Resistance to MPTP-Neurotoxicity in α-synuclein knockout mice is complemented by human α-synuclein and associated with increased β-synuclein and Akt activation

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Thomas, Bobby ^a,b   Mandir, Allen S ^a,c   West, Neva ^a   Liu, Ying ^a   Andrabi, Shaida A ^a   Stirling, Wanda ^a   Dawson, Valina L ^a   Dawson, Ted M ^a   Lee, Michael K ^a,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c GEORGETOWN UNIVERSITY HOSPITAL   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; BETA SYNUCLEIN; PROTEIN KINASE B; DOPAMINE RECEPTOR STIMULATING AGENT; NEUROTOXIN; ONCOPROTEIN;

ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; IMMUNOBLOTTING; IN VIVO STUDY; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; NORADRENERGIC NERVE; PHENOTYPE; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SENSITIVITY ANALYSIS; SEROTONINERGIC NERVE CELL; SIGNAL TRANSDUCTION; TRANSGENE; ANIMAL; ENZYME ACTIVATION; INTOXICATION; METABOLISM; MOUSE MUTANT; PHYSIOLOGY; TOXICITY AND INTOXICATION;

MUS; PARKINSONIA;

1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE; ALPHA-SYNUCLEIN; ANIMALS; BETA-SYNUCLEIN; CELL SURVIVAL; DOPAMINE AGENTS; ENZYME ACTIVATION; HUMANS; MICE; MICE, KNOCKOUT; MPTP POISONING; NEUROTOXICITY SYNDROMES; NEUROTOXINS; ONCOGENE PROTEIN V-AKT;

EID: 79551619339     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0016706     Document Type: Article

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