Effects of diet and ethanol on the expression and localization of cytochromes P450 2E1 and P450 2C7 in the colon of male rats

Biochemical Pharmacology

Volumn 51, Issue 1, 1996, Pages 61-69

  Hakkak, Reza ^a   Korourian, Soheila ^a   Ronis, Martin J J ^a   Ingelman Sundberg, Magnus ^a,b   Badger, Thomas M ^a,c  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

colon; CYP2C7; CYP2E1; diet; ethanol; nutrition

Indexed keywords

ALCOHOL; CYTOCHROME P450 ISOENZYME; UNSPECIFIC MONOOXYGENASE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COLON; COLON CANCER; CONTROLLED STUDY; DIET; ENZYME LOCALIZATION; ENZYME REGULATION; EPITHELIUM CELL; IMMUNOHISTOCHEMISTRY; INTRAGASTRIC DRUG ADMINISTRATION; LIVER; MALE; MICROSOME; NONHUMAN; NUTRITION; PRIORITY JOURNAL; RAT; RISK FACTOR; TOTAL PARENTERAL NUTRITION;

EID: 0030069934     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(95)02154-X     Document Type: Article

References (48)

1. Guengerich FP, Mammalian Cytochrome P450, Vols. 1 and 2. CRC Press, Boca Raton, FL, 1987.
2. Nebert DW, Nelson DR, Coon MJ, Estabrook RW, Feyereisen R, Fujii-Kuriyama Y, Gonzalez FJ, Gunsalus IC, Johnson EF, Loper JC, Sato R, Waterman MR and Waxman DJ, The P450 superfamily: Update on new sequences, gene mapping and recommended nomenclature. DNA Cell Biol 10: 1-10, 1991.
3. Guengerich FP, Roles of cytochrome P450 enzymes in chemical carcinogenesis and cancer chemotherapy. Cancer Res 48: 2946-2954, 1988.
4. Conney AH, Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons. GHA Clowes Memorial Lecture. Cancer Res 42: 4875-4917, 1982.
5. Bjelke E, Epidemiological Studies of Cancer of the Stomach, Colon and Rectum. Ph.D. thesis, University Microfilms, University of Michigan, Ann Arbor, MI, 1973.
6. Wynder EL and Shigematsu T, Environmental factors of cancer of the colon and rectum. Cancer 20: 1520-1561, 1967.
7. Kato I, Tominaga S and Ikari A, A case-control study of male colorectal cancer in Aichi Prefecture, Japan: With special reference to occupational activity level, drinking habits and family history. Jpn J Cancer Res 81: 115-121, 1990.
8. Kune S, Kune GA and Watson LF, Case-control study of alcoholic beverages as etiological factors: The Melborne colorectal cancer study. Nutr Cancer 9: 43-56, 1987.
9. Enstrom JE, Colorectal cancer and beer drinking. Br J Cancer 35: 674-683, 1977.
10. Pollack ES, Nomura AN, Heilbrun LK, Stemmermann GN and Green SB, Prospective study of alcohol consumption and cancer. N Engl J Med 310: 617-621, 1984.
11. Seitz HK, Czygan P, Waldherr R, Veith S, Raedsch R, Kassmodel H and Kommerell B, Enhancement of 1,2-dimethylhydrazine-induced retal carcinogenesis following chronic ethanol consumption in the rat. Gastroenterology 86: 886-891, 1984.
12. Hamilton SR, Hyland J, McAvinchey D, Chaudhry Y, Hartka L, Kim HT, Cichon P, Floyed J, Turjman N, Kessie G, Nair PP and Dick J, Effects of chronic dietary beer and ethanol consumption on experimental colonic carcinogenesis by azoxymethane in rats. Cancer Res 47: 1551-1559, 1987.
13. Garzon FT, Seitz HK, Simanowski UA, Berger MR and Schmahl D, Enhancement of acetoxymethylmethylnitrosamine (AMMN)-induced colorectal tumors following chronic ethanol consumption in rats. Gasteroenterology 90: 1424, 1986.
14. Rubin E and Lieber CS, Hepatic microsomal enzymes in man and rat, induction and inhibition by ethanol. Science 162: 690, 1968.
15. Lieber CS and DeCarli LM, Hepatic microsomal ethanol-oxidizing system. In vitro characteristics and adaptive properties in vivo. J Biol Chem 245: 2505-2512, 1970.
16. Gillette JR, Environmental factors in drug metabolism. Fedn Proc 35: 1142-1147, 1976.
17. Ronis MJ, Lindros K and Ingelman-Sundberg M, The CYP2E Subfamily in Cytochrome P450: Toxicological and Metabolic Aspects (Ed. Ioannides C), CRC Press, Boca Raton, FL, in press.
18. Garro AJ, Seitz HK and Leiber CS, Enhancement of dimethylnitrosamine metabolism and activation to a mutagen following chronic ethanol consumption. Cancer Res 41: 120-124, 1981.
19. Peng R, Tu YY and Yang CS, The induction and competitive inhibition of a high affinity microsomal nitrodimethylamine demethylase by ethanol. Carcinogenesis 3: 1457-1461, 1982.
20. Farinati F, Zhou Z, Bellah J, Lieber CS and Garro AJ, Effect of chronic ethanol consumption on activation of nitrosopyrrolidine to a mutagen by rat upper alimentary tract, lung and hepatic tissue. Drug Metab Dispos 13: 210-214, 1985.
21. Kokkinakis DM, Koop DR, Scarpelli DG, Coon MJ and Hollenberg PF, Metabolism of N-nitroso-2,6-dimethylmorphine by isozymes of rabbit liver microsomal cytochrome P450. Cancer Res 45: 619-624, 1985.
22. Lindros KO, Cai Y and Penttilä K, Role of ethanol-inducible cytochrome P-450 IIE1 in carbon tetrachloride-induced damage to centrilobular hepatocytes from ethanol-treated rats. Hepatology 12: 1092-1097, 1990.
23. Ronis MJJ, Huang J, Ingelman-Sundberg M and Badger TM, Effects of nutrition and alcohol on the microsomal monooxygenase system of rat kidney. FASEB J 5: A936, 1991.
24. Yang CS, Patten CJ, Ishizaki H and Yoo J-SH, Induction, purification, and characterization of cytochrome P450IIE. Methods Enzymol 206: 595-603, 1991.
25. Ding X and Coon MJ, Induction of cytochrome P450 isozyme 3a (P-450IIE1) in rabbit olfactory mucosa by ethanol and acetone. Drug Metab Dispos 18: 742-745, 1990.
26. Shirnizu M, Lasker JM, Tsutsumi M and Lieber CS, Immunohistochemical localization of ethanol-inducible P450IIE1 in the rat alimentary tract. Gastroenterology 99: 1044-1053, 1990.
27. Leo MA and Lieber CS, New pathway for retinol metabolism in liver microsomes. J Biol Chem 260: 5228-5231, 1985.
28. Leo MA, Iida S and Lieber CS, Retinoic acid metabolism by a system reconstituted with cytochrome P-450. Arch Biochem Biophys 234: 305-312, 1984.
29. Bandiera S, Ryan DE, Levin W and Thomas PE, Age-and sex-related expression of cytochromes P450f and P450g in rat liver. Arch Biochem Biophys 248: 658-676, 1986.
30. Hakkak R, Ronis MJJ and Badger TM, Effects of enterai nutrition and ethanol on cytochrome P450 distribution in small intestine of male rats. Gastroenterology 104: 1611-1618, 1993.
31. Johansson I, Kstrom G, Schölte B, Puzycki D, Jornvall H and Ingelman-Sundberg M, Ethanol-fasting-and acetone-mducible cytochrome P450 in rat liver: Regulation and characteristics of enzymes belonging to the IIB and IIE gene subfamilies. Biochemistry 27: 1925-1934, 1988.
32. Ronis MJ, Johansson A, Ingelman-Sundberg M and Badger TM, Biochemical characterization and regulation of P450-EtOH2 an ethanol inducible member of P450 gene family 2C. Alcohol Clin Exp Res 15: 353, 1991.
33. Ronis MJJ, Lumpkin CK, Ingelman-Sundherg M and Badger TM, Effects of short-term ethanol and nutrition on the hepatic microsomal monooxygenase system in a model utilizing total enteral nutrition in the rat. Alcohol Clin Ex Res 15: 693-699, 1991.
34. National Research Council, Nutrient Requirements for Laboratory Animals. National Research Council, Washington, DC, 1987.
35. Badger TM, Ronis MJJ, Lumpkin CK, Valentine CR, Shahare M, Irby D, Huang J, Mercado C, Thomas P, Ingelman-Sundberg M and Crouch J, Effects of chronic ethanol on growth hormone secretion and hepatic cytochrome P450 isozymes of the rat. J Pharmacol Exp Ther 264: 458-447, 1995.
36. Johansson I and Ingelman-Sundberg M, Carbon tetrachloride induced lipid peroxidation dependent on an ethanol-inducible form of rabbit liver microsomal cytochrome P450. FEBS Lett 183: 2467-2471, 1985.
37. Koop D, Hydroxylation of p-nitrophenol by rabbit ethanol-inducible cytochrome P450 isoivme 3a. Mol Pharmacol 29: 599-404, 1986.
38. Johansson I and Ingelman-Sundberg M, Benzene metabolism by ethanol-, acetone-, and benzene-inducible cytochrome P-450 (IIE1) in rat and rabbit liver microsomes. Cancer Res 48: 5387-5390, 1988.
39. Fiala ES, Investigations into the metabolism and mode of action of the colon carcinogens 1,2-dimethylhydrazine and azoxymethane. Cancer 40: 2436-2445, 1977.
40. Sohn OS, Ishizaki H, Yang CS and Fiala ES, Metabolism of azoxymethane, methylazoxymethanol and N-nitrosodimethylamine by cytochrome P450IIE1. Carcinogenesis 12: 127-131, 1991.
41. Leo MA and Lieber CS, Hepatic vitamin A depletion in alcoholic liver injury in man. N Engl J Med 307: 597-601, 1982.
42. Leo MA, Lowe N and Lieber CS, Interaction of drugs and retinol. Biochem Pharmacol 35: 3949-3953, 1986.
43. Sporn MB and Roberts AB, Role of retinoids in differentiation and carcinogenesis. Cancer Res 43: 3034-3040, 1983.
44. Rosenberg DW and Mankowski DC, Induction of CYP2E1 protein in mouse colon. Carcinogenesis : 15: 73-78, 1994-
45. Ronis MJJ, Huang J, Crouch J, Mercado C, Irby D, Valentine CR, Lumpkin CK, Ingelman-Sundberg M and Badger TM, Cytochrome P450 CYP2E1 induction during chronic alcohol exposure occurs by a two-step mechanism associated with blood alcohol concentration in rats. J Pharmacol Exp Ther 264: 944-950, 1993.
46. Hakkak R, Ronis MJJ, Irby D, Mercado C, Eldeib M and Badger TM, Modulation of hepatic and duodenal microsomal monoxygenase by dietary lipid and ethanol in a model system utilizing total enterai nutrition (TEN). Toxicologist 12: 405, 1992.
47. Takahashi H, Johansson I, French SW and Ingelman-Sundberg M, Effects of dietary fat composition on activities of the microsomal ethanol oxidizing system and ethanol-inducible cytochrome P450 (CYP2E1) in the liver of rats chronically fed ethanol. Pharmacol Toxicol 70: 347-352, 1992.
48. Badger TM, Ronis MJJ, Ingelman-Sundberg M and Hakkak R, Pulsatile blood alcohol and CYP2E1 induction during chronic alcohol infusions in rats. Alcohol 10: 453-457, 1993.