CYP2E1 potentiation of LPS and TNFα-induced hepatotoxicity by mechanisms involving enhanced oxidative and nitrosative stress, activation of MAP kinases, and mitochondrial dysfunction

Genes and Nutrition

Volumn 5, Issue 2, 2010, Pages 149-167

  Lu, Yongke ^a   Cederbaum, Arthur I ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alcohol; CYP2E1; Lipopolysaccharide; Oxidative stress; Tumor necrosis factor alpha

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALCOHOL; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ASPARTATE AMINOTRANSFERASE; CYCLOSPORIN A; CYTOCHROME P450 2E1; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRAZOLE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1;

ALCOHOL CONSUMPTION; ALCOHOL LIVER CIRRHOSIS; ALCOHOL LIVER DISEASE; CELL DAMAGE; CELL STIMULATION; CYTOKINE PRODUCTION; DISEASE MODEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; EXPERIMENTAL MOUSE; HUMAN; KUPFFER CELL; LIVER INJURY; LIVER TOXICITY; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN CARBOHYDRATE INTERACTION; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; REVIEW; RISK FACTOR;

EID: 77955982799     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-009-0150-5     Document Type: Review

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