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Volumn 116, Issue 6, 2013, Pages 647-652

Cultured stem cells as tools for toxicological assays

Author keywords

Developmental toxicity; Embryonic stem cell; Heavy metal; Neural stem cell; Safety assessment

Indexed keywords

ALTERNATIVE ASSESSMENT; CELL CULTURE TECHNIQUES; DEVELOPMENTAL TOXICITY; EMBRYONIC STEM CELLS; ETHICAL CONSIDERATIONS; NEURAL STEM CELL; SAFETY ASSESSMENTS; TOXIC SUBSTANCES;

EID: 84886445870     PISSN: 13891723     EISSN: 13474421     Source Type: Journal    
DOI: 10.1016/j.jbiosc.2013.05.028     Document Type: Review
Times cited : (25)

References (70)
  • 4
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K., Tanabe K., Ohnuki M., Narita M., Ichisaka T., Tomoda K., Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131:861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 5
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 7
    • 0036097575 scopus 로고    scopus 로고
    • Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods
    • Brown N.A. Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods. Altern. Lab. Anim. 2002, 30:177-198.
    • (2002) Altern. Lab. Anim. , vol.30 , pp. 177-198
    • Brown, N.A.1
  • 8
    • 84859990630 scopus 로고    scopus 로고
    • Embryonic stem cells in safety pharmacology and toxicology
    • Stummann T.C., Bremer S. Embryonic stem cells in safety pharmacology and toxicology. Adv. Exp. Med. Biol. 2012, 745:14-25.
    • (2012) Adv. Exp. Med. Biol. , vol.745 , pp. 14-25
    • Stummann, T.C.1    Bremer, S.2
  • 9
    • 79959877538 scopus 로고    scopus 로고
    • The validated embryonic stem cell test to predict embryotoxicity in vitro
    • Seiler A.E., Spielmann H. The validated embryonic stem cell test to predict embryotoxicity in vitro. Nat. Protoc. 2011, 6:961-978.
    • (2011) Nat. Protoc. , vol.6 , pp. 961-978
    • Seiler, A.E.1    Spielmann, H.2
  • 10
    • 1542618024 scopus 로고    scopus 로고
    • Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test
    • Seiler A., Visan A., Buesen R., Genschow E., Spielmann H. Improvement of an in vitro stem cell assay for developmental toxicity: the use of molecular endpoints in the embryonic stem cell test. Reprod. Toxicol. 2004, 18:231-240.
    • (2004) Reprod. Toxicol. , vol.18 , pp. 231-240
    • Seiler, A.1    Visan, A.2    Buesen, R.3    Genschow, E.4    Spielmann, H.5
  • 11
    • 0034028901 scopus 로고    scopus 로고
    • Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells
    • Niwa H., Miyazaki J., Smith A.G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat. Genet. 2000, 24:372-376.
    • (2000) Nat. Genet. , vol.24 , pp. 372-376
    • Niwa, H.1    Miyazaki, J.2    Smith, A.G.3
  • 15
    • 79957777958 scopus 로고    scopus 로고
    • Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors
    • other 4 authors
    • Li W., Sun W., Zhang Y., Wei W., Ambasudhan R., Xia P., Talantova M., Lin T., Kim J., Wang X., other 4 authors Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors. Proc. Natl. Acad. Sci. USA 2011, 108:8299-8304.
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 8299-8304
    • Li, W.1    Sun, W.2    Zhang, Y.3    Wei, W.4    Ambasudhan, R.5    Xia, P.6    Talantova, M.7    Lin, T.8    Kim, J.9    Wang, X.10
  • 17
    • 0347135824 scopus 로고    scopus 로고
    • Embryonic stem cells in drug discovery
    • McNeish J. Embryonic stem cells in drug discovery. Nat. Rev. Drug Discov. 2004, 3:70-80.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 70-80
    • McNeish, J.1
  • 18
    • 76749147859 scopus 로고    scopus 로고
    • In vitro assessment of eye irritancy using the Reconstructed Human Corneal Epithelial SkinEthic (TM) HCE model: application to 435 substances from consumer products industry
    • other 7 authors
    • Cotovio J., Grandidier M.H., Lelievre D., Bremond C., Amsellem C., Maloug S., Ovigne J.M., Loisel-Joubert S., Van Der Lee A., Minondo A., other 7 authors In vitro assessment of eye irritancy using the Reconstructed Human Corneal Epithelial SkinEthic (TM) HCE model: application to 435 substances from consumer products industry. Toxicol. In Vitro 2010, 24:523-537.
    • (2010) Toxicol. In Vitro , vol.24 , pp. 523-537
    • Cotovio, J.1    Grandidier, M.H.2    Lelievre, D.3    Bremond, C.4    Amsellem, C.5    Maloug, S.6    Ovigne, J.M.7    Loisel-Joubert, S.8    Van Der Lee, A.9    Minondo, A.10
  • 19
    • 0037334199 scopus 로고    scopus 로고
    • Mercuric chloride: toxicity and apoptosis in a human oligodendroglial cell line MO3.13
    • Issa Y., Watts D.C., Duxbury A.J., Brunton P.A., Watson M.B., Waters C.M. Mercuric chloride: toxicity and apoptosis in a human oligodendroglial cell line MO3.13. Biomaterials 2003, 24:981-987.
    • (2003) Biomaterials , vol.24 , pp. 981-987
    • Issa, Y.1    Watts, D.C.2    Duxbury, A.J.3    Brunton, P.A.4    Watson, M.B.5    Waters, C.M.6
  • 20
    • 0032008208 scopus 로고    scopus 로고
    • Cytotoxicity evaluation of 43 metal salts using murine fibroblasts and osteoblastic cells
    • Yamamoto A., Honma R., Sumita M. Cytotoxicity evaluation of 43 metal salts using murine fibroblasts and osteoblastic cells. J.Biomed. Mater. Res. 1998, 39:331-340.
    • (1998) J.Biomed. Mater. Res. , vol.39 , pp. 331-340
    • Yamamoto, A.1    Honma, R.2    Sumita, M.3
  • 22
    • 84857686988 scopus 로고    scopus 로고
    • Caco-2 cells cytotoxicity of nifuroxazide derivatives with potential activity against methicillin-resistant Staphylococcus aureus (MRSA)
    • Fernandes M.B., Goncalves J.E., Scotti M.T., de Oliveira A.A., Tavares L.C., Storpirtis S. Caco-2 cells cytotoxicity of nifuroxazide derivatives with potential activity against methicillin-resistant Staphylococcus aureus (MRSA). Toxicol. In Vitro 2012, 26:535-540.
    • (2012) Toxicol. In Vitro , vol.26 , pp. 535-540
    • Fernandes, M.B.1    Goncalves, J.E.2    Scotti, M.T.3    de Oliveira, A.A.4    Tavares, L.C.5    Storpirtis, S.6
  • 24
    • 82655173939 scopus 로고    scopus 로고
    • Evaluation of the use of human mesenchymal stem cells for acute toxicity tests
    • Scanu M., Mancuso L., Cao G. Evaluation of the use of human mesenchymal stem cells for acute toxicity tests. Toxicol. In Vitro 2011, 25:1989-1995.
    • (2011) Toxicol. In Vitro , vol.25 , pp. 1989-1995
    • Scanu, M.1    Mancuso, L.2    Cao, G.3
  • 25
    • 60249094665 scopus 로고    scopus 로고
    • Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells
    • Stummann T.C., Hareng L., Bremer S. Hazard assessment of methylmercury toxicity to neuronal induction in embryogenesis using human embryonic stem cells. Toxicology 2009, 257:117-126.
    • (2009) Toxicology , vol.257 , pp. 117-126
    • Stummann, T.C.1    Hareng, L.2    Bremer, S.3
  • 27
    • 44749089769 scopus 로고    scopus 로고
    • Successful validation of in vitro methods in toxicology by ZEBET, the National Centre for Alternatives in Germany at the BfR (Federal Institute for Risk Assessment)
    • Spielmann H., Grune B., Liebsch M., Seiler A., Vogel R. Successful validation of in vitro methods in toxicology by ZEBET, the National Centre for Alternatives in Germany at the BfR (Federal Institute for Risk Assessment). Exp. Toxicol. Pathol. 2008, 60:225-233.
    • (2008) Exp. Toxicol. Pathol. , vol.60 , pp. 225-233
    • Spielmann, H.1    Grune, B.2    Liebsch, M.3    Seiler, A.4    Vogel, R.5
  • 29
    • 34548846408 scopus 로고    scopus 로고
    • Effects of anti-inflammatory drugs on proliferation, cytotoxicity and osteogenesis in bone marrow mesenchymal stem cells
    • Chang J.K., Li C.J., Wu S.C., Yeh C.H., Chen C.H., Fu Y.C., Wang G.J., Ho M.L. Effects of anti-inflammatory drugs on proliferation, cytotoxicity and osteogenesis in bone marrow mesenchymal stem cells. Biochem. Pharmacol. 2007, 74:1371-1382.
    • (2007) Biochem. Pharmacol. , vol.74 , pp. 1371-1382
    • Chang, J.K.1    Li, C.J.2    Wu, S.C.3    Yeh, C.H.4    Chen, C.H.5    Fu, Y.C.6    Wang, G.J.7    Ho, M.L.8
  • 34
    • 33644956003 scopus 로고    scopus 로고
    • High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation
    • Tamm C., Duckworth J., Hermanson O., Ceccatelli S. High susceptibility of neural stem cells to methylmercury toxicity: effects on cell survival and neuronal differentiation. J.Neurochem. 2006, 97:69-78.
    • (2006) J.Neurochem. , vol.97 , pp. 69-78
    • Tamm, C.1    Duckworth, J.2    Hermanson, O.3    Ceccatelli, S.4
  • 35
    • 84863835842 scopus 로고    scopus 로고
    • Automated neurosphere sorting and plating by the COPAS large particle sorter is a suitable method for high-throughput 3D in vitro applications
    • Gassmann K., Baumann J., Giersiefer S., Schuwald J., Schreiber T., Merk H.F., Fritsche E. Automated neurosphere sorting and plating by the COPAS large particle sorter is a suitable method for high-throughput 3D in vitro applications. Toxicol. In Vitro 2012, 26:993-1000.
    • (2012) Toxicol. In Vitro , vol.26 , pp. 993-1000
    • Gassmann, K.1    Baumann, J.2    Giersiefer, S.3    Schuwald, J.4    Schreiber, T.5    Merk, H.F.6    Fritsche, E.7
  • 36
    • 36148976121 scopus 로고    scopus 로고
    • Embryotoxicity hazard assessment of methylmercury and chromium using embryonic stem cells
    • Stummann T.C., Hareng L., Bremer S. Embryotoxicity hazard assessment of methylmercury and chromium using embryonic stem cells. Toxicology 2007, 242:130-143.
    • (2007) Toxicology , vol.242 , pp. 130-143
    • Stummann, T.C.1    Hareng, L.2    Bremer, S.3
  • 37
    • 53449100719 scopus 로고    scopus 로고
    • Embryotoxicity hazard assessment of cadmium and arsenic compounds using embryonic stem cells
    • Stummann T.C., Hareng L., Bremer S. Embryotoxicity hazard assessment of cadmium and arsenic compounds using embryonic stem cells. Toxicology 2008, 252:118-122.
    • (2008) Toxicology , vol.252 , pp. 118-122
    • Stummann, T.C.1    Hareng, L.2    Bremer, S.3
  • 38
    • 79957868414 scopus 로고    scopus 로고
    • Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure
    • Zimmer B., Schildknecht S., Kuegler P.B., Tanavde V., Kadereit S., Leist M. Sensitivity of dopaminergic neuron differentiation from stem cells to chronic low-dose methylmercury exposure. Toxicol. Sci. 2011, 121:357-367.
    • (2011) Toxicol. Sci. , vol.121 , pp. 357-367
    • Zimmer, B.1    Schildknecht, S.2    Kuegler, P.B.3    Tanavde, V.4    Kadereit, S.5    Leist, M.6
  • 40
    • 18844446770 scopus 로고    scopus 로고
    • Toxicity testing: creating a revolution based on new technologies
    • Bhogal N., Grindon C., Combes R., Balls M. Toxicity testing: creating a revolution based on new technologies. Trends Biotechnol. 2005, 23:299-307.
    • (2005) Trends Biotechnol. , vol.23 , pp. 299-307
    • Bhogal, N.1    Grindon, C.2    Combes, R.3    Balls, M.4
  • 41
    • 79952080601 scopus 로고    scopus 로고
    • Stem cells in toxicology: fundamental biology and practical considerations
    • Kang K.S., Trosko J.E. Stem cells in toxicology: fundamental biology and practical considerations. Toxicol. Sci. 2011, 120:S269-S289.
    • (2011) Toxicol. Sci. , vol.120
    • Kang, K.S.1    Trosko, J.E.2
  • 42
    • 77950023356 scopus 로고    scopus 로고
    • Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment
    • Trosko J.E., Chang C.C. Factors to consider in the use of stem cells for pharmaceutic drug development and for chemical safety assessment. Toxicology 2010, 270:18-34.
    • (2010) Toxicology , vol.270 , pp. 18-34
    • Trosko, J.E.1    Chang, C.C.2
  • 43
    • 84863852417 scopus 로고    scopus 로고
    • Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn)
    • Theunissen P.T., Robinson J.F., Pennings J.L., van Herwijnen M.H., Kleinjans J.C., Piersma A.H. Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn). Toxicol. Appl. Pharmacol. 2012, 262:330-340.
    • (2012) Toxicol. Appl. Pharmacol. , vol.262 , pp. 330-340
    • Theunissen, P.T.1    Robinson, J.F.2    Pennings, J.L.3    van Herwijnen, M.H.4    Kleinjans, J.C.5    Piersma, A.H.6
  • 46
    • 77950994754 scopus 로고    scopus 로고
    • Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells
    • Duan Y., Ma X., Zou W., Wang C., Bahbahan I.S., Ahuja T.P., Tolstikov V., Zern M.A. Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells. Stem Cells 2010, 28:674-686.
    • (2010) Stem Cells , vol.28 , pp. 674-686
    • Duan, Y.1    Ma, X.2    Zou, W.3    Wang, C.4    Bahbahan, I.S.5    Ahuja, T.P.6    Tolstikov, V.7    Zern, M.A.8
  • 48
    • 84856485520 scopus 로고    scopus 로고
    • Anovel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval
    • Yamazaki K., Hihara T., Taniguchi T., Kohmura N., Yoshinaga T., Ito M., Sawada K. Anovel method of selecting human embryonic stem cell-derived cardiomyocyte clusters for assessment of potential to influence QT interval. Toxicol. In Vitro 2012, 26:335-342.
    • (2012) Toxicol. In Vitro , vol.26 , pp. 335-342
    • Yamazaki, K.1    Hihara, T.2    Taniguchi, T.3    Kohmura, N.4    Yoshinaga, T.5    Ito, M.6    Sawada, K.7
  • 51
    • 78951483473 scopus 로고    scopus 로고
    • Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons
    • Hogberg H.T., Sobanski T., Novellino A., Whelan M., Weiss D.G., Bal-Price A.K. Application of micro-electrode arrays (MEAs) as an emerging technology for developmental neurotoxicity: evaluation of domoic acid-induced effects in primary cultures of rat cortical neurons. Neurotoxicology 2011, 32:158-168.
    • (2011) Neurotoxicology , vol.32 , pp. 158-168
    • Hogberg, H.T.1    Sobanski, T.2    Novellino, A.3    Whelan, M.4    Weiss, D.G.5    Bal-Price, A.K.6
  • 52
    • 33845424655 scopus 로고    scopus 로고
    • Developmental neurotoxicity of industrial chemicals
    • Grandjean P., Landrigan P.J. Developmental neurotoxicity of industrial chemicals. Lancet 2006, 368:2167-2178.
    • (2006) Lancet , vol.368 , pp. 2167-2178
    • Grandjean, P.1    Landrigan, P.J.2
  • 53
    • 3242774357 scopus 로고    scopus 로고
    • Hazards of heavy metal contamination
    • Jarup L. Hazards of heavy metal contamination. Br. Med. Bull. 2003, 68:167-182.
    • (2003) Br. Med. Bull. , vol.68 , pp. 167-182
    • Jarup, L.1
  • 54
    • 57649149292 scopus 로고    scopus 로고
    • Lead in housing paints: an exposure source still not taken seriously for children lead poisoning in China
    • Lin G.Z., Peng R.F., Chen Q., Wu Z.G., Du L. Lead in housing paints: an exposure source still not taken seriously for children lead poisoning in China. Environ. Res. 2009, 109:1-5.
    • (2009) Environ. Res. , vol.109 , pp. 1-5
    • Lin, G.Z.1    Peng, R.F.2    Chen, Q.3    Wu, Z.G.4    Du, L.5
  • 55
    • 33846445663 scopus 로고    scopus 로고
    • Occupational and environmental human lead exposure in Brazil
    • Paoliello M.M., De Capitani E.M. Occupational and environmental human lead exposure in Brazil. Environ. Res. 2007, 103:288-297.
    • (2007) Environ. Res. , vol.103 , pp. 288-297
    • Paoliello, M.M.1    De Capitani, E.M.2
  • 57
    • 84855348327 scopus 로고    scopus 로고
    • When nano meets stem: the impact of nanotechnology in stem cell biology
    • Kaur S., Singhal B. When nano meets stem: the impact of nanotechnology in stem cell biology. J.Biosci. Bioeng. 2012, 113:1-4.
    • (2012) J.Biosci. Bioeng. , vol.113 , pp. 1-4
    • Kaur, S.1    Singhal, B.2
  • 58
    • 78650991303 scopus 로고    scopus 로고
    • Embryoid body culture of mouse embryonic stem cells using microwell and micropatterned chips
    • Sakai Y., Yoshiura Y., Nakazawa K. Embryoid body culture of mouse embryonic stem cells using microwell and micropatterned chips. J.Biosci. Bioeng. 2011, 111:85-91.
    • (2011) J.Biosci. Bioeng. , vol.111 , pp. 85-91
    • Sakai, Y.1    Yoshiura, Y.2    Nakazawa, K.3
  • 60
    • 35648967590 scopus 로고    scopus 로고
    • Application of multiple parallel perfused microbioreactors and three-dimensional stem cell culture for toxicity testing
    • Cui Z.F., Xu X., Trainor N., Triffitt J.T., Urban J.P., Tirlapur U.K. Application of multiple parallel perfused microbioreactors and three-dimensional stem cell culture for toxicity testing. Toxicol. In Vitro 2007, 21:1318-1324.
    • (2007) Toxicol. In Vitro , vol.21 , pp. 1318-1324
    • Cui, Z.F.1    Xu, X.2    Trainor, N.3    Triffitt, J.T.4    Urban, J.P.5    Tirlapur, U.K.6
  • 61
    • 70449403280 scopus 로고    scopus 로고
    • Preparation of coculture system with three extracellular matrices using capillary force lithography and layer-by-layer deposition
    • Takahashi S., Yamazoe H., Sassa F., Suzuki H., Fukuda J. Preparation of coculture system with three extracellular matrices using capillary force lithography and layer-by-layer deposition. J.Biosci. Bioeng. 2009, 108:544-550.
    • (2009) J.Biosci. Bioeng. , vol.108 , pp. 544-550
    • Takahashi, S.1    Yamazoe, H.2    Sassa, F.3    Suzuki, H.4    Fukuda, J.5
  • 62
    • 77954310208 scopus 로고    scopus 로고
    • Cell micropatterning inside a microchannel and assays under a stable concentration gradient
    • Okuyama T., Yamazoe H., Seto Y., Suzuki H., Fukuda J. Cell micropatterning inside a microchannel and assays under a stable concentration gradient. J.Biosci. Bioeng. 2010, 110:230-237.
    • (2010) J.Biosci. Bioeng. , vol.110 , pp. 230-237
    • Okuyama, T.1    Yamazoe, H.2    Seto, Y.3    Suzuki, H.4    Fukuda, J.5
  • 65
    • 79951678616 scopus 로고    scopus 로고
    • Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing
    • Zimmer B., Kuegler P.B., Baudis B., Genewsky A., Tanavde V., Koh W., Tan B., Waldmann T., Kadereit S., Leist M. Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. Cell Death Differ. 2011, 18:383-395.
    • (2011) Cell Death Differ. , vol.18 , pp. 383-395
    • Zimmer, B.1    Kuegler, P.B.2    Baudis, B.3    Genewsky, A.4    Tanavde, V.5    Koh, W.6    Tan, B.7    Waldmann, T.8    Kadereit, S.9    Leist, M.10
  • 66
    • 36048959586 scopus 로고    scopus 로고
    • An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds
    • Festag M., Viertel B., Steinberg P., Sehner C. An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. II. Testing of compounds. Toxicol. In Vitro 2007, 21:1631-1640.
    • (2007) Toxicol. In Vitro , vol.21 , pp. 1631-1640
    • Festag, M.1    Viertel, B.2    Steinberg, P.3    Sehner, C.4
  • 67
    • 36049005950 scopus 로고    scopus 로고
    • An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. I: establishment of the differentiation protocol
    • Festag M., Sehner C., Steinberg P., Viertel B. An in vitro embryotoxicity assay based on the disturbance of the differentiation of murine embryonic stem cells into endothelial cells. I: establishment of the differentiation protocol. Toxicol. In Vitro 2007, 21:1619-1630.
    • (2007) Toxicol. In Vitro , vol.21 , pp. 1619-1630
    • Festag, M.1    Sehner, C.2    Steinberg, P.3    Viertel, B.4
  • 68
    • 34447558368 scopus 로고    scopus 로고
    • Neural precursor cell influences on blood-brain barrier characteristics in rat brain endothelial cells
    • Lim J.C., Wolpaw A.J., Caldwell M.A., Hladky S.B., Barrand M.A. Neural precursor cell influences on blood-brain barrier characteristics in rat brain endothelial cells. Brain Res. 2007, 1159:67-76.
    • (2007) Brain Res. , vol.1159 , pp. 67-76
    • Lim, J.C.1    Wolpaw, A.J.2    Caldwell, M.A.3    Hladky, S.B.4    Barrand, M.A.5
  • 70
    • 84861200262 scopus 로고    scopus 로고
    • The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk
    • Kumar K.K., Aboud A.A., Bowman A.B. The potential of induced pluripotent stem cells as a translational model for neurotoxicological risk. Neurotoxicology 2012, 33:518-529.
    • (2012) Neurotoxicology , vol.33 , pp. 518-529
    • Kumar, K.K.1    Aboud, A.A.2    Bowman, A.B.3


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