Deduced amino acid sequence of an α-gliadin gene from spelt wheat (Spelta) includes sequences active in celiac disease

Cereal Chemistry

Volumn 76, Issue 4, 1999, Pages 548-551

  Kasarda, Donald D ^a   D'Ovidio, Renato ^b  

^a WESTERN REGIONAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF TUSCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CLONING; FOOD PRODUCTS;

AMINO ACID SEQUENCE; BREAD WHEAT; CELIAC DISEASE; DIFFERENT CLASS; LABELINGS; TRITICUM AESTIVUM L;

DNA SEQUENCES;

GLIADIN;

AMINO ACID SEQUENCE; ARTICLE; CELIAC DISEASE; DNA SEQUENCE; NONHUMAN; PROTEIN EXPRESSION; TAXONOMY; WHEAT;

TRITICUM AESTIVUM;

EID: 0032789809     PISSN: 00090352     EISSN: None     Source Type: Journal    
DOI: 10.1094/CCHEM.1999.76.4.548     Document Type: Article

References (36)

1. Abdel-Aal, E. S.-M., Hucl, P., and Sosulski, F. W. 1995. Compositional and nutritional characteristics of spring einkorn and spelt wheats. Cereal Chem. 72:621-624.
2. Abdel-Aal, E. S.-M., Hucl, P., and Sosulski, F. W. 1998. Food uses for ancient wheats. Cereal Foods World 43:763-766.
3. Anderson, O. D., and Greene, F. C. 1997. The α-gliadin gene family. II. DNA and protein sequence variation, subfamily structure, and origins of pseudogenes. Theor. Appl. Genet. 95:59-65.
4. Anderson, O. D., Litts, J. C., Gautier, M.-F., and Green, F. C. 1984. Nucleotide sequence and chromosome assignment of a wheat storage protein gene. Nucl. Acid Res. 12:8129-8144.
5. Ciclitira, P. J., Evans, D. J., Fagg, N. L. K., Lennox, E. S., and Dowling, R. H. 1984. Clinical testing of gliadins in coeliac disease. Clin. Sci. 66:357-364.
6. D'Ovidio, R., and Anderson, O. D. 1994. PCR analysis to distinguish between alleles of a member of a multigene family correlated with wheat quality. Theor. Appl. Genet. 88:759-763.
7. D'Ovidio, R., Tanzarella, O. A., and Porceddu, E. 1992. Isolation of an α-type gliadin gene from Triticum durum Desf. and genetic polymorphism at the Gli-2 loci. J. Genet. Breed. 46:41-48.
8. Dvorak, J., Luo, M.-C., Yang, Z.-L., and Zhang, H. B. 1998. The structure of the Aegilops tauschii genepool and the evolution of hexaploid wheat. Theor. Appl. Genet 97:657-670.
9. Egorev, T. A. 1988. The amino acid sequence of the fast avenin component (Avena saliva L.). J. Cereal Sec. 8:289-292.
10. Federmann, G. R., Goecke, E. U., and Steiner, A. M. 1992. Detection of adulteration of flour of spelt (Triticum spelta L.) with flour of wheat (Triticum aestivum L. emend. Fiori et Paol.) by electrophoresis. Plant Var. Seeds 5:123-125.
11. Forsell, F., and Wieser, H. 1995. Dinkel und Zöliakie. Z. Lebens. Unters. Forsch. 201:35-39.
12. Hardman, C. M., Garioch, J. J., Leonard, J. N., Thomas, J. J., Walker, M. M., Lortan J. E., Lister, A., and Fry, L. 1997. Absence of toxicity of oats in patients with dermatitis herpetiformis. N. Engl. J. Med. 337:1884-1887.
13. Harsch, S., Günther, T., Kling, C. I., Rozynek, B., and Hesemann, C. U. 1997. Characterization of spelt (Triticum spelta L.) forms by gel electrophoretic analyses of seed proteins. I. The gliadins. Theor. Appl. Genet. 94:52-60.
14. Howdle, P. D., and Losowsky, M. S. 1992. Coeliac disease in adults. Pages 49-80 in: Coeliac Disease. M. N. Marsh, ed. Blackwell Scientific: Oxford.
15. Janatuinen, E. K., Pikkarainen, P. H., Kemppainen, T. A., Kosma, V.-M., Järvinen, R. M. K., Uusitupa, I. J., and Julkunen, R. J. K. 1995. A comparison of diets with and without oats in adults with celiac disease. N. Engl. J. Med. 333:1033-1037.
16. Kagnoff, M. F., Austin, R. K., Hubert, J. J., Bernardin, J. E., and Kasarda, D. D. 1984. Possible role for a human adenovirus in the pathogenesis of celiac disease. J. Exp. Med. 160:1544-1557.
17. Kasarda, D. D. 1997 Gluten and gliadin: Precipitating factors in coeliac disease. Pages 195-212 in: Coeliac Disease: Proceedings of the 7th International Symposium on Coeliac Disease. M. Mäki, P. Collin, and J. K. Visakorpi, eds. Institute of Medical Technology: Tampere, Finland.
18. Kasarda, D. D., Okita, T. W., Bernardin, J. E., Baecker, P. A., Nimmo, C. C., Lew, E. J.-L., Dieter, M. D., and Greene, F. C. 1984. Nucleic acid (cDNA) and amino acid sequences of α-type gliadins from wheat (Triticum aestivum). Proc. Natl. Acad. Sci. USA 81:4712-4716.
19. Lafiandra, D., Benedettelli, S., Margiotta, B., and Porceddu, E. 1989. Chromosomal location of gliadin coding genes in T. aestivum ssp. spelta and evidence on the lack of components controlled by Gli-2 loci in wheat aneuploids. Theor. Appl. Genet. 78:177-183.
20. Maki, M., and Collin, P. 1997. Coeliac disease. Lancet 349:1755-1759.
21. MacKey, J. M., ed. 1966. Species relationships in Triticum. In: Proceedings of the Second Interntional Wheat Genetics Symposium. Hereditas [suppl.] vol. 2:237-275.
22. Marsh, M. N., Morgan, S., Ensari, A., Wardle, T., Lobley, R., Mills, C., and Auricchio, S. 1995. In vivo activity of peptides 31-43, 44-55, 56-68 of α-gliadin in gluten sensitive enteropathy (GSE). Gastroenterology 108:A871.
23. Marsh, M. N., Morgan, S., Moriarty, K. J., and Ensari, A. 1997. Intestinal lymphocyte responses to in vivo gluten challenge. Pages 125-137 in: Coeliac Disease: Proceedings of the 7th International Symposium on Coeliac Disease. M. Mäki, P. Collin, and J. K. Visakorpi, eds. Institute of Medical Technology: Tampere, Finland.
24. Morris, R., and Sears, E. R. 1967. The cytogenetics of wheat and its relatives. Pages 19-87 in: Wheat and Wheat Improvement. L. P. Reitz and K. S. Quisenberry, eds. Am. Soc. Agron.: Madison, WI.
25. Ranhotra, G. S., Gelroth, J. A., Glaser, B. K., and Lorenz, K. J. 1995. Baking and nutritional qualities of a spelt wheat sample. Lebensm. Wiss. Technol. 78:118-122.
26. Ranhotra, G. S., Gelroth, J. A., Glaser, B. K., and Lorenz, K. L. 1996a. Nutrient composition of spelt wheat. J. Food Comp. Anal. 9:81-84.
27. Ranhotra, G. S., Gelroth, J. A., Glaser, B. K., and Stallknecht, G. F. 1996b. Nutritional profile of three spelt wheat cultivars grown at five different locations. Cereal Chem. 73:533-535.
28. Reeves, C. D., and Okita, T. W. 1987. Analysis of α/β gliadin genes from diploid and hexaploid wheats. Gene 52:257-266.
29. Reunala, T., Collin, P., Holm, K., Pikkarainen, P., Miettinen, A., Vuolteenaho, N., and Mäki, M. 1998. Tolerance to oats in dermatitis herpetiformis. Gut 43:490-493.
30. Sambrook, J., Fritsch, E. F., and Maniatis, T. 1989. Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory Press: Cold Spring Harbor, NY.
31. Sanger, F., Nicklen. S., and Coulson, A. R. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
32. Shewry, P. R., Autran, J.-C., Nimmo, C. C., Lew, E. J.-L., and Kasarda, D. D. 1980. N-Terminal amino acid sequence homology of storage protein components from barley and a diploid wheat. Nature 286:520-522.
33. Srinivasan, U., Leonard, N., Jones, E., Kasarda, D. D., Weir, D. G., O'Farrelly, C., and Feighery, C. 1996. Absence of oats toxicity in adult celiac disease. BMJ 313:1300-1301.
34. Sturgess, R., Day, P., Ellis, H. J., Lundin, K. E. A., Gjertsen, H. A., Kontakou, M., and Ciclitira, P. J. 1994. Wheat peptide challenge in coeliac disease. Lancet 343:758-761.
35. Van de Wal, Y., Kooy, Y. M., van Veelen, P. A., Pena, S. A., Mearin, L. M., Molberg, O., Lundin, K. E. A., Sollid, L. M., Mutis, T., Benckhuijsen, W. E., Drijfhout, J. W., and Koning, F. 1998. Small intestinal T cells of celiac disease patients recognize a natural pepsin fragment of gliadin. Proc. Natl. Acad. Sci. USA 95:10050-10054.
36. Van Slageren, M. W. 1994. Wild wheats: A monograph of Aegilops L. and Amblyopyrum (Jaub. & Spach.). Eig. Wageningen Agric. Univ. Papers 94-7. Veenman Druckers: Wageningen, The Netherlands.