Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells

Toxicology and Applied Pharmacology

Volumn 265, Issue 1, 2012, Pages 83-92

  Yuan, Li ^a   Wang, Jing ^a   Xiao, Haifang ^a   Xiao, Chunxia ^a   Wang, Yutang ^a   Liu, Xuebo ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

Apoptosis; Isoorientin; Mitochondrial stress; NO; PI3K Akt; ROS

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ACETYLCYSTEINE; CASPASE 3; CYTOCHROME C; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOORIENTIN; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FOXO;

ANIMAL CELL; APOPTOSIS; ARTICLE; BUFFALO RAT; CELL STRAIN HEPG2; CONTROLLED STUDY; DNA FRAGMENTATION; DOSE RESPONSE; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; LIVER CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PROTEIN EXPRESSION; RAT;

ANTIOXIDANTS; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; CHROMONES; CYTOCHROMES C; DNA FRAGMENTATION; HUMANS; LUTEOLIN; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANES; MORPHOLINES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHATIDYLINOSITOL 3-KINASES; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

DROSOPHYLLUM LUSITANICUM; PATRINIA; PHYLLOSTACHYS PUBESCENS; RATTUS NORVEGICUS;

EID: 84867744044     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.09.022     Document Type: Article

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