-
1
-
-
84866456583
-
Preventing alzheimer's disease
-
Selkoe DJ. Preventing Alzheimer's disease. Science 2012; 337: 1488-92.
-
(2012)
Science
, vol.337
, pp. 1488-1492
-
-
Selkoe, D.J.1
-
2
-
-
34447316702
-
Genetics of alzheimer's disease: A centennial review
-
Ertekin-Taner N. Genetics of Alzheimer's disease: a centennial review. Neurol Clin 2007; 25: 611-67, v.
-
(2007)
Neurol Clin
, vol.25
, pp. 611-667
-
-
Ertekin-Taner, N.1
-
3
-
-
33845892752
-
Systematic meta "analyses of alzheimer disease genetic association studies: The alzgene database
-
Bertram L, McQueen MB, Mullin K, Blacker D, Tanzi RE. Systematic meta-Analyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet 2007; 39: 17-23.
-
(2007)
Nat Genet
, vol.39
, pp. 17-23
-
-
Bertram, L.1
McQueen, M.B.2
Mullin, K.3
Blacker, D.4
Tanzi, R.E.5
-
4
-
-
79952202597
-
Epigenetic regulation of aging
-
Rodriguez-Rodero S, Fernandez-Morera J, Fernandez AF, Menendez-Torre E, Fraga MF. Epigenetic regulation of aging. Discov Med 2010; 10: 225-33.
-
(2010)
Discov Med
, vol.10
, pp. 225-233
-
-
Rodriguez-Rodero, S.1
Fernandez-Morera, J.2
Fernandez, A.F.3
Menendez-Torre, E.4
Fraga, M.F.5
-
5
-
-
70349763297
-
Epigenetics, genomic mutations and cognitive function
-
Reichenberg, A, Mill J, MacCabe JH. Epigenetics, genomic mutations and cognitive function. Cogn Neuropsychiatry 2009; 14: 377-90.
-
(2009)
Cogn Neuropsychiatry
, vol.14
, pp. 377-390
-
-
Reichenberg, A.1
Mill, J.2
MacCabe, J.H.3
-
6
-
-
11144257694
-
Mechanisms of memory stabilization: Are consolidation and reconsolidation similar or distinct processes?
-
Alberini CM. Mechanisms of memory stabilization: are consolidation and reconsolidation similar or distinct processes? Trends Neurosci 2005; 28: 51-6.
-
(2005)
Trends Neurosci
, vol.28
, pp. 51-56
-
-
Alberini, C.M.1
-
7
-
-
0033856375
-
Maintenance-Type dna methyltransferase is highly expressed in post-mitotic neurons and localized in the cytoplasmic compartment
-
Inano K, Suetake I, Ueda T, Miyake Y, Nakamura M, Okada M, Tajima S. Maintenance-Type DNA methyltransferase is highly expressed in post-mitotic neurons and localized in the cytoplasmic compartment. J Biochem 2000; 128: 315-21.
-
(2000)
J Biochem
, vol.128
, pp. 315-321
-
-
Inano, K.1
Suetake, I.2
Ueda, T.3
Miyake, Y.4
Nakamura, M.5
Okada, M.6
Tajima, S.7
-
8
-
-
0032937871
-
Evidence that protein binding specifies sites of dna demethylation
-
Hsieh CL. Evidence that protein binding specifies sites of DNA demethylation. Mol Cell Biol 1999; 19: 46-56.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 46-56
-
-
Hsieh, C.L.1
-
9
-
-
0019318994
-
Dna methylation and gene function
-
Razin A, Riggs AD. DNA methylation and gene function. Science 1980; 210: 604-10.
-
(1980)
Science
, vol.210
, pp. 604-610
-
-
Razin, A.1
Riggs, A.D.2
-
10
-
-
77958580776
-
Dna methylation and memory formation
-
Day JJ, Sweatt JD. DNA methylation and memory formation. Nat Neurosci 2010; 13: 1319-23.
-
(2010)
Nat Neurosci
, vol.13
, pp. 1319-1323
-
-
Day, J.J.1
Sweatt, J.D.2
-
11
-
-
0025912318
-
Genomic organization of the human-Amyloid beta-protein precursor gene
-
Yoshikai S, Sasaki H, Doh-ura K, Furuya H, Sakaki Y. Genomic organization of the human-Amyloid beta-protein precursor gene. Gene 1991; 102: 291-2.
-
(1991)
Gene
, vol.102
, pp. 291-292
-
-
Yoshikai, S.1
Sasaki, H.2
Dohura, K.3
Furuya, H.4
Sakaki, Y.5
-
12
-
-
0033582693
-
Decrease with age in methylcytosines in the promoter region of receptor for advanced glycated end products (rage) gene in autopsy human cortex
-
Tohgi H, Utsugisawa K, Nagane Y, Yoshimura M, Ukitsu M, Genda Y. Decrease with age in methylcytosines in the promoter region of receptor for advanced glycated end products (RAGE) gene in autopsy human cortex. Brain Res Mol Brain Res 1999; 65: 124-8.
-
(1999)
Brain Res Mol Brain Res
, vol.65
, pp. 124-128
-
-
Tohgi, H.1
Utsugisawa, K.2
Nagane, Y.3
Yoshimura, M.4
Ukitsu, M.5
Genda, Y.6
-
13
-
-
10644237168
-
S-Adenosylmethionine/homocysteine cycle alterations modify dna methylation status with consequent deregulation of ps1 and bace and beta-Amyloid production
-
Fuso A, Seminara L, Cavallaro RA, D'Anselmi F, Scarpa S. S-Adenosylmethionine/homocysteine cycle alterations modify DNA methylation status with consequent deregulation of PS1 and BACE and beta-Amyloid production. Mol Cell Neurosci 2005; 28: 195-204.
-
(2005)
Mol Cell Neurosci
, vol.28
, pp. 195-204
-
-
Fuso, A.1
Seminara, L.2
Cavallaro, R.A.3
D'Anselmi, F.4
Scarpa, S.5
-
14
-
-
78650179659
-
Epigenetic changes in alzheimer's disease: Decrements in dna methylation
-
Mastroeni D, Grover A, Delvaux E, Whiteside C, Coleman PD, Rogers J. Epigenetic changes in Alzheimer's disease: decrements in DNA methylation. Neurobiol Aging 2010; 31: 2025-37.
-
(2010)
Neurobiol Aging
, vol.31
, pp. 2025-2037
-
-
Mastroeni, D.1
Grover, A.2
Delvaux, E.3
Whiteside, C.4
Coleman, P.D.5
Rogers, J.6
-
15
-
-
68949096744
-
Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for alzheimer's disease
-
Mastroeni D, McKee A, Grover A, Rogers J, Coleman PD. Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer's disease. PLoS One 2009; 4: e6617.
-
(2009)
PLoS One
, vol.4
-
-
Mastroeni, D.1
McKee, A.2
Grover, A.3
Rogers, J.4
Coleman, P.D.5
-
16
-
-
0025335914
-
Dna cytosine methylation in brain of patients with alzheimer's disease
-
Schwob NG, Nalbantoglu J, Hastings KE, Mikkelsen T, Cashman NR. DNA cytosine methylation in brain of patients with Alzheimer's disease. Ann Neurol 1990; 28: 91-4.
-
(1990)
Ann Neurol
, vol.28
, pp. 91-94
-
-
Schwob, N.G.1
Nalbantoglu, J.2
Hastings, K.E.3
Mikkelsen, T.4
Cashman, N.R.5
-
17
-
-
78649872779
-
Changes in presenilin 1 gene methylation pattern in diet-induced b vitamin deficiency
-
Fuso A, Nicolia V, Pasqualato A, Fiorenza MT, Cavallaro RA, Scarpa S. Changes in Presenilin 1 gene methylation pattern in diet-induced B vitamin deficiency. Neurobiol Aging 2011; 32: 187-99.
-
(2011)
Neurobiol Aging
, vol.32
, pp. 187-199
-
-
Fuso, A.1
Nicolia, V.2
Pasqualato, A.3
Fiorenza, M.T.4
Cavallaro, R.A.5
Scarpa, S.6
-
18
-
-
0036433415
-
Folate, vitamin b12 and vitamin b6 and one carbon metabolism
-
Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging 2002; 6: 39-42.
-
(2002)
J Nutr Health Aging
, vol.6
, pp. 39-42
-
-
Selhub, J.1
-
19
-
-
79960141859
-
Tissue-specific distribution of aberrant dna methylation associated with maternal low-folate status in human neural tube defects
-
Chang H, Zhang T, Zhang Z, Bao R, Fu C, Wang Z, Bao Y, Li Y, Wu L, Zheng X, Wu J. Tissue-specific distribution of aberrant DNA methylation associated with maternal low-folate status in human neural tube defects. J Nutr Biochem 2011; 22: 1172-7.
-
(2011)
J Nutr Biochem
, vol.22
, pp. 1172-1177
-
-
Chang, H.1
Zhang, T.2
Zhang, Z.3
Bao, R.4
Fu, C.5
Wang, Z.6
Bao, Y.7
Li, Y.8
Wu, L.9
Zheng, X.10
Wu, J.11
-
20
-
-
46849094315
-
Risk factors for alzheimer dementia in a community-based birth cohort at the age of 75 years
-
Fischer P, Zehetmayer S, Jungwirth S, Weissgram S, Krampla W, Hinterberger M, Torma S, Rainer M, Huber K, Hoenigschnabl S, Gelpi E, Bauer K, Leitha T, Bauer P, Tragl KH. Risk factors for Alzheimer dementia in a community-based birth cohort at the age of 75 years. Dement Geriatr Cogn Disord 2008; 25: 501-7.
-
(2008)
Dement Geriatr Cogn Disord
, vol.25
, pp. 501-507
-
-
Fischer, P.1
Zehetmayer, S.2
Jungwirth, S.3
Weissgram, S.4
Krampla, W.5
Hinterberger, M.6
Torma, S.7
Rainer, M.8
Huber, K.9
Hoenigschnabl, S.10
Gelpi, E.11
Bauer, K.12
Leitha, T.13
Bauer, P.14
Tragl, K.H.15
-
21
-
-
0037075257
-
Plasma homocysteine as a risk factor for dementia and alzheimer's disease
-
Seshadri S, Beiser A, Selhub J, Jacques PF, Rosenberg IH, D'Agostino RB, Wilson PW, Wolf PA. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002; 346: 476-83.
-
(2002)
N Engl J Med
, vol.346
, pp. 476-483
-
-
Seshadri, S.1
Beiser, A.2
Selhub, J.3
Jacques, P.F.4
Rosenberg, I.H.5
D'Agostino, R.B.6
Wilson, P.W.7
Wolf, P.A.8
-
22
-
-
0034922510
-
Csf-folate levels are decreased in late-onset ad patients
-
Serot JM, Christmann D, Dubost T, Bene MC, Faure GC. CSF-folate levels are decreased in late-onset AD patients. J Neural Transm 2001; 108: 93-9.
-
(2001)
J Neural Transm
, vol.108
, pp. 93-99
-
-
Serot, J.M.1
Christmann, D.2
Dubost, T.3
Bene, M.C.4
Faure, G.C.5
-
23
-
-
41249098662
-
B-vitamin deprivation induces hyperhomocysteinemia and brain s-Adenosylhomocysteine, depletes brain s-Adenosylmethionine, and enhances ps1 and bace expression and amyloid-beta deposition in mice
-
Fuso A, Nicolia V, Cavallaro RA, Ricceri L, D'Anselmi F, Coluccia P, Calamandrei G, Scarpa S. B-vitamin deprivation induces hyperhomocysteinemia and brain S-Adenosylhomocysteine, depletes brain S-Adenosylmethionine, and enhances PS1 and BACE expression and amyloid-beta deposition in mice. Mol Cell Neurosci 2008; 37: 731-46.
-
(2008)
Mol Cell Neurosci
, vol.37
, pp. 731-746
-
-
Fuso, A.1
Nicolia, V.2
Cavallaro, R.A.3
Ricceri, L.4
D'Anselmi, F.5
Coluccia, P.6
Calamandrei, G.7
Scarpa, S.8
-
24
-
-
20244361897
-
A pilot study of vitamins to lower plasma homocysteine levels in alzheimer disease
-
Aisen PS, Egelko S, Andrews H, Diaz-Arrastia R, Weiner M, DeCarli C, Jagust W, Miller JW, Green R, Bell K, Sano M. A pilot study of vitamins to lower plasma homocysteine levels in Alzheimer disease. Am J Geriatr Psychiatry 2003; 11: 246-9.
-
(2003)
Am J Geriatr Psychiatry
, vol.11
, pp. 246-249
-
-
Aisen, P.S.1
Egelko, S.2
Andrews, H.3
Diaz-Arrastia, R.4
Weiner, M.5
DeCarli, C.6
Jagust, W.7
Miller, J.W.8
Green, R.9
Bell, K.10
Sano, M.11
-
25
-
-
54049106963
-
Alzheimer disease cooperative study. High-dose b vitamin supplementation and cognitive decline in alzheimer disease: A randomized controlled trial
-
Aisen PS, Schneider LS, Sano M, Diaz-Arrastia R, van Dyck CH, Weiner MF, Bottiglieri T, Jin S, Stokes KT, Thomas RG, Thal LJ; Alzheimer Disease Cooperative Study. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. J Am Med Assoc 2008; 300: 1774-83.
-
(2008)
J Am Med Assoc
, vol.300
, pp. 1774-1783
-
-
Aisen, P.S.1
Schneider, L.S.2
Sano, M.3
Diaz-Arrastia, R.4
Van Dyck, C.H.5
Weiner, M.F.6
Bottiglieri, T.7
Jin, S.8
Stokes, K.T.9
Thomas, R.G.10
Thal, L.J.11
-
26
-
-
58149191631
-
Efficacy of a vitamin/nutriceutical formulation for early-stage alzheimer's disease: A 1-year, open-label pilot study with a 16-month caregiver extension
-
Chan A, Paskavitz J, Remington R, Rasmussen S, Shea TB. Efficacy of a vitamin/nutriceutical formulation for early-stage Alzheimer's disease: a 1-year, open-label pilot study with a 16-month caregiver extension. Am J Alzheimers Dis Other Demen 2008; 23: 571-85.
-
(2008)
Am J Alzheimers Dis Other Demen
, vol.23
, pp. 571-585
-
-
Chan, A.1
Paskavitz, J.2
Remington, R.3
Rasmussen, S.4
Shea, T.B.5
-
27
-
-
78649880974
-
Dna methylation and demethylation probed by small molecules
-
Szyf M. DNA methylation and demethylation probed by small molecules. Biochim Biophys Acta 2010; 1799: 750-9.
-
(2010)
Biochim Biophys Acta
, vol.1799
, pp. 750-759
-
-
Szyf, M.1
-
28
-
-
84867888439
-
Decoding the non-coding rnas in alzheimer's disease
-
Schonrock N, Gotz J. Decoding the non-coding RNAs in Alzheimer's disease. Cell Mol Life Sci 2012; 69: 3543-59.
-
(2012)
Cell Mol Life Sci
, vol.69
, pp. 3543-3559
-
-
Schonrock, N.1
Gotz, J.2
-
29
-
-
44049108170
-
Loss of microrna cluster mir-29a/b-1 in sporadic alzheimer's disease correlates with increased bace1/beta-secretase expression
-
Hébert SS, Horré K, Nicolaï L, Papadopoulou AS, Mandemakers W, Silahtaroglu AN, Kauppinen S, Delacourte A, De Strooper B. Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/beta-secretase expression. Proc Natl Acad Sci USA 2008; 105: 6415-20.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 6415-6420
-
-
Hébert, S.S.1
Horré, K.2
Nicolaï, L.3
Papadopoulou, A.S.4
Mandemakers, W.5
Silahtaroglu, A.N.6
Kauppinen, S.7
Delacourte, A.8
De Strooper, B.9
-
30
-
-
77953319294
-
Microrna-101 regulates amyloid precursor protein expression in hippocampal neurons
-
Vilardo E, Barbato C, Ciotti M, Cogoni C, Ruberti F. MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons. J Biol Chem 2010; 285: 18344-51.
-
(2010)
J Biol Chem
, vol.285
, pp. 18344-18351
-
-
Vilardo, E.1
Barbato, C.2
Ciotti, M.3
Cogoni, C.4
Ruberti, F.5
-
31
-
-
46749083733
-
Expression of a noncoding rna is elevated in alzheimer's disease and drives rapid feed-forward regulation of beta-secretase
-
Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G 3rd, Kenny PJ, Wahlestedt C. Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med 2008; 14: 723-30.
-
(2008)
Nat Med
, vol.14
, pp. 723-730
-
-
Faghihi, M.A.1
Modarresi, F.2
Khalil, A.M.3
Wood, D.E.4
Sahagan, B.G.5
Morgan, T.E.6
Finch, C.E.7
St Laurent, G.8
Kenny, P.J.9
Wahlestedt, C.10
-
32
-
-
79953858598
-
Delivery of sirna to the mouse brain by systemic injection of targeted exosomes
-
Alvarez-Erviti L, Seow Y, Yin H, Betts C, Lakhal S, Wood MJ. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 2011; 29: 341-5.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 341-345
-
-
Alvarez-Erviti, L.1
Seow, Y.2
Yin, H.3
Betts, C.4
Lakhal, S.5
Wood, M.J.6
-
33
-
-
0037111980
-
Integration of long-Term-memoryrelated synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure
-
Guan Z, Giustetto M, Lomvardas S, Kim JH, Miniaci MC, Schwartz JH, Thanos D, Kandel ER. Integration of long-Term-memoryrelated synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure. Cell 2002; 111: 483-93.
-
(2002)
Cell
, vol.111
, pp. 483-493
-
-
Guan, Z.1
Giustetto, M.2
Lomvardas, S.3
Kim, J.H.4
Miniaci, M.C.5
Schwartz, J.H.6
Thanos, D.7
Kandel, E.R.8
-
35
-
-
33746457753
-
Enhanced histone acetylation and transcription: A dynamic perspective
-
Clayton AL, Hazzalin CA, Mahadevan LC. Enhanced histone acetylation and transcription: a dynamic perspective. Mol Cell 2006; 23: 289-96.
-
(2006)
Mol Cell
, vol.23
, pp. 289-296
-
-
Clayton, A.L.1
Hazzalin, C.A.2
Mahadevan, L.C.3
-
36
-
-
77952168294
-
Altered histone acetylation is associated with age-dependent memory impairment in mice
-
Peleg S, Sananbenesi F, Zovoilis A, Burkhardt S, Bahari-Javan S, Agis-Balboa RC, Cota P, Wittnam JL, Gogol-Doering A, Opitz L, Salinas-Riester G, Dettenhofer M, Kang H, Farinelli L, Chen W, Fischer A. Altered histone acetylation is associated with age-dependent memory impairment in mice. Science 2010; 328: 753-6.
-
(2010)
Science
, vol.328
, pp. 753-756
-
-
Peleg, S.1
Sananbenesi, F.2
Zovoilis, A.3
Burkhardt, S.4
Bahari-Javan, S.5
Agis-Balboa, R.C.6
Cota, P.7
Wittnam, J.L.8
Gogol-Doering, A.9
Opitz, L.10
Salinas-Riester, G.11
Dettenhofer, M.12
Kang, H.13
Farinelli, L.14
Chen, W.15
Fischer, A.16
-
37
-
-
4644261125
-
Regulation of histone acetylation during memory formation in the hippocampus
-
Levenson JM, O'Riordan KJ, Brown KD, Trinh MA, Molfese DL, Sweatt JD. Regulation of histone acetylation during memory formation in the hippocampus. J Biol Chem 2004; 279: 40545-59.
-
(2004)
J Biol Chem
, vol.279
, pp. 40545-40559
-
-
Levenson, J.M.1
O'Riordan, K.J.2
Brown, K.D.3
Trinh, M.A.4
Molfese, D.L.5
Sweatt, J.D.6
-
38
-
-
2942748204
-
To learn better, keep the hat on
-
Martin KC, Sun YE. To learn better, keep the HAT on. Neuron 2004; 42: 879-81.
-
(2004)
Neuron
, vol.42
, pp. 879-881
-
-
Martin, K.C.1
Sun, Y.E.2
-
39
-
-
33744793463
-
Erk/mapk regulates hippocampal histone phosphorylation following contextual fear conditioning
-
Chwang WB, O'Riordan KJ, Levenson JM, Sweatt JD. ERK/MAPK regulates hippocampal histone phosphorylation following contextual fear conditioning. Learn Mem 2006; 13: 322-8.
-
(2006)
Learn Mem
, vol.13
, pp. 322-328
-
-
Chwang, W.B.1
O'Riordan, K.J.2
Levenson, J.M.3
Sweatt, J.D.4
-
40
-
-
36249006058
-
The nuclear kinase mitogen-And stress-Activated protein kinase 1 regulates hippocampal chromatin remodeling in memory formation
-
Chwang WB, Arthur JS, Schumacher A, Sweatt JD. The nuclear kinase mitogen-And stress-Activated protein kinase 1 regulates hippocampal chromatin remodeling in memory formation. J Neurosci 2007; 27: 12732-42.
-
(2007)
J Neurosci
, vol.27
, pp. 12732-12742
-
-
Chwang, W.B.1
Arthur, J.S.2
Schumacher, A.3
Sweatt, J.D.4
-
41
-
-
34248523169
-
Recovery of learning and memory is associated with chromatin remodelling
-
Fischer A, Sananbenesi F, Wang X, Dobbin M, Tsai LH. Recovery of learning and memory is associated with chromatin remodelling. Nature 2007; 447: 178-82.
-
(2007)
Nature
, vol.447
, pp. 178-182
-
-
Fischer, A.1
Sananbenesi, F.2
Wang, X.3
Dobbin, M.4
Tsai, L.H.5
-
42
-
-
34250026412
-
Histone deacetylase inhibitors enhance memory and synaptic plasticity via creb: Cbp-dependent transcriptional activation
-
Vecsey CG, Hawk JD, Lattal KM, Stein JM, Fabian SA, Attner MA, Cabrera SM, McDonough CB, Brindle PK, Abel T, Wood MA. Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation. J Neurosci 2007; 27: 6128-40.
-
(2007)
J Neurosci
, vol.27
, pp. 6128-6140
-
-
Vecsey, C.G.1
Hawk, J.D.2
Lattal, K.M.3
Stein, J.M.4
Fabian, S.A.5
Attner, M.A.6
Cabrera, S.M.7
McDonough, C.B.8
Brindle, P.K.9
Abel, T.10
Wood, M.A.11
-
43
-
-
33744814069
-
Combinatorial chromatin modifications and memory storage: A code for memory?
-
Wood MA, Hawk JD, Abel T. Combinatorial chromatin modifications and memory storage: a code for memory? Learn Mem 2006; 13: 241-4.
-
(2006)
Learn Mem
, vol.13
, pp. 241-244
-
-
Wood, M.A.1
Hawk, J.D.2
Abel, T.3
-
44
-
-
67349220155
-
Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an alzheimer's disease mouse model
-
Ricobaraza A, Cuadrado-Tejedor M, Pérez-Mediavilla A, Frechilla D, Del Río J, García-Osta A. Phenylbutyrate ameliorates cognitive deficit and reduces tau pathology in an Alzheimer's disease mouse model. Neuropsychopharmacology 2009; 34: 1721-32.
-
(2009)
Neuropsychopharmacology
, vol.34
, pp. 1721-1732
-
-
Ricobaraza, A.1
Cuadrado-Tejedor, M.2
Pérez-Mediavilla, A.3
Frechilla, D.4
Del Río, J.5
García-Osta, A.6
-
45
-
-
67649310030
-
Dysregulation of histone acetylation in the app/ ps1 mouse model of alzheimer's disease
-
Francis YI, Fa M, Ashraf H, Zhang H, Staniszewski A, Latchman DS, Arancio O. Dysregulation of histone acetylation in the APP/ PS1 mouse model of Alzheimer's disease. J Alzheimers Dis 2009; 18: 131-9.
-
(2009)
J Alzheimers Dis
, vol.18
, pp. 131-139
-
-
Francis, Y.I.1
Fa, M.2
Ashraf, H.3
Zhang, H.4
Staniszewski, A.5
Latchman, D.S.6
Arancio, O.7
-
46
-
-
75549087631
-
Treatment of alzheimer's disease cognitive symptoms
-
Abel C, Allegri RF, Garau L, Genovese O, Mangone CA. Treatment of Alzheimer's disease cognitive symptoms. Vertex 2008; 19(Suppl): 39-47.
-
(2008)
Vertex
, vol.19
, Issue.SUPPL.
, pp. 39-47
-
-
Abel, C.1
Allegri, R.F.2
Garau, L.3
Genovese, O.4
Mangone, C.A.5
-
48
-
-
80053586271
-
Long-Term phenylbutyrate administration prevents memory deficits in tg2576 mice by decreasing abeta
-
Ricobaraza A, Cuadrado-Tejedor M, Garcia-Osta A. Long-Term phenylbutyrate administration prevents memory deficits in Tg2576 mice by decreasing Abeta. Front Biosci (Elite Ed) 2011; 3: 1375-84.
-
(2011)
Front Biosci (Elite Ed
, vol.3
, pp. 1375-1384
-
-
Ricobaraza, A.1
Cuadrado-Tejedor, M.2
Garcia-Osta, A.3
-
49
-
-
84859712559
-
Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of alzheimer disease
-
Ricobaraza A, Cuadrado-Tejedor M, Marco S, Perez-Otano I, Garcia-Osta A. Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease. Hippocampus 2012; 22: 1040-50.
-
(2012)
Hippocampus
, vol.22
, pp. 1040-1050
-
-
Ricobaraza, A.1
Cuadrado-Tejedor, M.2
Marco, S.3
Perez-Otano, I.4
Garcia-Osta, A.5
-
50
-
-
84055183864
-
Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for alzheimer's disease
-
Cuadrado-Tejedor M, Garcia-Osta A, Ricobaraza A, Oyarzabal J, Franco R. Defining the mechanism of action of 4-phenylbutyrate to develop a small-molecule-based therapy for Alzheimer's disease. Curr Med Chem 2011; 18: 5545-53.
-
(2011)
Curr Med Chem
, vol.18
, pp. 5545-5553
-
-
Cuadrado-Tejedor, M.1
Garcia-Osta, A.2
Ricobaraza, A.3
Oyarzabal, J.4
Franco, R.5
-
51
-
-
76749091005
-
Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of alzheimer's disease
-
Kilgore M, Miller CA, Fass DM, Hennig KM, Haggarty SJ, Sweatt JD, Rumbaugh G. Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2010; 35: 870-80.
-
(2010)
Neuropsychopharmacology
, vol.35
, pp. 870-880
-
-
Kilgore, M.1
Miller, C.A.2
Fass, D.M.3
Hennig, K.M.4
Haggarty, S.J.5
Sweatt, J.D.6
Rumbaugh, G.7
-
52
-
-
80051984937
-
Sodium butyrate improves memory function in an alzheimer's disease mouse model when administered at an advanced stage of disease progression
-
Govindarajan N, Agis-Balboa RC, Walter J, Sananbenesi F, Fischer A. Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression. J Alzheimers Dis 2011; 26: 187-97.
-
(2011)
J Alzheimers Dis
, vol.26
, pp. 187-197
-
-
Govindarajan, N.1
Agis-Balboa, R.C.2
Walter, J.3
Sananbenesi, F.4
Fischer, A.5
-
53
-
-
38649124003
-
Epigenetic targets of hdac inhibition in neurodegenerative and psychiatric disorders
-
Abel T, Zukin RS. Epigenetic targets of HDAC inhibition in neurodegenerative and psychiatric disorders. Curr Opin Pharmacol 2008; 8: 57-64.
-
(2008)
Curr Opin Pharmacol
, vol.8
, pp. 57-64
-
-
Abel, T.1
Zukin, R.S.2
-
54
-
-
65549123471
-
Hdac2 negatively regulates memory formation and synaptic plasticity
-
Guan JS, Haggarty SJ, Giacometti E, Dannenberg JH, Joseph N, Gao J, Nieland TJ, Zhou Y, Wang X, Mazitschek R, Bradner JE, DePinho RA, Jaenisch R, Tsai LH. HDAC2 negatively regulates memory formation and synaptic plasticity. Nature 2009; 459: 55-60.
-
(2009)
Nature
, vol.459
, pp. 55-60
-
-
Guan, J.S.1
Haggarty, S.J.2
Giacometti, E.3
Dannenberg, J.H.4
Joseph, N.5
Gao, J.6
Nieland, T.J.7
Zhou, Y.8
Wang, X.9
Mazitschek, R.10
Bradner, J.E.11
DePinho, R.A.12
Jaenisch, R.13
Tsai, L.H.14
-
55
-
-
79958008166
-
Hdac3 and the molecular brake pad hypothesis
-
McQuown SC, Wood MA. HDAC3 and the molecular brake pad hypothesis. Neurobiol Learn Mem 2011; 96: 27-34.
-
(2011)
Neurobiol Learn Mem
, vol.96
, pp. 27-934
-
-
McQuown, S.C.1
Wood, M.A.2
-
56
-
-
84859540297
-
Hdac1 regulates fear extinction in mice
-
Bahari-Javan S, Maddalena A, Kerimoglu C, Wittnam J, Held T, Bähr M, Burkhardt S, Delalle I, Kügler S, Fischer A, Sananbenesi F. HDAC1 regulates fear extinction in mice. J Neurosci 2012; 32: 5062-73.
-
(2012)
J Neurosci
, vol.32
, pp. 5062-5073
-
-
Bahari-Javan, S.1
Maddalena, A.2
Kerimoglu, C.3
Wittnam, J.4
Held, T.5
Bähr, M.6
Burkhardt, S.7
Delalle, I.8
Kügler, S.9
Fischer, A.10
Sananbenesi, F.11
-
58
-
-
84864862726
-
An essential role for histone deacetylase 4 in synaptic plasticity and memory formation
-
Kim MS, Akhtar MW, Adachi M, Mahgoub M, Bassel-Duby R, Kavalali ET, Olson EN, Monteggia LM. An essential role for histone deacetylase 4 in synaptic plasticity and memory formation. J Neurosci 2012; 32: 10879-86.
-
(2012)
J Neurosci
, vol.32
, pp. 10879-10886
-
-
Kim, M.S.1
Akhtar, M.W.2
Adachi, M.3
Mahgoub, M.4
Bassel-Duby, R.5
Kavalali, E.T.6
Olson, E.N.7
Monteggia, L.M.8
-
59
-
-
84871946821
-
Reducing hdac6 ameliorates cognitive deficits in a mouse model for alzheimer's disease
-
Govindarajan N, Rao P, Burkhardt S, Sananbenesi F, Schlüter OM, Bradke F, Lu J, Fischer A. Reducing HDAC6 ameliorates cognitive deficits in a mouse model for Alzheimer's disease. EMBO Mol Med 2013; 5: 52-63.
-
(2013)
EMBO Mol Med
, vol.5
, pp. 52-63
-
-
Govindarajan, N.1
Rao, P.2
Burkhardt, S.3
Sananbenesi, F.4
Schlüter, O.M.5
Bradke, F.6
Lu, J.7
Fischer, A.8
-
60
-
-
0344640906
-
Domain-selective small-molecule inhibitor of histone deacetylase 6 (hdac6)-mediated tubulin deacetylation
-
Haggarty SJ, Koeller KM, Wong JC, Grozinger CM, Schreiber SL. Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation. Proc Natl Acad Sci USA 2003; 100: 4389-94.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 4389-4394
-
-
Haggarty, S.J.1
Koeller, K.M.2
Wong, J.C.3
Grozinger, C.M.4
Schreiber, S.L.5
-
61
-
-
44649158252
-
Hdac6: A key regulator of cytoskeleton cell migration and cell "cell interactions
-
Valenzuela-Fernandez A, Cabrero JR, Serrador JM, Sanchez-Madrid F. HDAC6: a key regulator of cytoskeleton, cell migration and cell-cell interactions. Trends Cell Biol 2008; 18: 291-7.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 291-297
-
-
Valenzuela-Fernandez, A.1
Cabrero, J.R.2
Serrador, J.M.3
Sanchez-Madrid, F.4
-
62
-
-
84862777943
-
An epigenetic blockade of cognitive functions in the neurodegenerating brain
-
Gräff J, Rei D, Guan JS, Wang WY, Seo J, Hennig KM, Nieland TJ, Fass DM, Kao PF, Kahn M, Su SC, Samiei A, Joseph N, Haggarty SJ, Delalle I, Tsai LH. An epigenetic blockade of cognitive functions in the neurodegenerating brain. Nature 2012; 483: 222-6.
-
(2012)
Nature
, vol.483
, pp. 222-226
-
-
Gräff, J.1
Rei, D.2
Guan, J.S.3
Wang, W.Y.4
Seo, J.5
Hennig, K.M.6
Nieland, T.J.7
Fass, D.M.8
Kao, P.F.9
Kahn, M.10
Su, S.C.11
Samiei, A.12
Joseph, N.13
Haggarty, S.J.14
Delalle, I.15
Tsai, L.H.16
-
63
-
-
49549083278
-
Histone deacetylase 6 interacts with the microtubule-Associated protein tau
-
Ding H, Dolan PJ, Johnson GV. Histone deacetylase 6 interacts with the microtubule-Associated protein tau. J Neurochem 2008; 106: 2119-30.
-
(2008)
J Neurochem
, vol.106
, pp. 2119-2130
-
-
Ding, H.1
Dolan, P.J.2
Johnson, G.V.3
-
64
-
-
0030240325
-
Reduction of acetylated alpha-Tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in alzheimer's disease
-
Hempen B, Brion JP. Reduction of acetylated alpha-Tubulin immunoreactivity in neurofibrillary tangle-bearing neurons in Alzheimer's disease. J Neuropathol Exp Neurol 1996; 55: 964-72.
-
(1996)
J Neuropathol Exp Neurol
, vol.55
, pp. 964-972
-
-
Hempen, B.1
Brion, J.P.2
-
65
-
-
58149314221
-
Valproic acid inhibits abeta production, neuritic plaque formation, and behavioral deficits in alzheimer's disease mouse models
-
Qing H, He G, Ly PT, Fox CJ, Staufenbiel M, Cai F, Zhang Z, Wei S, Sun X, Chen CH, Zhou W, Wang K, Song W. Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J Exp Med 2008; 205: 2781-9.
-
(2008)
J Exp Med
, vol.205
, pp. 2781-2789
-
-
Qing, H.1
He, G.2
Ly, P.T.3
Fox, C.J.4
Staufenbiel, M.5
Cai, F.6
Zhang, Z.7
Wei, S.8
Sun, X.9
Chen, C.H.10
Zhou, W.11
Wang, K.12
Song, W.13
-
66
-
-
84874661821
-
Oral administration of histone deacetylase inhibitor ms-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model
-
Zhang ZY, Schluesener HJ. Oral administration of histone deacetylase inhibitor MS-275 ameliorates neuroinflammation and cerebral amyloidosis and improves behavior in a mouse model. J Neuropathol Exp Neurol 2013; 72: 178-85.
-
(2013)
J Neuropathol Exp Neurol
, vol.72
, pp. 178-185
-
-
Zhang, Z.Y.1
Schluesener, H.J.2
-
67
-
-
79957852572
-
Valproate reduces tau phosphorylation via cyclindependent kinase 5 and glycogen synthase kinase 3 signaling pathways
-
Hu JP, Xie JW, Wang CY, Wang T, Wang X, Wang SL, Teng WP, Wang ZY. Valproate reduces tau phosphorylation via cyclindependent kinase 5 and glycogen synthase kinase 3 signaling pathways. Brain Res Bull 2011; 85: 194-200.
-
(2011)
Brain Res Bull
, vol.85
, pp. 194-200
-
-
Hu, J.P.1
Xie, J.W.2
Wang, C.Y.3
Wang, T.4
Wang, X.5
Wang, S.L.6
Teng, W.P.7
Wang, Z.Y.8
-
68
-
-
84888630942
-
Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the alzheimer s disease-like phenotype of a commonly used mouse model
-
Cuadrado-Tejedor M, Ricobaraza AL, Torrijo R, Franco R, Garcia-Osta A. Phenylbutyrate is a multifaceted drug that exerts neuroprotective effects and reverses the Alzheimer s disease-like phenotype of a commonly used mouse model. Curr Pharm Des 2013; 10: 390-405.
-
(2013)
Curr Pharm Des
, vol.10
, pp. 390-405
-
-
Cuadrado-Tejedor, M.1
Ricobaraza, A.L.2
Torrijo, R.3
Franco, R.4
Garcia-Osta, A.5
-
69
-
-
84868549261
-
Mercaptoacetamidebased class ii hdac inhibitor lowers abeta levels and improves learning and memory in a mouse model of alzheimer's disease
-
Sung YM, Lee T, Yoon H, DiBattista AM, Song JM, Sohn Y, Moffat EI, Turner RS, Jung M, Kim J, Hoe HS. Mercaptoacetamidebased class II HDAC inhibitor lowers Abeta levels and improves learning and memory in a mouse model of Alzheimer's disease. Exp Neurol 2013; 239: 192-201.
-
(2013)
Exp Neurol
, vol.239
, pp. 192-201
-
-
Sung, Y.M.1
Lee, T.2
Yoon, H.3
DiBattista, A.M.4
Song, J.M.5
Sohn, Y.6
Moffat, E.I.7
Turner, R.S.8
Jung, M.9
Kim, J.10
Hoe, H.S.11
-
70
-
-
65949122957
-
Tau-An inhibitor of deacetylase hdac6 function
-
Perez M, Santa-Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero JR, Sanchez-Madrid F, Dawson HN, Vitek MP, Perry G, Smith MA, Avila J. Tau-An inhibitor of deacetylase HDAC6 function. J Neurochem 2009; 109: 1756-66.
-
(2009)
J Neurochem
, vol.109
, pp. 1756-1766
-
-
Perez, M.1
Santa-Maria, I.2
Gomez De Barreda, E.3
Zhu, X.4
Cuadros, R.5
Cabrero, J.R.6
Sanchez-Madrid, F.7
Dawson, H.N.8
Vitek, M.P.9
Perry, G.10
Smith, M.A.11
Avila, J.12
-
71
-
-
70349096650
-
Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection
-
Monti B, Polazzi E, Contestabile A. Biochemical, molecular and epigenetic mechanisms of valproic acid neuroprotection. Curr Mol Pharmacol 2009; 2: 95-109.
-
(2009)
Curr Mol Pharmacol
, vol.2
, pp. 95-109
-
-
Monti, B.1
Polazzi, E.2
Contestabile, A.3
-
72
-
-
57749170458
-
The many roles of histone deacetylases in development and physiology: Implications for disease and therapy
-
Haberland M, Montgomery RL, Olson EN. The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 2009; 10: 32-42.
-
(2009)
Nat Rev Genet
, vol.10
, pp. 32-42
-
-
Haberland, M.1
Montgomery, R.L.2
Olson, E.N.3
-
74
-
-
34447308268
-
Sirt1 deacetylase protects against neurodegeneration in models for alzheimer's disease and amyotrophic lateral sclerosis
-
Kim D, Nguyen MD, Dobbin MM, Fischer A, Sananbenesi F, Rodgers JT, Delalle I, Baur JA, Sui G, Armour SM, Puigserver P, Sinclair DA, Tsai LH. SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. Embo J 2007; 26: 3169-79.
-
(2007)
Embo J
, vol.26
, pp. 3169-3179
-
-
Kim, D.1
Nguyen, M.D.2
Dobbin, M.M.3
Fischer, A.4
Sananbenesi, F.5
Rodgers, J.T.6
Delalle, I.7
Baur, J.A.8
Sui, G.9
Armour, S.M.10
Puigserver, P.11
Sinclair, D.A.12
Tsai, L.H.13
-
75
-
-
64049092736
-
Sirtuin 1 reduction parallels the accumulation of tau in alzheimer disease
-
Julien C, Tremblay C, Emond V, Lebbadi M, Salem N Jr, Bennett DA, Calon F. Sirtuin 1 reduction parallels the accumulation of tau in Alzheimer disease. J Neuropathol Exp Neurol 2009; 68: 48-58.
-
(2009)
J Neuropathol Exp Neurol
, vol.68
, pp. 48-58
-
-
Julien, C.1
Tremblay, C.2
Emond, V.3
Lebbadi, M.4
Salem Jr., N.5
Bennett, D.A.6
Calon, F.7
-
76
-
-
84871379266
-
The effects of sirt1 on alzheimer's disease models
-
Donmez, G. The effects of SIRT1 on Alzheimer's disease models. Int J Alzheimers Dis 2012; 2012: 509-529.
-
(2012)
Int J Alzheimers Dis
, vol.2012
, pp. 509-529
-
-
Donmez, G.1
-
77
-
-
57449120637
-
Therapeutic potential of resveratrol in alzheimer's disease
-
Vingtdeux V, Dreses-Werringloer U, Zhao H, Davies P, Marambaud P. Therapeutic potential of resveratrol in Alzheimer's disease. BMC Neurosci 2008; 9(Suppl 2): S6.
-
(2008)
BMC Neurosci
, vol.9
, Issue.SUPPL. 2
-
-
Vingtdeux, V.1
Dreses-Werringloer, U.2
Zhao, H.3
Davies, P.4
Marambaud, P.5
-
78
-
-
58149267462
-
Nicotinamide restores cognition in alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of thr231-phosphotau
-
Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM. Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci 2008; 28: 11500-10.
-
(2008)
J Neurosci
, vol.28
, pp. 11500-11510
-
-
Green, K.N.1
Steffan, J.S.2
Martinez-Coria, H.3
Sun, X.4
Schreiber, S.S.5
Thompson, L.M.6
LaFerla, F.M.7
-
79
-
-
0037291214
-
The human sir2 ortholog, sirt2, is an nad+-dependent tubulin deacetylase
-
North BJ, Marshall BL, Borra MT, Denu JM, Verdin E. The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. Mol Cell 2003; 11: 437-44.
-
(2003)
Mol Cell
, vol.11
, pp. 437-444
-
-
North, B.J.1
Marshall, B.L.2
Borra, M.T.3
Denu, J.M.4
Verdin, E.5
-
80
-
-
33746824192
-
Neuronal sirt1 activation as a novel mechanism underlying the prevention of alzheimer disease amyloid neuropathology by calorie restriction
-
Qin W, Yang T, Ho L, Zhao Z, Wang J, Chen L, Zhao W, Thiyagarajan M, MacGrogan D, Rodgers JT, Puigserver P, Sadoshima J, Deng H, Pedrini S, Gandy S, Sauve AA, Pasinetti GM. Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction. J Biol Chem 2006; 281: 21745-54.
-
(2006)
J Biol Chem
, vol.281
, pp. 21745-21754
-
-
Qin, W.1
Yang, T.2
Ho, L.3
Zhao, Z.4
Wang, J.5
Chen, L.6
Zhao, W.7
Thiyagarajan, M.8
MacGrogan, D.9
Rodgers, J.T.10
Puigserver, P.11
Sadoshima, J.12
Deng, H.13
Pedrini, S.14
Gandy, S.15
Sauve, A.A.16
Pasinetti, G.M.17
-
81
-
-
78649891582
-
Tuning acetylation levels with hat activators: Therapeutic strategy in neurodegenerative diseases
-
Selvi BR, Cassel JC, Kundu TK, Boutillier AL. Tuning acetylation levels with HAT activators: therapeutic strategy in neurodegenerative diseases. Biochim Biophys Acta 2010; 1799: 840-53.
-
(2010)
Biochim Biophys Acta
, vol.1799
, pp. 840-853
-
-
Selvi, B.R.1
Cassel, J.C.2
Kundu, T.K.3
Boutillier, A.L.4
-
82
-
-
0035339491
-
Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator cbp in rubinstein-Taybi syndrome
-
Murata T, Kurokawa R, Krones A, Tatsumi K, Ishii M, Taki T, Masuno M, Ohashi H, Yanagisawa M, Rosenfeld MG, Glass CK, Hayashi Y. Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome. Hum Mol Genet 2001; 10: 1071-6.
-
(2001)
Hum Mol Genet
, vol.10
, pp. 1071-1076
-
-
Murata, T.1
Kurokawa, R.2
Krones, A.3
Tatsumi, K.4
Ishii, M.5
Taki, T.6
Masuno, M.7
Ohashi, H.8
Yanagisawa, M.9
Rosenfeld, M.G.10
Glass, C.K.11
Hayashi, Y.12
-
83
-
-
84857674697
-
Long-Term memory deficits in huntington's disease are associated with reduced cbp histone acetylase activity
-
Giralt A, Puigdellívol M, Carretón O, Paoletti P, Valero J, Parra-Damas A, Saura CA, Alberch J, Ginés S. Long-Term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity. Hum Mol Genet 2012; 21: 1203-16.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 1203-1216
-
-
Giralt, A.1
Puigdellívol, M.2
Carretón, O.3
Paoletti, P.4
Valero, J.5
Parra-Damas, A.6
Saura, C.A.7
Alberch, J.8
Ginés, S.9
-
84
-
-
78651072485
-
Cbp gene transfer increases bdnf levels and ameliorates learning and memory deficits in a mouse model of alzheimer's disease
-
Caccamo A, Maldonado MA, Bokov AF, Majumder S, Oddo S. CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2010; 107: 22687-92.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 22687-22692
-
-
Caccamo, A.1
Maldonado, M.A.2
Bokov, A.F.3
Majumder, S.4
Oddo, S.5
-
86
-
-
56149122976
-
Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: Delivery of membrane-impermeable molecule to modulate gene expression in vivo
-
Elvi BR, Jagadeesan D, Suma BS, Nagashankar G, Arif M, Balasubramanyam K, Eswaramoorthy M, Kundu TK. Intrinsically fluorescent carbon nanospheres as a nuclear targeting vector: delivery of membrane-impermeable molecule to modulate gene expression in vivo. Nano Lett 2008; 8: 3182-8.
-
(2008)
Nano Lett
, vol.8
, pp. 3182-3188
-
-
Elvi, B.R.1
Jagadeesan, D.2
Suma, B.S.3
Nagashankar, G.4
Arif, M.5
Balasubramanyam, K.6
Eswaramoorthy, M.7
Kundu, T.K.8
-
88
-
-
77957001697
-
Acetylation of tau inhibits its degradation and contributes to tauopathy
-
Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Huang EJ, Shen Y, Masliah E, Mukherjee C, Meyers D, Cole PA, Ott M, Gan L. Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 2010; 67: 953-66.
-
(2010)
Neuron
, vol.67
, pp. 953-966
-
-
Min, S.W.1
Cho, S.H.2
Zhou, Y.3
Schroeder, S.4
Haroutunian, V.5
Seeley, W.W.6
Huang, E.J.7
Shen, Y.8
Masliah, E.9
Mukherjee, C.10
Meyers, D.11
Cole, P.A.12
Ott, M.13
Gan, L.14
-
89
-
-
77956176874
-
Regulation of sirt1 in cellular functions: Role of polyphenols
-
Chung S, Yao H, Caito S, Hwang JW, Arunachalam G, Rahman I. Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys 2010; 501: 79-90.
-
(2010)
Arch Biochem Biophys
, vol.501
, pp. 79-90
-
-
Chung, S.1
Yao, H.2
Caito, S.3
Hwang, J.W.4
Arunachalam, G.5
Rahman, I.6
-
90
-
-
82955165827
-
Gallic acid, a histone acetyltransferase inhibitor, suppresses beta-Amyloid neurotoxicity by inhibiting microglialmediated neuroinflammation
-
Kim MJ, Seong AR, Yoo JY, Jin CH, Lee YH, Kim YJ, Lee J, Jun WJ, Yoon HG. Gallic acid, a histone acetyltransferase inhibitor, suppresses beta-Amyloid neurotoxicity by inhibiting microglialmediated neuroinflammation. Mol Nutr Food Res 2011; 55: 1798-808.
-
(2011)
Mol Nutr Food Res
, vol.55
, pp. 1798-1808
-
-
Kim, M.J.1
Seong, A.R.2
Yoo, J.Y.3
Jin, C.H.4
Lee, Y.H.5
Kim, Y.J.6
Lee, J.7
Jun, W.J.8
Yoon, H.G.9
-
91
-
-
45749089694
-
Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and alzheimer's disease
-
Begum AN, Jones MR, Lim GP, Morihara T, Kim P, Heath DD, Rock CL, Pruitt MA, Yang F, Hudspeth B, Hu S, Faull KF, Teter B, Cole GM, Frautschy SA. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Ther 2008; 326: 196-208.
-
(2008)
J Pharmacol Exp Ther
, vol.326
, pp. 196-208
-
-
Begum, A.N.1
Jones, M.R.2
Lim, G.P.3
Morihara, T.4
Kim, P.5
Heath, D.D.6
Rock, C.L.7
Pruitt, M.A.8
Yang, F.9
Hudspeth, B.10
Hu, S.11
Faull, K.F.12
Teter, B.13
Cole, G.M.14
Frautschy, S.A.15
-
93
-
-
84875439722
-
Stay on target
-
Editorial
-
Editorial. Stay on target. Nat Chem Biol 2013; 9: 193.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 193
-
-
-
94
-
-
84867395940
-
Dna methylation inhibitors in cancer: Recent and future approaches
-
Gros C, Fahy J, Halby L, Dufau I, Erdmann A, Gregoire JM, Ausseil F, Vispé S, Arimondo PB. DNA methylation inhibitors in cancer: recent and future approaches. Biochimie 2012; 94: 2280-96.
-
(2012)
Biochimie
, vol.94
, pp. 2280-296
-
-
Gros, C.1
Fahy, J.2
Halby, L.3
Dufau, I.4
Erdmann, A.5
Gregoire, J.M.6
Ausseil, F.7
Vispé, S.8
Arimondo, P.B.9
-
95
-
-
58549094898
-
Curcumin is a potent dna hypomethylation agent
-
Liu Z, Xie Z, Jones W, Pavlovicz RE, Liu S, Yu J, Li PK, Lin J, Fuchs JR, Marcucci G, Li C, Chan KK. Curcumin is a potent DNA hypomethylation agent. Bioorg Med Chem Lett 2009; 19: 706-9.
-
(2009)
Bioorg Med Chem Lett
, vol.19
, pp. 706-709
-
-
Liu, Z.1
Xie, Z.2
Jones, W.3
Pavlovicz, R.E.4
Liu, S.5
Yu, J.6
Li, P.K.7
Lin, J.8
Fuchs, J.R.9
Marcucci, G.10
Li, C.11
Chan, K.K.12
-
96
-
-
33645086120
-
Functional diversity of dna methyltransferase inhibitors in human cancer cell lines
-
Stresemann C, Brueckner B, Musch T, Stopper H, Lyko F. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res 2006; 66: 2794-800.
-
(2006)
Cancer Res
, vol.66
, pp. 2794-2800
-
-
Stresemann, C.1
Brueckner, B.2
Musch, T.3
Stopper, H.4
Lyko, F.5
-
97
-
-
66249127951
-
A new class of quinolinebased dna hypomethylating agents reactivates tumor suppressor genes by blocking dna methyltransferase 1 activity and inducing its degradation
-
Datta J, Ghoshal K, Denny WA, Gamage SA, Brooke DG, Phiasivongsa P, Redkar S, Jacob ST. A new class of quinolinebased DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degradation. Cancer Res 2009; 69: 4277-85.
-
(2009)
Cancer Res
, vol.69
, pp. 4277-4285
-
-
Datta, J.1
Ghoshal, K.2
Denny, W.A.3
Gamage, S.A.4
Brooke, D.G.5
Phiasivongsa, P.6
Redkar, S.7
Jacob, S.T.8
-
98
-
-
77955355838
-
Rational design and simple chemistry yield a superior, neuroprotective hdac6 inhibitor, tubastatin a
-
Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J Am Chem Soc 2010; 132: 10842-6.
-
(2010)
J Am Chem Soc
, vol.132
, pp. 10842-10846
-
-
Butler, K.V.1
Kalin, J.2
Brochier, C.3
Vistoli, G.4
Langley, B.5
Kozikowski, A.P.6
-
100
-
-
84874638204
-
Potent and selective inhibition of histone deacetylase 6 (hdac6) does not require a surface-binding motif
-
Epub ahead of print]
-
Wagner FF, Olson DE, Gale JP, Kaya T, Weïwer M, Aidoud N, Thomas M, Davoine EL, Lemercier BC, Zhang YL, Holson EB. Potent and selective inhibition of histone deacetylase 6 (HDAC6) does not require a surface-binding motif. J Med Chem 2013. [Epub ahead of print]
-
J Med Chem 2013
-
-
Wagner, F.F.1
Olson, D.E.2
Gale, J.P.3
Kaya, T.4
Weïwer, M.5
Aidoud, N.6
Thomas, M.7
Davoine, E.L.8
Lemercier, B.C.9
Zhang, Y.L.10
Holson, E.B.11
-
101
-
-
84875241051
-
Hdac6 mutations rescue human tau-induced microtubule defects in drosophila
-
Xiong Y, Zhao K, Wu J, Xu Z, Jin S, Zhang YQ. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila. Proc Natl Acad Sci USA 2013; 110: 4604-9.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 4604-4609
-
-
Xiong, Y.1
Zhao, K.2
Wu, J.3
Xu, Z.4
Jin, S.5
Zhang, Y.Q.6
-
102
-
-
84879092346
-
Selective class iia histone deacetylase inhibition via a nonchelating zinc-binding group
-
Lobera M, Madauss KP, Pohlhaus DT, Wright QG, Trocha M, Schmidt DR, Baloglu E, Trump RP, Head MS, Hofmann GA, Murray-Thompson M, Schwartz B,Chakravorty S, Wu Z, Mander PK, Kruidenier L, Reid RA, Burkhart W, Turunen BJ, Rong JX, Wagner C, Moyer MB, Wells C, Hong X, Moore JT, Williams JD, Soler D, Ghosh S, Nolan MA. Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group. Nat Chem Biol 2013; 9: 319-25.
-
(2013)
Nat Chem Biol
, vol.9
, pp. 319-325
-
-
Lobera, M.1
Madauss, K.P.2
Pohlhaus, D.T.3
Wright, Q.G.4
Trocha, M.5
Schmidt, D.R.6
Baloglu, E.7
Trump, R.P.8
Head, M.S.9
Hofmann, G.A.10
Murray-Thompson, M.11
Schwartz, B.12
Chakravorty, S.13
Wu, Z.14
Mander, P.K.15
Kruidenier, L.16
Reid, R.A.17
Burkhart, W.18
Turunen, B.J.19
Rong, J.X.20
Wagner, C.21
Moyer, M.B.22
Wells, C.23
Hong, X.24
Moore, J.T.25
Williams, J.D.26
Soler, D.27
Ghosh, S.28
Nolan, M.A.29
more..
-
103
-
-
79955979595
-
Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in ad transgenic mice
-
Wiley JC, Pettan-Brewer C, Ladiges WC. Phenylbutyric acid reduces amyloid plaques and rescues cognitive behavior in AD transgenic mice. Aging Cell 2011; 10: 418-28.
-
(2011)
Aging Cell
, vol.10
, pp. 418-428
-
-
Wiley, J.C.1
Pettan-Brewer, C.2
Ladiges, W.C.3
-
104
-
-
78651470146
-
Effect of inhibiting histone deacetylase with short-chain carboxylic acids and their hydroxamic acid analogs on vertebrate development and neuronal chromatin
-
Fass DM, Shah R, Ghosh B, Hennig K, Norton S, Zhao WN, Reis SA, Klein PS, Mazitschek R, Maglathlin RL, Lewis TA, Haggarty SJ. Effect of inhibiting histone deacetylase with short-chain carboxylic acids and their hydroxamic acid analogs on vertebrate development and neuronal chromatin. ACS Med Chem Lett 2010; 2: 39-42.
-
(2010)
ACS Med Chem Lett
, vol.2
, pp. 39-42
-
-
Fass, D.M.1
Shah, R.2
Ghosh, B.3
Hennig, K.4
Norton, S.5
Zhao, W.N.6
Reis, S.A.7
Klein, P.S.8
Mazitschek, R.9
Maglathlin, R.L.10
Lewis, T.A.11
Haggarty, S.J.12
-
105
-
-
37849019672
-
Determination of the class and isoform selectivity of smallmolecule histone deacetylase inhibitors
-
Khan N, Jeffers M, Kumar S, Hackett C, Boldog F, Khramtsov N, Qian X, Mills E, Berghs SC, Carey N, Finn PW, Collins LS, Tumber A, Ritchie JW, Jensen PB, Lichenstein HS, Sehested M. Determination of the class and isoform selectivity of smallmolecule histone deacetylase inhibitors. Biochem J 2008; 409: 581-9.
-
(2008)
Biochem J
, vol.409
, pp. 581-589
-
-
Khan, N.1
Jeffers, M.2
Kumar, S.3
Hackett, C.4
Boldog, F.5
Khramtsov, N.6
Qian, X.7
Mills, E.8
Berghs, S.C.9
Carey, N.10
Finn, P.W.11
Collins, L.S.12
Tumber, A.13
Ritchie, J.W.14
Jensen, P.B.15
Lichenstein, H.S.16
Sehested, M.17
|