Role for intestinal CYP2E1 in alcohol-induced circadian gene-mediated intestinal hyperpermeability

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 305, Issue 2, 2013, Pages

  Forsyth, Christopher B ^a   Voigt, Robin M ^a   Shaikh, Maliha ^a   Tang, Yueming ^a   Cederbaum, Arthur I ^b   Turek, Fred W ^c   Keshavarzian, Ali ^a,d  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Clock genes; Cytochrome P450 isoform 2E1; Ethanol; Leaky gut; Oxidative stress

Indexed keywords

ACETYLCYSTEINE; ALCOHOL; CYTOCHROME P450 2E1; HYDROGEN PEROXIDE; MESSENGER RNA; PER2 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR CLOCK;

ALCOHOL METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL STRAIN CACO 2; CIRCADIAN RHYTHM; COLON; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; INTESTINAL HYPERPERMEABILITY; INTESTINE CELL; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA PERMEABILITY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

CLOCK GENES; CYTOCHROME P450 ISOFORM 2E1; ETHANOL; LEAKY GUT; OXIDATIVE STRESS;

ANIMALS; CACO-2 CELLS; CLOCK PROTEINS; CYTOCHROME P-450 CYP2E1; ETHANOL; GENE EXPRESSION REGULATION; HUMANS; INTESTINES; MALE; MICE; MICE, INBRED C57BL; PERIOD CIRCADIAN PROTEINS; PERMEABILITY; RNA, MESSENGER;

EID: 84880147970     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00354.2012     Document Type: Article

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