A novel osteotropic biomaterial OG-PLG: In vitro efficacy

Journal of Biomedical Materials Research - Part A

Volumn 74, Issue 2, 2005, Pages 247-253

  Whang, Kyumin ^a   Grageda, Edgar ^a   Khan, Ambereen ^a   McDonald, Jonathan ^a   Lawton, Mark ^a   Satsangi, Neera ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Bone regeneration; Rat bone marrow cells; Simvastatin grafted to poly(lactide co glycolide) (OG PLG); Statin

Indexed keywords

ALKALINE EARTH METALS; BONE; CELLS; DEGRADATION; ENZYMES; GRAFT COPOLYMERS; GRAFTING (CHEMICAL); SAPONIFICATION;

BONE MARROW CELLS (BMC); OSTEOTROPIC BIOMATERIALS; RELEASE KINETICS; STATINS;

BIOMATERIALS;

ALKALINE PHOSPHATASE; BIOMATERIAL; POLYGLACTIN; SIMVASTATIN;

ANIMAL CELL; ARTICLE; BONE CELL; BONE MARROW CELL; BONE PROSTHESIS; BONE REGENERATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DEGRADATION KINETICS; DIFFUSION; DRUG SYNTHESIS; FREEZE DRYING; IN VITRO STUDY; MALE; MINERALIZATION; NONHUMAN; PROSTHESIS MATERIAL; PROTEIN EXPRESSION; RAT; SAPONIFICATION; STATISTICAL SIGNIFICANCE;

ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; BONE REGENERATION; CULTURE MEDIA; LACTIC ACID; MALE; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, INBRED LEW; SIMVASTATIN;

EID: 22244464589     PISSN: 00219304     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbm.a.30370     Document Type: Article

References (22)

1. Kenley RA, Yim K, Abrams J, Ron E, Turek T, Marden LJ, Hollinger JO. Biotechnology and bone graft substitutes. Pharm Res 1993;10:1393-1401.
2. Wang X, Tokuda H, Hatakeyama D, Hirade K, Niwa M, Ito H, Kato K, Kozawa O. Mechanism of simvastatin on induction of heat shock protein in osteoblasts. Arch Biochem Biophys 2003;415(1):6-13.
3. Mundy G, Garrett R, Harris S, Chan J, Chen D, Rossini G, Boyce B, Zhao M, Gutierrez G. Stimulation of bone formation in vitro and in rodents by statins. Science 1999;286(5446):1946-1949.
4. Sugiyama M, Kodama T, Konishi K, Abe K, Asami S, Oikawa S. Compactin and simvastatin, but not pravastatin, induce bone morphogenetic protein-2 in human osteosarcoma cells. Biochem Biophys Res Commun 2000;271(3):688-692.
5. Maeda T, Matsunuma A, Kawane T, Horiuchi N. Simvastatin promotes osteoblast differentiation and mineralization in MC3T3-E1 cells. Biochem Biophys Res Commun 2001;280(3):874-877.
6. Phillips BW, Belmonte N, Vernochet C, Ailhaud G, Dani C. Compactin enhances osteogenesis in murine embryonic stem cells. Biochem Biophys Res Commun 2001;284(2):478-484.
7. Song C, Guo Z, Ma Q, Chen Z, Liu Z, Jia H, Dang G. Simvastatin induces osteoblastic differentiation and inhibits adipocytic differentiation in mouse bone marrow stromal cells. Biochem Biophys Res Commun 2003;308(3):458-462.
8. Maeda T, Kawane T, Horiuchi N. Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. Endocrinology 2003;144(2): 681-692.
9. Ohnaka K, Shimoda S, Nawata H, Shimokawa H, Kaibuchi K, Iwamoto Y, Takayanagi R. Pitavastatin enhanced BMP-2 and osteocalcin expression by inhibition, of Rho-associated kinase in human osteoblasts. Biochem Biophys Res Commun 2001; 287(2):337-342.
10. Ohno T, Shigetomi M, Ihara K, Matsunaga T, Hashimoto T, Kawano H, Sugiyama T, Kawai S. Skeletal reconstruction by vascularized allogenic bone transplantation: effects of statin in rats. Transplantation 2003;76(5):869-871.
11. Wong RW, Rabie AB. Statin collagen grafts used to repair defects in the parietal bone of rabbits. Br J Oral Maxillofac Surg 2003;41(4):244-248.
12. Cummings SR, Bauer DC. Do statins prevent both cardiovascular disease and fracture? JAMA 2000;283(24):3255-3257.
13. Meier CR, Schlienger RG, Kraenzlin ME, Schlegel B, Jick H. HMG-CoA reductase inhibitors and the risk of fractures. JAMA 2000;283(24):3205-3210.
14. Wang PS, Solomon DH, Mogun H, Avorn J. HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients. JAMA 2000;283(24):3211-3216.
15. Haberstadt C, Anderson P, Bartel R, Cohen R, Naughton G. Physiological cultured skin substitutes for wound healing. Mater Res Soc Symp Proc 1992;252:323-330.
16. Whang K, McDonald JW, Khan A, Satsangi N. A novel osteotropic biomaterial OG-PLG: Synthesis and in vitro release. J Biomed Mater Res 2005. Forthcoming.
17. Aubin JE. Osteoprogenitor cell frequency in rat bone marrow stromal populations: role for heterotypic cell-cell interactions in osteoblast differentiation. J Cell Biochem 1999;72(3):396-410.
18. Bi LX, Simmons DJ, Mainous E. Expression of BMP-2 by rat bone marrow stromal cells in culture. Calcif Tissue Int 1999; 64(1):63-68.
19. Keyomarsi K, Sandoval L, Band V, Pardee AB. Synchronization of tumor and normal cells from G1 to multiple cell cycles by lovastatin. Cancer Res 1991;51(13):3602-3609.
20. Todd PA, Goa KL. Simvastatin. A review of its pharmacological properties and therapeutic potential in hypercholesterolaemia. Drugs 1990;40(4):583-607.
21. Whang K, Thomas CK, Nuber G, Healy KE. A novel method to fabricate bioabsorbable scaffolds. Polymer 1995;36:837-842.
22. Harris SE, Sabatini M, Harris MA, Feng JQ, Wozney J, Mundy GR. Expression of bone morphogenetic protein messenger RNA in prolonged cultures of fetal rat calvarial cells. J Bone Miner Res 1994;9(3):389-394.