Functionalization of biomaterials with small osteoinductive moieties

Acta Biomaterialia

Volumn 9, Issue 11, 2013, Pages 8773-8789

  Maia, F Raquel ^a,b   Bidarra, Sílvia J ^a   Granja, Pedro L ^a,b   Barrias, Cristina C ^a  

^a INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

Biofunctionalization; Biomaterials; Bone regeneration; Osteogenesis; Small moieties

Indexed keywords

CELL CULTURE; CELL MEMBRANES; CELL SIGNALING; FLOWCHARTING; LIGANDS; STEM CELLS;

BIOFUNCTIONALIZATION; BONE REGENERATION; CELL-BE; CELL/B.E; FUNCTIONALIZATIONS; HUMAN MESENCHYMAL STEM CELLS; MESENCHYMAL STEM CELL; OSTEOGENESIS; OSTEOINDUCTIVE; SMALL MOIETY;

BIOMATERIALS;

AGAROSE; ALGINIC ACID; AMELOGENIN; BIOMATERIAL; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 9; COLLAGEN BINDING PROTEIN; COLLAGEN FIBRIL; COLLAGEN TYPE 1; DENTIN MATRIX PROTEIN 1; FIBRONECTIN; FLAVONOID; FORSKOLIN; HYDROXYAPATITE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MACROGOL; MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN; OSTEOGENIC PROTEIN 1; PEPTIDE; PHENAMIL; POLYETHERURETHAN; POLYETHYLENE TEREPHTHALATE; POLYGLACTIN; POLYMER; RESVERATROL; SILK FIBROIN;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; BIOLOGICAL ACTIVITY; BIOMINERALIZATION; BONE DEVELOPMENT; BONE MINERALIZATION; BONE REGENERATION; CELL ADHESION; CELL DIFFERENTIATION; CELL FUNCTION; CERAMICS; CHEMICAL BOND; DENTIN; FRACTURE HEALING; HIGH THROUGHPUT SCREENING; HUMAN; MESENCHYMAL STEM CELL; OSSIFICATION; OSTEOBLAST; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

BIOFUNCTIONALIZATION; BIOMATERIALS; BONE REGENERATION; OSTEOGENESIS; SMALL MOIETIES;

AMINO ACID SEQUENCE; ANIMALS; BIOCOMPATIBLE MATERIALS; HUMANS; MESENCHYMAL STROMAL CELLS; MOLECULAR SEQUENCE DATA; OSSEOINTEGRATION; PEPTIDES; SMALL MOLECULE LIBRARIES;

EID: 84885024380     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.08.004     Document Type: Review

References (199)

1. M.F. Pittenger, A.M. Mackay, S.C. Beck, R.K. Jaiswal, R. Douglas, and J.D. Mosca Multilineage potential of adult human mesenchymal stem cells Science 284 1999 143 147 (Pubitemid 29282067)
2. S.A. Kuznetsov, P.H. Krebsbach, K. Satomura, J. Kerr, M. Riminucci, and D. Benayahu Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo J Bone Miner Res 12 1997 1335 1347 (Pubitemid 27375376)
3. D.X. Wang, Y. He, L. Bi, Z.H. Qu, J.W. Zou, and Z. Pan Enhancing the bioactivity of poly(lactic-co-glycolic acid) scaffold with a nano-hydroxyapatite coating for the treatment of segmental bone defect in a rabbit model Int J Nanomed 8 2013 1855 1865
4. A.J. Firestone, and J.K. Chen Controlling destiny through chemistry: small-molecule regulators of cell fate ACS Chem Biol 5 2009 15 34
5. A.J. Engler, S. Sen, H.L. Sweeney, and D.E. Discher Matrix elasticity directs stem cell lineage specification Cell 126 2006 677 689 (Pubitemid 44233625)
6. J. Tang, R. Peng, and J. Ding The regulation of stem cell differentiation by cell-cell contact on micropatterned material surfaces Biomaterials 31 2010 2470 2476
7. R. Peng, X. Yao, and J. Ding Effect of cell anisotropy on differentiation of stem cells on micropatterned surfaces through the controlled single cell adhesion Biomaterials 32 2011 8048 8057
8. R. Peng, X. Yao, B. Cao, J. Tang, and J. Ding The effect of culture conditions on the adipogenic and osteogenic inductions of mesenchymal stem cells on micropatterned surfaces Biomaterials 33 2012 6008 6019
9. X. Yao, R. Peng, and J. Ding Effects of aspect ratios of stem cells on lineage commitments with and without induction media Biomaterials 34 2013 930 939
10. Y. Ito Covalently immobilized biosignal molecule materials for tissue engineering Soft Matter 4 2008 46 56
11. D.S.W. Benoit, M.P. Schwartz, A.R. Durney, and K.S. Anseth Small functional groups for controlled differentiation of hydrogel-encapsulated human mesenchymal stem cells Nat Mater 7 2008 816 823
12. J.M. Curran, R. Chen, and J.A. Hunt The guidance of mesenchymal stem cell differentiation in vitro by controlled modifications to the cell substrate Biomaterials 27 2006 4783 4793 (Pubitemid 43849975)
13. J.M. Curran, R. Chen, and J.A. Hunt Controlling the phenotype and function of mesenchymal stem cells in vitro by adhesion to silane-modified clean glass surfaces Biomaterials 26 2005 7057 7067 (Pubitemid 41095528)
14. J.E. Phillips, T.A. Petrie, F.P. Creighton, and A.J. Garcia Human mesenchymal stem cell differentiation on self-assembled monolayers presenting different surface chemistries Acta Biomater 6 2010 12 20
15. C.C. Barrias, M.C.L. Martins, G. Almeida-Porada, M.A. Barbosa, and P.L. Granja The correlation between the adsorption of adhesive proteins and cell behaviour on hydroxyl-methyl mixed self-assembled monolayers Biomaterials 30 2009 307 316
16. M.P. Lutolf, and J.A. Hubbell Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering Nat Biotechnol 23 2005 47 55 (Pubitemid 41724624)
17. Y. Suzuki, M. Tanihara, K. Suzuki, A. Saitou, W. Sufan, and Y. Nishimura Alginate hydrogel linked with synthetic oligopeptide derived from BMP-2 allows ectopic osteoinduction in vivo J Biomed Mater Res 50 2000 405 409 (Pubitemid 30180733)
18. H. Shin, S. Jo, and A.G. Mikos Modulation of marrow stromal osteoblast adhesion on biomimetic oligo[poly(ethylene glycol) fumarate] hydrogels modified with Arg-Gly-Asp peptides and a poly(ethylene glycol) spacer J Biomed Mater Res 61 2002 169 179 (Pubitemid 34602363)
19. A. Saito, Y. Suzuki, S. Ogata, C. Ohtsuki, and M. Tanihara Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope BBA Proteins Proteom 1651 2003 60 67 (Pubitemid 38234553)
20. H. Shin, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos Attachment, proliferation, and migration of marrow stromal osteoblasts cultured on biomimetic hydrogels modified with an osteopontin-derived peptide Biomaterials 25 2004 895 906 (Pubitemid 37371997)
21. X. He, J. Ma, and E. Jabbari Effect of grafting RGD and BMP-2 protein-derived peptides to a hydrogel substrate on osteogenic differentiation of marrow stromal cells Langmuir 24 2008 12508 12516
22. A. Horii, X. Wang, F. Gelain, and S. Zhang Biological designer self-assembling peptide nanofiber scaffolds significantly enhance osteoblast proliferation, differentiation and 3-D migration PLoS ONE 2 2007 e190
23. K.B. Fonseca, S.J. Bidarra, M.J. Oliveira, P.L. Granja, and C.C. Barrias Molecularly designed alginate hydrogels susceptible to local proteolysis as three-dimensional cellular microenvironments Acta Biomater 7 2011 1674 1682
24. S.J. Bidarra, C.C. Barrias, M.A. Barbosa, R. Soares, and P.L. Granja Immobilization of human mesenchymal stem cells within RGD-grafted alginate microspheres and assessment of their angiogenic potential Biomacromolecules 11 2010 1956 1964
25. M.B. Evangelista, S.X. Hsiong, R. Fernandes, P. Sampaio, H.-J. Kong, and C.C. Barrias Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix Biomaterials 28 2007 3644 3655 (Pubitemid 46863373)
26. G.A. Silva, C. Czeisler, K.L. Niece, E. Beniash, D.A. Harrington, and J.A. Kessler Selective differentiation of neural progenitor cells by high-epitope density nanofibers Science 303 2004 1352 1355 (Pubitemid 38269424)
27. X. Niu, Q. Feng, M. Wang, X. Guo, and Q. Zheng Porous nano-HA/collagen/PLLA scaffold containing chitosan microspheres for controlled delivery of synthetic peptide derived from BMP-2 J Control Release 134 2009 111 117
28. C.D. Reyes, T.A. Petrie, K.L. Burns, Z. Schwartz, and A.J. García Biomolecular surface coating to enhance orthopaedic tissue healing and integration Biomaterials 28 2007 3228 3235 (Pubitemid 46654219)
29. A. Rezania, C.H. Thomas, A.B. Branger, C.M. Waters, and K.E. Healy The detachment strength and morphology of bone cells contacting materials modified with a peptide sequence found within bone sialoprotein J Biomed Mater Res 37 1997 9 19 (Pubitemid 27427559)
30. S. Sofia, M.B. McCarthy, G. Gronowicz, and D.L. Kaplan Functionalized silk-based biomaterials for bone formation J Biomed Mater Res 54 2001 139 148
31. M.D. Pierschbacher, and E. Ruoslahti Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule Nature 309 1984 30 33 (Pubitemid 14134132)
32. B.K. Brandley, and R.L. Schnaar Covalent attachment of an Arg-Gly-Asp sequence peptide to derivatizable polyacrylamide surfaces: support of fibroblast adhesion and long-term growth Anal Biochem 172 1988 270 278
33. J.A. Rowley, and D.J. Mooney Alginate type and RGD density control myoblast phenotype J Biomed Mater Res 60 2002 217 223 (Pubitemid 34194582)
34. G.M. Harbers, and K.E. Healy The effect of ligand type and density on osteoblast adhesion, proliferation, and matrix mineralization J Biomed Mater Res A 75A 2005 855 869 (Pubitemid 41772703)
35. J. Huang, S.V. Gräter, F. Corbellini, S. Rinck, E. Bock, and R. Kemkemer Impact of order and disorder in RGD nanopatterns on cell adhesion Nano Lett 9 2009 1111 1116
36. J. Huang, and J. Ding Nanostructured interfaces with RGD arrays to control cell-matrix interaction Soft Matter 6 2010 3395 3401
37. J. Sun, S.V. Graeter, L. Yu, S. Duan, J.P. Spatz, and J. Ding Technique of surface modification of a cell-adhesion-resistant hydrogel by a cell-adhesion-available inorganic microarray Biomacromolecules 9 2008 2569 2572
38. J. Sun, J. Tang, and J. Ding Cell orientation on a stripe-micropatterned surface Chin Sci Bull 54 2009 3154 3159
39. P. Liu, J. Sun, J. Huang, R. Peng, J. Tang, and J. Ding Fabrication of micropatterns of nanoarrays on a polymeric gel surface Nanoscale 2 2010 122 127
40. X. Wang, C. Yan, K. Ye, Y. He, Z. Li, and J. Ding Effect of RGD nanospacing on differentiation of stem cells Biomaterials 34 2013 2865 2874
41. S.X. Hsiong, T. Boontheekul, N. Huebsch, and D.J. Mooney Cyclic arginine-glycine-aspartate peptides enhance three-dimensional stem cell osteogenic differentiation Tissue Eng Part A 15 2009 263 272
42. K.B. Fonseca, F.R. Maia, F.A. Cruz, D. Andrade, M.A. Juliano, and P.L. Granja Enzymatic, physicochemical and biological properties of MMP-sensitive alginate hydrogels Soft Matter 9 2013 3283 3292
43. F. Munarin, P. Petrini, M.C. Tanzi, M.A. Barbosa, and P.L. Granja Biofunctional chemically modified pectin for cell delivery Soft Matter 8 2012 4731 4739
44. F. Munarin, S.G. Guerreiro, M.A. Grellier, M.C. Tanzi, M.A. Barbosa, and P. Petrini Pectin-based injectable biomaterials for bone tissue engineering Biomacromolecules 12 2011 568 577
45. M. Grellier, P.L. Granja, J.-C. Fricain, S.J. Bidarra, M. Renard, and R. Bareille The effect of the co-immobilization of human osteoprogenitors and endothelial cells within alginate microspheres on mineralization in a bone defect Biomaterials 30 2009 3271 3278
46. A. Shekaran, and A.J. García Extracellular matrix-mimetic adhesive biomaterials for bone repair J Biomed Mater Res A 96A 2011 261 272
47. J.A. Rowley, G. Madlambayan, and D.J. Mooney Alginate hydrogels as synthetic extracellular matrix materials Biomaterials 20 1999 45 53 (Pubitemid 29002544)
48. S.J. Bidarra, C.C. Barrias, K.B. Fonseca, M.A. Barbosa, R.A. Soares, and P.L. Granja Injectable in situ crosslinkable RGD-modified alginate matrix for endothelial cells delivery Biomaterials 32 2011 7897 7904
49. Z. Zhang, Y. Lai, L. Yu, and J. Ding Effects of immobilizing sites of RGD peptides in amphiphilic block copolymers on efficacy of cell adhesion Biomaterials 31 2010 7873 7882
50. Y. Lai, C. Xie, Z. Zhang, W. Lu, and J. Ding Design and synthesis of a potent peptide containing both specific and non-specific cell-adhesion motifs Biomaterials 31 2010 4809 4817
51. N.M. Moore, N.J. Lin, N.D. Gallant, and M.L. Becker Synergistic enhancement of human bone marrow stromal cell proliferation and osteogenic differentiation on BMP-2-derived and RGD peptide concentration gradients Acta Biomater 7 2011 2091 2100
52. M.M. Martino, M. Mochizuki, D.A. Rothenfluh, S.A. Rempel, J.A. Hubbell, and T.H. Barker Controlling integrin specificity and stem cell differentiation in 2D and 3D environments through regulation of fibronectin domain stability Biomaterials 30 2009 1089 1097
53. A.J. García, J.E. Schwarzbauer, and D. Boettiger Distinct activation states of α5β1 integrin show differential binding to RGD and synergy domains of fibronectin Biochemistry 41 2002 9063 9069 (Pubitemid 34787263)
54. G.A. Hudalla, and W.L. Murphy Biomaterials that regulate growth factor activity via bioinspired interactions Adv Funct Mater 21 2011 1754 1768
55. G.A. Hudalla, J.T. Koepsel, and W.L. Murphy Surfaces that sequester serum-borne heparin amplify growth factor activity Adv Mater 23 2011 5415 5418
56. G.A. Hudalla, N.A. Kouris, J.T. Koepsel, B.M. Ogle, and W.L. Murphy Harnessing endogenous growth factor activity modulates stem cell behavior Integr Biol 3 2011 832 842
57. A. Mata, Y. Geng, K.J. Henrikson, C. Aparicio, S.R. Stock, and R.L. Satcher Bone regeneration mediated by biomimetic mineralization of a nanofiber matrix Biomaterials 31 2010 6004 6012
58. J.-Y. Lee, J.-E. Choo, Y.-S. Choi, J.-S. Suh, S.-J. Lee, and C.-P. Chung Osteoblastic differentiation of human bone marrow stromal cells in self-assembled BMP-2 receptor-binding peptide-amphiphiles Biomaterials 30 2009 3532 3541
59. B. Acharya, S.-Y. Chun, S.-Y. Kim, C. Moon, H.-I. Shin, and E.K. Park Surface immobilization of MEPE peptide onto HA/β-TCP ceramic particles enhances bone regeneration and remodeling J Biomed Mater Biomed Res B 100B 2012 841 849
60. J.N. Yewle, D.A. Puleo, and L.G. Bachas Bifunctional bisphosphonates for delivering PTH (1-34) to bone mineral with enhanced bioactivity Biomaterials 34 2013 3141 3149
61. V. Wang, G. Misra, and B. Amsden Immobilization of a bone and cartilage stimulating peptide to a synthetic bone graft J Mater Sci Mater Med 19 2008 2145 2155
62. R.E. Jung, D.L. Cochran, O. Domken, R. Seibl, A.A. Jones, and D. Buser The effect of matrix bound parathyroid hormone on bone regeneration Clin Oral Implan Res 18 2007 319 325
63. O.F. Zouani, C. Chollet, B. Guillotin, and M.-C. Durrieu Differentiation of pre-osteoblast cells on poly(ethylene terephthalate) grafted with RGD and/or BMPs mimetic peptides Biomaterials 31 2010 8245 8253
64. O.F. Zouani, J. Kalisky, E. Ibarboure, and M.-C. Durrieu Effect of BMP-2 from matrices of different stiffnesses for the modulation of stem cell fate Biomaterials 34 2013 2157 2166
65. X. He, X. Yang, and E. Jabbari Combined effect of osteopontin and BMP-2 derived peptides grafted to an adhesive hydrogel on osteogenic and vasculogenic differentiation of marrow stromal cells Langmuir 28 2012 5387 5397
66. Z.-Y. Lin, Z.-X. Duan, X.-D. Guo, J.-F. Li, H.-W. Lu, and Q.-X. Zheng Bone induction by biomimetic PLGA-(PEG-ASP)n copolymer loaded with a novel synthetic BMP-2-related peptide in vitro and in vivo J Control Release 144 2010 190 195
67. J.L. Sharon, and D.A. Puleo The use of N-terminal immobilization of PTH(1-34) on PLGA to enhance bioactivity Biomaterials 29 2008 3137 3142
68. K.S. Stakleff, F. Lin, L.A. Smith Callahan, M.B. Wade, A. Esterle, and J. Miller Resorbable, amino acid-based poly(ester urea)s crosslinked with osteogenic growth peptide with enhanced mechanical properties and bioactivity Acta Biomater 9 2013 5132 5142
69. J.-Y. Lee, J.-E. Choo, H.-J. Park, J.-B. Park, S.-C. Lee, and I. Jo Injectable gel with synthetic collagen-binding peptide for enhanced osteogenesis in vitro and in vivo Biochem Biophys Res Commun 357 2007 68 74 (Pubitemid 46574501)
70. A. Saito, Y. Suzuki, S.-I. Ogata, C. Ohtsuki, and M. Tanihara Prolonged ectopic calcification induced by BMP-2-derived synthetic peptide J Biomed Mater Res A 70A 2004 115 121 (Pubitemid 38849818)
71. J.T. Connelly, T.A. Petrie, A.J. García, and M.E. Levenston Fibronectin- and collagen-mimetic ligands regulate bone marrow stromal cell chondrogenesis in three-dimensional hydrogels Eur Cells Mater 22 2011 168 176 discussion 76-77
72. G.A. Hudalla, and W.L. Murphy Using "click" chemistry to prepare SAM substrates to study stem cell adhesion Langmuir 25 2009 5737 5746
73. M. Mrksish, and G.M. Whitesides Using self-assembled monolayers to understand the interactions of man made surfaces with proteins and cells Annu Rev Biophys Biomol 25 1996 55 78
74. A. Ulman Formation and structure of self-assembled monolayers Chem Rev 96 1996 1533 1554 (Pubitemid 126639367)
75. M. Mrksich Using self-assembled monolayers to model the extracellular matrix Acta Biomater 5 2009 832 841
76. C. Yan, J. Sun, and J. Ding Critical areas of cell adhesion on micropatterned surfaces Biomaterials 32 2011 3931 3938
77. J.T. Koepsel, S.G. Loveland, M.P. Schwartz, S. Zorn, D.G. Belair, and N.N. Le A chemically-defined screening platform reveals behavioral similarities between primary human mesenchymal stem cells and endothelial cells Integr Biol 4 2012 1508 1521
78. M. Mrksich Tailored substrates for studies of attached cell culture Cell Mol Life Sci 54 1998 653 662 (Pubitemid 28379668)
79. J. Maciel, M.I. Oliveira, R.M. Gonçalves, and M.A. Barbosa The effect of adsorbed fibronectin and osteopontin on macrophage adhesion and morphology on hydrophilic and hydrophobic model surfaces Acta Biomater 8 2012 3669 3677
80. 2 and COOH functionalized surfaces Biotechnol Bioeng 108 2011 3009 3018
81. Y. Arima, and H. Iwata Effect of wettability and surface functional groups on protein adsorption and cell adhesion using well-defined mixed self-assembled monolayers Biomaterials 28 2007 3074 3082 (Pubitemid 46602519)
82. J.T. Elliott, J.T. Woodward, A. Umarji, Y. Mei, and A. Tona The effect of surface chemistry on the formation of thin films of native fibrillar collagen Biomaterials 28 2007 576 585 (Pubitemid 44649266)
83. H. Wang, Y. He, B.D. Ratner, and S. Jiang Modulating cell adhesion and spreading by control of FnIII7-10 orientation on charged self-assembled monolayers (SAMs) of alkanethiolates J Biomed Mater Res A 77A 2006 672 678 (Pubitemid 47240770)
84. L. Liu, S. Chen, C.M. Giachelli, B.D. Ratner, and S. Jiang Controlling osteopontin orientation on surfaces to modulate endothelial cell adhesion J Biomed Mater Res A 74A 2005 23 31 (Pubitemid 41099247)
85. B.G. Keselowsky, D.M. Collard, and A.J. García Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation PNAS 102 2005 5953 5957 (Pubitemid 40594236)
86. M.A. Lan, C.A. Gersbach, K.E. Michael, B.G. Keselowsky, and A.J. García Myoblast proliferation and differentiation on fibronectin-coated self assembled monolayers presenting different surface chemistries Biomaterials 26 2005 4523 4531 (Pubitemid 40269268)
87. M.H. Lee, D.A. Brass, R. Morris, R.J. Composto, and P. Ducheyne The effect of non-specific interactions on cellular adhesion using model surfaces Biomaterials 26 2005 1721 1730 (Pubitemid 39575315)
88. N. Faucheux, R. Schweiss, K. Lützow, C. Werner, and T. Groth Self-assembled monolayers with different terminating groups as model substrates for cell adhesion studies Biomaterials 25 2004 2721 2730 (Pubitemid 38202319)
89. B.G. Keselowsky, D.M. Collard, and A.J. García Surface chemistry modulates focal adhesion composition and signaling through changes in integrin binding Biomaterials 25 2004 5947 5954 (Pubitemid 38747017)
90. B.G. Keselowsky, D.M. Collard, and A.J. García Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion J Biomed Mater Res A 66A 2003 247 259 (Pubitemid 37517224)
91. C.A. Scotchford, C.P. Gilmore, E. Cooper, G.J. Leggett, and S. Downes Protein adsorption and human osteoblast-like cell attachment and growth on alkylthiol on gold self-assembled monolayers J Biomed Mater Res 59 2002 84 99
92. K.B. McClary, T. Ugarova, and D.W. Grainger Modulating fibroblast adhesion, spreading, and proliferation using self-assembled monolayer films of alkylthiolates on gold J Biomed Mater Res 50 2000 428 439 (Pubitemid 30180736)
93. V.A. Tegoulia, and S.L. Cooper Leukocyte adhesion on model surfaces under flow: effects of surface chemistry, protein adsorption, and shear rate J Biomed Mater Res 50 2000 291 301 (Pubitemid 30180721)
94. S. Margel, E.A. Vogler, L. Firment, T. Watt, S. Haynie, and D.Y. Sogah Peptide, protein, and cellular interactions with self-assembled monolayer model surfaces J Biomed Mater Res 27 1993 1463 1476 (Pubitemid 23341473)
95. P.L. Granja, M.A. Barbosa, L. Pouységu, B. De Jéso, F. Rouais, and C. Baquey Cellulose phosphates as biomaterials. Mineralization of chemically modified regenerated cellulose hydrogels J Mater Sci 36 2001 2163 2172 (Pubitemid 32517473)
96. P.L. Granja, B.D. Jéso, R. Bareille, F. Rouais, C. Baquey, and M.A. Barbosa Cellulose phosphates as biomaterials. In vitro biocompatibility studies React Funct Polym 66 2006 728 739 (Pubitemid 43928832)
97. A.R. Murphy, P.S. John, and D.L. Kaplan Modification of silk fibroin using diazonium coupling chemistry and the effects on hMSC proliferation and differentiation Biomaterials 29 2008 2829 2838
98. D.A. Wang, C.G. Williams, F. Yang, N. Cher, H. Lee, and J.H. Elisseeff Bioresponsive phosphoester hydrogels for bone tissue engineering Tissue Eng Part A 11 2005 201 213 (Pubitemid 40515188)
99. Wang. D-a Williams CG, Li Q, Sharma B, Elisseeff JH. Synthesis and characterization of a novel degradable phosphate-containing hydrogel Biomaterials 24 2003 3969 3980 (Pubitemid 36794402)
100. C.R. Nuttelman, M.C. Tripodi, and K.S. Anseth Synthetic hydrogel niches that promote hMSC viability Matrix Biol 24 2005 208 218 (Pubitemid 40732594)
101. C.R. Nuttelman, D.S.W. Benoit, M.C. Tripodi, and K.S. Anseth The effect of ethylene glycol methacrylate phosphate in PEG hydrogels on mineralization and viability of encapsulated hMSCs Biomaterials 27 2006 1377 1386 (Pubitemid 41739563)
102. N.R. Gandavarapu, P.D. Mariner, M.P. Schwartz, and K.S. Anseth Extracellular matrix protein adsorption to phosphate-functionalized gels from serum promotes osteogenic differentiation of human mesenchymal stem cells Acta Biomater 9 2013 4525 4534
103. E. Jabbari Osteogenic peptides in bone regeneration Curr Pharm Des 12 2013 45 56
104. Y.J. Choi, J.Y. Lee, C.-P. Chung, and Y.J. Park Enhanced osteogenesis by collagen-binding peptide from bone sialoprotein in vitro and in vivo J Biomed Mater Res A 101A 2013 547 554
105. H.K. Kim, J.H. Kim, D.S. Park, K.S. Park, S.S. Kang, and J.S. Lee Osteogenesis induced by a bone forming peptide from the prodomain region of BMP-7 Biomaterials 33 2012 7057 7063
106. D.M. Sousa, H. Herzog, and M. Lamghari NPY signalling pathway in bone homeostasis: Y1 receptor as a potential drug target Curr Drug Targets 10 2009 9 19
107. L. Teixeira, D.M. Sousa, A.F. Nunes, M.M. Sousa, H. Herzog, and M. Lamghari NPY revealed as a critical modulator of osteoblast function in vitro: new insights into the role of Y1 and Y2 receptors J Cell Biochem 107 2009 908 916
108. H.D. Amin, I. Olsen, J.C. Knowles, and N. Donos Differential effect of amelogenin peptides on osteogenic differentiation in vitro: identification of possible new drugs for bone repair and regeneration Tissue Eng Part A 18 2012 1193 1202
109. H.H. Luu, W.X. Song, X. Luo, D. Manning, J. Luo, and Z.L. Deng Distinct roles of bone morphogenetic proteins in osteogenic differentiation of mesenchymal stem cells J Orthop Res 25 2007 665 677 (Pubitemid 46730519)
110. K. Miyazono, Y. Kamiya, and M. Morikawa Bone morphogenetic protein receptors and signal transduction J Biochem 147 2010 35 51
111. S.C. Little, and M.C. Mullins Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis Nat Cell Biol 11 2009 637 643
112. V.C. Foletta, M.A. Lim, J. Soosairajah, A.P. Kelly, E.G. Stanley, and M. Shannon Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1 J Cell Biol 162 2003 1089 1098 (Pubitemid 37174191)
113. P.A. Hoodless, T. Haerry, S. Abdollah, M. Stapleton, M.B. Oconnor, and L. Attisano MADR1, a MAD-related protein that functions in BMP2 signaling pathways Cell 85 1996 489 500 (Pubitemid 26157188)
114. M. Fujii, K. Takeda, T. Imamura, H. Aoki, T.K. Sampath, and S. Enomoto Roles of bone morphogenetic protein type I receptors and smad proteins in osteoblast and chondroblast differentiation Mol Biol Cell 10 1999 3801 3813 (Pubitemid 29534026)
115. K.-S. Lee, H.-J. Kim, Q.-L. Li, X.-Z. Chi, C. Ueta, and T. Komori Runx2 is a common target of transforming growth factor β1 and bone morphogenetic protein 2, and cooperation between Runx2 and Smad5 induces osteoblast-specific gene expression in the pluripotent mesenchymal precursor cell line C2C12 Mol Cell Biol 20 2000 8783 8792 (Pubitemid 32245911)
116. A. Javed, J.-S. Bae, F. Afzal, S. Gutierrez, J. Pratap, and S.K. Zaidi Structural coupling of Smad and Runx2 for execution of the BMP2 osteogenic signal J Biol Chem 283 2008 8412 8422
117. T. Kirsch, W. Sebald, and M.K. Dreyer Crystal structure of the BMP-2-BRIA ectodomain complex Nat Struct Biol 7 2000 492 496 (Pubitemid 30414472)
118. T. Kirsch, J. Nickel, and W. Sebald BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II EMBO J 19 2000 3314 3324 (Pubitemid 30428209)
119. P. Knaus, and W. Sebald Cooperativity of binding epitopes and receptor chains in the BMP/TGF beta superfamily Cytokine Growth Factor Rew 382 2001 1189 1195 (Pubitemid 32894025)
120. H. Senta, H. Park, E. Bergeron, O. Drevelle, D. Fong, and E. Leblanc Cell responses to bone morphogenetic proteins and peptides derived from them: biomedical applications and limitations Cytokine Growth Factor Rew 20 2009 213 222
121. H. Egusa, Y. Kaneda, Y. Akashi, Y. Hamada, T. Matsumoto, and M. Saeki Enhanced bone regeneration via multimodal actions of synthetic peptide SVVYGLR on osteoprogenitors and osteoclasts Biomaterials 30 2009 4676 4686
122. Guang-Zan LI, Lian-Fang FENG, Xue-Ping GU, Zhong-Bin XU, Guo-Hua HU, and L. Jin-Hua Synthesis of PSt-TMI copolymer and studies of the copolymerization kinetics J Funct Polym 127 2005 33
123. W.D. Staatz, J.J. Walsh, T. Pexton, and S.A. Santoro The alpha 2 beta 1 integrin cell surface collagen receptor binds to the alpha 1 (I)-CB3 peptide of collagen J Biol Chem 265 1990 4778 4781
124. Y. Takeuchi, M. Suzawa, T. Kikuchi, E. Nishida, T. Fujita, and T. Matsumoto Differentiation and transforming growth factor-β receptor down-regulation by collagen-α2β1 integrin interaction is mediated by focal adhesion kinase and its downstream signals in murine osteoblastic cells J Biol Chem 272 1997 29309 29316 (Pubitemid 27498224)
125. C.D. Reyes, and A.J. García Engineering integrin-specific surfaces with a triple-helical collagen-mimetic peptide J Biomed Mater Res A 65A 2003 511 523 (Pubitemid 38075882)
126. A.M. Wojtowicz, A. Shekaran, M.E. Oest, K.M. Dupont, K.L. Templeman, and D.W. Hutmacher Coating of biomaterial scaffolds with the collagen-mimetic peptide GFOGER for bone defect repair Biomaterials 31 2010 2574 2582
127. C. Qin, O. Baba, and W.T. Butler Post-translational modifications of SIBLING proteins and their roles in osteogenesis and dentinogenesis Crit Rev Oral Biol Med 15 2004 126 136
128. S. Chen, L. Chen, A. Jahangiri, B. Chen, Y. Wu, and H.-H. Chuang Expression and processing of small integrin-binding ligand N-linked glycoproteins in mouse odontoblastic cells Arch. Oral Biol. 53 2008 879 889
129. K.A. Staines, V.E. MacRae, and C. Farquharson The importance of the SIBLING family of proteins on skeletal mineralisation and bone remodelling J Endocrinol 214 2012 241 255
130. Y. Chen, B.S. Bal, and J.P. Gorski Calcium and collagen binding properties of osteopontin, bone sialoprotein, and bone acidic glycoprotein-75 from bone J Biol Chem 267 1992 24871 24878
131. L.W. Fisher, D.A. Torchia, B. Fohr, M.F. Young, and N.S. Fedarko Flexible structures of SIBLING proteins, bone sialoprotein, and osteopontin Biochem Biophys Res Commun 280 2001 460 465 (Pubitemid 32912812)
132. P. Bianco, M. Riminucci, E. Bonucci, J.D. Termine, and P.G. Robey Bone sialoprotein (BSP) secretion and osteoblast differentiation: relationship to bromodeoxyuridine incorporation, alkaline phosphatase, and matrix deposition J Histochem Cytochem 41 1993 183 191 (Pubitemid 23039097)
133. A. Rezania, and K.E. Healy Biomimetic peptide surfaces that regulate adhesion, spreading, cytoskeletal organization, and mineralization of the matrix deposited by osteoblast-like cells Biotechnol Progr 15 1999 19 32 (Pubitemid 29087584)
134. A. Rezania, and K.E. Healy The effect of peptide surface density on mineralization of a matrix deposited by osteogenic cells J Biomed Mater Res 52 2000 595 600
135. O. Drevelle, E. Bergeron, H. Senta, M.-A. Lauzon, S. Roux, and G. Grenier Effect of functionalized polycaprolactone on the behavior of murine preosteoblasts Biomaterials 31 2010 6468 6476
136. O. Drevelle, A. Daviau, M.-A. Lauzon, and N. Faucheux Effect of BMP-2 and/or BMP-9 on preosteoblasts attached to polycaprolactone functionalized by adhesive peptides derived from bone sialoprotein Biomaterials 34 2013 1051 1062
137. T. Hayashibara, T. Hiraga, B. Yi, M. Nomizu, Y. Kumagai, and R. Nishimura A synthetic peptide fragment of human MEPE stimulates new bone formation in vitro and in vivo J Bone Miner Res 19 2004 455 462 (Pubitemid 38787401)
138. W.N. Addison, Y. Nakano, T. Loisel, P. Crine, and M.D. McKee MEPE-ASARM peptides control extracellular matrix mineralization by binding to hydroxyapatite: an inhibition regulated by PHEX cleavage of ASARM J Bone Miner Res 23 2008 1638 1649
139. A.P. Sprowson, A.W. McCaskie, and M.A. Birch ASARM-truncated MEPE and AC-100 enhance osteogenesis by promoting osteoprogenitor adhesion J Orthop Res 26 2008 1256 1262
140. K. Merry, R. Dodds, A. Littlewood, and M. Gowen Expression of osteopontin mRNA by osteoclasts and osteoblasts in modelling adult human bone J Cell Sci 104 1993 1013 1020 (Pubitemid 23154308)
141. D.T. Denhardt, and X. Guo Osteopontin: a protein with diverse functions FASEB J 7 1993 1475 1482 (Pubitemid 24003267)
142. J.W. Suttie Synthesis of vitamin K-dependent proteins FASEB J 7 1993 445 452 (Pubitemid 23108559)
143. T. Saito, A.L. Arsenault, M. Yamauchi, Y. Kuboki, and M.A. Crenshaw Mineral induction by immobilized phosphoproteins Bone 21 1997 305 311 (Pubitemid 27454083)
144. H. Shin, K. Zygourakis, M.C. Farach-Carson, M.J. Yaszemski, and A.G. Mikos Modulation of differentiation and mineralization of marrow stromal cells cultured on biomimetic hydrogels modified with Arg-Gly-Asp containing peptides J Biomed Mater Res A 69 2004 535 543 (Pubitemid 38668179)
145. M. Takahata, H. Awad, R. O'Keefe, S. Bukata, and E. Schwarz Endogenous tissue engineering: PTH therapy for skeletal repair Cell Tissue Res 347 2012 545 552
146. I. Arrighi, S. Mark, M. Alvisi, B. von Rechenberg, J.A. Hubbell, and J.C. Schense Bone healing induced by local delivery of an engineered parathyroid hormone prodrug Biomaterials 30 2009 1763 1771
147. R.I. Gafni, J.S. Brahim, P. Andreopoulou, N. Bhattacharyya, M.H. Kelly, and B.A. Brillante Daily parathyroid hormone 1-34 replacement therapy for hypoparathyroidism induces marked changes in bone turnover and structure J Bone Miner Res 27 2012 1811 1820
148. I. Bab, D. Gazit, M. Chorev, A. Muhlrad, A. Shteyer, and Z. Greenberg Histone H4-related osteogenic growth peptide (OGP): a novel circulating stimulator of osteoblastic activity EMBO J 11 1992 1867 1873
149. Z. Hui, L. Yu, Y. Xiaoli, H. Xiang, Z. Fan, and H. Ningbo C-terminal pentapeptide of osteogenic growth peptide regulates hematopoiesis in early stage J Cell Biochem 101 2007 1423 1429 (Pubitemid 47242773)
150. L. Mattii, B. Battolla, S. Moscato, R. Fazzi, S. Galimberti, and N. Bernardini The small peptide OGP(10-14) acts through Src kinases and RhoA pathways in Mo-7e cells: morphologic and immunologic evaluation Med Sci Monitor 14 2008 BR103 BR108
151. R. Fazzi, R. Testi, S. Trasciatti, S. Galimberti, S. Rosini, and F. Piras Bone and bone-marrow interactions: haematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide. Mobilizing properties on white blood cells and peripheral blood stem cells in mice Leukemia Res 26 2002 19 27 (Pubitemid 33081088)
152. S.M.S. Miguel, M. Namdar-Attar, T. Noh, B. Frenkel, and I. Bab ERK1/2-activated de novo Mapkapk2 synthesis is essential for osteogenic growth peptide mitogenic signaling in osteoblastic cells J Biol Chem 280 2005 37495 37502 (Pubitemid 41642358)
153. N. Gabarin, H. Gavish, A. Muhlrad, Y.-C. Chen, M. Namdar-Attar, and R.A. Nissenson Mitogenic Gi protein-MAP kinase signaling cascade in MC3T3-E1 osteogenic cells: activation by C-terminal pentapeptide of osteogenic growth peptide [OGP(10-14)] and attenuation of activation by cAMP J Cell Biochem 81 2001 594 603 (Pubitemid 32417084)
154. A.P. Acharya, N.V. Dolgova, N.M. Moore, C.Q. Xia, M.J. Clare-Salzler, and M.L. Becker The modulation of dendritic cell integrin binding and activation by RGD-peptide density gradient substrates Biomaterials 31 2010 7444 7454
155. Z.-X. Chen, M. Chang, Y.-L. Peng, L. Zhao, Y.-R. Zhan, and L.-J. Wang Osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)] acts on rat bone marrow mesenchymal stem cells to promote differentiation to osteoblasts and to inhibit differentiation to adipocytes Regul Peptides 142 2007 16 23 (Pubitemid 46755903)
156. M. Shuqiang, W. Kunzheng, D. Xiaoqiang, W. Wei, Z. Mingyu, and W. Daocheng Osteogenic growth peptide incorporated into PLGA scaffolds accelerates healing of segmental long bone defects in rabbits J Plast Reconstr Aesthet Surg 61 2008 1558 1560
157. S. Saska, R.M. Scarel-Caminaga, L.N. Teixeira, L.P. Franchi, R.A.D. Santos, and A.M.M. Gaspar Characterization and in vitro evaluation of bacterial cellulose membranes functionalized with osteogenic growth peptide for bone tissue engineering J Mater Sci Mater Med 23 2012 2253 2266
158. N.M. Moore, N.J. Lin, N.D. Gallant, and M.L. Becker The use of immobilized osteogenic growth peptide on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast proliferation Biomaterials 31 2010 1604 1611
159. S. Pregizer, S.K. Baniwal, X. Yan, Z. Borok, and B. Frenkel Progressive recruitment of Runx2 to genomic targets despite decreasing expression during osteoblast differentiation J Cell Biochem 105 2008 965 970
160. K.J. Manton, D.F.M. Leong, S.M. Cool, and V. Nurcombe Disruption of heparan and chondroitin sulfate signaling enhances mesenchymal stem cell-derived osteogenic differentiation via bone morphogenetic protein signaling pathways Stem Cells 25 2007 2845 2854 (Pubitemid 350127869)
161. C. Dombrowski, S.J. Song, P. Chuan, X. Lim, E. Susanto, and A.A. Sawyer Heparan sulfate mediates the proliferation and differentiation of rat mesenchymal stem cells Stem Cells Dev 18 2009 661 670
162. D.S.W. Benoit, A.R. Durney, and K.S. Anseth The effect of heparin-functionalized PEG hydrogels on three-dimensional human mesenchymal stem cell osteogenic differentiation Biomaterials 28 2007 66 77 (Pubitemid 44427907)
163. V. Vacharathit, E.A. Silva, and D.J. Mooney Viability and functionality of cells delivered from peptide conjugated scaffolds Biomaterials 32 2011 3721 3728
164. L. Gilmore, S. Rimmer, S.L. McArthur, S. Mittar, D. Sun, and S. MacNeil Arginine functionalization of hydrogels for heparin binding - a supramolecular approach to developing a pro-angiogenic biomaterial Biotechnol Bioeng 110 2013 296 317
165. B. Ganss, R.H. Kim, and J. Sodek Bone sialoprotein Crit Rev Oral Biol Med 10 1999 79 98 (Pubitemid 29510048)
166. J. Sodek, B. Ganss, and M.D. McKee Osteopontin Crit Rev Oral Biol Med 11 2000 279 303
167. T.D. Sargeant, C. Aparicio, J.E. Goldberger, H. Cui, and S.I. Stupp Mineralization of peptide amphiphile nanofibers and its effect on the differentiation of human mesenchymal stem cells Acta Biomater 8 2012 2456 2465
168. J.S. Lee, J.S. Lee, A. Wagoner-Johnson, and W.L. Murphy Modular peptide growth factors for substrate-mediated stem cell differentiation Angew Chem Int Ed 48 2009 6266 6269
169. J.S. Lee, J.S. Lee, and W.L. Murphy Modular peptides promote human mesenchymal stem cell differentiation on biomaterial surfaces Acta Biomater 6 2010 21 28
170. Q.Q. Hoang, F. Sicheri, A.J. Howard, and D.S.C. Yang Bone recognition mechanism of porcine osteocalcin from crystal structure Nature 425 2003 977 980 (Pubitemid 37376930)
171. S. Prieto, A. Shkilnyy, C. Rumplasch, A. Ribeiro, F.J. Arias, and J.C. Rodríguez-Cabello Biomimetic calcium phosphate mineralization with multifunctional elastin-like recombinamers Biomacromolecules 12 2011 1480 1486
172. D.S.W. Benoit, C.R. Nuttelman, S.D. Collins, and K.S. Anseth Synthesis and characterization of a fluvastatin-releasing hydrogel delivery system to modulate hMSC differentiation and function for bone regeneration Biomaterials 27 2006 6102 6110 (Pubitemid 44414974)
173. R.F. Reinoso, A. SánchezNavarro, M.J. García, and J.R. Prous Preclinical pharmacokinetics of statins Method Find Exp Clin 24 2002 593 613 (Pubitemid 36109399)
174. G. Mundy, R. Garrett, S. Harris, J. Chan, D. Chen, and G. Rossini Stimulation of bone formation in vitro and in rodents by statins Science 286 1999 1946 1949 (Pubitemid 129515901)
175. C.J. Edwards, and T.D. Spector Statins as modulators of bone formation Arthritis Res 4 2002 151 153 (Pubitemid 34460752)
176. K. Whang, E. Grageda, A. Khan, J. McDonald, M. Lawton, and N. Satsangi A novel osteotropic biomaterial OG-PLG: In vitro efficacy J Biomed Mater Res A 74A 2005 247 253 (Pubitemid 40995539)
177. K.W. Park, H. Waki, W.-K. Kim, B.S.J. Davies, S.G. Young, and F. Parhami The small molecule phenamil induces osteoblast differentiation and mineralization Mol Cell Biol 29 2009 3905 3914
178. X. Wu, S. Ding, Q. Ding, N.S. Gray, and P.G. Schultz A small molecule with osteogenesis-inducing activity in multipotent mesenchymal progenitor cells J Am Chem Soc 124 2002 14520 14521 (Pubitemid 35425009)
179. H. Alves, K. Dechering, C. Van Blitterswijk, and J. De Boer High-throughput assay for the identification of compounds regulating osteogenic differentiation of human mesenchymal stromal cells PLoS ONE 6 2011 e26678
180. D.M. Brey, N.A. Motlekar, S.L. Diamond, R.L. Mauck, J.P. Garino, and J.A. Burdick High-throughput screening of a small molecule library for promoters and inhibitors of mesenchymal stem cell osteogenic differentiation Biotechnol Bioeng 108 2011 163 174
181. J. Doorn, M. Leusink, N. Groen, J. Van De Peppel, J.P.T.M. Van Leeuwen, and C.A. Van Blitterswijk Diverse effects of cyclic AMP variants on osteogenic and adipogenic differentiation of human mesenchymal stromal cells Tissue Eng Part A 18 2012 1431 1442
182. J. Doorn, R. Siddappa, C.A. Van Blitterswijk, and J. De Boer Forskolin enhances in vivo bone formation by human mesenchymal stromal cells Tissue Eng Part A 18 2012 558 567
183. J.-F. Zhang, G. Li, C.-Y. Chan, C.-L. Meng, M.C.-M. Lin, and Y.-C. Chen Flavonoids of Herba epimedii regulate osteogenesis of human mesenchymal stem cells through BMP and Wnt/β-catenin signaling pathway Mol Cell Endocrinol 314 2010 70 74
184. P.-C. Tseng, S.-M. Hou, R.-J. Chen, H.-W. Peng, C.-F. Hsieh, and M.-L. Kuo Resveratrol promotes osteogenesis of human mesenchymal stem cells by upregulating RUNX2 gene expression via the SIRT1/FOXO3A axis J Bone Miner Res 26 2011 2552 2563
185. M. Shakibaei, P. Shayan, F. Busch, C. Aldinger, C. Buhrmann, and C. Lueders Resveratrol mediated modulation of Sirt-1/Runx2 promotes osteogenic differentiation of mesenchymal stem cells: potential role of Runx2 deacetylation PLoS ONE 7 2012 e35712
186. S.Y. Tzeng, B.P. Hung, W.L. Grayson, and J.J. Green Cystamine-terminated poly(beta-amino ester)s for siRNA delivery to human mesenchymal stem cells and enhancement of osteogenic differentiation Biomaterials 33 2012 8142 8151
187. D. Pandita, J.L. Santos, J. Rodrigues, A.P. Pêgo, P.L. Granja, and H. Tomás Gene delivery into mesenchymal stem cells: a biomimetic approach using RGD nanoclusters based on poly(amidoamine) dendrimers Biomacromolecules 12 2011 472 481
188. J.L. Santos, E. Oramas, A.P. Pêgo, P.L. Granja, and H. Tomás Osteogenic differentiation of mesenchymal stem cells using PAMAM dendrimers as gene delivery vectors J Control Release 134 2009 141 148
189. J.L. Santos, H. Oliveira, D. Pandita, J. Rodrigues, A.P. Pêgo, and P.L. Granja Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells J Control Release 144 2010 55 64
190. J.L. Santos, D. Pandita, J. Rodrigues, A.P. Pêgo, P.L. Granja, and G. Balian Receptor-mediated gene delivery using PAMAM dendrimers conjugated with peptides recognized by mesenchymal stem cells Mol Pharm 7 2010 763 774
191. J.L. Santos, D. Pandita, J. Rodrigues, A.P. Pêgo, P.L. Granja, and H. Tomás Non-viral gene delivery to mesenchymal stem cells: methods, strategies and application in bone tissue engineering and regeneration Curr Gene Ther 11 2011 46 57
192. J.J. Jacob, G.B.J. Andersson, J.E. Bell, S.L. Weinstein, J.P. Dormans, and S.M. Gnatz The Burden of Musculoskeletal Diseases in the United States: Prevalence, Societal and Economic Cost 2008 American Academy of Orthopaedic Surgeons Rosemont, IL
193. A. Peters, D.M. Brey, and J.A. Burdick High-throughput and combinatorial technologies for tissue engineering applications Tissue Eng Part B 15 2009 225 239
194. D.G. Anderson, S. Levenberg, and R. Langer Nanoliter-scale synthesis of arrayed biomaterials and application to human embryonic stem cells Nat Biotechnol 22 2004 863 866 (Pubitemid 38886605)
195. W. Luo, and M.N. Yousaf Developing a self-assembled monolayer microarray to study stem cell differentiation J Colloid Interf Sci 360 2011 325 330
196. N.F. Huang, B. Patlolla, O. Abilez, H. Sharma, J. Rajadas, and R.E. Beygui A matrix micropatterning platform for cell localization and stem cell fate determination Acta Biomater 6 2010 4614 4621
197. M.D. Kurkuri, C. Driever, G. Johnson, G. McFarland, H. Thissen, and N.H. Voelcker Multifunctional polymer coatings for cell microarray applications Biomacromolecules 10 2009 1163 1172
198. T.G. Fernandes, S.-J. Kwon, S.S. Bale, M.-Y. Lee, M.M. Diogo, and D.S. Clark Three-dimensional cell culture microarray for high-throughput studies of stem cell fate Biotechnol Bioeng 106 2010 106 118
199. H.V. Unadkat, M. Hulsman, K. Cornelissen, B.J. Papenburg, R.K. Truckenmüller, and A.E. Carpenter An algorithm-based topographical biomaterials library to instruct cell fate PNAS 108 2011 16565 16570