CYP2E1 potentiates binge alcohol-induced gut leakiness, steatohepatitis, and apoptosis

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 1238-1245

  Abdelmegeed, Mohamed A ^a   Banerjee, Atrayee ^a   Jang, Sehwan ^a   Yoo, Seong Ho ^b   Yun, Jun Won ^a   Gonzalez, Frank J ^c   Keshavarzian, Ali ^d   Song, Byoung Joon ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b Seoul National University College of Medicine   (South Korea)

^c NATIONAL CANCER INSTITUTE   (United States)

^d RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Apoptosis; Binge ethanol; CYP2E1; Free radicals; Gut leakiness; Liver; Oxidative stress; Steatohepatitis

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CLOMETHIAZOLE; CYTOCHROME P450 2E1; ENDOTOXIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN KINASE B; SUPEROXIDE DISMUTASE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BINGE DRINKING; CONTROLLED STUDY; ENTEROBACTERIACEAE; ENZYME ACTIVITY; ENZYME REPRESSION; FEEDING; FEMALE; LAMINA PROPRIA; LIPID METABOLISM; LIPID PEROXIDATION; LIVER CELL; LIVER HISTOLOGY; MITOCHONDRION; NICK END LABELING; NONALCOHOLIC FATTY LIVER; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; WILD TYPE;

ENTEROBACTERIACEAE; MUS;

3-NITROTYROSINE; 3-NT; AFLD; ALANINE AMINOTRANSFERASE; ALCOHOLIC FATTY LIVER DISEASE; ALCOHOLIC LIVER DISEASE; ALCOHOLIC STEATOHEPATITIS; ALD; ALDH2; ALT; APOPTOSIS; ASH; BINGE ETHANOL; CHLORMETHIAZOLE; CMZ; CYP2E1; CYP2E1-NULL-DEXTROSE; CYP2E1-NULL-ETHANOL; CYTOCHROME P450 2E1; FREE RADICALS; GUT LEAKINESS; HAE; HIGH-POWER FIELD; HPF; HYDROXYALKENAL; LIVER; MALONDIALDEHYDE; MDA; MITOCHONDRIAL ALDEHYDE DEHYDROGENASE 2; MITOCHONDRIAL SUPEROXIDE DISMUTASE; N-ACETYLCYSTEINE; NAC; NAFLD; NASH; NONALCOHOLIC FATTY LIVER DISEASE; NONALCOHOLIC STEATOHEPATITIS; NULL-DEX; NULL-ETOH; OXIDATIVE STRESS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-Α; PPAR-Α; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; RNS; ROS; SOD2; STEATOHEPATITIS; TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE DUTP NICK-END LABELING; TG; TNF-Α; TRIGLYCERIDE; TUMOR NECROSIS FACTOR-Α; TUNEL; WILD-TYPE; WILD-TYPE-DEXTROSE; WILD-TYPE-ETHANOL.; WT; WT-DEX; WT-ETOH;

ANIMALS; APOPTOSIS; BINGE DRINKING; CYTOCHROME P-450 CYP2E1; CYTOKINES; ENDOTOXEMIA; ENDOTOXINS; ENTEROBACTERIACEAE; ETHANOL; FATTY LIVER; FEMALE; INTESTINES; LIPID METABOLISM; LIVER; MALE; MICE; MICE, KNOCKOUT; OXIDATIVE STRESS; SIGNAL TRANSDUCTION;

EID: 84885366143     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.09.009     Document Type: Article

References (44)

1. K.R. Merikangas, and V.L. McClair Epidemiology of substance use disorders Hum. Genet. 131 2012 779 789
2. M.C. Dufour, F.S. Stinson, and M.F. Caces Trends in cirrhosis morbidity and mortality: United States, 1979-1988 Semin. Liver Dis. 13 1993 109 125 (Pubitemid 23183168)
3. M.R. Lucey, P. Mathurin, and T.R. Morgan Alcoholic hepatitis N. Engl. J. Med. 360 2009 2758 2769
4. F. Stickel, and H.K. Seitz Alcoholic steatohepatitis Best Pract. Res. Clin. Gastroenterol 24 2010 683 693
5. K. Begriche, A. Igoudjil, D. Pessayre, and B. Fromenty Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it Mitochondrion 6 2006 1 28
6. V.L. Massey, and G.E. Arteel Acute alcohol-induced liver injury Front. Physiol. 3 2012 193
7. B. Schnabl Linking intestinal homeostasis and liver disease Curr. Opin. Gastroenterol. 29 2013 264 270
8. V. Purohit, B. Gao, and B.J. Song Molecular mechanisms of alcoholic fatty liver Alcohol. Clin. Exp. Res. 33 2009 191 205
9. A.I. Cederbaum Role of CYP2E1 in ethanol-induced oxidant stress, fatty liver and hepatotoxicity Dig. Dis. 28 2010 802 811
10. C. Bode, V. Kugler, and J.C. Bode Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess J. Hepatol. 4 1987 8 14 (Pubitemid 17045538)
11. A. Keshavarzian, A. Farhadi, C.B. Forsyth, J. Rangan, S. Jakate, M. Shaikh, A. Banan, and J.Z. Fields Evidence that chronic alcohol exposure promotes intestinal oxidative stress, intestinal hyperpermeability and endotoxemia prior to development of alcoholic steatohepatitis in rats J. Hepatol. 50 2009 538 547
12. L. Yang, D. Wu, X. Wang, and A.I. Cederbaum Cytochrome P4502E1, oxidative stress, JNK, and autophagy in acute alcohol-induced fatty liver Free Radic. Biol. Med. 53 2012 1170 1180
13. D. Wu, X. Wang, R. Zhou, L. Yang, and A.I. Cederbaum Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy Free Radic. Biol. Med. 53 2012 1346 1357
14. M.A. Abdelmegeed, K.H. Moon, J.P. Hardwick, F.J. Gonzalez, and B.J. Song Role of peroxisome proliferator-activated receptor-α in fasting-mediated oxidative stress Free Radic. Biol. Med. 47 2009 767 778
15. K.H. Moon, B.L. Hood, P. Mukhopadhyay, M. Rajesh, M.A. Abdelmegeed, Y.I. Kwon, T.P. Conrads, T.D. Veenstra, B.J. Song, and P. Pacher Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion Gastroenterology 135 2008 1344 1357
16. E.A. Mutlu, P.M. Gillevet, H. Rangwala, M. Sikaroodi, A. Naqvi, P.A. Engen, M. Kwasny, C.K. Lau, and A. Keshavarzian Colonic microbiome is altered in alcoholism Am. J. Physiol. Gastrointest. Liver Physiol. 302 2012 G966 978
17. J. Ewaschuk, R. Endersby, D. Thiel, H. Diaz, J. Backer, M. Ma, T. Churchill, and K. Madsen Probiotic bacteria prevent hepatic damage and maintain colonic barrier function in a mouse model of sepsis Hepatology 46 2007 841 850 (Pubitemid 47436131)
18. B.J. Song, M.A. Abdelmegeed, S.H. Yoo, B.J. Kim, S.A. Jo, I. Jo, and K.H. Moon Post-translational modifications of mitochondrial aldehyde dehydrogenase and biomedical implications J. Proteomics 74 2011 2691 2702
19. J.W. Han, X.R. Zhan, X.Y. Li, B. Xia, Y.Y. Wang, J. Zhang, and B.X. Li Impaired PI3K/Akt signal pathway and hepatocellular injury in high-fat fed rats World J. Gastroenterol. 16 2010 6111 6118
20. A.R. Hussain, S.O. Ahmed, M. Ahmed, O.S. Khan, S. Al Abdulmohsen, L.C. Platanias, K.S. Al-Kuraya, and S. Uddin Cross-talk between NFkB and the PI3-kinase/AKT pathway can be targeted in primary effusion lymphoma (PEL) cell lines for efficient apoptosis PLoS One 7 2012 e39945
21. S. Liu, T.H. Yeh, and V.P. Singh beta-Catenin is essential for ethanol metabolism and protection against alcohol-mediated liver steatosis in mice Hepatology 55 2012 931 940
22. B. Viollet, M. Foretz, and B. Guigas Activation of AMP-activated protein kinase in the liver: a new strategy for the management of metabolic hepatic disorders J. Physiol. (London) 574 2012 41 53
23. M.A. Abdelmegeed, A. Banerjee, and S.H. Yoo Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis J. Hepatol 57 2012 860 866
24. H. Zong, M. Armoni, and C. Harel Cytochrome P-450 CYP2E1 knockout mice are protected against high-fat diet-induced obesity and insulin resistance Am. J. Physiol. Endocrinol. Metab. 302 2012 E532 539
25. C.S. Lieber Cytochrome P-4502E1: its physiological and pathological role Physiol. Rev. 77 1997 517 544 (Pubitemid 27184347)
26. Y. Lu, J. Zhuge, and X. Wang Cytochrome P450 2E1 contributes to ethanol-induced fatty liver in mice Hepatology 47 2008 1483 1494 (Pubitemid 351702732)
27. H. Kono, B.U. Bradford, and M. Yin CYP2E1 is not involved in early alcohol-induced liver injury Am. J. Physiol. Gastrointest. Liver Physiol. 277 1999 G1259 1267
28. A. Butura, K. Nilsson, and K. Morgan The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model J. Hepatol. 50 2009 572 583
29. M.N. Strong, N. Yoneyama, and A.M. Fretwell Binge drinking experience in adolescent mice shows sex differences and elevated ethanol intake in adulthood Horm. Behav. 58 2010 82 90
30. J.C. Lambert, Z. Zhou, and L. Wang Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice J. Pharmacol. Exp. Ther 305 2003 880 886 (Pubitemid 36617964)
31. I. Bergheim, L. Guo, and M.A. Davis Metformin prevents alcohol-induced liver injury in the mouse: critical role of plasminogen activator inhibitor-1 Gastroenterology 130 2006 2099 2112 (Pubitemid 43816952)
32. D. Wu, and A. Cederbaum Cytochrome P4502E1 sensitizes to tumor necrosis factor alpha-induced liver injury through activation of mitogen-activated protein kinases in mice Hepatology 47 2008 1005 1017 (Pubitemid 351449692)
33. Y. Lu, and A.I. Cederbaum CYP2E1 potentiation of LPS and TNFalpha-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction Genes Nutr. 5 2010 149 167
34. Y. Tang, C.B. Forsyth, and A. Farhadi Nitric oxide-mediated intestinal injury is required for alcohol-induced gut leakiness and liver damage Alcohol. Clin. Exp. Res. 33 2009 1220 1230
35. A. Banan, A. Farhadi, and J.Z. Fields The delta-isoform of protein kinase C causes inducible nitric-oxide synthase and nitric oxide up-regulation: key mechanism for oxidant-induced carbonylation, nitration, and disassembly of the microtubule cytoskeleton and hyperpermeability of barrier of intestinal epithelia J. Pharmacol. Exp. Ther 305 2003 482 494 (Pubitemid 36459161)
36. C.B. Forsyth, R.M. Voigt, and M. Shaikh Role for intestinal Cyp2e1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability Am. J. Physiol. Gastrointest. Liver Physiol. 305 2013 G185 195
37. M.A. Abdelmegeed, K.H. Moon, C. Chen, F.J. Gonzalez, and B.J. Song Role of cytochrome p450 2E1 in protein nitration and ubiquitin-mediated degradation during acetaminophen toxicity Biochem. Pharmacol. 79 2010 57 66
38. M.A. Abdelmegeed, S. Jang, A. Banerjee, J.P. Hardwick, and B.J. Song Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury Free Radic. Biol. Med. 60 2013 211 222
39. B.J. Roberts, S.E. Shoaf, K.S. Jeong, and B.J. Song Induction of CYP2E1 in liver, kidney, brain and intestine during chronic ethanol administration and withdrawal: evidence that CYP2E1 possesses a rapid phase half-life of 6 h or less Biochem. Biophys. Res. Commun. 205 1994 1064 1071
40. R. Hakkak, S. Korourian, M.J. Ronis, M. Ingelman-Sundberg, and T.M. Badger Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats Biochem. Pharmacol. 51 1996 61 69 (Pubitemid 26020680)
41. L.L. Huang, J.B. Wan, and B. Wang Suppression of acute ethanol-induced hepatic steatosis by docosahexaenoic acid is associated with downregulation of stearoyl-CoA desaturase 1 and inflammatory cytokines. Prostaglandins Leukotrienes Essent Fatty Acids 88 2013 347 353
42. K.H. Moon, B.L. Hood, and B.J. Kim Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats Hepatology 44 2006 1218 1230 (Pubitemid 44748372)
43. Z. Zhou, X. Sun, and Y.J. Kang Ethanol-induced apoptosis in mouse liver: Fas- and cytochrome c-mediated caspase-3 activation pathway Am. J. Pathol. 159 2001 329 338 (Pubitemid 33704218)
44. W.X. Ding, M. Li, X. Chen, H.M. Ni, C.W. Lin, W. Gao, and B. Lu Autophagy reduces acute ethanol-induced hepatotoxicity and steatosis in mice Gastroenterology 139 2010 1740 1752