Concanavalin A/IFN-gamma triggers autophagy-related necrotic hepatocyte death through IRGM1-mediated lysosomal membrane disruption

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Chang, Chih Peng ^a   Yang, Ming Chen ^a   Lei, Huan Yao ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CATHEPSIN L; CONCANAVALIN A; GAMMA INTERFERON; GUANOSINE TRIPHOSPHATASE; IMMUNITY RELATED GUANOSINE TRIPHOSPHATASE FAMILY M MEMBER 1; UNCLASSIFIED DRUG; GUANINE NUCLEOTIDE BINDING PROTEIN; IFI1 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL DEATH; CELL LINE; CONTROLLED STUDY; ENZYME RELEASE; HEPATITIS; LIVER CELL; LIVER LYSOSOME; LYSOSOME MEMBRANE; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; MOUSE; NONHUMAN; PROTEIN TRANSPORT; ANIMAL; BAGG ALBINO MOUSE; CELL MEMBRANE; CELL STRAIN HEPG2; CYTOLOGY; ENDOCYTOSIS; HUMAN; LIVER CELL CARCINOMA; LIVER TUMOR; LYSOSOME; METABOLISM; NECROSIS; PERMEABILITY; TUMOR CELL LINE;

ANIMALS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CATHEPSIN B; CATHEPSIN L; CELL LINE, TUMOR; CELL MEMBRANE; CONCANAVALIN A; ENDOCYTOSIS; GTP-BINDING PROTEINS; HEP G2 CELLS; HEPATOCYTES; HUMANS; INTERFERON-GAMMA; LIVER NEOPLASMS; LYSOSOMES; MICE; MICE, INBRED BALB C; NECROSIS; PERMEABILITY;

EID: 82655189171     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028323     Document Type: Article

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