Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5′-phosphate decarboxylase-catalyzed reactions

Biochemistry

Volumn 52, Issue 42, 2013, Pages 7500-7511

  Goryanova, Bogdana ^a   Goldman, Lawrence M ^a   Amyes, Tina L ^a   Gerlt, John A ^b   Richard, John P ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLATION; DEUTERIUM; ENZYMES; POSITIVE IONS; REACTION INTERMEDIATES; STABILIZATION; SUBSTRATES; YEAST;

CATALYZED REACTIONS; DECARBOXYLATION REACTIONS; DEUTERIUM EXCHANGE; GUANIDINIUM CATIONS; MICHAELIS CONSTANTS; OPEN CONFORMATION; SIDE-CHAIN INTERACTIONS; TRANSITION STATE STABILIZATION;

CATALYSIS;

1 (BETA DEXTRO ERYTHROFURANOSYL) 5 FLUOROURACIL; 1 (BETA DEXTRO ERYTHROFURANOSYL)OROTIC ACID; 5 FLUOROOROTIDINE 5' MONOPHOSPHATE; ARGININE; DEUTERIUM; FLUOROURIDINE PHOSPHATE; FURAN DERIVATIVE; GUANIDINE DERIVATIVE; OROTIDINE; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; PHOSPHORUS DERIVATIVE; PYRIMIDINE; UNCLASSIFIED DRUG; URIDINE DERIVATIVE; VINYL DERIVATIVE;

ARTICLE; CHEMICAL INTERACTION; CONFORMATIONAL TRANSITION; DECARBOXYLATION; ENZYME MECHANISM; ENZYME SUBSTRATE; MICHAELIS CONSTANT; MOLECULAR STABILITY; MUTATION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 84886797956     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401117y     Document Type: Article

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