Compound-specific effects of diverse neurodevelopmental toxicants on global gene expression in the neural embryonic stem cell test (ESTn)

Toxicology and Applied Pharmacology

Volumn 262, Issue 3, 2012, Pages 330-340

  Theunissen, P T ^a,b   Robinson, J F ^a,b,c   Pennings, J L A ^a,c   van Herwijnen, M H ^b   Kleinjans, J C S ^b,c   Piersma, A H ^a,c,d  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c Netherlands Toxicogenomics Centre   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Adverse and adaptive responses; Alternative test method; Embryonic stem cells; Neural differentiation; Neural embryonic stem cell test (ESTn); Toxicogenomics

Indexed keywords

ACETALDEHYDE; CARBAMAZEPINE; FLUSILAZOLE; PENICILLIN G; PHENYTOIN; PHTHALIC ACID; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; CYTOTOXICITY; DEVELOPMENTAL TOXICITY; EMBRYONIC STEM CELL; GENE CONTROL; GENE EXPRESSION; GENETIC ASSOCIATION; IN VITRO STUDY; MORPHOGENESIS; MOUSE; NERVE CELL DIFFERENTIATION; NEUROTOXICITY; NONHUMAN; WNT SIGNALING PATHWAY;

ACETALDEHYDE; ANIMALS; CARBAMAZEPINE; DIETHYLHEXYL PHTHALATE; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MICE; NEURAL STEM CELLS; NEURITES; PENICILLIN G; PHENYTOIN; SILANES; TOXICITY TESTS; TRIAZOLES;

ANIMALIA; MURINAE;

EID: 84863852417     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2012.05.011     Document Type: Article

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