Novel whole-cell antibiotic biosensors for compound discovery

Applied and Environmental Microbiology

Volumn 73, Issue 20, 2007, Pages 6436-6443

  Urban, Andreas ^a,b   Eckermann, Stefan ^a,c   Fast, Beate ^a,d   Metzger, Susanne ^a   Gehling, Matthias ^a,e   Ziegelbauer, Karl ^a   Rübsamen Waigmann, Helga ^a,b   Freiberg, Christoph ^a  

^a BAYER PHARMA AG   (Germany)

^b AiCuris GmbH   (Germany)

^c NOVARTIS PHARMA AG   (Switzerland)

^d BASF SE   (Germany)

^e TU DORTMUND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC ACTIVITIES; ANTIBIOTIC BIOSENSORS; ENVIRONMENTAL BIOLOGY;

BIOACTIVITY; BIOSENSORS; BIOSYNTHESIS; DNA SEQUENCES; PROTEINS; RNA;

ANTIBIOTICS;

ACTINONIN; ANTIBIOTIC AGENT; AZASERINE; AZITHROMYCIN; CEFOXITIN; CHLORAMPHENICOL; CIPROFLOXACIN; DOXYCYCLINE; ERYTHROMYCIN; FATTY ACID DERIVATIVE; FERRIMYCIN A1; FIREFLY LUCIFERASE; FUSIDIC ACID; GENTAMICIN; KANAMYCIN; LINEZOLID; METICILLIN; MITOMYCIN C; MOXIFLOXACIN; NALIDIXIC ACID; NATURAL PRODUCT; NISIN; NOVOBIOCIN; OXACILLIN; PUROMYCIN; RIFAMPICIN; STREPTOVARICIN; TRIMETHOPRIM; TROVAFLOXACIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIBIOTICS; BACTERIUM; DETECTION METHOD; ENZYME; FLY; GENE; INHIBITION; SENSOR;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL WALL; BACTERIAL GENE; BACTERIAL STRAIN; BIOSENSOR; DNA SYNTHESIS; FABHB GENE; GENE FUSION; HIGH THROUGHPUT SCREENING; NONHUMAN; PROMOTER REGION; PROTEIN SYNTHESIS; REPORTER GENE; VALIDATION PROCESS; YHEI GENE; YORB GENE; YPUA GENE; YVGS GENE;

ANTI-BACTERIAL AGENTS; BACILLUS SUBTILIS; BACTERIAL PROTEINS; BIOSENSING TECHNIQUES; CELL MEMBRANE; DNA, BACTERIAL; FATTY ACIDS; MICROBIAL SENSITIVITY TESTS; PROMOTER REGIONS (GENETICS); RNA, BACTERIAL;

BACILLUS SUBTILIS;

EID: 35448931532     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/AEM.00586-07     Document Type: Article

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