Catalysis by orotidine 5′-monophosphate decarboxylase: Effect of 5-fluoro and 4′-Substituents on the decarboxylation of two-part substrates

Biochemistry

Volumn 52, Issue 3, 2013, Pages 537-546

  Goryanova, Bogdana ^a   Spong, Krisztina ^a   Amyes, Tina L ^a   Richard, John P ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONAL CHANGE; DECARBOXYLASES; DESTABILIZING EFFECT; DIANIONS; ENHANCED REACTIVITY; MONOPHOSPHATES; NATURAL SUBSTRATES; OH GROUP; RATE LIMITING; RATE-LIMITING STEPS; SECOND-ORDER RATE CONSTANTS; THIRD-ORDER; TRANSITION STATE;

CARBOXYLATION; CARBOXYLIC ACIDS; CATALYSIS; CONFORMATIONS; ENZYMES; IRON OXIDES; RATE CONSTANTS;

SUBSTRATES;

1 (BETA DEXTRO ERYTHROFURANOSYL) 5 FLUOROOROTIC ACID; 5' DEOXY 5 FLUOROOROTIDINE; OROTIDINE; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; PHOSPHITE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL INTERACTION; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; DECARBOXYLATION; PRIORITY JOURNAL; SYNTHESIS;

BIOCATALYSIS; BUFFERS; DECARBOXYLATION; ENZYME ACTIVATION; ENZYME STABILITY; KINETICS; MUTANT PROTEINS; OROTIC ACID; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; OSMOLAR CONCENTRATION; PHOSPHITES; PROTEIN CONFORMATION; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SUBSTRATE SPECIFICITY; URIDINE; URIDINE MONOPHOSPHATE;

EID: 84872763037     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301650d     Document Type: Article

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