Acute alcohol-induced liver injury

Frontiers in Physiology

Volumn 3 JUN, Issue , 2012, Pages

  Massey, Veronica L ^a   Arteel, Gavin E ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

Acute; Alcohol; Hepatic; Inflammation; Steatosis

Indexed keywords

EID: 84866383925     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2012.00193     Document Type: Review

References (78)

1. Adachi, Y., Bradford, B. U., Gao, W., Bojes, H. K., and Thurman, R. G. (1994). Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 20, 453-460.
2. Adachi, Y., Moore, L. E., Bradford, B. U., Gao, W.,and Thurman, R. G. (1995). Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108, 218-224.
3. Alessi, M. C., Bastelica, D., Mavri, A., Morange, P., Berthet, B., Grino, M., and Juhan-Vague, I. (2003). Plasma PAI-1 levels are more strongly related to liver steatosis than to adipose tissue accumulation. Arte-rioscler. Thromb. Vasc. Biol. 23, 1262-1268.
4. Arteel, G. E. (2008). New role of plas-minogen activator inhibitor-1 in alcohol-induced liver injury. J. Gas-troenterol. Hepatol. 23, S54-S59.
5. Barrio, E., Tome, S., Rodriguez, I., Gude, F., Sanchex-Leira, J., Perez-Becerra, E., and Gonzalez-Quintela, A. (2004). Liver disease in heavy drinkers with and without alcohol withdrawal syndrome. Alcohol. Clin. Exp. Res. 28, 131-136.
6. Beier, J. I., Luyendyk, J. P., Guo, L., von Montfort, C., Staunton, D. E., and Arteel, G. E. (2009). Fibrin accumulation plays a critical role in the sensitization to lipopolysaccharide-induced liver injury caused by ethanol in mice. Hepatology 49, 1545-1553.
7. Bergheim, I., Guo, L., Davis, M. A., Lambert, J. C., Beier, J. I., Duveau, I., Luyendyk, J. P., Roth, R. A., and Arteel, G. E. (2006). Metformin prevents alcohol-induced liver injury in the mouse: critical role of plasmino-gen activator inhibitor-1. Gastroen-terology 130, 2099-2112.
8. Bergheim, I., McClain, C. J., and Arteel, G. E. (2005). Treatment of alcoholic liver disease. Dig. Dis. 23, 275-284.
9. Beutler, B. (2009). Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases. Immunol. Rev. 227, 248-263.
10. Bode, C. H., Kugler, V., and Bode, J. C. H. (1987). Endotoxemia in patients with alcoholic and non-alcoholic cirrhosis and in subjects with no evidence of chronic liver disease following acute alcohol excess. J. Hepatol. 4, 8-14.
11. Carloni, V., Romanelli, R. G., Pinzani, M., Laffi, G., and Gentilini, P. (1996).Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells. Gastroenterology 110, 1127-1136.
12. Carson, E. J., and Pruett, S. B. (1996). Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol. Alcohol. Clin. Exp. Res. 20, 132-138.
13. Cheresh, D. A., Berliner, S. A., Vicente, V., and Ruggeri, Z. M. (1989). Recognition of distinct adhesive sites on fibrinogen by related integrins on platelets and endothelial cells. Cell 58, 945-953.
14. Crabb, D. W. (1999). Pathogenesis of alcoholic liver disease: newer mechanisms of injury. Keio. J. Med. 48, 184-188.
15. Day, C. P., and James, O. F. (1998). Steatohepatitis: a tale of two "hits?" Gastroenterology 114, 842-845.
16. Dimmitt, S. B., Rakic, V., Puddey, I. B., Baker, R., Oostryck, R., Adams, M. J., Chesterman, C. N., Burke, V., and Beilin, L. J. (1998). The effects of alcohol on coagulation and fib-rinolytic factors: a controlled trial. Blood Coagul. Fibrinolysis 9, 39-45.
17. Dolganiuc, A., and Szabo, G. (2009). In vitro and in vivo models of acute alcohol exposure. World J. Gastroen-terol. 15, 1168-1177.
18. Donohue, T. M. Jr., Osna, N., Tram-bly, C., Whitaker, N., Thomes, P., Todero, S., and Davis, J. S. (2011). Early growth response-1 contributes to steatosis development after acute ethanol administration. Alcohol. Clin. Exp. Res. 36, 759-767.
19. Enomoto, N., Ikejima, K., Bradford, B. U., Rivera, C. A., Kono, H., Brenner, D. A., and Thurman, R. G. (1998). Alcohol causes both tolerance and sensitization of rat Kupf-fer cells via mechanisms dependent on endotoxin. Gastroenterology 115, 443-451.
20. Enomoto, N., Ikejima, K., Yamashina, S., Enomoto, A., Nishiura, T., Nishimura, T., Brenner, D. A., Schemmer, P., Bradford, B. U., Rivera, C. A., Zhong, Z., and Thurman, R. G. (2000). Kupf-fer cell-derived prostaglandin E(2) is involved in alcohol-induced fat accumulation in rat liver. Am. J. Physiol. 279, G100-G106.
21. Espevik, T., Figari, I. S., Shalaby, M. R., Lackides, G. A., Lewis, G. D., Shepard, H. M., and Palladino, M. A. Jr. (1987). Inhibition of cytokineproduction by cyclosporin A and transforming growth factor beta. J. Exp. Med. 166, 571-576.
22. Fearns, C., and Loskutoff, D. J. (1997). Induction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-alpha. Am. J. Pathol. 150, 579-590.
23. Feingold, K. R.,and Grunfeld, C. (1987). Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo. J. Clin. Invest. 80, 184-190.
24. Fukui, H., Brauner, B., Bode, J. C., and Bode, C. (1991). Plasma endotoxin concentrations in patients with alcoholic and non-alcoholic liver disease: reevaluation with an improved chromogenic assay. J. Hepatol. 12, 162-169.
25. Gamble, L., Mason, C. M., and Nelson, S. (2006). The effects of alcohol on immunity and bacterial infection in the lung. Med. Mal. Infect. 36, 72-77.
26. Gentilello, L. M., Cobean, R. A., Walker, A. P., Moore, E. E., Wertz, M. J., and Dellinger, E. P. (1993). Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma. J. Trauma. 35, 669-674.
27. Gershman, H., and Steeper, J. (1991). Rate of clearance of ethanol from the blood of intoxicated patients in the emergency department. J. Emerg. Med. 9, 307-311.
28. Goral, J., and Kovacs, E. J. (2005). In vivo ethanol exposure down-regulates TLR2-, TLR4-, and TLR9-mediated macrophage inflammatory response by limiting p38 and ERK1/2 activation. J. Immunol. 174, 456-463.
29. Griffin, R., Poe, A. M., Cross, J. M., Rue, L. W., and Mcgwin, G. (2009). The association between blood alcohol level and infectious complications among burn patients. J. Burn Care Rehabil. 30, 395-399.
30. Grunfield, C., Soued, M., Adi, S., Moser, A. H., Dinarello, C. A., and Fein-gold, K. R. (1990). Evidence for two classes of cytokines that stimulate hepatic lipogenesis: relationships among tumor necrosis factor, interleukin-1 and interferon-alpha. Endocrinology 127, 46-54.
31. Hardardottir, I., Doerrler, W., Fein-gold, K. R., and Grunfeld, C. (1992). Cytokines stimulate lipoly-sis and decrease lipoprotein lipase activity in cultured fat cells by aprostaglandin independent mechanism. Biochem. Biophys. Res. Com-mun. 186, 237-243.
32. Holdsworth, S. R., Thomson, N. M., Glasgow, E. F., and Atkins, R. C. (1979). The effect of defibri-nation on macrophage participation in rabbit nephrotoxic nephritis: studies using glomerular culture and electronmicroscopy. Clin. Exp. Immunol. 37, 38-43.
33. Hu, K. Q., Yu, A. S., Tiyyagura, L., Redeker, A. G., and Reynolds, T. B. (2001). Hyperfibrinolytic activity in hospitalized cirrhotic patients in a referral liver unit. Am. J. Gastroen-terol. 96, 1581-1586.
34. Iimuro, Y., Ikejima, K., Rose, M. L., Bradford, B. U., and Thur-man, R. G. (1996). Nimodip-ine, a dihydropyridine-type calcium channel blocker, prevents alcoholic hepatitis due to chronic intragas-tric ethanol exposure in the rat. Hepatology 24, 391-397.
35. Ishak, K. G., Zimmerman, H. J., and Ray, M. B. (1991). Alcoholic liver disease: pathologic, pathogenetic and clinical aspects. Alcohol. Clin. Exp. Res. 15, 45-66.
36. Jones, J. D., Barber, B., Engrav, L., and Heimback, D. (1991). Alcohol use and burn injury. J. Burn Care Reha-bil. 12, 148-152.
37. Kaiser, J. P., Beier, J. I., Zhang, J., David, H. J., von Montfort, C., Guo, L., Zheng, Y., Monia, B. P.
38. Keshavarzian, A., Choudhary, S., Holems, E. W., Yong, S., Banan, A., Jakate, S., and Fields, J. Z. (2001). Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats. J. Pharmacol. Exp. Ther. 299, 442-448.
39. Kitching, A. R., Kong, Y. Z., Huang, X. R., Davenport, P., Edgtton, K. L., Carmeliet, P., Holdsworth, S. R., and Tipping, P. G. (2003). Plasmino-gen activator inhibitor-1 is a significant determinant of renal injury in experimental crescentic glomeru-lonephritis. J. Am. Soc. Nephrol. 14, 1487-1495.
40. Kono, H., Rusyn, I., Yin, M., Gabele, E., Yamashina, S., Dikalova, A., Kadi-iska, M. B., Connor, H. D., Mason, R. P., Segal, B. H., Bradford, B. U., Holland, S. M., and Thurman, R. G. (2000). NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J. Clin. Invest. 106, 867-872.
41. Kruithof, E. K. (1988). Plasminogen activator inhibitors - a review. Enzyme 40, 113-121.
42. Lambert, J. C., Zhou, Z., Wang, L., Song, Z., McClain, C. J., and Kang, Y. J. (2003). Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice. J. Pharmacol. Exp. Ther. 305, 880-886.
43. Lin, J. N., Tsai, Y. S., Lai, C. H., Chen, Y. H., Tsai, S. S., Lin, H. L., Huang, C. K., Lin, H. H. (2009). Risk factors for mortality of bacteremic patients in the emergency department. Acad. Emerg. Med. 16, 749-755.
44. Loike, J. D., el Khoury, J., Cao, L., Richards, C. P., Rascoff, H., Mandev-ille, J. T., Maxfield, F. R., and Silver-stein, S. C. (1995). Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl-phenylalanine. J. Exp. Med. 181, 1763-1772.
45. Ma, L. J., Mao, S. L., Taylor, K. L., Kan-janabuch, T., Guan, Y., Zhang, Y., Brown, N. J., Swift, L. L., McGuin-ness, O. P., Wasserman, D. H., Vaughan, D. E., and Fogo, A. B. (2004). Prevention of obesity and insulin resistance in mice lacking plasminogen activator inhibitor 1. Diabetes 53, 336-346.
46. Ma, T. Y., Nguyen, D., Bui, V., Nguyen, H., and Hoa, N. (1999). Ethanol Modulation of intestinal epithelial tight junction barrier. Am. J. Physiol. 276, G965-G974.
47. Marques-Vidal, P., Cambou, J. P., Nicaud, V., Luc, G., Evans, A., Arveiler, D., Bingham, A., and Cam-bien, F. (1995). Cardiovascular risk factors and alcohol consumption in France and Northern Ireland. Atherosclerosis 115, 225-232.
48. Marshall, L. J., Ramdin, L. S., Brooks, T., D'Phil, P. C., and Shute, J. K. (2003). Plasminogen activator inhibitor-1 supports IL-8-mediated neutrophil transendothelial migration by inhibition of the constitutive shedding of endothelial IL-8/heparan sulfate/syndecan-1 complexes. J. Immunol. 171, 2057-2065.
49. Mathurin, P., Deng, Q. G., Keshavarz-ian, A., Choudhary, S., Holmes, E. W., and Tsukamoto, H. (2000). Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology 32, 1008-1017.
50. Mcclain, C. J., and Cohen, D. A. (1989). Increased tumor necrosis factor production by monocytes in alcoholic hepatitis. Hepatology 9, 349-351.
51. McKim, S. E., Gabele, E., Isayama, F., Lambert, J. C., Tucker, L. M., Wheeler, M. D., Connor, H. D., Mason, R. P., Doll, M. A., Hein, D. W., and Arteel, G. E. (2003). Inducible nitric oxide synthase is required in alcohol-induced liver injury: studies with knockout mice. Gastroenterol-ogy 125, 1834-1844.
52. Mukamal, K. J., Jadhav, P. P., D'Agostino, R. B., Massaro, J. M., Mittleman, M. A., Lipinska, I., Sutherland, P. A., Matheney, T., Levy, D., Wilson, P. W., Ellison, R. C., Silbershatz, H., Muller, J. E., and Tofler, G. H. (2001). Alcohol consumption and hemosta-tic factors: analysis of the Framing-ham offspring cohort. Circulation 104, 1367-1373.
53. Nachiappan, V., Curtiss, D., Corkey, B. E., and Kilpatrick, L. (1994). Cytokines inhibit fatty acid oxidation in isolated rat hepatocytes: synergy among TNF, IL-6 and IL-1. Shock 1, 123-129.
54. Nanji, A. A., Khettry, U., and Sadrzadeh, S. M. H. (1994). Lactobacillus feeding reduces endotoxemia and severity of experimental alcoholic liver disease. Proc. Soc. Exp. Biol. Med. 205, 243-247.
55. Nolan, J. P. (2010). The role of intestinal endotoxin in liver injury: a long and evolving history. Hepatology 52, 1829-1835.
56. Ontko, J. A. (1973). Effects of ethanol on the metabolism of free fatty acids in isolated liver cells. J. Lipid Res. 14, 78-86.
57. Pruett, S. B., Zheng, Q., Fan, R., Matthews, K., and Schwab, C. (2004). Ethanol suppresses cytokine responses induced through Toll-like receptors as well as innate resistance to Escherichia coli in a mouse model for binge drinking. Alcohol 33, 147-155.
58. Purohit, V., Bode, J. C., Bode, C., Brenner, D. A., Choudhry, M. A., Hamilton, F., Kang, Y. J., Keshavarzian, A., Rao, R., Sartor, R. B., Swanson, C., and Turner, J. R. (2008). Alcohol, intestinal bacterial growth, intestinal permeability to endotoxin, and medical consequences: summary of a symposium. Alcohol 42, 349-361.
59. Qi, J., Goralnick, S., and Kreutzer, D. L. (1997). Fibrin regulation of interleukin-8 gene expression in human vascular endothelial cells. Blood 90, 3595-3602.
60. Radek, K. A., Kovacs, E. J., and Dip-ietro, L. A. (2012). Matrix prote-olytic activity during wound healing: modulation by acute ethanol exposure. Alcohol. Clin. Exp. Res. 31, 1045-1052.
61. Radek, K. A., Matthies, A. M., Burns, A. L., Heinrich, S. A., Kovacs, E. J., and Dipietro, L. A. (2005). Acuteethanol exposure impairs angiogen-esis and the proliferative phase of wound healing. Am. J. Physiol. Heart Circ. Physiol. 289, 1084-1090.
62. Rivara, F. P., Jurkovich, G. J., Gurney, J. G., Seguin, D., Fligner, C. L., Ries, R., Raisys, V. A., and Copass, M. (1993). The magnitude of acute and chronic alcohol abuse in trauma patients. Arch. Surg. 128, 907-912.
63. Sato, Y., Tsuboi, R., Lyons, R., Moses, H., and Rifkin, D. B. (1990). Characterization of the activation of latent TGF-beta by co-cultures of endothe-lial cells and pericytes or smooth muscle cells: a self-regulating system. J. Cell Biol. 111, 757-763.
64. Siegmund, S. V., Haas, S., and Singer, M. V. (2005). Animal models and their results in gastrointestinal alcohol research. Dig. Dis. 23, 181-194.
65. Substance Abuse and Mental Health Services Administration. (2011). Results from the 2010 National Survey on Drug Use and Health: Summary of National Findings. Rockville, MD: Substance Abuse and Mental Health Services Administration.
66. Tamai, H., Horie, Y., Kato, S., Yokoyama, H., and Ishii, H. (2002). Long-term ethanol feeding enhances susceptibility of the liver to orally administered lipopolysaccharides in rats. Alcohol. Clin. Exp. Res. 26, 75S-80S.
67. Tamai, H., Kato, S., Horie, Y., Ohki, E., Yokoyama, H., and Ishii, H. (2000). Effect of acute ethanol administration on the intestinal absorption of endotoxin in rats. Alcohol. Clin. Exp. Res. 24, 390-394.
68. Tran-Thang, C., Fasel-Felley, J., Pra-long, G., Hofstetter, J. R., Bach-mann, F., and Kruithof, E. K. (1989). Plasminogen activators and plasminogen activator inhibitors in liver deficiencies caused by chronic alcoholism or infectious hepatitis. Thromb. Haemost. 62, 651-653.
69. Tsukamoto, H., Takei, Y., McClain, C. J., Joshi-Barve, S., Hill, D., Schmidt, J., Deaciuc, I., Barve, S., Colell, A., Garcia-Ruiz, C., Kaplowitz, N., Fernandez-Checa, J. C., Yokoyama, H., Okamura, Y., Nakamura, Y., Ishii, H., Chawla, R. K., Barve, S., Joshi-Barve, S., Watson, W. H., Nelson, W. J., Lin, M., Ohata, M., Motomura, K., Enomoto, K., Ikejima, K., Kita-mura, T., Oide, H., Hirose, M., Bradford, B. U., Rivera, C. A., Kono, H., Peter, S., Yamashina, S., Konno, A., Ishikawa, H., Shimizu, H., Sato, N., and Thurman, R. (2001). How is the liver primed or sensitized for alcoholic liver disease? Alcohol. Clin. Exp. Res. 25, 171S-181S.
70. U. S. Department of Health and Human Services. (2000). 10th Special Reportto the U. S. Congress on Alcohol and Research.
71. van Ginneken, V. J. (2008). Liver fattening during feast and famine: an evolutionary paradox. Med. Hypotheses 70, 924-928.
72. Violi, F., Ferro, D., Basili, S., Quintarelli, C., Saliola, M., Alessandri, C., Cordova, C., and Balsano, F. (1992). Hyperfibrinolysis increases the risk of gastrointestinal hemorrhage in patients with advanced cirrhosis. Hepatology 15, 672-676.
73. Weschsler, H., and Austin, S. B. (1998). Binge drinking: the five/four measure. J. Stud. Alcohol 59, 122-124.
74. World Health Organization. (2011). Global Status Report on Alcohol and Health. Geneva: WHO Press.
75. Yang, S. Q., Lin, H. Z., Lane, M. D., Clemens, M., and Diehl, A. M. (1997). Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steato-hepatitis. Proc. Natl. Acad. Sci. U.S.A. 94, 2557-2562.
76. Yin, M., Bradford, B. U., Wheeler, M. D., Uesugi, T., Froh, M., Goyert, S. M., and Thurman, R. G. (2001). Reduced early alcohol-induced liver injury in cd14-deficient mice. J. Immunol. 166, 4737-4742.
77. Zhong, W., McClain, C. J., Cave, M., Kang, Y. J., and Zhou, Z. (2010). The role of zinc deficiency in alcohol-induced intestinal barrier dysfunction. Am. J. Physiol. 298, G625- G633.
78. Zhou, H. F., Chan, H. W., Wickline, S. A., Lanza, G. M., and Pham, C. T. (2009). Alphavbeta3-targeted nanotherapy suppresses inflammatory arthritis in mice. FASEB J. 23, 2978-2985.