Targeting of the GTPase Irgm1 to the phagosomal membrane via PtdIns(3,4)P2 and PtdIns(3,4,5)P3 promotes immunity to mycobacteria

Nature Immunology

Volumn 10, Issue 8, 2009, Pages 907-917

  Tiwari, Sangeeta ^a   Choi, Han Pil ^a   Matsuzawa, Takeshi ^a,c   Pypaert, Marc ^b   MacMicking, John D ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Osaka City University   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; INTERFERON INDUCIBLE GUANOSINE TRIPHOSPHATASE IRGM1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BACTERIAL IMMUNITY; CONTROLLED STUDY; EMBRYO; ENZYME INHIBITION; ENZYME ISOLATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MEMBRANE BINDING; MOUSE; MYCOBACTERIUM; NONHUMAN; PHAGOSOME; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; SIGNAL TRANSDUCTION; WILD TYPE;

ANIMALS; CELLS, CULTURED; GTP-BINDING PROTEINS; IMMUNITY, INNATE; INTERFERON-GAMMA; INTRACELLULAR MEMBRANES; LYSOSOMES; MACROPHAGES; MICE; MYCOBACTERIUM TUBERCULOSIS; PHAGOSOMES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOL PHOSPHATES; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; SNARE PROTEINS;

EID: 67651174262     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1759     Document Type: Article

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