Wheat Proteins and Peptides

Bioactive Proteins and Peptides as Functional Foods and Nutraceuticals

Volumn , Issue , 2010, Pages 289-303

  Kumagai, Hitomi ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Baker's asthma, occupational respiratory disorder by inhaling wheat flour; United States Department of Agriculture (USDA) Foreign Agricultural Service; Wheat albumin and diabetes prevention; Wheat allergy allergies, abnormal inflammatory responses of immune system to food; Wheat classification and wheat protein classification; Wheat gliadins, monomeric proteins separated into 35 50 components; Wheat peptide and hypertension prevention; Wheat production and consumption; Wheat protein epitope structure; Wheat proteins and peptides

Indexed keywords

EID: 84886478594     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780813811048.ch20     Document Type: Chapter

References (113)

1. Alvarez AM, Adachi T, Nakase M, Aoki N, Nakamura R, Matsuda T. 1995. Classification of rice allergenic protein cDNAs belonging to the α-amylase/trypsin inhibitor gene family. Biochim Biophys Acta 1251 (2): 201-204.
2. Amano M, Ogawa H, Kojima K, Kamidaira T, Suetsugu S, Yoshihama M, Satoh T, Samejima T, Matsumoto I. 1998. Identification of the major allergens in wheat flour responsible for baker's asthma. Biochem J 330 (3): 1229-1234.
3. Anderson OD, Greene FC. 1997. The α-gliadin gene family. II. DNA and protein sequence variation, subfamily structure, and origins of pseudogenes. Theor Appl Genet 95 (1-2): 59-65.
4. Anderson OD, Hsia CC, Torres V. 2001. The wheat γ-gliadin genes: Characterization of ten new sequences and further understanding of γ-gliadin gene family structure. Theor Appl Genet 103 (2-3): 323-330.
5. Anderson OD, Litts JC, Greene FC. 1997. The α-gliadin gene family. I. Characterization of ten new wheat α-gliadin genomic clones, evidence for limited sequence conservation of flanking DNA, and Southern analysis of the gene family. Theor Appl Genet 95 (1-2): 50-58.
6. Arentz-Hansen H, K ö rner R, Molberg Ø, Quarsten H, Vader W, Kooy YMC, Lundin KEA, Koning F, Roepstorff P, Sollid LM, McAdam SN. 2000a. The intestinal T cell response to α-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase. J Exp Med 191 (4): 603-612.
7. Arentz-Hansen H, McAdam SN, Molberg Ø, Fleckenstein B, Lundin KEA, Jorgensen TJD, Jung G, Roepstorff P, Sollid LM. 2002. Celiac lesion T cells recognize epitopes that cluster in regions of gliadins rich in proline residues. Gastroenterology 123 (3): 803-809.
8. Arentz-Hansen H, McAdam SN, Molberg Ø, Kristiansen C, Sollid LM. 2000b. Production of a panel of recombinant gliadins for the characterization of T cell reactivity in coeliac disease. Gut 46 (1): 46-51.
9. Battais F, Mothes T, Moneret-Vautrin DA, Pineau F, Kanny G, Popineau Y, Bodinier M, Denery-Papini S. 2005. Identification of IgE-binding epitopes on gliadins for patients with food allergy to wheat. Allergy 60 (6): 815-821.
10. Battais F, Pineau F, Popineau Y, Aparicio C, Kanny G, Guerin L, Moneret-Vautrin DA, Denery-Papini S. 2003. Food allergy to wheat: Identification of immunogloglin E and immunoglobulin G-binding proteins with sequential extracts and purified proteins from wheat flour. Clin Exp Allergy 33 (7): 962-970.
11. Buonocore V, De Biasi M-G, Giardina P, Poerio E, Silano V. 1985. Purification and properties of an α-amylase tetrameric inhibitor from wheat kernel. Biochim Biophys Acta 831 (1): 40-48.
12. Capparelli R, Amoroso MG, Palumbo D, Iannaccone M, Faleri C, Cresti M. 2005. Two plant puroindolines colocalize in wheat seed and in vitro synergistically fight against pathogens. Plant Mol Biol 58 (6): 857-867.
13. Charnet P, Molle G, Marion D, Rousset M, Lullien-Pellerin V. 2003. Puroindolines form ion channels in biological membranes . Biophys J 84 (4): 2416-2426.
14. Choudhury A, Maeda K, Murayama R, Dimagno EP. 1996. Character of a wheat amylase inhibitor preparation and effects on fasting human pancreaticobiliary secretions and hormones. Gastroenterology 111 (5): 1313-1320.
15. Deponte R, Parlamenti R, Petrucci T, Silano V, Tomasi M. 1976. Albumin α-amylase inhibitor families from wheat flour. Cereal Chem 53 (5): 805-820.
16. Dieterich W, Esslinger B, Trapp D, Hahn E, Huff T, Seilmeier W, Wieser H, Schuppan D. 2006. Cross linking to tissue transglutaminase and collagen favours gliadin toxicity in coeliac disease. Gut 55 (4): 478-484.
17. Dubreil L, Gaborit T, Bouchet B, Gallant DJ, Broekaert WF, Quillien L, Marion D. 1998. Spatial and temporal distribution of the major isoforms of puroindoline (puroindoline-a and puroindoline-b) and non-specific lipid transfer protein (ns-LTPle1) of Triticum aestivum seeds. Relationships with their in vitro antifungal properties. Plant Sci 138 (2): 121-135.
18. DuPont FM, Vensel WH, Chan R, Kasarda DD. 2000. Characterization of the 1B-type ω-gliadins from Triticum aestivum cultivar butte. Cereal Chem 77 (5): 607-614.
19. Evrard A, Lagarde V, Joudrier P, Gautier M-F. 2008. Puroindoline-a and puroindoline-b interact with the Saccharomyces cerevisiae plasma membrane through different amino acids present in their tryptophan-rich domain. J Cereal Sci 48 (2): 379-386.
20. Field JM, Shewry PR, Miflin BJ. 1983. Solubilization and characterization of wheat gluten proteins: Correlations between the amount of aggregated proteins and baking quality. J Sci Food Agric 34 (4): 370-377.
21. Gao S, Gu YQ, Wu J, Coleman-Derr D, Huo N, Crossman C, Jia J, Zuo Q, Ren Z, Anderson OD, Kong X. 2007. Rapid evolution and complex structural organization in genomic regions harboring multiple prolamin genes in the polyploid wheat genome. Plant Mol Biol 65 (1-2): 189-203.
22. Gómez L, Martin E, Hernandez D, Sánchez-Monge R, Barber D, Del Pozo V, De Andres B, Armentia A, Lahoz-Otin C, Palomino P. 1990. Members of the α-amylase inhibitors family from wheat endosperm are major allergens associated with baker's asthma. FEBS Lett 261 (1): 85-88.
23. Gu YQ, Salse J, Coleman-Derr D, Dupin A, Crossman C, Lazo Gerard R, Huo N, Belcram H, Ravel C, Charmet G, Charles M, Anderson OD, Chalhoub B. 2006. Types and rates of sequence evolution at the high-molecular-weight glutenin locus in hexaploid wheat and its ancestral genomes. Genetics 174 (3): 1493-1504.
24. Handoyo T, Akagawa M, Morita N, Maeda T, Mitsunaga T. 2008. Hypoallergenic characteristics of wheat flour produced by stepwise polishing. Intl J Food Prop. 11 (2): 243-252.
25. Hsia CC, Anderson OD. 2001. Isolation and characterization of wheat ω-gliadin genes. Theor Appl Genet 103 (1): 37-44.
26. Hughes DA, Mills C. 2001. Food allergy: A problem on the increase. Biologist 48 (5): 201-204.
27. James JM, Sixbey JP, Helm RM, Bannon GA, Burks AW. 1997. Wheat α-amylase inhibitor: A second route of allergic sensitization . J Allergy Clin Immunol 99 (2): 239-244.
28. Jones SM, MagnolfiCF, Cooke SK, Sampson HA. 1995. Immunologic cross-reactivity among cereal grains and grasses in children with food hypersensitivity. J Allergy Clin Immunol 96 (3): 341-351.
29. Kasarda DD, Autran JC, Lew EJL, Nimmo CC, Shewry PR. 1983. N-Terminal amino acid sequences of ω-gliadins and ω-secalins. Implications for the evolution of prolamin genes. Biochim Biophys Acta 747 (1-2): 138-150.
30. Kasarda DD, D'Ovidio R. 1999. Deduced amino acid sequence of an a-gliadin gene from spelt wheat (spelta) includes sequences active in celiac disease. Cereal Chem 76 (4): 548-551.
31. Kasarda DD, Okita TW, Bernardin JE, Baecker PA, Nimmo CC, Lew EJL, Dietler MD, Greene FC. 1984. Nucleic acid (cDNA) and amino acid sequences of α-type gliadins from wheat (Triticum aestivum). Proc Natl Acad Sci USA 81 (15): 4712-4716.
32. Kawasaki T, Seki E, Osajima K, Yoshida M, Asada K, Matsui T, Osajima Y. 2000. Antihypertensive effect of valyl-tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects. J Hum Hypertens 14 (8): 519-523.
33. Kihara H (ed.). 1954. Studies on Wheats, 2nd ed. Tokyo: Yokendo (in Japanese).
34. Kodama T, Miyazaki T, Kitamura I, Suzuki Y, Namba Y, Sakurai J, Torikai Y, Inoue S. 2005. Effects of single and long-term administration of wheat albumin on blood glucose control: Randomized controlled clinical trials. Eur J Clin Nutr 59 (3): 384-392.
35. Koike D, Yamadera K, DiMagno EP. 1995. Effect of a wheat amylase inhibitor on canine carbohydrate digestion, gastrointestinal function, and pancreatic growth. Gastroenterology 108 (4): 1221-1229.
36. Kumagai H, Suda A, Sakurai H, Kumagai H, Arai S, Inomata N, Ikezawa Z. 2007. Improvement of digestibility, reduction in allergenicity, and induction of oral tolerance of wheat gliadin by deamidation. Biosci Biotech Biochem 71 (4): 977-985.
37. Lehto M, Palosuo K, Varjonen E, Majuri M-L, Andersson U, Reunala T, Alenius H. 2003. Humoral and cellular responses to gliadin in wheat-dependent, exercise-induced anaphylaxis. Clin Exp Allergy 33 (1): 90-95.
38. Leszczyńska J, La̧cka̧ A, Bryszewska M. 2006. The use of transglutaminase in the reduction of immunoreactivity of wheat flour. Food Agric Immunol 17 (1-4): 1-9.
39. Liu C-Y, Shepherd KW. 1995. Inheritance of B subunits of glutenin and ω-and γ-gliadins in tetraploid wheats. Theor Appl Genet 90 (7-8): 1149-1157.
40. MacRitchie F. 1984. Baking quality of wheat flours. Adv Food Res 29: 201-277.
41. Maeda K, Kakabayashi S, Matsubara H. 1985. Complete amino acid sequence of an α-amylase inhibitor in wheat kernel (0.19-inhibitor). Biochim Biophys Acta 828 (3): 213-221.
42. Maruyama N, Ichise K, Katsube T, Kishimoto T, Kawase S-I, Matsumura Y, Takeuchi Y, Sawada T, Utsumi S. 1998. Identifi cation of major wheat allergens by means of the Escherichia coli expression system. Eur J Biochem 255 (3): 739-745.
43. Maruyama S, Miyoshi S, Kaneko T, Tanaka H. 1989. Angiotensin I-converting enzyme inhibitory activities of synthetic peptides related to the tandem repeated sequence of a maize endosperm protein. Agric Biol Chem 53 (4): 1077-1081.
44. Masci S, Egorov TA, Ronchi C, Kuzmicky DD, Kasarda DD, Lafiandra D. 1999. Evidence for the presence of only one cysteine residue in the D-type low molecular weight subunits of wheat subunits of wheat glutenin. J Cereal Sci 29 (1): 17-25.
45. Masci S, Lafiandra D, Porceddu E, Lew EJL, Tao HP, Kasarda DD. 1993. D-glutenin subunits: N-terminal sequences and evidence for the presence of cysteine. Cereal Chem 70 (5): 581-585.
46. Masci S, Porceddu E, Colaprico G, Lafiandra D. 1991. Comparison of the B and D subunits of glutenin encoded at the Glu-D3 locus in two biotypes of the common wheat cultivar Newton with different technological characteristics. J Cereal Sci 14 (1): 35-46.
47. Matsui T, Li C-H, Osajima Y. 1999. Preparation and characterization of novel bioactive peptides responsible for angiotensin I-converting enzyme inhibition from wheat germ. J Pept Sci 5 (7): 289-297.
48. Matsui T, Li C-H, Tanaka T, Maki T, Osajima Y, Matsumoto K. 2000. Depressor effect of wheat germ hydrolysate and its novel angiotensin I-converting enzyme inhibitory peptide, Ile-Val-Tyr, and the metabolism in rat and human plasma. Biol Pharm Bull 23 (4): 427-431.
49. Matsui T, Matsufuji H, Seki E, Osajima K, Nakashima M, Osajima Y. 1993. Inhibition of angiotensin I-converting enzyme by Bacillus licheniformis alkaline protease hydrolyzates derived from sardine muscle. Biosci Biotech Biochem 57 (6): 922-925.
50. Matsuo H, Kohno K, Morita E. 2005a. Molecular cloning, recombinant expression and IgE-binding epitope of ω-5 gliadin, a major allergen in wheat-dependent exercise-induced anaphylaxis . FEBS J 272 (17): 4431-4438.
51. Matsuo H, Kohno K, Niihara H, Morita E. 2005b. Specific IgE determination to epitope peptides of ω-5 gliadin and high molecular weight glutenin subunit is a useful tool for diagnosis of wheat-dependent exercise-induced anaphylaxis. J Immunol 175 (12): 8116-8122.
52. Matsuo H, Morimoto K, Akaki T, Kaneko S, Kusatake K, Kuroda T, Niihara H, Hide M, Morita E. 2005c. Exercise and aspirin increase levels of circulating gliadin peptides in patients with wheat-dependent exercise-induced anaphylaxis. Clin Exp Allergy 35 (4): 461-466.
53. Matsuo H, Morita E, Tatham AS, Morimoto K, Horikawa T, Osuna H, Ikezawa Z, Kaneko S, Kohno K, Dekio S. 2004. Identification of the IgE-binding epitope in ω-5 gliadin, a major allergen in wheat-dependent exercise-induced anaphylaxis . J Biol Chem 279 (13): 12135-12140.
54. Mittag D, Niggemann B, Sander I, Reese I, Fiedler E-M, Worm M, Vieths S, Reese G. 2004. Immunoglobulin E-reactivity of wheat-allergic subjects (baker's asthma, food allergy, wheat-dependent, exercise-induced anaphylaxis) to wheat protein fractions with different solubility and digestibility. Mol Nutr Food Res 48 (5): 380-389.
55. Miyoshi W, Ishikawa H, Kaneko T, Fukui F, Tanaka H, Maruyama S. 1991. Structures and activity of angiotensin-converting enzyme inhibitors in an α-zein hydrolysate. Agric Biol Chem 55 (5): 1313-1318.
56. Morita E, Kameyoshi Y, Mihara S, Hiragun T, Yamamoto S. 2001. γ-Gliadin: A presumptive allergen causing wheat-dependent exercise-induced anaphylaxis. Brit J Dermatol 145 (1): 182-184.
57. Morita E, Kohno K, Matsuo H. 2007. Food-dependent exercise-induced anaphylaxis. J Dermatol Sci 47 (2): 109-117.
58. Morita E, Matsuo H, Mihara S, Morimoto K, Savage AWJ, Tatham AS. 2003. Fast ω-gliadin is a major allergen in wheat-dependent exercise-induced anaphylaxis. J Dermatol Sci 33 (2): 99-104.
59. Morita E, Yamamura Y, Mihara S, Kameyoshi Y, Yamamoto S. 2000. Food-dependent exercise-induced anaphylaxis: A report of two cases and determination of wheat-γ-gliadin as the presumptive allergen. Brit J Dermatol 143 (5): 1059-1063.
60. Morris CF. 2002. Puroindolines: The molecular genetic basis of wheat grain hardness. Plant Mol Biol 48 (5-6): 633-647.
61. Motoi H, Kodama T. 2003. Isolation and characterization of angiotensin I-converting enzyme inhibitory peptides from wheat gliadin hydrolysate. Nahrung 47 (5): 354-358.
62. Nagao S (ed.). 1998. Wheat Sciences, 3rd ed. Tokyo: Asakura Publishing (in Japanese).
63. Nakamura Y, Yamamoto N, Sakai K, Okubo A, Yamazaki S, Takano T. 1995. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci 78 (4): 777-783.
64. Nakase M, Adachi T, Urisu A, Miyashita T, Alvarez AM, Nagasaka S, Aoki N, Nakamura R, Matsuda T. 1996. Rice (Oryza sativa L.) α-amylase inhibitors of 14-16 kDa are potential allergens and products of a multigene family. J Agric Food Chem 44 (9): 2624-2628.
65. Okita TW. 1984. Identification and DNA sequence analysis of a γ-type gliadin cDNA plasmid from winter wheat. Plant Mol Biol 3 (6): 325-332.
66. Okita TW, Cheesbrough V, Reeves CD. 1985. Evolution and heterogeneity of the α-/ β-type and γ-type gliadin DNA sequences. J Biol Chem 260 (13): 8203-8213.
67. Østergaard H, Rasmussen SK, Roberts TH, Hejgaard J 2000. Inhibitory serpins from wheat grain with reactive centers resembling glutamine-rich repeats of prolamin storage proteins. Cloning and characterization of five major molecular forms. J Biol Chem 275 (43): 33272-33279.
68. Özdemir N, Cloutier S. 2005. Expression analysis and physical mapping of low-molecular-weight glutenin loci in hexaploid wheat (Triticum aestivum L.). Genome 48 (3): 401-410.
69. Palosuo K, Alenius H, Varjonen E, Koivuluhta M, Mikkola J, Keskinen H, Kalkkinen N, Reunala T. 1999. A novel wheat gliadin as a cause of exercise-induced anaphylaxis. J Allergy Clin Immunol 103 (5): 912-917.
70. Palosuo K, Varjonen E, Kekki O-M, Klemola T, Kalkkinen N, Alenius H, Reunala T. 2001. Wheat ω-5 gliadin is a major allergen in children with immediate allergy to ingested wheat. J Allergy Clin Immunol 108 (4): 634-638.
71. Pastorello EA, Farioli L, Conti A, Pravettoni V, Bonomi S, Iametti S, Fortunato D, Scibilia J, Bindslev-Jensen C, Ballmer-Weber B, Robino AM, and Ortolani C. 2007. Wheat IgE-mediated food allergy in European patients: α-Amylase inhibitors, lipid transfer proteins and low-molecular-weight glutenins. Allergenic molecules recognized by double-blind, placebo-controlled food challenge. Intl Arch Allergy Immunol 144 (1): 10-22.
72. Payne PI, Law CN, Mudd EE. 1980. Control by homoeologous group 1 chromosomes of the high-molecular-weight subunits of glutenin, a major protein of wheat endosperm. Theor Appl Genet 58 (3-4): 113-120.
73. Piston F, Dorado G, Martin A, Barro F. 2006. Cloning of nine γ-gliadin mRNAs (cDNAs) from wheat and the molecular characterization of comparative transcript levels of γ-gliadin subclasses. J Cereal Sci 43 (1): 120-128.
74. Posch A, Weiss W, Wheeler C, Dunn MJ, Goerg A. 1995. Sequence analysis of wheat grain allergens separated by two-dimensional electrophoresis with immobilized pH gradients. Electrophoresis 16 (7): 1115-1119.
75. Rafalski JA. 1986. Structure of wheat gamma-gliadin genes. Gene 43 (3): 221-229.
76. Sabelli PA, Shewry PR. 1991. Characterization and organization of gene families at the Gli-1 loci of bread and durum wheats by restriction fragment analysis. Theor Appl Genet 83 (2): 209-216.
77. Sánchez-Monge R, Barber D, Mendez E, García-Olmedo F, Salcedo G. 1986. Genes encoding α-amylase inhibitors are located in the short arms of chromosomes 3B, 3D and 6D of wheat (Triticum aestivum L.). Theor Appl Genet 72 (1): 108-113.
78. Sánchez-Monge R, García-Casado G, Lopez-Otin C, Armentia A, Salcedo G. 1997. Wheat flour peroxidase is a prominent allergen associated with baker's asthma. Clin Exp Allergy 27 (10): 1130-1137.
79. Sánchez-Monge R, Gómez L, Barber D, Lopez-Otin C, Armentia A, Salcedo G. 1992. Wheat and barley allergens associated with baker's asthma. Glycosylated subunits of the alpha-amylase-inhibitor family have enhanced IgE-binding capacity. Biochem J 281 (2): 401-405.
80. Sander I, Flagge A, Merget R, Halder TM, Meyer HE, Baur X. 2001. Identification of wheat flour allergens by means of 2-dimensional immunoblotting. J Allergy Clin Immunol 107 (5): 907-913.
81. Sandiford CP, Tatham AS, Fido R, Welch JA, Jones MG, Tee RD, Shewry PR, Newman Taylor AJ. 1997. Identification of the major water/salt insoluble wheat proteins involved in cereal hypersensitivity. Clin Exp Allergy 27 (10): 1120-1129.
82. Scheets K, Hedgcoth C. 1988. Nucleotide sequence of a γ-gliadin gene: Comparisons with other γ-gliadin sequences show the structure of γ-gliadin genes and the general primary structure of γ-gliadins. Plant Sci 57 (2): 141-150.
83. Shani N, Steffen-Campbell JD, Anderson OD, Greene FC, Galili G. 1992. Role of the amino-and carboxy-terminal regions in the folding and oligomerization of wheat high molecular weight glutenin subunits. Plant Physiol 98 (2): 433-441.
84. Shewry PR, Halford NG, Belton PS, Tatham AS. 2002. The structure and properties of gluten: An elastic protein from wheat grain. Philos T R Soc B, Biol Sci 357 (1418): 133-142.
85. Shewry PR, Halford NG, Tatham AS. 1992. High-molecular-weight subunits of wheat glutenin. J Cereal Sci 15 (2): 105-120.
86. Shewry PR, Lafiandra D, Salcedo G, Aragoncillo C, Garcia-Olmedo F, Lew EJL, Dietler MD, Kasarda DD. 1984. N-Terminal amino acid sequences of chloroform/methanol-soluble proteins and albumins from endosperms of wheat, barley and related species. Homology with inhibitors of α-amylase and trypsin and with 2S storage globulins. FEBS Lett 175 (2): 359-363.
87. Shewry PR, Tatham AS. 1990. The prolamin storage proteins of cereal seeds: Structure and evolution. Biochemical J 267 (1): 1-12.
88. Shewry PR, Tatham AS, Forde J, Kreis M, Miflin BJ. 1986. The classification and nomenclature of wheat gluten proteins: A reassessment. J Cereal Sci 4 (2): 97-106.
89. Silano V, Pocchiari F, Kasarda DD. 1973. Physical characterization of α-amylase inhibitors from wheat. Biochim Biophys Acta-Protein Struct 317 (1): 139-148.
90. Simonato B, De Lazzari F, Pasini G, Polato F, Giannattasio M, Gemignani C, Peruffo AD, Santucci B, Plebani M, Curioni A. 2001. IgE binding to soluble and insoluble wheat flour proteins in atopic and non-atopic patients suffering from gastrointestinal symptoms after wheat ingestion. Clin Exp Allergy 31 (11): 1771-1778.
91. Singh J, Blundell M, Tanner G, Skerritt JH. 2001. Albumin and globulin proteins of wheat flour: Immunological and N-terminal sequence characterization. J Cereal Sci 34: 85-103.
92. Sjöström H, Lundin KE, Molberg Ø, Körner R, McAdam SN, Anthonsen D, Quarsten H, Norén O, Roepstorff P, Thorsby E, Sollid LM. 1998. Identification of a gliadin T-cell epitope in coeliac disease: General importance of gliadins deamidation for intestinal T-cell recognition. Scand J Immunol 48 (2): 111-115.
93. Sturgess R, Day P, Ellis HJ, Lundin KE, Gjertsen HA, Kontakou M, Ciclitira PJ. 1994. Wheat peptide challenge in coeliac disease. Lancet 343 (8900): 758-761.
94. Sugiyama T, Rafalski A, Soll D. 1986. The nucleotide sequence of a wheat γ-gliadin genomic clone. Plant Sci 44 (3): 205-209.
95. Tanabe S. 2004. IgE-binding abilities of pentapeptides, QQPFP and PQQPF, in wheat gliadin. J Nutr Sci Vitaminol 50 (5): 367-370.
96. Tanabe S, Arai S, Yanagihara Y, Mita H, Takahashi K, Watanabe M. 1996. A major wheat allergen has a Gln-Gln-Gln-Pro-Pro motif identified as an IgE-binding epitope. Biochem Biophys Res Commun 219 (2): 290-293.
97. Tatham AS, Shewry PR. 1991. Conformational analysis of the secalin storage proteins of rye (Secale cereale L.). J Cereal Sci 14 (1): 15-23.
98. Vader W, Kooy Y, Van Veelen P, De Ru A, Harris D, Benckhuijsen W, Pena S, Mearin L, Drijfhout JW, Koning F. 2002. The gluten response in children with celiac disease is directed toward multiple gliadin and glutenin peptides. Gastroenterology 122 (7): 1729-1737.
99. Varjonen E, Vainio E, Kalimo K, Juntunen-Backman K, Savolainen J 1995. Skin-prick test and RAST responses to cereals in children with atopic dermatitis. Characterization of IgE-binding components in wheat and oats by an immunoblotting method. Clin Exp Allergy 25 (11): 1100-1117.
100. von Büren M, Lüthy J, Hübner P. 2000. A spelt-specific γ-gliadin gene: Discovery and detection. Theor Appl Genet 100 (2): 271-279.
101. Wang J-R, Yan Z-H, Wei Y-M, Nevo E, Baum BR, Zheng Y-L. 2006. Molecular characterization of dimeric alpha-amylase inhibitor genes in wheat and development of genome allele-specific primers for the genes located on chromosome 3BS and 3DS. J Cereal Sci 43 (3): 360-368.
102. Watanabe J, Tanabe S, Sonoyama K, Kuroda M, Watanabe M. 2001a. IgE-reactive 60 kDa glycoprotein occurring in wheat flour. Biosci Biotech Biochem 65 (8): 1729-1735.
103. Watanabe J, Tanabe S, Watanabe M, Kasai T, Sonoyama K. 2001b. Consumption of hypoallergenic flour prevents gluten-induced airway inflammation in Brown Norway rats. Biosci Biotech Biochem 65 (8): 1729-1735.
104. Watanabe M, Suzuki T, Ikezawa Z, Arai S. 1994. Controlled enzymatic treatment of wheat proteins for production of hypoallergenic flour. Biosci Biotech Biochem 58 (2): 388-390.
105. Watanabe M, Tanabe S, Suzuki T, Ikezawa Z, Arai S. 1995. Primary structure of an allergenic peptide occurring in the chymotryptic hydrolysate of gluten. Biosci Biotech Biochem 59 (8): 1596-1597.
106. Watanabe M, Watanabe J, Sonoyama K, Tanabe S. 2000. Novel method for producing hypoallergenic wheat flour by enzymatic fragmentation of the constituent allergens and its application to food processing. Biosci Biotech Biochem 64 (12): 2663-2667.
107. Weiss W, Huber G, Engel K-H, Pethran A, Dunn MJ, Gooley AA, Goerg A. 1997. Identification and characterization of wheat grain albumin/globulin allergens. Electrophoresis 18 (5): 826-833.
108. Weiss W, Vogelmeier C, Görg A. 1993. Electrophoretic characterization of wheat grain allergens from different cultivars involved in bakers'asthma. Electrophoresis 14 (8): 805-816.
109. Wiesser H. 2000. Comparative investigations of gluten proteins from different wheat species. I. Qualitative and quantitative composition of gluten protein types. Eur Food Res Technol 211 (4): 262-268.
110. Woychik JH, Boundy JA, Dimler RL. 1961. Starch gel electrophoresis of wheat gluten proteins with concentrated urea. Arch Biochem Biophys 94: 477-482.
111. Wrigley CW. 1996. Biopolymers: Giant proteins with flour power. Nature 381 (6585): 738-739.
112. Yamashita H, Nanba Y, Onishi M, Kimoto M, Hiemori M, Tsuji H. 2002. Identification of a wheat allergen, Tri a Bd 36K, as a peroxidase. Biosci Biotech Biochem 66: 2487-2490.
113. Yokoyama K, Chiba H, Yoshikawa M. 1992. Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci Biotech Biochem 56 (10): 1541-1545.