487
-
-
Tamura, O.1
Hashimoto, M.2
Kobayashi, Y.3
Katoh, T.4
Nakatani, K.5
Kamada, M.6
Hayakawa, I.7
Akiba, T.8
Terashima, S.9
-
87
-
-
45349105691
-
-
G. Tayal, S. Kundra and A. Grewal, J. Anaesth. Clin. Pharmacol., 2008, 24, 211.
-
(2008)
J. Anaesth. Clin. Pharmacol.
, vol.24
, pp. 211
-
-
Tayal, G.1
Kundra, S.2
Grewal, A.3
-
88
-
-
33845301207
-
-
Y. Wang, J. Bolós and N. Serradell, Drugs Future, 2006, 31, 788.
-
(2006)
Drugs Future
, vol.31
, pp. 788
-
-
Wang, Y.1
Bolós, J.2
Serradell, N.3
-
89
-
-
1342308486
-
-
Y. Takagi, T. Nakajima, A. Shimazaki, M. Kageyama, T. Matsugi, Y. Matsumura, B. T. Gabelt, P. L. Kaufman and H. Hara, Exp. Eye Res., 2004, 78, 767.
-
(2004)
Exp. Eye Res.
, vol.78
, pp. 767
-
-
Takagi, Y.1
Nakajima, T.2
Shimazaki, A.3
Kageyama, M.4
Matsugi, T.5
Matsumura, Y.6
Gabelt, B.T.7
Kaufman, P.L.8
Hara, H.9
-
90
-
-
48749122609
-
-
A. Sutton, P. Gouws and A. Ropo, Int. J. Clin. Pharmacol. Ther., 2008, 46, 400.
-
(2008)
Int. J. Clin. Pharmacol. Ther.
, vol.46
, pp. 400
-
-
Sutton, A.1
Gouws, P.2
Ropo, A.3
-
92
-
-
33646489465
-
-
P. D. Bishop, K. B. Lewis, J. Schultz and K. M. Walker, Semin. Thromb. Haemost., 2006, 32(Suppl. 1), 86.
-
(2006)
Semin. Thromb. Haemost.
, vol.32
, Issue.SUPPL. 1
, pp. 86
-
-
Bishop, P.D.1
Lewis, K.B.2
Schultz, J.3
Walker, K.M.4
-
94
-
-
33845513582
-
-
H. Saito, I. Maruyama, S. Shimazaki, Y. Yamamoto, N. Aikawa, R. Ohno, A. Hirayama, T. Matsuda, H. Asakura, M. Nakashima and N. Aoki, J. Thromb. Haemost, 2007, 5, 31.
-
(2007)
J. Thromb. Haemost
, vol.5
, pp. 31
-
-
Saito, H.1
Maruyama, I.2
Shimazaki, S.3
Yamamoto, Y.4
Aikawa, N.5
Ohno, R.6
Hirayama, A.7
Matsuda, T.8
Asakura, H.9
Nakashima, M.10
Aoki, N.11
-
95
-
-
19944432294
-
-
S. Moll, C. Lindley, S. Pescatore, D. Morrison, K. Tsuruta, M. Mohri, M. Serada, M. Sata, H. Shimizu, K. Yamada and G. C. White, II, J. Thromb. Haemost, 2004, 2, 1745.
-
(2004)
J. Thromb. Haemost
, vol.2
, pp. 1745
-
-
Moll, S.1
Lindley, C.2
Pescatore, S.3
Morrison, D.4
Tsuruta, K.5
Mohri, M.6
Serada, M.7
Sata, M.8
Shimizu, H.9
Yamada, K.10
White II, G.C.11
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