Prevention of alterations in intestinal permeability is involved in zinc inhibition of acute ethanol-induced liver damage in mice

Journal of Pharmacology and Experimental Therapeutics

Volumn 305, Issue 3, 2003, Pages 880-886

  Lambert, Jason C ^a   Zhou, Zhanxiang ^a   Wang, Lipeng ^a   Song, Zhenyuan ^a   McClain, Craig J ^a   Kang, Y James ^a  

^a University of Louisville School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ENDOTOXIN; TUMOR NECROSIS FACTOR ALPHA; ZINC SULFATE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTOXEMIA; HISTOPATHOLOGY; INTESTINE MUCOSA PERMEABILITY; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ENDOTOXEMIA; ETHANOL; INTESTINES; LIVER DISEASES, ALCOHOLIC; MALE; MICE; PERMEABILITY; TUMOR NECROSIS FACTOR-ALPHA; ZINC;

EID: 0038814267     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.102.047852     Document Type: Article

References (40)

1. Adachi Y, Bradford BU, Gao W, Bojes HK, and Thurman RG (1994) Inactivation of Kupffer cells prevents early alcohol-induced liver injury. Hepatology 2:453-460.
2. Adachi Y, Moore LE, Bradford BU, Gao W, and Thurman RG (1995) Antibiotics prevent liver injury in rats following long-term exposure to ethanol. Gastroenterology 108:218-224.
3. Alam AN, Sarker SA, and Wahed MA (1994) Enteric protein loss and intestinal permeability changes in children during acute shigellosis and after recovery: effect of zinc supplementation. Gut 35:1707-1711.
4. Arthur MJP, Kowalski-Saunders P, and Wright R (1988) Effect of endotoxin on release of reactive oxygen intermediates by rat hepatic macrophages. Gastroenterology 95:1588-1594.
5. Bachmann S, Caldwell-Kenkel JC, Currin RT, Lichtman SN, Steffen R, Thurman RG, and Lemasters JJ (1992) Protection by pentoxifylline against graft failure from storage injury after orthotopic rat liver transplantation with arterialization. Transpl Int 5:S345-S350.
6. Beck IT and Dinda PK (1981) Acute exposure of small intestine to ethanol: effects on morphology and function. Dig Dis Sci 26:817-838.
7. Bjarnason I, Ward K, and Peters TJ (1984) The leaky gut of alcoholism: possible route of entry for toxic compounds. Lancet 1:179-182.
8. Bode JCH (1990) Alcohol and the gastrointestinal tract, in Advances in Internal Medicine and Pediatrics (Frick HP, Harnack GA, Martini GA and Prader A eds) pp 1-75, Springer-Verlag, New York.
9. Carson EJ and Pruett SB (1996) Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol. Alcohol Clin Exp Res 20:132-138.
10. Cunningham-Rundles S, Bockman RS, Lin A, Giardina PV, Hilgartner MW, Caldwell-Brown D, and Carter DM (1990) Physiological and pharmacological effects of zinc on immune response. Ann NY Acad Sci 587:113-122.
11. Deaciuc IV, D'Souza NB, and Spitzer JJ (1995) Tumor necrosis factor-α cell-surface receptors of liver parenchymal and nonparenchymal cells during acute and chronic alcohol administration to rats. Alcohol Clin Exp Res 19:332-338.
12. Decker K (1990) Biologically active products of stimulated liver macrophages (Kupffer cells). Eur J Biochem 192:245-261.
13. Draper LR, Gyure LA, Hall JG, and Robertson D (1983) Effect of alcohol on the integrity of the intestinal epithelium. Gut 24:399-404.
14. Enomoto N, Ikejima K, Bradford B, Rivera C, Kono H, Brenner DA, and Thurman RG (1998) Alcohol causes both tolerance and sensitization of rat Kupffer cells via mechanisms dependent on endotoxin. Gastroenterology 115:443-451.
15. Garcia Soriano F, Liaudet L, Marton A, Hasko G, Batista Lorigados C, Deitch EA, and Szabo C (2001) Inosine improves gut permeability and vascular reactivity in endotoxic shock. Crit Care Med 29:703-708.
16. Honchel R, Shedlovsky S, Cohen D, Marsano L, Lee E, and McClain C (1990) Is hepatic cytoprotection really cytokine protection? Progress in leukocyte biology, in The Physiological and Pathological Effects of Cytokines (Dinarello CA, Kluger MJ, Powanda MC and Oppenheim JJ eds) pp 275-280, Wiley-Liss, New York.
17. Iimuro Y, Gallucci RM, Luster MI, Kono H, and Thurman RG (1997) Antibodies to tumor necrosis factor alpha attenuate hepatic necrosis and inflammation caused by chronic exposure to ethanol in the rat. Hepatology 26:1530-1537.
18. Kamimura S and Tsukamoto H (1995) Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatology 22:1304-1309.
19. Keshavarzian A, Choudhary S, Holmes EW, Yong S, Banan A, Jakate S, and Fields JZ (2001) Preventing gut leakiness by oats supplementation ameliorates alcohol-induced liver damage in rats. J Pharmacol Exp Ther 299:442-448.
20. Keshavarzian A, Fields JZ, Vaeth J, and Holmes EW (1994) The differing effects of acute and chronic alcohol on gastric and intestinal permeability. Am J Gastroenterol 89:2205-2211.
21. Lambert JC, Zhou Z, and Kang YJ (2003) Suppression of fas-mediated signaling pathway is involved in zinc inhibition of ethanol-induced liver apoptosis. Exp Biol Med 228:406-412.
22. Lieber CS (2000) Alcohol: its metabolism and interaction with nutrients. Annu Rev Nutr 20:395-430.
23. Liu J, Liu Y, Hartley D, Klaassen CD, Shehin-Johnson SE, et al. (1999) Metallothionein-I/II knockout mice are sensitive to acetaminophen-induced hepatotoxicity. J Pharmacol Exp Ther 289:580-586.
24. Luster MI, Germolec DR, Yoshida T, Kayama F, and Thompson M (1994) Endotoxin-induced cytokine gene expression and excretion in the liver. Hepatology 19:480-488.
25. Martinez F, Abril ER, Earnest DL, and Watson RR (1992) Ethanol and cytokine secretion. Alcohol 9:455-458.
26. Mathurin P, Deng Q-G, Keshavarzian A, Choudary S, Holmes EW, and Tsukamoto H (2000) Exacerbation of alcoholic liver injury by enteral endotoxin in rats. Hepatology 32:1008-1017.
27. Millan MS, Morris GP, Beck IT, and Henson JT (1980) Villous damage induced by suction biopsy and by acute ethanol intake in the normal human small intestine. Dig Dis Sci 25:513-525.
28. Rivera CA, Bradford BU, Seabra V, and Thurman RG (1998) Role of endotoxin in the hypermetabolic state after acute ethanol exposure. Am J Physiol 275:G1252-G1258.
29. Saba TM (1970) Physiology and pathophysiology of the reticuloendothelial system. Arch Intern Med 126:1031-1052.
30. Shibayama Y, Asaka S, and Nakata K (1991) Endotoxin hepatotoxicity augmented by ethanol. Exp Mol Pathol 55:196-202.
31. Snyder SL and Walker RI (1976) Inhibition of lethality in endotoxin-challenged mice treated with zinc chloride. Infect Immun 13:998-1000.
32. Sturniolo GC, Di Leo V, Ferronato A, D'Odorico A, and D'Inca R (2001) Zinc supplementation tightens "leaky gut" in Crohn's disease. Inflamm Bowel Dis 7:94-98.
33. Su GL (2002) Lipopolysaccharides in liver injury-molecular mechanisms of Kupffer cell activation. Am J Physiol Gastrointest Liver Physiol 283:G256-G265.
34. Takano H, Satoh M, Shimada A, Sagai M, Yoshikawa T, and Tohyama C (2000) Cytoprotection by metallothionein against gastroduodenal mucosal injury caused by ethanol in mice. Lab Invest 80:371-377.
35. Tamai H, Kato S, Horie Y, Ohki E, Yokoyama H, and Ishii H (2000) Effect of acute ethanol administration on the intestinal absorption of endotoxin in rats. Alcohol Clin Exp Res 24:390-394.
36. Tracey KJ, Lowry SF, Fahey TJ, Albert JD, and Shires GT (1987) Anti-cachetin TNF monoclonal antibodies prevent septic shock during lethal endotoxemia. Nature (Lond) 330:662-664.
37. Worthington BS, Meserole L, and Syrotuck JA (1978) Effect of daily ethanol ingestion on intestinal permeability to macromolecules. Am J Dig Dis 23:23-32.
38. Yi JH, Ni RY, Luo DD, and Li SL (1999) Intestinal flora translocation and overgrowth in upper gastrointestinal tract induced by hepatic failure. World J Gastroenterol 5:327-329.
39. Zhou Z, Sun X, and Kang YJ (2001) Ethanol-induced apoptosis in mouse liver: fas and cytochrome c-mediated caspase-3 activation pathway. Am J Pathol 159:329-338.
40. Zhou Z, Sun X, Lambert JC, Saari JT, and Kang YJ (2002) Metallothionein-independent zinc protection from alcoholic liver injury. Am J Pathol 160:2267-2274.