Injectable in situ crosslinkable RGD-modified alginate matrix for endothelial cells delivery

Biomaterials

Volumn 32, Issue 31, 2011, Pages 7897-7904

  Bidarra, Sílvia J ^a,b   Barrias, Cristina C ^a   Fonseca, Keila B ^a,b   Barbosa, Mário A ^a,b   Soares, Raquel A ^c   Granja, Pedro L ^a,b  

^a INEB INSTITUTO DE ENGENHARIA BIOMÉDICA   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c University of Porto   (Portugal)

Author keywords

Alginate; Cell adhesion; Endothelial cell; RGD peptide; Scaffold

Indexed keywords

3-D ENVIRONMENTS; ALGINATE HYDROGELS; ALGINATE MATRIX; CELL-BASED THERAPY; CELLULAR NETWORK; CROSS-LINKABLE; IN-SITU; IN-SITU FORMING; IN-VITRO; MATRIX; MICROENVIRONMENTS; PROLIFERATIVE CELLS; REVASCULARIZATION; RGD PEPTIDE; VASCULAR CELLS;

ADHESION; ALGINATE; CELL ADHESION; CELL IMMOBILIZATION; CELL PROLIFERATION; CELLULAR NEURAL NETWORKS; HYDROGELS; PEPTIDES; SCAFFOLDS (BIOLOGY); THREE DIMENSIONAL; TISSUE;

ENDOTHELIAL CELLS;

ALGINIC ACID; ANGIOPOIETIN 2; ARGINYLGLYCYLASPARTIC ACID; MATRIGEL; MESSENGER RNA; MOLECULAR SCAFFOLD; VON WILLEBRAND FACTOR;

ARTICLE; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CELL TRANSPORT; CELL VIABILITY; CROSS LINKING; ENDOTHELIUM CELL; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROGEL; IMMOBILIZED CELL; IMMUNOFLUORESCENCE; IN SITU CROSSLINKING; IN VITRO STUDY; MICROENVIRONMENT; PHENOTYPE; PRIORITY JOURNAL; UMBILICAL VEIN ENDOTHELIAL CELL;

ALGINATES; ANGIOPOIETIN-2; CELL MOVEMENT; CELL PROLIFERATION; CELL SHAPE; CELL SURVIVAL; CELLS, CULTURED; CROSS-LINKING REAGENTS; EXTRACELLULAR MATRIX; FLUORESCEINS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDROGELS; INJECTIONS; MATRIX METALLOPROTEINASES; OLIGOPEPTIDES; SOLUTIONS; SUCCINIMIDES;

EID: 80051827430     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.07.013     Document Type: Article

References (35)

1. Unger R.E., Sartoris A., Peters K., Motta A., Migliaresi C., Kunkel M., et al. Tissue-like self-assembly in cocultures of endothelial cells and osteoblasts and the formation of microcapillary-like structures on three-dimensional porous biomaterials. Biomaterials 2007, 28:3965-3976.
2. Hofmann A., Ritz U., Verrier S., Eglin D., Alini M., Fuchs S., et al. The effect of human osteoblasts on proliferation and neo-vessel formation of human umbilical vein endothelial cells in a long-term 3D co-culture on polyurethane scaffolds. Biomaterials 2008, 29:4217-4226.
3. Santos M.I., Unger R.E., Sousa R.A., Reis R.L., Kirkpatrick C.J. Crosstalk between osteoblasts and endothelial cells co-cultured on a polycaprolactone-starch scaffold and the in vitro development of vascularization. Biomaterials 2009, 30:4407-4415.
4. Fuchs S., Ghanaati S., Orth C., Barbeck M., Kolbe M., Hofmann A., et al. Contribution of outgrowth endothelial cells from human peripheral blood on in vivo vascularization of bone tissue engineered constructs based on starch polycaprolactone scaffolds. Biomaterials 2009, 30:526-534.
5. Place E.S., Evans N.D., Stevens M.M. Complexity in biomaterials for tissue engineering. Nat Mater 2009, 8:457-470.
6. Rivron N.C., Liu J., Rouwkema J., De Boer J., Van Blitterswijk C.A. Engineering vascularised tissues in vitro. Eur Cell Mater 2008, 15:27-40.
7. Drury J.L., Mooney D.J. Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials 2003, 24:4337-4351.
8. Hall H. Modified fibrin hydrogel matrices: both, 3D-scaffolds and local and controlled release systems to stimulate angiogenesis. Curr Pharm Des 2007, 13:3597-3607.
9. Xiao Z.S., Ahmad S., Liu Y., Prestwich G.D. Synthesis and evaluation of injectable, in situ crosslinkable synthetic extracellular matrices for tissue engineering. J Biomed Mater Res A 2006, 79:902-912.
10. Boontheekul T., Kong H.-J., Mooney D.J. Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials 2005, 26:2455-2465.
11. Evangelista M.B., Hsiong S.X., Fernandes R., Sampaio P., Kong H.-J., Barrias C.C., et al. Upregulation of bone cell differentiation through immobilization within a synthetic extracellular matrix. Biomaterials 2007, 28:3644-3655.
12. Rowley J.A., Madlambayan G., Mooney D.J. Alginate hydrogels as synthetic extracellular matrix materials. Biomaterials 1999, 20:45-53.
13. Kong H.J., Smith M.K., Mooney D.J. Designing alginate hydrogels to maintain viability of immobilized cells. Biomaterials 2003, 24:4023-4029.
14. Bidarra S.J., Barrias C.C., Barbosa M.A., Soares R., Granja P.L. Immobilization of human mesenchymal stem cells within RGD-grafted alginate microspheres and assessment of their angiogenic potential. Biomacromolecules 2010, 11:1956-1964.
15. Grellier M., Granja P.L., Fricain J.-C., Bidarra S.J., Renard M., Bareille R., et al. The effect of the co-immobilization of human osteoprogenitors and endothelial cells within alginate microspheres on mineralization in a bone defect. Biomaterials 2009, 30:3271-3278.
16. Silva E.A., Kim E.S., Hyun J.K., Mooney D.J. Material-based deployment enhances efficacy of endothelial progenitor cells. Proc Natl Acad Sci USA 2008, 105:14347-14352.
17. Shung A.K., Behravesh E., Jo S., Mikos A.G. Crosslinking characteristics of and cell adhesion to an injectable poly(propylene fumarate-co-ethylene glycol) hydrogel using a water-soluble crosslinking system. Tissue Eng 2003, 9:243-254.
18. Davis M.E., Motion J.P.M., Narmoneva D.A., Takahashi T., Hakuno D., Kamm R.D., et al. Injectable self-assembling peptide nanofibers create intramyocardial microenvironments for endothelial cells. Circulation 2005, 111:442-450.
19. Kraehenbuehl T.P., Ferreira L.S., Hayward A.M., Nahrendorf M., van der Vlies A.J., Vasile E., et al. Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction. Biomaterials 2011, 32:1102-1109.
20. Suggs L.J., Mikos A.G. Development of poly(propylene fumarate-co-ethylene glycol) as an injectable carrier for endothelial cells. Cell Transplant 1999, 8:345-350.
21. Kraehenbuehl T.P., Ferreira L.S., Zammaretti P., Hubbell J.A., Langer R. Cell-responsive hydrogel for encapsulation of vascular cells. Biomaterials 2009, 30:4318-4324.
22. Fonseca K., Bidarra S.J., Oliveira M.J., Granja P.L., Barrias C.C. Molecularly-designed alginate hydrogels susceptible to local proteolysis as 3D cellular microenvironments. Acta Biomater 2011, 7:1674-1682.
23. Kuo C.K., Ma P.X. Ionically crosslinked alginate hydrogels as scaffolds for tissue engineering: Part 1. Structure, gelation rate and mechanical properties. Biomaterials 2001, 22:511-521.
24. Oliveira S., Almeida I., Costa P., Barrias C., Ferreira M., Bahia M., et al. Characterization of polymeric solutions as injectable vehicles for hydroxyapatite microspheres. AAPS PharmSciTech 2010, 11:852-858.
25. Fiedler U., Scharpfenecker M., Koidl S., Hegen A., Grunow V., Schmidt J.M., et al. The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodies. Blood 2004, 103:4150-4156.
26. Jackson C. Matrix metalloproteinases and angiogenesis. Curr Opin Nephrol Hypertens 2002, 11:295-299.
27. Jay S.M., Shepherd B.R., Bertram J.P., Pober J.S., Saltzman W.M. Engineering of multifunctional gels integrating highly efficient growth factor delivery with endothelial cell transplantation. FASEB J 2008, 22:2949-2956.
28. Stupack D.G., Cheresh D.A. Apoptotic cues from the extracellular matrix: regulators of angiogenesis. Oncogene 2003, 22:9022-9029.
29. Yu J., Gu Y., Du K.T., Mihardja S., Sievers R.E., Lee R.J. The effect of injected RGD modified alginate on angiogenesis and left ventricular function in a chronic rat infarct model. Biomaterials 2009, 30:751-756.
30. Fujio Y., Walsh K. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J Biol Chem 1999, 274:16349-16354.
31. Harfouche R., Hussain S.N.A. Signaling and regulation of endothelial cell survival by angiopoietin-2. Am J Physiol Heart Circ Physiol 2006, 291:1635-1645.
32. Daly C., Pasnikowski E., Burova E., Wong V., Aldrich T.H., Griffiths J., et al. Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci USA 2006, 103:15491-15496.
33. Pusztaszeri M.P., Seelentag W., Bosman F.T. Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem 2006, 54:385-395.
34. Yan L., Moses M., Huang S., Ingber D. Adhesion-dependent control of matrix metalloproteinase-2 activation in human capillary endothelial cells. J Cell Sci 2000, 113:3979-3987.
35. Nguyen M., Arkell J., Jackson C.J. Human endothelial gelatinases and angiogenesis. Int J Biochem Cell Biol 2001, 33:960-970.