Mechanisms of Action of Microbicides

Russell, Hugo & Ayliffe's: Principles and Practice of Disinfection, Preservation and Sterilization

Volumn , Issue , 2012, Pages 95-107

  Lambert, Peter A ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

Alkylating agents; Antimicrobial action; Mechanism of action; Metal ion binding agents; Microbicide; Mode of action; Nucleic acid binding agents; Oxidizing agents; Protein denaturants; Target site

Indexed keywords

EID: 84887154410     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118425831.ch5     Document Type: Chapter

References (193)

1. Schweizer, H.P. (2001) Triclosan: a widely used biocide and its link to antibiotics. FEMS Microbiology Letters, 202, 1-7.
2. Russell, A.D. (2003) Biocide use and antibiotic resistance: the relevance of laboratory findings to clinical and environmental situations. Lancet Infectious Diseases, 3, 794-803.
3. Maillard, J.-Y. (2005) Antimicrobial biocides in the healthcare environment: efficacy, usage, policies, and perceived problems. Therapeutics and Clinical Risk Management, 1, 307-320.
4. Russell, A.D. and McDonnell, G. (2000) Concentration: a major factor in studying biocidal action. Journal of Hospital Infection, 44, 1-3.
5. Heath, R.J. et al. (1998) Broad spectrum antimicrobial biocides target the FabI component of fatty acid synthesis. Journal of Biological Chemistry, 273, 30316-30320.
6. Heath, R.J. et al. (1999) Mechanism of triclosan inhibition of bacterial fatty acid synthesis. Journal of Biological Chemistry, 274, 11110-11114.
7. Slater-Radosti, C. et al. (2001) Biochemical and genetic characterization of the action of triclosan on Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 48, 1-6.
8. Payne, D.J. et al. (2002) Discovery of a novel and potent class of FabI-directed antibacterial agents. Antimicrobial Agents and Chemotherapy, 46, 3118-3124.
9. Villalain, J. et al. (2001) Membranotropic effects of the antibacterial agent triclosan. Archives of Biochemistry and Biophysics, 390, 128-136.
10. Hugo, W.B. and Longworth, A.R. (1966) The effect of chlorhexidine on the electrophoretic mobility, cytoplasmic constituents, dehydrogenase activity and cell walls of Escherichia coli and Staphylococcus aureus. Journal of Pharmacy and Pharmacology, 18, 569-578.
11. Russell, A.D. and Day, M.J. (1993) Antibacterial activity of chlorhexidine. Journal of Hospital Infection, 25, 229-238.
12. Maillard, J.-Y. (2002) Bacterial target sites for biocide action. Journal of Applied Microbiology, 92, 16S-27S.
13. Hugo, W.B. (1991) A brief history of heat and chemical preservation and disinfection. Journal of Applied Bacteriology, 71, 9-18.
14. Hugo, W.B. and Longworth, A.R. (1964) Effect of chlorhexidine diacetate on "protoplasts" and spheroplasts of Escherichia coli, protoplasts of Bacillus mega-terium and the Gram staining reaction of Staphylococcus aureus. Journal of Pharmacy and Pharmacology, 16, 751-758.
15. Hugo, W.B. and Longworth, A.R. (1965) Cytological aspects of the mode of action of chlorhexidine diacetate. Journal of Pharmacy and Pharmacology, 17, 28-32.
16. Hugo, W.B. and Bloomfield, S.F. (1971) Studies on the mode of action of the phenolic antibacterial agent fentichlor against Staphylococcus aureus and Escherichia coli. I. The adsorption of fentichlor by the bacterial cell and its antibacterial activity. Journal of Applied Bacteriology, 34, 557-567.
17. Hugo, W.B. and Bloomfield, S.F. (1971) Studies on the mode of action of the phenolic antibacterial agent fentichlor against Staphylococcus aureus and Escherichia coli. II. The effects of fentichlor on the bacterial membrane and the cytoplasmic constituents of the cell. Journal of Applied Bacteriology, 34, 569-578.
18. Hugo, W.B. and Bloomfield, S.F. (1971) Studies on the mode of action of the phenolic antibacterial agent fentichlor against Staphylococcus aureus and Escherichia coli. III. The effect of fentichlor on the metabolic activities of Staphylococcus aureus and Escherichia coli. Journal of Applied Bacteriology, 34, 579-591.
19. Fraud, S. et al. (2001) Comparison of the mycobactericidal activity of ortho-phthalaldehyde, glutaraldehyde and other dialdehydes by a quantitative suspension test. Journal of Hospital Infection, 48, 214-221.
20. Walsh, S.E. et al. (2001) Possible mechanisms for the relative efficacies of ortho-phthalaldehyde and glutaraldehyde against glutaraldehyde-resistant Mycobacterium chelonae. Journal of Applied Microbiology, 91, 80-92.
21. Power, E.G. and Russell, A.D. (1990) Sporicidal action of alkaline glutaralde-hyde: factors influencing activity and a comparison with other aldehydes. Journal of Applied Bacteriology, 69, 261-268.
22. Williams, N.D. and Russell, A.D. (1993) Revival of Bacillus subtilis spores from biocide-induced injury in the germination process. Journal of Applied Bacteriology, 75, 76-81.
23. Russell, A.D. and Furr, J.R. (1996) Biocides: mechanisms of antifungal action and fungal resistance. Science Progress, 79, 27-48.
24. Maillard, J.-Y. and Russell, A.D. (1997) Viricidal activity and mechanisms of action of biocides. Science Progress, 80, 287-315.
25. Khunkitti, W. et al. (1996) The lethal effects of biguanides on cysts and trophozoites of Acanthamoeba castellanii. Journal of Applied Bacteriology, 81, 73-77.
26. Khunkitti, W. et al. (1997) Effects of biocides on Acanthamoeba castellanii as measured by flow cytometry and plaque assay. Journal of Antimicrobial Chemotherapy, 40, 227-233.
27. Khunkitti, W. et al. (1997) Aspects of the mechanisms of action of biguanides on trophozoites and cysts of Acanthamoeba castellanii. Journal of Applied Microbiology, 82, 107-114.
28. Khunkitti, W. et al. (1998) Acanthamoeba castellanii: growth, encystment, excystment and biocide susceptibility. Journal of Infection, 36, 43-48.
29. Turner, N.A. et al. (2000) Emergence of resistance to biocides during differentiation of Acanthamoeba castellanii. Journal of Antimicrobial Chemotherapy, 46, 27-34.
30. Richards, R.M. and Cavill, R.H. (1979) Electron-microscope study of the effect of chlorhexidine on Pseudomonas aeruginosa. Microbios, 26, 85-93.
31. Richards, R.M. and Cavill, R.H. (1981) Electron microscope study of the effect of benzalkonium, chlorhexidine and polymyxin on Pseudomonas cepacia. Microbios, 29, 23-31.
32. Tattawasart, U. et al. (2000) Cytological changes in chlorhexidine-resistant isolates of Pseudomonas stutzeri. Journal of Antimicrobial Chemotherapy, 45, 145-152.
33. Thraenhart, O. et al. (1977) Morphological alteration and desintegration of dane particles after exposure with "Gigasept". A first methological attempt for the evaluation of the virucidal efficacy of a chemical disinfectant against hepa-titisvirus B (author's transl.). Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene: Originale B, 164, 1-21.
34. Thraenhart, O. et al. (1978) Influence of different disinfection conditions on the structure of the hepatitis B virus (Dane particle) as evaluated in the morphological alteration and disintegration test (MADT). Zentralblatt fur Bakte-riologie, Mikrobiologie und Hygiene: Originale A, 242, 299-314.
35. Maillard, J.-Y. et al. (1995) Electronmicroscopic investigation of the effects of biocides on Pseudomonas aeruginosa PAO bacteriophage F116. Journal of Medical Microbiology, 42, 415-420.
36. Bruinsma, G.M. et al. (2001) Effects of cell surface damage on surface properties and adhesion of Pseudomonas aeruginosa. Journal of Microbiological Methods, 45, 95-101.
37. Sharma, P.K. and Rao, K.H. (2002) Analysis of different approaches for evaluation of surface energy of microbial cells by contact angle goniometry. Advances in Colloid and Interface Sciences, 98, 341-463.
38. Khunkitti, W. et al. (1999) X-ray microanalysis of chlorine and phosphorus content in biguanide-treated Acanthamoeba castellanii. Journal of Applied Microbiology, 86, 453-459.
39. Maillard, J.-Y. et al. (1995) Energy dispersive analysis of X-rays study of the distribution of chlorhexidine diacetate and cetylpyridinium chloride on the Pseudomonas aeruginosa bacteriophage F116. Letters in Applied Microbiology, 20, 357-360.
40. Amro, N.A. et al. (2000) High-resolution atomic force microscopy studies of the Escherichia coli 8 outer membrane: structural basis for permeability. Lang-muir, 16, 2789-2796.
41. Kotra, L.P. et al. (2000) Visualizing bacteria at high resolution. American Society for Microbiology News, 66, 675-681.
42. Li, A. et al. (2007) Atomic force microscopy study of the antimicrobial action of Sushi peptides on Gram negative bacteria. Biochimica et Biophysica Acta, 1768, 411-418.
43. Dufrene, Y.F. (2002) Atomic force microscopy, a powerful tool in microbiology. Journal of Bacteriology, 184, 5205-5213.
44. Denyer, S.P. and Hugo, W.B. (1991) Biocide-induced damage to the bacterial cytoplasmic membrane. Society for Applied Bacteriology Technical Series, 30, 171-188.
45. Gilbert, P. et al. (1991) Interaction of biocides with model membranes and isolated membrane fragments. Society for Applied Bacteriology Technical Series, 27, 155-170.
46. Gutsmann, T. et al. (1999) Molecular mechanisms of interaction of rabbit CAP18 with outer membranes of gram-negative bacteria. Biochemistry, 38, 13643-13653.
47. Giffard, C.J. et al. (1996) Interaction of nisin with planar lipid bilayers monitored by fluorescence recovery after photobleaching. Journal of Membrane Biology, 151, 293-300.
48. Lohner, K. and Prenner, E.J. (1999) Differential scanning calorimetry and X-ray diffraction studies of the specificity of the interaction of antimicrobial peptides with membrane-mimetic systems. Biochimica et Biophysica Acta, 1462, 141-156.
49. La Rocca, P. et al. (1999) Simulation studies of the interaction of antimicrobial peptides and lipid bilayers. Biochimica et Biophysica Acta, 1462, 185-200.
50. Lambert, P.A. and Hammond, S.M. (1973) Potassium fluxes, first indications of membrane damage in micro-organisms. Biochemical and Biophysical Research Communications, 54, 796-799.
51. Kroll, R.G. and Anagnostopoulos, G.D. (1981) Potassium fluxes on hyperosmotic shock and the effect of phenol and bronopol (2-bromo-2-nitropropan-1,3-diol) on deplasmolysis of Pseudomonas aeruginosa. Journal of Applied Bacteriology, 51, 313-323.
52. Cox, S.D. et al. (1998) Tea tree oil causes K+ leakage and inhibits respiration in Escherichia coli. Letters in Applied Microbiology, 26, 355-358.
53. Orlov, D.S. et al. (2002) Potassium release, a useful tool for studying antimicrobial peptides. Journal of Microbiological Methods, 49, 325-328.
54. Breukink, E. et al. (1997) The C-terminal region of nisin is responsible for the initial interaction of nisin with the target membrane. Biochemistry, 36, 6968-6976.
55. Silberstein, A. et al. (1999) Membrane destabilization assay based on potassium release from liposomes. Biochimica et Biophysica Acta, 1461, 103-112.
56. Dinning, A.J. et al. (1998) Pyrithione biocides as inhibitors of bacterial ATP synthesis. Journal of Applied Microbiology, 85, 141-146.
57. Von Ohle, C. et al. (2010) Real time microsensor measurement of local metabolic activities in ex vivo dental biofilms exposed to sucrose and treated with chlorhexidine. Applied and Environmental Microbiology, 76, 2326-2334.
58. Hope, C.K. and Wilson, M. (2004) Analysis of the effects of chlorhexidine on oral biofilm vitality and structure based on viability profiling and an indicator of membrane integrity. Antimicrobial Agents and Chemotherapy, 48, 1461-1468.
59. Shen, Y. et al. (2009) Evaluation of the effect of two chlorhexidine preparations on biofilm bacteria in vitro: a three-dimensional quantitative analysis. Journal of Endodontics, 35, 981-985.
60. Noyce, J.O. et al. (2006) Potential use of copper surfaces to reduce survival of epidemic meticillin-resistant Staphylococcus aureus in the healthcare environment. Journal of Hospital Infection, 63, 289-297.
61. Kim, J.G. et al. (1999) Application of ozone for enhancing the microbiological safety and quality of foods: a review. Journal of Food Protection, 62, 1071-1087.
62. Lehtinen, J. et al. (2004) Green fluorescent protein-propidium iodide (GFP-PI) based assay for flow cytometric measurement of bacterial viability. Cytometry A, 60, 165-172.
63. Lehtinen, J. et al. (2006) Real-time monitoring of antimicrobial activity with the multiparameter microplate assay. Journal of Microbiological Methods, 66, 381-389.
64. Giuliodori, A.M. et al. (2007) Review on bacterial stress topics. Annals of the New York Academy of Science, 1113, 95-104.
65. Russell, A.D. (2003) Similarities and differences in the responses of microorganisms to biocides. Journal of Antimicrobial Chemotherapy, 52, 750-763.
66. Nde, C.W. et al. (2008) Toxicogenomic response of Pseudomonas aeruginosa to ortho-phenylphenol. BMC Genomics, 9, 473-491.
67. Jang, H.J. et al. (2008) Microarray analysis of toxicogenomic effects of ortho-phenylphenol in Staphylococcus aureus. BMC Genomics, 9, 411-431.
68. Jang, H.J. et al. (2008) Microarray analysis of toxicogenomic effects of triclosan on Staphylococcus aureus. Applied Microbiology and Biotechnology, 78, 695707.
69. Bailey, A.M. et al. (2009) Exposure of Escherichia coli and Salmonella enterica serovar Typhimurium to triclosan induces a species-specific response, including drug detoxification. Journal of Antimicrobial Chemotherapy, 64, 973-985.
70. Nde, C.W. et al. (2009) Global transcriptomic response of Pseudomonas aeruginosa to chlorhexidine diacetate. Environmental Science and Technology, 43, 8406-8415.
71. Allen, M.J. et al. (2006) The response of Escherichia coli to exposure to the biocide polyhexamethylene biguanide. Microbiology, 152, 989-1000.
72. Raafat, D. et al. (2008) Insights into the mode of action of chitosan as an antibacterial compound. Applied and Environmental Microbiology, 74, 3764-3773.
73. Maseda, H. et al. (2009) Mutational upregulation of a resistance-nodulation-cell division-type multidrug efflux pump, SdeAB, upon exposure to a biocide, cetylpyridinium chloride, and antibiotic resistance in Serratia marcescens. Antimicrobial Agents and Chemotherapy, 53, 5230-5235.
74. Chang, W. et al. (2006) Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide. Journal of Bacteriology, 188, 16481659.
75. Hobbs, E.C. et al. (2010) Small RNAs and small proteins involved in resistance to cell envelope stress and acid shock in Escherichia coli: analysis of a bar-coded mutant collection. Journal of Bacteriology, 192, 59-67.
76. Hemm, M.R. et al. (2010) Small stress response proteins in Escherichia coli: proteins missed by classical proteomic studies. Journal of Bacteriology, 192, 46-58.
77. Freiberg, C. et al. (2005) Discovering the mechanism of action of novel antibacterial agents through transcriptional profiling of conditional mutants. Antimicrobial Agents and Chemotherapy, 49, 749-759.
78. Hutter, B. et al. (2004) Panel of Bacillus subtilis reporter strains indicative of various modes of action. Antimicrobial Agents and Chemotherapy, 48, 2588-2594.
79. Urban, A. et al. (2007) Novel whole-cell antibiotic biosensors for compound discovery. Applied and Environmental Microbiology, 73, 6436-6443.
80. Gilbert, P. et al. (1990) Influence of growth rate on susceptibility to antimicrobial agents: biofilms, cell cycle, dormancy, and stringent response. Antimicrobial Agents and Chemotherapy, 34, 1865-1868.
81. Brown, M.R. et al. (1990) Influence of growth rate on susceptibility to antimicrobial agents: modification of the cell envelope and batch and continuous culture studies. Antimicrobial Agents and Chemotherapy, 34, 1623-1628.
82. Evans, D.J. et al. (1990) Effect of growth-rate on resistance of gram-negative biofilms to cetrimide. Journal of Antimicrobial Chemotherapy, 26, 473-478.
83. Mah, T.F. and O'Toole, G.A. (2001) Mechanisms of biofilm resistance to antimicrobial agents. Trends in Microbiology, 9, 34-39.
84. Gilbert, P. and McBain, A.J. (2001) Biofilms: their impact on health and their recalcitrance toward biocides. American Journal of Infection Control, 29, 252-255.
85. Gilbert, P. et al. (2002) The physiology and collective recalcitrance of microbial biofilm communities. Advances in Microbial Physiology, 46, 202-256.
86. Luppens, S.B. et al. (2002) The effect of the growth phase of Staphylococcus aureus on resistance to disinfectants in a suspension test. Journal of Food Protection, 65, 124-129.
87. Luppens, S.B. et al. (2002) Development of a standard test to assess the resistance of Staphylococcus aureus biofilm cells to disinfectants. Applied and Environmental Microbiology, 68, 4194-4200.
88. Stewart, P.S. et al. (2001) Biofilm penetration and disinfection efficacy of alkaline hypochlorite and chlorosulfamates. Journal of Applied Microbiology, 91, 525-532.
89. Bloomfield, S.F. et al. (1994) An evaluation of the repeatability and reproducibility of a surface test for the activity of disinfectants. Journal of Applied Bacteriology, 76, 86-94.
90. Zelver, N. et al. (1999) Measuring antimicrobial effects on biofilm bacteria: from laboratory to field. Methods in Enzymology, 310, 608-628.
91. Gilbert, P. et al. (2001) Assessment of resistance towards biocides following the attachment of micro-organisms to, and growth on surfaces. Journal of Applied Microbiology, 91, 248-254.
92. Hamilton, M.A. (2002) Testing antimicrobials against biofilm bacteria. Journal of AOAC International, 85, 479-485.
93. Springthorpe, V.S. and Sattar, S.A. (2005) Carrier tests to assess microbicidal activities of chemical disinfectants for use on medical devices and environmental surfaces. Journal of AOAC International, 88, 182-201.
94. Buckingham-Meyer, K. et al. (2007) Comparative evaluation of biofilm disinfectant efficacy tests. Journal of Microbiological Methods, 70, 236-244.
95. Ntsama-Essomba, C. et al. (1997) Resistance of Escherichia coli growing as biofilms to disinfectants. Veterinary Research, 28, 353-363.
96. Russell, A.D. (1995) Mechanisms of bacterial resistance to biocides. International Biodeterioration and Biodegradation, 36, 247-265.
97. Russell, A.D. (1998) Mechanisms of bacterial resistance to antibiotics and biocides. Progress in Medicinal Chemistry, 35, 133-197.
98. Russell, A.D. (1999) Bacterial resistance to disinfectants: present knowledge and future problems. Journal of Hospital Infection, 43, S57-S68.
99. Russell, A.D. (2002) Mechanisms of antimicrobial action of antiseptics and disinfectants: an increasingly important area of investigation. Journal of Antimicrobial Chemotherapy, 49, 597-599.
100. Denyer, S.P. and Stewart, G.S.A.B. (1998) Mechanisms of action of disinfectants. International Biodeterioration and Biodegradation, 41, 261-268.
101. McDonnell, G. and Russell, A.D. (1999) Antiseptics and disinfectants: activity, action, and resistance. Clinical Microbiology Reviews, 12, 147-179.
102. Denyer, S.P. (1990) Mechanisms of action of biocides. International Biodeterioration and Biodegradation, 26, 89-100.
103. Denyer, S.P. and Maillard, J.-Y. (2002) Cellular impermeability and uptake of biocides and antibiotics in Gram-negative bacteria. Journal of Applied Microbiology, 92, 35S-45S.
104. Giles, C.H. et al. (1960) Studies in adsorption. XI. A system of classification of solution adsorption isotherms, and its use in diagnosis of adsorption mechanisms and in measurement of specific areas of solids. Journal of the Chemical Society, 111, 3973-3993.
105. Hiom, S.J. et al. (1995) Uptake of 14C-chlorhexidine gluconate by Saccharo-myces cerevisiae, Candida albicans and Candida glabrata. Letters in Applied Microbiology, 21, 20-22.
106. Salt, W.G. and Wiseman, D. (1970) The relation between the uptake of cetylt-rimethylammonium bromide by Escherichia coli and its effects on cell growth and viability. Journal of Pharmacy and Pharmacology, 22, 261-264.
107. Broxton, P. et al. (1984) Binding of some polyhexamethylene biguanides to the cell envelope of Escherichia coli ATCC 8739. Microbios,, 163, 15-22.
108. Sakagami, Y. et al. (1989) Mechanism of resistance to benzalkonium chloride by Pseudomonas aeruginosa. Applied and Environmental Microbiology, 55, 2036-2040.
109. Loughlin, M.F. et al. (2002) Pseudomonas aeruginosa cells adapted to benzal-konium chloride show resistance to other membrane-active agents but not to clinically relevant antibiotics. Journal of Antimicrobial Chemotherapy, 49, 631-639.
110. Davies, A. et al. (1968) Comparison of the action of vantocil, cetrimide and chlorhexidine on Escherichia coli and its spheroplasts and the protoplasts of gram positive bacteria. Journal of Applied Bacteriology, 31, 448-461.
111. Rosenberg, M. (1991) Basic and applied aspects of microbial adhesion at the hydrocarbon : water interface. Critical Reviews in Microbiology, 18, 159-173.
112. Jones, D.S. et al. (1991) The effects of three non-antibiotic, antimicrobial agents on the surface hydrophobicity of certain micro-organisms evaluated by different methods. Journal of Applied Bacteriology, 71, 218-227.
113. Majtan, V. and Majtanova, L. (2000) Effect of new quaternary bisammonium compounds on the growth and cell surface hydrophobicity of Enterobacter cloacae. Central European Journal of Public Health, 8, 80-82.
114. Anil, S. et al. (2001) The impact of chlorhexidine gluconate on the relative cell surface hydrophobicity of oral Candida albicans. Oral Disease, 7, 119-122.
115. Vaara, M. (1992) Agents that increase the permeability of the outer membrane. Microbiological Reviews, 56, 395-411.
116. Yasuda, K. et al. (2009) Mode of action of novel polyamines increasing the permeability of bacterial outer membrane. International Journal of Antimicrobial Agents, 24, 67-71.
117. Gorman, S.P. et al. (1980) Antimicrobial activity, uses and mechanism of action of glutaraldehyde. Journal of Applied Bacteriology, 48, 161-190.
118. Hancock, R.E. and Wong, P.G. (1984) Compounds which increase the permeability of the Pseudomonas aeruginosa outer membrane. Antimicrobial Agents and Chemotherapy, 26, 48-52.
119. Lambert, P.A. (1991) Action on cell walls and outer layers. Society for Applied Bacteriology Technical Series, 30, 121-134.
120. Sheppard, F.C. et al. (1997) Flow cytometric analysis of chlorhexidine action. FEMS Microbiology Letters, 154, 283-288.
121. Caron, G.N. et al. (1998) Assessment of bacterial viability status by flow cytometry and single cell sorting. Journal of Applied Microbiology, 84, 988-998.
122. Lannigan, R. and Bryan, L.E. (1985) Decreased susceptibility of Serratia marc-escens to chlorhexidine related to the inner membrane. Journal of Antimicrobial Chemotherapy, 15, 559-565.
123. Shapiro, S. and Guggenheim, B. (1995) The action of thymol on oral bacteria. Oral Microbiology and Immunology, 10, 241-246.
124. Cox, S.D. et al. (2000) The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil). Journal of Applied Microbiology, 88, 170-175.
125. Lambert, P.A. and Smith, A.R. (1976) Antimicrobial action of dodecyldieth-anolamine: induced membrane damage in Escherichia coli. Microbios, 15, 199-202.
126. Shepherd, J.A. et al. (1988) Antibacterial action of 2-bromo-2-nitropropane-1,3-diol (bronopol). Antimicrobial Agents and Chemotherapy, 32, 1693-1698.
127. Chapman, J.S. and Diehl, M.A. (1995) Methylchloroisothiazolone-induced growth inhibition and lethality in Escherichia coli. Journal of Applied Bacteriology, 78, 134-141.
128. Ooi, N. et al. (2009) XF-73, a novel antistaphylococcal membrane-active agent with rapid bactericidal activity. Journal of Antimicrobial Chemotherapy, 64, 735-740.
129. Ooi, N. et al. (2010) XF-70 and XF-73, novel antibacterial agents active against slow-growing and non-dividing cultures of Staphylococcus aureus including biofilms. Journal of Antimicrobial Chemotherapy, 65, 72-78.
130. Comas, J. and Vives-Rego, J. (1997) Assessment of the effects of gramicidin, formaldehyde, and surfactants on Escherichia coli by flow cytometry using nucleic acid and membrane potential dyes. Cytometry, 29, 58-64.
131. Akiyama, Y. (2002) Proton-motive force stimulates the proteolytic activity of FtsH, a membrane-bound ATP-dependent protease in Escherichia coli. Proceedings of the National Academy of Sciences, 99, 8066-8071.
132. Bloomfield, S.F. (1974) The effect of the phenolic antibacterial agent fentichlor on energy coupling in Staphylococcus aureus. Journal of Applied Bacteriology, 37, 117-131.
133. Denyer, S.P. and Hugo, W.B. (1977) The mode of action of tetradecyltrimethyl ammonium bromide (CTAB) on Staphylococcus aureus. Journal of Pharmacy and Pharmacology, 29 (Suppl.), 66 pp.
134. Gilbert, P. et al. (1977) The lethal action of 2-phenoxyethanol and its analogues upon Escherichia coli NCTC 5933. Microbios, 19, 125-141.
135. Eklund, T. (1985) The effect of sorbic acid and esters of p-hydroxybenzoic acid on the protonmotive force in Escherichia coli membrane vesicles. Journal of General Microbiology, 131, 73-76.
136. Maget-Dana, R. (1999) The monolayer technique: a potent tool for studying the interfacial properties of antimicrobial and membrane-lytic peptides and their interactions with lipid membranes. Biochimica et Biophysica Acta, 1462, 109-140.
137. Seefeld, M.A. et al. (2001) Inhibitors of bacterial enoyl acyl carrier protein reductase (FabI): 2,9-disubstituted 1,2,3,4-tetrahydropyrido(3,4-b)indoles as potential antibacterial agents. Bioorganic and Medicinal Chemistry Letters, 11, 2241-2224.
138. Miller, W.H. et al. (2002) Discovery of aminopyridine-based inhibitors of bacterial enoyl-ACP reductase (FabI). Journal of Medicinal Chemistry, 45, 3246-3256.
139. Suller, M.T. and Russell, A.D. (2000) Triclosan and antibiotic resistance in Staphylococcus aureus. Journal of Antimicrobial Chemotherapy, 46, 11-18.
140. Darzynkiewicz, Z. (1990) Differential staining of DNA and RNA in intact cells and isolated cell nuclei with acridine orange. Methods in Cell Biology, 33, 285-298.
141. Allen, M.J. et al. (2004) Cooperativity in the binding of the cationic biocide polyhexamethylene biguanide to nucleic acids. Biochemical and Biophysical Research Communications, 318, 397-404.
142. Del Sal, G. et al. (1989) The CTAB-DNA precipitation method: a common mini-scale preparation of template DNA from phagemids, phages or plasmids suitable for sequencing. BioTechniques, 7, 514-520.
143. Loshon, C.A. et al. (1999) Formaldehyde kills spores of Bacillus subtilis by DNA damage and small, acid-soluble spore proteins of the alpha/beta-type protect spores against this DNA damage. Journal of Applied Microbiology, 87, 8-14.
144. van Sittert, N.J. et al. (2000) Formation of DNA adducts and induction of mutagenic effects in rats following 4 weeks inhalation exposure to ethylene oxide as a basis for cancer risk assessment. Mutation Research, 447, 27-48.
145. Trewick, S.C. et al. (2002) Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage. Nature, 419, 174-178.
146. Falnes, P.O. et al. (2002) AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature, 419, 178-182.
147. Domingue, E.L. et al. (1988) Effects of three oxidizing biocides on Legionella pneumophila serogroup 1. Applied and Environmental Microbiology, 54, 741747.
148. Rice, R.G. (2002) Ozone and anthrax-knowns and unknowns. Ozone-Science and Engineering, 24, 151-158.
149. Khadre, M.A. and Yousef, A.E. (2001) Sporicidal action of ozone and hydrogen peroxide: a comparative study. International Journal of Food Microbiology, 71, 131-138.
150. von Gunten, U. and Pinkernell, U. (2000) Ozonation of bromide-containing drinking waters: a delicate balance between disinfection and bromate formation. Water Science and Technology, 41, 53-59.
151. Ferng, S.F. (2002) Ozone-induced DNA single strand-breaks in guinea pig tracheobronchial epithelial cells in vivo. Inhalation Toxicology, 14, 621-633.
152. Bornholdt, J. et al. (2002) Inhalation of ozone induces DNA strand breakage and inflammation in mice. Mutation Research, 520, 63-71.
153. Small, D.A. et al. (2007) Toxicogenomic analysis of sodium hypochlorite antimicrobial mechanisms in Pseudomonas aeruginosa. Applied Microbiology and Biotechnology, 74, 176-185.
154. Small, D.A. et al. (2007) Comparative global transcription analysis of sodium hypochlorite, peracetic acid, and hydrogen peroxide on Pseudomonas aeruginosa. Applied Microbiology and Biotechnology, 76, 1093-1105.
155. Jang, H.J. et al. (2009) Global transcriptome analysis of the Mycobacterium bovis BCG response to sodium hypochlorite. Applied Microbiology and Biotechnology, 85, 127-140.
156. Deng, D.M. et al. (2007) The adaptive response of Streptococcus mutans towards oral care products: involvement of the ClpP serine protease. European Journal of Oral Science, 115, 363-370.
157. Santos, P.M. et al. (2004) Insights into Pseudomonas putida KT2440 response to phenol-induced stress by quantitative proteomics. Proteomics, 4, 26402652.
158. Thurman, R.B. and Gerba, C.P. (1988) Molecular mechanisms of viral inactivation by water disinfectants. Advances in Applied Microbiology, 33, 75-105.
159. Collier, P.J. et al. (1990) Growth inhibitory and biocidal activity of some iso-thiazolone biocides. Journal of Applied Bacteriology, 69, 569-577.
160. Collier, P.J. et al. (1990) Chemical reactivity of some isothiazolone biocides. Journal of Applied Bacteriology, 69, 578-584.
161. Narayan, M. et al. (2000) Oxidative folding of proteins. Accounts of Chemical Research, 33, 805-812.
162. Liau, S.Y. et al. (1997) Interaction of silver nitrate with readily identifiable groups: relationship to the antibacterial action of silver ions. Letters in Applied Microbiology, 25, 279-283.
163. Espirito Santo, C. et al. (2008) Contribution of copper ion resistance to survival of Escherichia coli on metallic copper surfaces. Applied and Environmental Microbiology, 74, 977-986.
164. Rossmoore, H.W. and Sondossi, M. (1988) Applications and mode of action of formaldehyde condensate biocides. Advances in Applied Microbiology, 33, 223-277.
165. Jiang, W. and Schwendeman, S.P. (2000) Formaldehyde-mediated aggregation of protein antigens: comparison of untreated and formalinized model antigens. Biotechnology and Bioengineering, 70, 507-517.
166. Eklund, B. et al. (2002) Use of ethylenediaminetetraacetic acid in pulp mills and effects on metal mobility and primary production. Environmental Toxicology and Chemistry, 21, 1040-1051.
167. Neidle, S. and Abraham, Z. (1984) Structural and sequence-dependent aspects of drug intercalation into nucleic acids. CRC Critical Reviews of Biochemistry, 17, 73-121.
168. Wilson, W.D. et al. (1994) The interaction of intercalators and groove-binding agents with DNA triple-helical structures: the influence of ligand structure, DNA backbone modifications and sequence. Journal of Molecular Recognition, 7, 89-98.
169. Ingram, L.O. and Buttke, T.M. (1984) Effects of alcohols on micro-organisms. Advances in Microbial Physiology, 25, 253-300.
170. Lucchini, J.J. et al. (1990) Antibacterial activity of phenolic compounds and aromatic alcohols. Research in Microbiology, 141, 499-510.
171. Gilby, A.R. and Few, A.V. (1960) Lysis of protoplasts of Micrococcus lysodeikti-cus by ionic detergents. Journal of General Microbiology, 23, 19-26.
172. Fay, J.P. and Farias, R.N. (1977) Inhibitory action of a non-metabolizable fatty acid on the growth of Escherichia coli: role of metabolism and outer membrane integrity. Journal of Bacteriology, 132, 790-795.
173. Salton, M.R. (1968) Lytic agents, cell permeability, and monolayer penetrability. Journal of General Physiology, 52, 227S-252S.
174. Russell, A.D. (1986) Chlorhexidine: antibacterial action and bacterial resistance. Infection, 14, 212-215.
175. Levy, C.W. et al. (1999) Molecular basis of triclosan activity. Nature, 398, 383-384.
176. McMurry, L.M. et al. (1999) Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan. Antimicrobial Agents and Chemotherapy, 43, 711-713.
177. Levy, S.B. (2000) Antibiotic and antiseptic resistance: impact on public health. Pediatric Infectious Disease Journal, 19, S120-S122.
178. Levy, S.B. (2001) Antibacterial household products: cause for concern. Emerging Infectious Diseases, 7, 512-515.
179. Levy, S.B. (2002) Active efflux, a common mechanism for biocide and antibiotic resistance. Journal of Applied Microbiology, 92, 65S-71S.
180. Poole, K. (2002) Mechanisms of bacterial biocide and antibiotic resistance. Journal of Applied Microbiology, 92, 55S-64S.
181. Ng, M.E. et al. (2002) Biocides and antibiotics with apparently similar actions on bacteria: is there the potential for cross-resistance? Journal of Hospital Infection, 51, 147-149.
182. Russell, A.D. (2002) Introduction of biocides into clinical practice and the impact on antibiotic-resistant bacteria. Journal of Applied Microbiology, 92, 121S-135S.
183. Maillard, J.-Y. (2007) Bacterial resistance to biocides in the healthcare environment: shall we be concerned? Journal of Hospital Infection, 65(Suppl. 2), 60-72.
184. Maillard, J.-Y. and Denyer, S.P. (2009) Emerging bacterial resistance following biocide exposure: should we be concerned? Chemica Oggi, 27, 26-28.
185. Chuanchuen, R. et al. (2008) Susceptibilities to antimicrobials and disinfectants in Salmonella isolates obtained from poultry and swine in Thailand. Journal of Veterinary Medical Science, 70, 595-601.
186. McCay, P.H. et al. (2010) Effect of subinhibitory concentrations of benzalko-nium chloride on the competitiveness of Pseudomonas aeruginosa grown in continuous culture. Microbiology, 156, 30-38.
187. Fraise, A.P. (2002) Susceptibility of antibiotic-resistant cocci to biocides. Journal of Applied Microbiology, 92, 158S-162S.
188. Joynson, J.A. et al. (2002) Adaptive resistance to benzalkonium chloride, amikacin and tobramycin: the effect on susceptibility to other antimicrobials. Journal of Applied Microbiology, 93, 96-107.
189. Rose, H. et al. (2009) Biocide susceptibility of the Burkholderia cepacia complex. Journal of Antimicrobial Chemotherapy, 63, 502-510.
190. Cottell, A. et al. (2009) Triclosan-tolerant bacteria: changes in susceptibility to antibiotics. Journal of Hospital Infection, 72, 71-76.
191. Block, C. and Furman, M. (2002) Association between intensity of chlorhexi-dine use and micro-organisms of reduced susceptibility in a hospital environment. Journal of Hospital Infection, 51, 201-206.
192. Murtough, S.M. et al. (2001) Biocide rotation in the healthcare setting: is there a case for policy implementation? Journal of Hospital Infection, 48, 1-6.
193. Murtough, S.M. et al. (2002) A survey of rotational use of biocides in hospital pharmacy aseptic units. Journal of Hospital Infection, 50, 228-231.