Cooperativity of binding epitopes and receptor chains in the BMP/TGFβ superfamily

Biological Chemistry

Volumn 382, Issue 8, 2001, Pages 1189-1195

  Knaus, P ^a   Sebald, W ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Binding epitope; BMP receptor; Bone morphogenetic protein (BMP); Smad; TGF superfamily

Indexed keywords

ALKALINE PHOSPHATASE; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN RECEPTOR; EPITOPE; MEMBRANE RECEPTOR; MONOMER; PROTEIN SERINE THREONINE KINASE; PROTEIN SERINE THREONINE KINASE RECEPTOR 1; PROTEIN SERINE THREONINE KINASE RECEPTOR 2; RECEPTOR SUBTYPE; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; ASSAY; BINDING AFFINITY; BIOSENSOR; CONTROLLED STUDY; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; HOMEOSTASIS; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; RECEPTOR BINDING; RECEPTOR UPREGULATION; REGULATORY MECHANISM; REPORTER GENE; SIGNAL TRANSDUCTION; TISSUE; WRIST;

ALKALINE PHOSPHATASE; ANIMALS; BINDING SITES; BIOSENSING TECHNIQUES; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; DIMERIZATION; DNA-BINDING PROTEINS; EPITOPES; EXTRACELLULAR MATRIX; MICE; MUSCLE, SKELETAL; MUTATION; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034826931     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.2001.149     Document Type: Article

References (22)

1. JunB is involved in the inhibition of myogenic differentiation by bone morphogenetic protein-2
2. Bone morphogenetic protein-3 is a negative regulator of bone density
3. Bone morphogenetic protein receptor complexes on the surface of live cells: A new oligomerization mode for serine/threonine kinase receptors
4. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
5. Heterodimeric bone morphogenetic proteins show enhanced activity in vitro and in vivo
6. Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2
7. Identification and functional characterization of a Smad binding element (SBE) in the JunB promoter that acts as a transforming growth factor-beta, activin, and bone morphogenetic protein-inducible enhancer
8. The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms
9. BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II
10. Isolation of recombinant BMP receptor IA ectodomain and its 2:1 complex with BMP-2
11. TGF-beta signal transduction
12. How cells read TGF-beta signals
13. TGF-beta signaling by smad proteins
14. A kinase domain-truncated type I receptor blocks bone morphogenetic protein-2-induced signal transduction in C2C12 myoblasts
15. Ventral mesoderm induction and patterning by bone morphogenetic protein heterodimers in Xenopus embryos
16. Silencing of TGF-beta signalling by the pseudoreceptor BAMBI
17. Specificity, diversity, and regulation in TGF-beta superfamily signaling
18. Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I receptor
19. Role of morphogenetic proteins in skeletal tissue engineering and regeneration
20. Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity
21. Crystal structure of human bone morphogenetic protein-2 at 2.7 Å resolution
22. Global and local determinants for the kinetics of interleukin-4/interleukin-4 receptor alpha chain interaction. A biosensor study employing recombinant interleukin-4-binding protein