Practical Synthesis of 5-Phospho-D-ribosyl α-1-Pyrophosphate (PRPP): Enzymatic Routes from Ribose 5-Phosphate or Ribose1

Journal of the American Chemical Society

Volumn 105, Issue 25, 1983, Pages 7428-7435

  Gross, Akiva ^a   Abril, Obsidiana ^a   Lewis, Jerome M ^a   Geresh, Shimona ^a   whitesides, George M ^b  

^a HARVARD UNIVERSITY   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0343334836     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja00363a037     Document Type: Article

References (47)

1. Supported by the National Institutes of Health, Grant GM 30367.
2. Weizmann Fellow, 1981-1983.
3. Weizmann Fellow, 1979-1981.
4. To whom inquiries should be addressed at Harvard University.
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36. In the synthesis of PRPP directly from D-ribose, 3 equiv of PEP are needed. Recently developed large-scale syntheses of acetyl phosphate (disodium salt) would now probably make this the preferred system for ATP regeneration (Crans, D. C.; Whitesides, G. M. J. Org. Chem., in press. Kazlauskas, R.; Whitesides, G. M., unpublished data).
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42. All operations were performed at 0-4 °C unless otherwise mentioned.
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