메뉴 건너뛰기




Volumn 10, Issue 4, 2013, Pages 709-721

Epigenetics of Alzheimer's Disease and Frontotemporal Dementia

Author keywords

Alzheimer's disease; Epigenetic drugs; Epigenetics; Frontotemporal dementia; Neurodegeneration; Therapy

Indexed keywords

UNTRANSLATED RNA;

EID: 84886304753     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-013-0219-0     Document Type: Review
Times cited : (29)

References (155)
  • 1
    • 79956142378 scopus 로고    scopus 로고
    • The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    • McKhann GM, Knopman DS, Chertkow H, et al. The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011;7: 263-269.
    • (2011) Alzheimers Dement , vol.7 , pp. 263-269
    • McKhann, G.M.1    Knopman, D.S.2    Chertkow, H.3
  • 3
    • 78751657715 scopus 로고    scopus 로고
    • Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States
    • Rocca WA, Petersen RC, Knopman DS, et al. Trends in the incidence and prevalence of Alzheimer's disease, dementia, and cognitive impairment in the United States. Alzheimers Dement 2011;7: 80-93.
    • (2011) Alzheimers Dement , vol.7 , pp. 80-93
    • Rocca, W.A.1    Petersen, R.C.2    Knopman, D.S.3
  • 5
    • 84875367680 scopus 로고    scopus 로고
    • Frontotemporal degeneration, the next therapeutic frontier: Molecules and animal models for frontotemporal degeneration drug development
    • Boxer AL, Gold M, Huey E, et al. Frontotemporal degeneration, the next therapeutic frontier: Molecules and animal models for frontotemporal degeneration drug development. Alzheimers Dement 2012;9: 188-176.
    • (2012) Alzheimers Dement , vol.9 , pp. 176-188
    • Boxer, A.L.1    Gold, M.2    Huey, E.3
  • 6
    • 0142116386 scopus 로고    scopus 로고
    • Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies
    • Klucken J, McLean PJ, Gomez-Tortosa E, Ingelsson M, Hyman BT. Neuritic alterations and neural system dysfunction in Alzheimer's disease and dementia with Lewy bodies. Neurochem Res 2003;28: 1683-1691.
    • (2003) Neurochem Res , vol.28 , pp. 1683-1691
    • Klucken, J.1    McLean, P.J.2    Gomez-Tortosa, E.3    Ingelsson, M.4    Hyman, B.T.5
  • 7
    • 4344630985 scopus 로고    scopus 로고
    • BACE1: the beta-secretase enzyme in Alzheimer's disease
    • Vassar R. BACE1: the beta-secretase enzyme in Alzheimer's disease. J Mol Neurosci 2004;23: 105-114.
    • (2004) J Mol Neurosci , vol.23 , pp. 105-114
    • Vassar, R.1
  • 8
    • 0034233455 scopus 로고    scopus 로고
    • Role of presenilin in gamma-secretase cleavage of amyloid precursor protein
    • Xia W. Role of presenilin in gamma-secretase cleavage of amyloid precursor protein. Exp Gerontol 2000;35: 453-460.
    • (2000) Exp Gerontol , vol.35 , pp. 453-460
    • Xia, W.1
  • 9
    • 33645105621 scopus 로고    scopus 로고
    • Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms
    • Bentahir M, Nyabi O, Verhamme J, et al. Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms. J Neurochem 2006;96: 732-742.
    • (2006) J Neurochem , vol.96 , pp. 732-742
    • Bentahir, M.1    Nyabi, O.2    Verhamme, J.3
  • 10
    • 34548812551 scopus 로고    scopus 로고
    • The role of amyloid beta peptide 42 in Alzheimer's disease
    • Findeis MA. The role of amyloid beta peptide 42 in Alzheimer's disease. Pharmacol Ther 2007;116: 266-286.
    • (2007) Pharmacol Ther , vol.116 , pp. 266-286
    • Findeis, M.A.1
  • 11
    • 84988044300 scopus 로고    scopus 로고
    • TREM2 and Alzheimer's disease
    • Niemitz E. TREM2 and Alzheimer's disease. Nat Genet 2012;45: 11-11.
    • (2012) Nat Genet , vol.45 , pp. 11
    • Niemitz, E.1
  • 12
    • 79951722994 scopus 로고    scopus 로고
    • Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE epsilon 4 allele
    • van Der Flier WM, Pijnenburg YA, Fox NC, Scheltens P. Early-onset versus late-onset Alzheimer's disease: the case of the missing APOE epsilon 4 allele. Lancet 2011;10: 280-288.
    • (2011) Lancet , vol.10 , pp. 280-288
    • van Der Flier, W.M.1    Pijnenburg, Y.A.2    Fox, N.C.3    Scheltens, P.4
  • 13
    • 0033358671 scopus 로고    scopus 로고
    • Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum
    • Campion D, Dumanchin C, Hannequin D, et al. Early-onset autosomal dominant Alzheimer disease: prevalence, genetic heterogeneity, and mutation spectrum. Am J Hum Genet 1999;65: 664-670.
    • (1999) Am J Hum Genet , vol.65 , pp. 664-670
    • Campion, D.1    Dumanchin, C.2    Hannequin, D.3
  • 14
    • 34547669095 scopus 로고    scopus 로고
    • Genetic heterogeneity of Alzheimer's disease: complexity and advances
    • Lambert J-C, Amouyel P. Genetic heterogeneity of Alzheimer's disease: complexity and advances. Psychoneuroendocrinology 2007;32(Suppl. 1): S62-70.
    • (2007) Psychoneuroendocrinology , vol.32 , Issue.SUPPL. 1
    • Lambert, J.-C.1    Amouyel, P.2
  • 15
    • 0021882237 scopus 로고
    • Heterogeneity in dementia of the Alzheimer type: Evidence of subgroups
    • Mayeux R, Stern Y, Spanton S. Heterogeneity in dementia of the Alzheimer type: Evidence of subgroups. Neurology 1985;35: 453-453.
    • (1985) Neurology , vol.35 , pp. 453
    • Mayeux, R.1    Stern, Y.2    Spanton, S.3
  • 16
    • 0041318900 scopus 로고    scopus 로고
    • Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers
    • Gold G, Blouin J-L, Herrmann FR, et al. Specific BACE1 genotypes provide additional risk for late-onset Alzheimer disease in APOE epsilon 4 carriers. Am J Med Genet B Neuropsychiatr Genet 2003;119B: 44-47.
    • (2003) Am J Med Genet B Neuropsychiatr Genet , vol.119 B , pp. 44-47
    • Gold, G.1    Blouin, J.-L.2    Herrmann, F.R.3
  • 17
    • 79952823979 scopus 로고    scopus 로고
    • Classification of primary progressive aphasia and its variants
    • Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants. Neurology 2011;76: 1006-1014.
    • (2011) Neurology , vol.76 , pp. 1006-1014
    • Gorno-Tempini, M.L.1    Hillis, A.E.2    Weintraub, S.3
  • 19
    • 84858622829 scopus 로고    scopus 로고
    • Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study
    • Majounie E, Renton AE, Mok K, et al. Frequency of the C9orf72 hexanucleotide repeat expansion in patients with amyotrophic lateral sclerosis and frontotemporal dementia: a cross-sectional study. Lancet Neurol 2012;11: 323-330.
    • (2012) Lancet Neurol , vol.11 , pp. 323-330
    • Majounie, E.1    Renton, A.E.2    Mok, K.3
  • 23
    • 84864981763 scopus 로고    scopus 로고
    • Recent advances in the molecular basis of frontotemporal dementia
    • Rademakers R, Mackenzie IRA. Recent advances in the molecular basis of frontotemporal dementia. Nat Rev Neurol 2013;8: 423-434.
    • (2013) Nat Rev Neurol , vol.8 , pp. 423-434
    • Rademakers, R.1    Mackenzie, I.R.A.2
  • 24
    • 81855172495 scopus 로고    scopus 로고
    • Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation
    • Ambegaokar SS, Jackson GR. Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation. Hum Mol Genet 2011;20: 4947-4977.
    • (2011) Hum Mol Genet , vol.20 , pp. 4947-4977
    • Ambegaokar, S.S.1    Jackson, G.R.2
  • 25
    • 69349098474 scopus 로고    scopus 로고
    • Epigenetics: definition, mechanisms and clinical perspective
    • Dupont C, Armant DR, Brenner CA. Epigenetics: definition, mechanisms and clinical perspective. Semin Reprod Med 2009;27: 351-357.
    • (2009) Semin Reprod Med , vol.27 , pp. 351-357
    • Dupont, C.1    Armant, D.R.2    Brenner, C.A.3
  • 26
    • 0014668932 scopus 로고
    • DNA Ticketing theory of memory
    • Griffith JS, Mahler HR. DNA Ticketing theory of memory. Nature 1969;223: 580-582.
    • (1969) Nature , vol.223 , pp. 580-582
    • Griffith, J.S.1    Mahler, H.R.2
  • 27
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T. Chromatin modifications and their function. Cell 2007;128: 693-705.
    • (2007) Cell , vol.128 , pp. 693-705
    • Kouzarides, T.1
  • 28
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl BD, Allis CD. The language of covalent histone modifications. Nature 2000;403: 41-45.
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 29
    • 84860371870 scopus 로고    scopus 로고
    • Combinatorial complexity in chromatin structure and function: revisiting the histone code
    • Rando OJ. Combinatorial complexity in chromatin structure and function: revisiting the histone code. Curr Opin Genet Develop 2012;22: 148-155.
    • (2012) Curr Opin Genet Develop , vol.22 , pp. 148-155
    • Rando, O.J.1
  • 30
    • 84861665777 scopus 로고    scopus 로고
    • Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain
    • Tweedie-Cullen RY, Brunner AM, Grossmann J, et al. Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain. PloS One 2012;7: e36980.
    • (2012) PloS One , vol.7
    • Tweedie-Cullen, R.Y.1    Brunner, A.M.2    Grossmann, J.3
  • 31
    • 40649111338 scopus 로고    scopus 로고
    • Non-coding RNAs, epigenetics and complexity
    • Costa FF. Non-coding RNAs, epigenetics and complexity. Gene 2008;410: 9-17.
    • (2008) Gene , vol.410 , pp. 9-17
    • Costa, F.F.1
  • 32
    • 84871218168 scopus 로고    scopus 로고
    • Epigenetics and developmental plasticity across species
    • Champagne FA. Epigenetics and developmental plasticity across species. Develop Psychobiol 2013;55: 33-41.
    • (2013) Develop Psychobiol , vol.55 , pp. 33-41
    • Champagne, F.A.1
  • 33
    • 0032960181 scopus 로고    scopus 로고
    • Cancer epigenetics comes of age
    • Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet 1999;21: 163-167.
    • (1999) Nat Genet , vol.21 , pp. 163-167
    • Jones, P.A.1    Laird, P.W.2
  • 34
    • 32544431582 scopus 로고    scopus 로고
    • Epigenetics and human disease: translating basic biology into clinical applications
    • Rodenhiser D, Mann M. Epigenetics and human disease: translating basic biology into clinical applications. CMAJ 2006;174: 341-348.
    • (2006) Cmaj , vol.174 , pp. 341-348
    • Rodenhiser, D.1    Mann, M.2
  • 36
    • 77952168294 scopus 로고    scopus 로고
    • Altered histone acetylation is associated with age-dependent memory impairment in mice
    • Peleg S, Sananbenesi F, Zovoilis A, et al. (2010). Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 328: 753-756.
    • (2010) Science , vol.328 , pp. 753-756
    • Peleg, S.1    Sananbenesi, F.2    Zovoilis, A.3
  • 37
    • 77649336633 scopus 로고    scopus 로고
    • Epigenetics and aging
    • Rando TA. Epigenetics and aging. Exp Gerontol 2010;45: 253-254.
    • (2010) Exp Gerontol , vol.45 , pp. 253-254
    • Rando, T.A.1
  • 38
    • 2942705826 scopus 로고    scopus 로고
    • Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration
    • Alarcón JM, Malleret G, Touzani K, et al. Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. Neuron 2004;42: 947-959.
    • (2004) Neuron , vol.42 , pp. 947-959
    • Alarcón, J.M.1    Malleret, G.2    Touzani, K.3
  • 39
    • 58149347147 scopus 로고    scopus 로고
    • Epigenetics in the nervous system
    • Jiang Y, Langley B, Lubin FD, et al. Epigenetics in the nervous system. J Neurosci 2008;28: 11753-11759.
    • (2008) J Neurosci , vol.28 , pp. 11753-11759
    • Jiang, Y.1    Langley, B.2    Lubin, F.D.3
  • 40
    • 13244276460 scopus 로고    scopus 로고
    • Epigenetic mechanisms in memory formation
    • Levenson JM, Sweatt JD. Epigenetic mechanisms in memory formation. Nat Rev Neurosci 2005;6: 108-118.
    • (2005) Nat Rev Neurosci , vol.6 , pp. 108-118
    • Levenson, J.M.1    Sweatt, J.D.2
  • 41
    • 27544454705 scopus 로고    scopus 로고
    • Chromatin remodeling in neural development and plasticity
    • Hsieh J, Gage FH. Chromatin remodeling in neural development and plasticity. Curr Opin Cell Biol 2005;17: 664-671.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 664-671
    • Hsieh, J.1    Gage, F.H.2
  • 42
    • 77952678006 scopus 로고    scopus 로고
    • Epigenetic control of neural precursor cell fate during development
    • Hirabayashi Y, Gotoh Y. Epigenetic control of neural precursor cell fate during development. Nat Rev Neurosci 2010;11: 377-388.
    • (2010) Nat Rev Neurosci , vol.11 , pp. 377-388
    • Hirabayashi, Y.1    Gotoh, Y.2
  • 43
    • 84857062545 scopus 로고    scopus 로고
    • DNA methylation signatures in development and aging of the human prefrontal cortex
    • Numata S, Ye T, Hyde TM, et al. DNA methylation signatures in development and aging of the human prefrontal cortex. Am J Hum Genet 2012;90: 260-272.
    • (2012) Am J Hum Genet , vol.90 , pp. 260-272
    • Numata, S.1    Ye, T.2    Hyde, T.M.3
  • 44
    • 41149090082 scopus 로고    scopus 로고
    • DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons
    • Siegmund KD, Connor CM, Campan M, et al. DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons. PloS One 2007;2: e895.
    • (2007) PloS One , vol.2
    • Siegmund, K.D.1    Connor, C.M.2    Campan, M.3
  • 45
    • 82255192294 scopus 로고    scopus 로고
    • 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging
    • Szulwach KE, Li X, Li Y, et al. 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging. Nat Neurosci 2011;14: 1607-1616.
    • (2011) Nat Neurosci , vol.14 , pp. 1607-1616
    • Szulwach, K.E.1    Li, X.2    Li, Y.3
  • 46
    • 79960276209 scopus 로고    scopus 로고
    • Balancing histone methylation activities in psychiatric disorders
    • Peter CJ, Akbarian S. Balancing histone methylation activities in psychiatric disorders. Trends Mol Med 2011;17: 372-379.
    • (2011) Trends Mol Med , vol.17 , pp. 372-379
    • Peter, C.J.1    Akbarian, S.2
  • 48
    • 0034596477 scopus 로고    scopus 로고
    • Somatic mutation in MECP2 as a non-fatal neurodevelopmental disorder in males
    • Clayton-Smith J, Watson P, Ramsden S, Black G. Somatic mutation in MECP2 as a non-fatal neurodevelopmental disorder in males. Lancet 2000;356: 830-832.
    • (2000) Lancet , vol.356 , pp. 830-832
    • Clayton-Smith, J.1    Watson, P.2    Ramsden, S.3    Black, G.4
  • 49
    • 0033804436 scopus 로고    scopus 로고
    • A mutation in the rett syndrome gene, MECP2, causes X-linked mental retardation and progressive spasticity in males
    • Meloni I, Bruttini M, Longo I, et al. A mutation in the rett syndrome gene, MECP2, causes X-linked mental retardation and progressive spasticity in males. Am J Hum Genet 2000;67: 982-985.
    • (2000) Am J Hum Genet , vol.67 , pp. 982-985
    • Meloni, I.1    Bruttini, M.2    Longo, I.3
  • 50
    • 79957623760 scopus 로고    scopus 로고
    • Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss
    • Klein CJ, Botuyan M-V, Wu Y, et al. Mutations in DNMT1 cause hereditary sensory neuropathy with dementia and hearing loss. Nat Genet 2011;43: 595-600.
    • (2011) Nat Genet , vol.43 , pp. 595-600
    • Klein, C.J.1    Botuyan, M.-V.2    Wu, Y.3
  • 51
    • 79958846467 scopus 로고    scopus 로고
    • Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2
    • De Greef JC, Wang J, Balog J, et al. Mutations in ZBTB24 are associated with immunodeficiency, centromeric instability, and facial anomalies syndrome type 2. Am J Hum Genet 2011;88: 796-804.
    • (2011) Am J Hum Genet , vol.88 , pp. 796-804
    • De Greef, J.C.1    Wang, J.2    Balog, J.3
  • 52
    • 0033547330 scopus 로고    scopus 로고
    • Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene
    • Xu GL, Bestor TH, Bourc'his D, et al. Chromosome instability and immunodeficiency syndrome caused by mutations in a DNA methyltransferase gene. Nature 1999;402: 187-191.
    • (1999) Nature , vol.402 , pp. 187-191
    • Xu, G.L.1    Bestor, T.H.2    Bourc'his, D.3
  • 53
    • 80051908751 scopus 로고    scopus 로고
    • A role for repressive histone methylation in cocaine-induced vulnerability to stress
    • Covington HE, Maze I, Sun H, et al. A role for repressive histone methylation in cocaine-induced vulnerability to stress. Neuron 2011;71: 656-670.
    • (2011) Neuron , vol.71 , pp. 656-670
    • Covington, H.E.1    Maze, I.2    Sun, H.3
  • 54
    • 63649125648 scopus 로고    scopus 로고
    • Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
    • Lim DA, Huang Y-C, Swigut T, et al. Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells. Nature 2009;458: 529-533.
    • (2009) Nature , vol.458 , pp. 529-533
    • Lim, D.A.1    Huang, Y.-C.2    Swigut, T.3
  • 55
    • 77957680712 scopus 로고    scopus 로고
    • Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex
    • Pereira JD, Sansom SN, Smith J, Dobenecker M-W, Tarakhovsky A, Livesey FJ. Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex. Proc Natl Acad Sci U S A 2010;107: 15957-15962.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 15957-15962
    • Pereira, J.D.1    Sansom, S.N.2    Smith, J.3    Dobenecker, M.-W.4    Tarakhovsky, A.5    Livesey, F.J.6
  • 56
    • 38849159213 scopus 로고    scopus 로고
    • A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD)
    • Adegbola A, Gao H, Sommer S, Browning M. A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD). Am J Med Genet A 2008;146A: 505-511.
    • (2008) Am J Med Genet A , vol.146 A , pp. 505-511
    • Adegbola, A.1    Gao, H.2    Sommer, S.3    Browning, M.4
  • 57
    • 51849102077 scopus 로고    scopus 로고
    • The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment
    • Burgold T, Spreafico F, De Santa F, et al. The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment. PloS One 2008;3: e3034.
    • (2008) PloS One , vol.3
    • Burgold, T.1    Spreafico, F.2    De Santa, F.3
  • 58
    • 34249900454 scopus 로고    scopus 로고
    • The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation
    • Tahiliani M, Mei P, Fang R, et al. The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation. Nature 2007;447: 601-605.
    • (2007) Nature , vol.447 , pp. 601-605
    • Tahiliani, M.1    Mei, P.2    Fang, R.3
  • 59
    • 84872601036 scopus 로고    scopus 로고
    • Histone acetylation: molecular mnemonics on the chromatin
    • Gräff J, Tsai L-H. Histone acetylation: molecular mnemonics on the chromatin. Nat Rev Neurosci 2013;14: 97-111.
    • (2013) Nat Rev Neurosci , vol.14 , pp. 97-111
    • Gräff, J.1    Tsai, L.-H.2
  • 60
    • 84864126183 scopus 로고    scopus 로고
    • Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease
    • Qureshi IA, Mehler MF. Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease. Nat Rev Neurosci 2012;13: 528-541.
    • (2012) Nat Rev Neurosci , vol.13 , pp. 528-541
    • Qureshi, I.A.1    Mehler, M.F.2
  • 61
    • 84866947025 scopus 로고    scopus 로고
    • Emerging roles forlong non-coding RNAs in cancer and neurological disorders
    • Niland CN, Merry CR, Khalil AM. Emerging roles forlong non-coding RNAs in cancer and neurological disorders. Front Genet 2012;3: 25.
    • (2012) Front Genet , vol.3 , pp. 25
    • Niland, C.N.1    Merry, C.R.2    Khalil, A.M.3
  • 63
    • 84875273571 scopus 로고    scopus 로고
    • Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders
    • Spadaro PA, Bredy TW. Emerging role of non-coding RNA in neural plasticity, cognitive function, and neuropsychiatric disorders. Front Genet 2012;3: 132.
    • (2012) Front Genet , vol.3 , pp. 132
    • Spadaro, P.A.1    Bredy, T.W.2
  • 64
    • 84880963657 scopus 로고    scopus 로고
    • Long noncoding RNAs in development and disease of the central nervous system
    • Ng S-Y, Lin L, Soh BS, Stanton LW. Long noncoding RNAs in development and disease of the central nervous system. Trends Genet 2013;29: 461-468.
    • (2013) Trends Genet , vol.29 , pp. 461-468
    • Ng, S.-Y.1    Lin, L.2    Soh, B.S.3    Stanton, L.W.4
  • 66
    • 84895877629 scopus 로고    scopus 로고
    • Chromatin-bound RNA and the neurobiology of psychiatric disease
    • Jul 3 [Epub ahead of print]
    • Tushir JS, Akbarian S. Chromatin-bound RNA and the neurobiology of psychiatric disease. Neuroscience 2013 Jul 3 [Epub ahead of print].
    • (2013) Neuroscience
    • Tushir, J.S.1    Akbarian, S.2
  • 67
    • 84875432959 scopus 로고    scopus 로고
    • Epigenetic therapy: use of agents targeting deacetylation and methylation in cancer management
    • Chan TA. Epigenetic therapy: use of agents targeting deacetylation and methylation in cancer management. Onco Targets Ther 2013;6: 223-232.
    • (2013) Onco Targets Ther , vol.6 , pp. 223-232
    • Chan, T.A.1
  • 68
    • 78650012970 scopus 로고    scopus 로고
    • To selectivity and beyond
    • Mack GS. To selectivity and beyond. Nat Biotechnol 2010;28: 1259-1266.
    • (2010) Nat Biotechnol , vol.28 , pp. 1259-1266
    • Mack, G.S.1
  • 69
    • 69449086451 scopus 로고    scopus 로고
    • DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain
    • Barrachina M, Ferrer I. DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain. J Neuropathol Exp Neurol 2009;68: 880-891.
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 880-891
    • Barrachina, M.1    Ferrer, I.2
  • 70
    • 78649381716 scopus 로고    scopus 로고
    • A DNA methylation study of the amyloid precursor protein gene in several brain regions from patients with familial Alzheimer disease
    • Brohede J, Rinde M, Winblad B, Graff C. A DNA methylation study of the amyloid precursor protein gene in several brain regions from patients with familial Alzheimer disease. J Neurogenet 2010;24: 179-181.
    • (2010) J Neurogenet , vol.24 , pp. 179-181
    • Brohede, J.1    Rinde, M.2    Winblad, B.3    Graff, C.4
  • 71
    • 84859412462 scopus 로고    scopus 로고
    • Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex
    • Bakulski KM, Dolinoy DC, Sartor MA, et al. Genome-wide DNA methylation differences between late-onset Alzheimer's disease and cognitively normal controls in human frontal cortex. J Alzheimers Dis 2012;29: 571-588.
    • (2012) J Alzheimers Dis , vol.29 , pp. 571-588
    • Bakulski, K.M.1    Dolinoy, D.C.2    Sartor, M.A.3
  • 72
    • 79960255428 scopus 로고    scopus 로고
    • DNA methylation in repetitive elements and Alzheimer disease
    • Bollati V, Galimberti D, Pergoli L, et al. DNA methylation in repetitive elements and Alzheimer disease. Brain Behav Immun 2011;25: 1078-1083.
    • (2011) Brain Behav Immun , vol.25 , pp. 1078-1083
    • Bollati, V.1    Galimberti, D.2    Pergoli, L.3
  • 73
    • 0035947207 scopus 로고    scopus 로고
    • Metabolic regulation of brain Abeta by neprilysin
    • Iwata N, Tsubuki S, Takaki Y, et al. Metabolic regulation of brain Abeta by neprilysin. Science 2001;292: 1550-1552.
    • (2001) Science , vol.292 , pp. 1550-1552
    • Iwata, N.1    Tsubuki, S.2    Takaki, Y.3
  • 74
    • 56949102195 scopus 로고    scopus 로고
    • The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells
    • Chen K-L, Wang SS-S, Yang Y-Y, Yuan R-Y, Chen R-M, Hu C-J. The epigenetic effects of amyloid-beta(1-40) on global DNA and neprilysin genes in murine cerebral endothelial cells. Biochem Biophys Res Commun 2009;378: 57-61.
    • (2009) Biochem Biophys Res Commun , vol.378 , pp. 57-61
    • Chen, K.-L.1    Wang, S.S.-S.2    Yang, Y.-Y.3    Yuan, R.-Y.4    Chen, R.-M.5    Hu, C.-J.6
  • 75
    • 84879114551 scopus 로고    scopus 로고
    • Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration
    • Galimberti D, D'Addario C, Dell'osso B, et al. Progranulin gene (GRN) promoter methylation is increased in patients with sporadic frontotemporal lobar degeneration. Neurol Sci?2013;34: 899-903.
    • (2013) Neurol Sci , vol.34 , pp. 899-903
    • Galimberti, D.1    D'Addario, C.2    Dell'osso, B.3
  • 76
    • 84878863605 scopus 로고    scopus 로고
    • Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion
    • May 22 [Epub ahead of print]
    • Xi Z, Zinman L, Moreno D, Schymick J, et al. Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion. Am J Hum Genet 2013 May 22 [Epub ahead of print].
    • (2013) Am J Hum Genet
    • Xi, Z.1    Zinman, L.2    Moreno, D.3    Schymick, J.4
  • 77
    • 34447305738 scopus 로고    scopus 로고
    • Folate deprivation increases presenilin expression, gamma-secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S-adenosyl methionine
    • Chan A, Shea TB. Folate deprivation increases presenilin expression, gamma-secretase activity, and Abeta levels in murine brain: potentiation by ApoE deficiency and alleviation by dietary S-adenosyl methionine. J Neurochem 2007;102: 753-760.
    • (2007) J Neurochem , vol.102 , pp. 753-760
    • Chan, A.1    Shea, T.B.2
  • 78
    • 10644237168 scopus 로고    scopus 로고
    • S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production
    • Fuso A, Seminara L, Cavallaro RA, D'Anselmi F, Scarpa S. S-adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-amyloid production. Mol Cell Neurosci 2005;28: 195-204.
    • (2005) Mol Cell Neurosci , vol.28 , pp. 195-204
    • Fuso, A.1    Seminara, L.2    Cavallaro, R.A.3    D'Anselmi, F.4    Scarpa, S.5
  • 79
    • 41249098662 scopus 로고    scopus 로고
    • B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice
    • Fuso A, Nicolia V, Cavallaro RA, et al. B-vitamin deprivation induces hyperhomocysteinemia and brain S-adenosylhomocysteine, depletes brain S-adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice. Mol Cell Neurosci 2008;37: 731-746.
    • (2008) Mol Cell Neurosci , vol.37 , pp. 731-746
    • Fuso, A.1    Nicolia, V.2    Cavallaro, R.A.3
  • 80
    • 67650809239 scopus 로고    scopus 로고
    • S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters
    • Lin H-C, Hsieh H-M, Chen Y-H, Hu M-L. S-Adenosylhomocysteine increases beta-amyloid formation in BV-2 microglial cells by increased expressions of beta-amyloid precursor protein and presenilin 1 and by hypomethylation of these gene promoters. Neurotoxicology 2009;30: 622-627.
    • (2009) Neurotoxicology , vol.30 , pp. 622-627
    • Lin, H.-C.1    Hsieh, H.-M.2    Chen, Y.-H.3    Hu, M.-L.4
  • 81
    • 0037464488 scopus 로고    scopus 로고
    • Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease?
    • Scarpa S, Fuso A, D'Anselmi F, Cavallaro RA. Presenilin 1 gene silencing by S-adenosylmethionine: a treatment for Alzheimer disease? FEBS Lett 2003;541: 145-148.
    • (2003) FEBS Lett , vol.541 , pp. 145-148
    • Scarpa, S.1    Fuso, A.2    D'Anselmi, F.3    Cavallaro, R.A.4
  • 82
    • 84861174335 scopus 로고    scopus 로고
    • Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro
    • Bihaqi SW, Zawia NH. Alzheimer's disease biomarkers and epigenetic intermediates following exposure to Pb in vitro. Curr Alzheimer Res 2012;9: 555-562.
    • (2012) Curr Alzheimer Res , vol.9 , pp. 555-562
    • Bihaqi, S.W.1    Zawia, N.H.2
  • 83
    • 84863594106 scopus 로고    scopus 로고
    • Lead exposure in pheochromocytoma cells induces persistent changes in amyloid precursor protein gene methylation patterns
    • Li Y-Y, Chen T, Wan Y, Xu S. Lead exposure in pheochromocytoma cells induces persistent changes in amyloid precursor protein gene methylation patterns. Environ Toxicol 2012;27: 495-502.
    • (2012) Environ Toxicol , vol.27 , pp. 495-502
    • Li, Y.-Y.1    Chen, T.2    Wan, Y.3    Xu, S.4
  • 84
    • 84860409543 scopus 로고    scopus 로고
    • Epigenetic mechanisms of amyloid-β production in anisomycin-treated SH-SY5Y cells
    • Guo X, Wu X, Ren L, Liu G, Li L. Epigenetic mechanisms of amyloid-β production in anisomycin-treated SH-SY5Y cells. Neuroscience 2011;194: 272-281.
    • (2011) Neuroscience , vol.194 , pp. 272-281
    • Guo, X.1    Wu, X.2    Ren, L.3    Liu, G.4    Li, L.5
  • 85
    • 84863757162 scopus 로고    scopus 로고
    • Epigenetic modifications in frontal cortex from Alzheimer ' s disease and bipolar disorder patients
    • Rao JS, Keleshian VL, Klein S, Rapoport SI. Epigenetic modifications in frontal cortex from Alzheimer ' s disease and bipolar disorder patients. Transl Psychiatry 2012;2: 1-7.
    • (2012) Transl Psychiatry , vol.2 , pp. 1-7
    • Rao, J.S.1    Keleshian, V.L.2    Klein, S.3    Rapoport, S.I.4
  • 86
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
    • Tahiliani M, Koh KP, Shen Y, et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009;324: 930-935.
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 87
    • 68949096744 scopus 로고    scopus 로고
    • Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease
    • Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PloS One 2009;4: e6617.
    • (2009) PloS One , vol.4
    • Mastroeni, D.1    McKee, A.2    Grover, A.3    Rogers, J.4    Coleman, P.D.5
  • 88
    • 84883371239 scopus 로고    scopus 로고
    • Epigenetics in Friedreich's ataxia: challenges and opportunities for therapy
    • 852080
    • Sandi C, Al-Mahdawi S, Pook MA. Epigenetics in Friedreich's ataxia: challenges and opportunities for therapy. Genet Res Int 2013;852080.
    • (2013) Genet Res Int
    • Sandi, C.1    Al-Mahdawi, S.2    Pook, M.A.3
  • 90
    • 0032741429 scopus 로고    scopus 로고
    • Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene
    • Chiurazzi P, Grazia Pomponi M, Pietrobono R, Bakker CE, Neri G, Oostra BA. Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene. Hum Mol Genet 1999;8: 2317-2323.
    • (1999) Hum Mol Genet , vol.8 , pp. 2317-2323
    • Chiurazzi, P.1    Grazia Pomponi, M.2    Pietrobono, R.3    Bakker, C.E.4    Neri, G.5    Oostra, B.A.6
  • 91
    • 0347955358 scopus 로고    scopus 로고
    • Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains
    • Rice JC, Briggs SD, Ueberheide B, et al. Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol Cell 2003;12: 1591-1598.
    • (2003) Mol Cell , vol.12 , pp. 1591-1598
    • Rice, J.C.1    Briggs, S.D.2    Ueberheide, B.3
  • 92
    • 84872224226 scopus 로고    scopus 로고
    • The potential of HDAC inhibitors as cognitive enhancers
    • Gräff J, Tsai L-H. The potential of HDAC inhibitors as cognitive enhancers. Annu Rev Pharmacol Toxicol 2013;53: 311-330.
    • (2013) Annu Rev Pharmacol Toxicol , vol.53 , pp. 311-330
    • Gräff, J.1    Tsai, L.-H.2
  • 93
    • 57749170458 scopus 로고    scopus 로고
    • The many roles of histone deacetylases in development and physiology: implications for disease and therapy
    • Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 2009;10: 32-42.
    • (2009) Nat Rev Genet , vol.10 , pp. 32-42
    • Haberland, M.1    Montgomery, R.L.2    Olson, E.N.3
  • 94
    • 0032030770 scopus 로고    scopus 로고
    • Histone acetylation and transcriptional regulatory mechanisms
    • Struhl K. Histone acetylation and transcriptional regulatory mechanisms. Genes Develop 1998;12: 599-606.
    • (1998) Genes Develop , vol.12 , pp. 599-606
    • Struhl, K.1
  • 95
    • 84859463823 scopus 로고    scopus 로고
    • Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells
    • Kubicek S, Gilbert JC, Fomina-Yadlin D, et al. Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells. Proce Natl Acad Sci U S A 2012;109: 5364-5369.
    • (2012) Proce Natl Acad Sci U S A , vol.109 , pp. 5364-5369
    • Kubicek, S.1    Gilbert, J.C.2    Fomina-Yadlin, D.3
  • 96
    • 84861587577 scopus 로고    scopus 로고
    • Mutations in the chromatin modifier gene KANSL1 cause the 17q21.31 microdeletion syndrome
    • Koolen DA, Kramer JM, Neveling K, et al. Mutations in the chromatin modifier gene KANSL1 cause the 17q21. 31 microdeletion syndrome. Nat Genet 2012;44: 639-641.
    • (2012) Nat Genet , vol.44 , pp. 639-641
    • Koolen, D.A.1    Kramer, J.M.2    Neveling, K.3
  • 97
    • 84874197424 scopus 로고    scopus 로고
    • Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice
    • Kerimoglu C, Agis-Balboa RC, Kranz A, et al. Histone-methyltransferase MLL2 (KMT2B) is required for memory formation in mice. J Neurosci?2013;33: 3452-3464.
    • (2013) J Neurosci , vol.33 , pp. 3452-3464
    • Kerimoglu, C.1    Agis-Balboa, R.C.2    Kranz, A.3
  • 98
    • 2942731425 scopus 로고    scopus 로고
    • CBP histone acetyltransferase activity is a critical component of memory consolidation
    • Korzus E, Rosenfeld MG, Mayford M. CBP histone acetyltransferase activity is a critical component of memory consolidation. Neuron 2004;42: 961-972.
    • (2004) Neuron , vol.42 , pp. 961-972
    • Korzus, E.1    Rosenfeld, M.G.2    Mayford, M.3
  • 100
    • 78651479525 scopus 로고    scopus 로고
    • HDAC3 is a critical negative regulator of long-term memory formation
    • McQuown SC, Barrett RM, Matheos DP, et al. HDAC3 is a critical negative regulator of long-term memory formation. J Neurosci 2011;31: 764-774.
    • (2011) J Neurosci , vol.31 , pp. 764-774
    • McQuown, S.C.1    Barrett, R.M.2    Matheos, D.P.3
  • 101
    • 79959995900 scopus 로고    scopus 로고
    • Selective impact of MeCP2 and associated histone deacetylases on the dynamics of evoked excitatory neurotransmission
    • Nelson ED, Bal M, Kavalali ET, Monteggia LM. Selective impact of MeCP2 and associated histone deacetylases on the dynamics of evoked excitatory neurotransmission. J Neurophysiol 2011;106: 193-201.
    • (2011) J Neurophysiol , vol.106 , pp. 193-201
    • Nelson, E.D.1    Bal, M.2    Kavalali, E.T.3    Monteggia, L.M.4
  • 102
    • 65549123471 scopus 로고    scopus 로고
    • HDAC2 negatively regulates memory formation and synaptic plasticity
    • Guan J-S, Haggarty SJ, Giacometti E, et al. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009;459: 55-60.
    • (2009) Nature , vol.459 , pp. 55-60
    • Guan, J.-S.1    Haggarty, S.J.2    Giacometti, E.3
  • 104
    • 84862777943 scopus 로고    scopus 로고
    • An epigenetic blockade of cognitive functions in the neurodegenerating brain
    • Gräff J, Rei D, Guan J-S, et al. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012;483: 222-226.
    • (2012) Nature , vol.483 , pp. 222-226
    • Gräff, J.1    Rei, D.2    Guan, J.-S.3
  • 105
    • 79957999588 scopus 로고    scopus 로고
    • Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity
    • Haggarty SJ, Tsai L-H. Probing the role of HDACs and mechanisms of chromatin-mediated neuroplasticity. Neurobiol Learn Mem 2011;96: 41-52.
    • (2011) Neurobiol Learn Mem , vol.96 , pp. 41-52
    • Haggarty, S.J.1    Tsai, L.-H.2
  • 106
    • 49549083278 scopus 로고    scopus 로고
    • Histone deacetylase 6 interacts with the microtubule-associated protein tau
    • Ding H, Dolan PJ, Johnson GVW. Histone deacetylase 6 interacts with the microtubule-associated protein tau. J Neurochem 2008;106: 2119-2130.
    • (2008) J Neurochem , vol.106 , pp. 2119-2130
    • Ding, H.1    Dolan, P.J.2    Johnson, G.V.W.3
  • 107
    • 84871946821 scopus 로고    scopus 로고
    • Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease
    • Govindarajan N, Rao P, Burkhardt S, et al. Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. EMBO Mol Med 2013;5: 52-63.
    • (2013) EMBO Mol Med , vol.5 , pp. 52-63
    • Govindarajan, N.1    Rao, P.2    Burkhardt, S.3
  • 108
    • 84864862726 scopus 로고    scopus 로고
    • An essential role for histone deacetylase 4 in synaptic plasticity and memory formation
    • Kim M-S, Akhtar MW, Adachi M, et al. An essential role for histone deacetylase 4 in synaptic plasticity and memory formation. J Neurosci 2012;32: 10879-10886.
    • (2012) J Neurosci , vol.32 , pp. 10879-10886
    • Kim, M.-S.1    Akhtar, M.W.2    Adachi, M.3
  • 109
    • 84883788666 scopus 로고    scopus 로고
    • Epigenetic targeting of histone deacetylase: Therapeutic potential in Parkinson's disease?
    • May 24 [Epub ahead of print]
    • Harrison IF, Dexter DT. Epigenetic targeting of histone deacetylase: Therapeutic potential in Parkinson's disease? Pharmacol Ther 2013 May 24 [Epub ahead of print].
    • (2013) Pharmacol Ther
    • Harrison, I.F.1    Dexter, D.T.2
  • 110
    • 77249087051 scopus 로고    scopus 로고
    • Chemical phylogenetics of histone deacetylases
    • Bradner JE, West N, Grachan ML, et al. Chemical phylogenetics of histone deacetylases. Nat Chem Biol 2010;6: 238-243.
    • (2010) Nat Chem Biol , vol.6 , pp. 238-243
    • Bradner, J.E.1    West, N.2    Grachan, M.L.3
  • 111
    • 34248523169 scopus 로고    scopus 로고
    • Recovery of learning and memory is associated with chromatin remodelling
    • Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai L-H. Recovery of learning and memory is associated with chromatin remodelling. Nature 2007;447: 178-182.
    • (2007) Nature , vol.447 , pp. 178-182
    • Fischer, A.1    Sananbenesi, F.2    Wang, X.3    Dobbin, M.4    Tsai, L.-H.5
  • 112
    • 84876010140 scopus 로고    scopus 로고
    • Loss of histone deacetylase 2 improves working memory and accelerates extinction learning
    • Morris MJ, Mahgoub M, Na ES, Pranav H, Monteggia LM. Loss of histone deacetylase 2 improves working memory and accelerates extinction learning. J Neurosci 2013;33: 6401-6411.
    • (2013) J Neurosci , vol.33 , pp. 6401-6411
    • Morris, M.J.1    Mahgoub, M.2    Na, E.S.3    Pranav, H.4    Monteggia, L.M.5
  • 113
    • 57049177826 scopus 로고    scopus 로고
    • Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity
    • Kim D, Frank CL, Dobbin MM, et al. Deregulation of HDAC1 by p25/Cdk5 in neurotoxicity. Neuron 2008;60: 803-817.
    • (2008) Neuron , vol.60 , pp. 803-817
    • Kim, D.1    Frank, C.L.2    Dobbin, M.M.3
  • 114
    • 79955534069 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia
    • Cenik B, Sephton CF, Dewey CM, et al. Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. J Biol Chem 2011;286: 16101-16108.
    • (2011) J Biol Chem , vol.286 , pp. 16101-16108
    • Cenik, B.1    Sephton, C.F.2    Dewey, C.M.3
  • 115
    • 77957001697 scopus 로고    scopus 로고
    • Acetylation of tau inhibits its degradation and contributes to tauopathy
    • Min S-W, Cho S-H, Zhou Y, et al. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 2010;67: 953-966.
    • (2010) Neuron , vol.67 , pp. 953-966
    • Min, S.-W.1    Cho, S.-H.2    Zhou, Y.3
  • 116
    • 33745480963 scopus 로고    scopus 로고
    • Specific microRNAs modulate embryonic stem cell-derived neurogenesis
    • Krichevsky AM, Sonntag K-C, Isacson O, Kosik KS. Specific microRNAs modulate embryonic stem cell-derived neurogenesis. Stem Cells 2006;24: 857-864.
    • (2006) Stem Cells , vol.24 , pp. 857-864
    • Krichevsky, A.M.1    Sonntag, K.-C.2    Isacson, O.3    Kosik, K.S.4
  • 117
    • 59749089928 scopus 로고    scopus 로고
    • miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex
    • De Pietri Tonelli D, Pulvers JN, Haffner C, Murchison EP, Hannon GJ, Huttner WB. miRNAs are essential for survival and differentiation of newborn neurons but not for expansion of neural progenitors during early neurogenesis in the mouse embryonic neocortex. Development 2008;135: 3911-3921.
    • (2008) Development , vol.135 , pp. 3911-3921
    • De Pietri Tonelli, D.1    Pulvers, J.N.2    Haffner, C.3    Murchison, E.P.4    Hannon, G.J.5    Huttner, W.B.6
  • 118
    • 84887907810 scopus 로고    scopus 로고
    • Advances in the Genetics and Epigenetics of Neurodegenerative Diseases
    • Coppedè F. Advances in the Genetics and Epigenetics of Neurodegenerative Diseases. Epigenet Neurodegener Dis 2013;1: 2-30.
    • (2013) Epigenet Neurodegener Dis , vol.1 , pp. 2-30
    • Coppedè, F.1
  • 119
    • 77957735016 scopus 로고    scopus 로고
    • Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
    • Hébert SS, Papadopoulou AS, Smith P, et al. Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration. Hum Mol Genet 2010;19: 3959-3969.
    • (2010) Hum Mol Genet , vol.19 , pp. 3959-3969
    • Hébert, S.S.1    Papadopoulou, A.S.2    Smith, P.3
  • 120
    • 47849124269 scopus 로고    scopus 로고
    • Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways
    • Cogswell JP, Ward J, Taylor IA, et al. Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways. J Alzheimers Dis 2008;14: 27-41.
    • (2008) J Alzheimers Dis , vol.14 , pp. 27-41
    • Cogswell, J.P.1    Ward, J.2    Taylor, I.A.3
  • 121
    • 64049092736 scopus 로고    scopus 로고
    • Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease
    • Julien C, Tremblay C, Emond V, et al. Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J Neuropathol Exp Neurol 2009;68: 48-58.
    • (2009) J Neuropathol Exp Neurol , vol.68 , pp. 48-58
    • Julien, C.1    Tremblay, C.2    Emond, V.3
  • 122
    • 84860653372 scopus 로고    scopus 로고
    • Neurodegeneration the RNA way
    • Renoux AJ, Todd PK. Neurodegeneration the RNA way. Prog Neurobiol 2012;97: 173-189.
    • (2012) Prog Neurobiol , vol.97 , pp. 173-189
    • Renoux, A.J.1    Todd, P.K.2
  • 123
    • 84872501669 scopus 로고    scopus 로고
    • Non-coding RNAs in Alzheimer's disease
    • Tan L, Yu J-T, Hu N, Tan L. Non-coding RNAs in Alzheimer's disease. Mol Neurobiol 2013;47: 382-393.
    • (2013) Mol Neurobiol , vol.47 , pp. 382-393
    • Tan, L.1    Yu, J.-T.2    Hu, N.3    Tan, L.4
  • 124
    • 44049108170 scopus 로고    scopus 로고
    • Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression
    • Hébert SS, Horré K, Nicolaï L, et al. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci U S A 2008;105: 6415-6420.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 6415-6420
    • Hébert, S.S.1    Horré, K.2    Nicolaï, L.3
  • 126
    • 59049087888 scopus 로고    scopus 로고
    • MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1
    • Boissonneault V, Plante I, Rivest S, Provost P. MicroRNA-298 and microRNA-328 regulate expression of mouse beta-amyloid precursor protein-converting enzyme 1. J Biol Chem 2009;284: 1971-1981.
    • (2009) J Biol Chem , vol.284 , pp. 1971-1981
    • Boissonneault, V.1    Plante, I.2    Rivest, S.3    Provost, P.4
  • 127
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1
    • Wang W-X, Rajeev BW, Stromberg AJ, et al. The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1. J Neurosci 2008;28: 1213-1223.
    • (2008) J Neurosci , vol.28 , pp. 1213-1223
    • Wang, W.-X.1    Rajeev, B.W.2    Stromberg, A.J.3
  • 128
    • 61349110680 scopus 로고    scopus 로고
    • MicroRNA regulation of Alzheimer's Amyloid precursor protein expression
    • Hébert SS, Horré K, Nicolaï L, et al. MicroRNA regulation of Alzheimer's Amyloid precursor protein expression. Neurobiol Dis 2009;33: 422-428.
    • (2009) Neurobiol Dis , vol.33 , pp. 422-428
    • Hébert, S.S.1    Horré, K.2    Nicolaï, L.3
  • 129
    • 79151483332 scopus 로고    scopus 로고
    • MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed
    • Long JM, Lahiri DK. MicroRNA-101 downregulates Alzheimer's amyloid-β precursor protein levels in human cell cultures and is differentially expressed. Biochem Biophys Res Commun 2011;404: 889-895.
    • (2011) Biochem Biophys Res Commun , vol.404 , pp. 889-895
    • Long, J.M.1    Lahiri, D.K.2
  • 130
    • 46749083733 scopus 로고    scopus 로고
    • Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase
    • Faghihi MA, Modarresi F, Khalil AM, et al. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med 2008;14: 723-730.
    • (2008) Nat Med , vol.14 , pp. 723-730
    • Faghihi, M.A.1    Modarresi, F.2    Khalil, A.M.3
  • 131
    • 80054684399 scopus 로고    scopus 로고
    • Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs
    • Saxena A, Carninci P. Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs. Bioessays?2011;33: 830-839.
    • (2011) Bioessays , vol.33 , pp. 830-839
    • Saxena, A.1    Carninci, P.2
  • 132
    • 84855177724 scopus 로고    scopus 로고
    • The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease
    • Fang M, Wang J, Zhang X, et al. The miR-124 regulates the expression of BACE1/β-secretase correlated with cell death in Alzheimer's disease. Toxicol Lett 2012;209: 94-105.
    • (2012) Toxicol Lett , vol.209 , pp. 94-105
    • Fang, M.1    Wang, J.2    Zhang, X.3
  • 133
    • 70349884016 scopus 로고    scopus 로고
    • Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells
    • Perry MM, Williams AE, Tsitsiou E, Larner-Svensson HM, Lindsay MA. Divergent intracellular pathways regulate interleukin-1beta-induced miR-146a and miR-146b expression and chemokine release in human alveolar epithelial cells. FEBS Lett 2009;583: 3349-3355.
    • (2009) FEBS Lett , vol.583 , pp. 3349-3355
    • Perry, M.M.1    Williams, A.E.2    Tsitsiou, E.3    Larner-Svensson, H.M.4    Lindsay, M.A.5
  • 134
    • 33747608638 scopus 로고    scopus 로고
    • NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • Taganov KD, Boldin MP, Chang K-J, Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 2006;103: 12481-12486.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.-J.3    Baltimore, D.4
  • 135
    • 79953180492 scopus 로고    scopus 로고
    • Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
    • Tollervey JR, Curk T, Rogelj B, et al. Characterizing the RNA targets and position-dependent splicing regulation by TDP-43. Nat Neurosci 2011;14: 452-458.
    • (2011) Nat Neurosci , vol.14 , pp. 452-458
    • Tollervey, J.R.1    Curk, T.2    Rogelj, B.3
  • 136
    • 84857772495 scopus 로고    scopus 로고
    • TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
    • Kawahara Y, Mieda-Sato A. TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes. Proc Natl Acad Sci U S A 2012;109: 3347-3352.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 3347-3352
    • Kawahara, Y.1    Mieda-Sato, A.2
  • 137
    • 84866373102 scopus 로고    scopus 로고
    • Role of exosomes/microvesicles in the nervous system and use in emerging therapies
    • Lai CP-K, Breakefield XO. Role of exosomes/microvesicles in the nervous system and use in emerging therapies. Front Physiol 2012;3: 228.
    • (2012) Front Physiol , vol.3 , pp. 228
    • Lai, C.P.-K.1    Breakefield, X.O.2
  • 138
    • 84860353437 scopus 로고    scopus 로고
    • Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation
    • Modarresi F, Faghihi MA, Lopez-Toledano MA, et al. Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nat Biotechnol 2012;30: 453-459.
    • (2012) Nat Biotechnol , vol.30 , pp. 453-459
    • Modarresi, F.1    Faghihi, M.A.2    Lopez-Toledano, M.A.3
  • 139
    • 12344273726 scopus 로고    scopus 로고
    • The blood-brain barrier: bottleneck in brain drug development
    • Pardridge WM. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2005;2: 3-14.
    • (2005) NeuroRx , vol.2 , pp. 3-14
    • Pardridge, W.M.1
  • 140
    • 0037452775 scopus 로고    scopus 로고
    • Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease
    • Hockly E, Richon VM, Woodman B, et al. Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease. Proc Natl Acad Sci U S A 2003;100: 2041-2046.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2041-2046
    • Hockly, E.1    Richon, V.M.2    Woodman, B.3
  • 142
    • 44349114629 scopus 로고    scopus 로고
    • HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model
    • Rai M, Soragni E, Jenssen K, et al. HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. PloS One 2008;3: e1958.
    • (2008) PloS One , vol.3
    • Rai, M.1    Soragni, E.2    Jenssen, K.3
  • 148
    • 0035937595 scopus 로고    scopus 로고
    • Nanoparticulate systems for brain delivery of drugs
    • Kreuter J. Nanoparticulate systems for brain delivery of drugs. Adv Drug Deliv Rev 2001;47: 65-81.
    • (2001) Adv Drug Deliv Rev , vol.47 , pp. 65-81
    • Kreuter, J.1
  • 149
    • 34447114618 scopus 로고    scopus 로고
    • Transvascular delivery of small interfering RNA to the central nervous system
    • Kumar P, Wu H, McBride JL, et al. Transvascular delivery of small interfering RNA to the central nervous system. Nature 2007;448: 39-43.
    • (2007) Nature , vol.448 , pp. 39-43
    • Kumar, P.1    Wu, H.2    McBride, J.L.3
  • 150
    • 3142731321 scopus 로고    scopus 로고
    • Intravenous, non-viral RNAi gene therapy of brain cancer
    • Pardridge WM. Intravenous, non-viral RNAi gene therapy of brain cancer. Exp Opin Biol Ther 2004;4: 1103-1113.
    • (2004) Exp Opin Biol Ther , vol.4 , pp. 1103-1113
    • Pardridge, W.M.1
  • 151
    • 84886311462 scopus 로고    scopus 로고
    • Nanoparticles for brain drug delivery
    • Masserini M. Nanoparticles for brain drug delivery. ISRN Biochemistry 2013; 1-18.
    • (2013) ISRN Biochemistry , pp. 1-18
    • Masserini, M.1
  • 152
    • 84863489478 scopus 로고    scopus 로고
    • Involvement of long noncoding RNAs in diseases affecting the central nervous system
    • Pastori C, Wahlestedt C. Involvement of long noncoding RNAs in diseases affecting the central nervous system. RNA Biology 2012;9: 860-870.
    • (2012) RNA Biology , vol.9 , pp. 860-870
    • Pastori, C.1    Wahlestedt, C.2
  • 154
    • 84869089691 scopus 로고    scopus 로고
    • Epigenetic inheritance of disease and disease risk
    • Bohacek J, Mansuy IM. Epigenetic inheritance of disease and disease risk. Neuropsychopharmacology 2013;38: 220-236.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 220-236
    • Bohacek, J.1    Mansuy, I.M.2
  • 155
    • 84872770694 scopus 로고    scopus 로고
    • Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine
    • Hackett JA, Sengupta R, Zylicz JJ, et al. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science 2013;339: 448-452.
    • (2013) Science , vol.339 , pp. 448-452
    • Hackett, J.A.1    Sengupta, R.2    Zylicz, J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.