Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex

Journal of Medicinal Chemistry

Volumn 54, Issue 16, 2011, Pages 5671-5679

  Ou, Tian Miao ^a   Lin, Jing ^a   Lu, Yu Jing ^b   Hou, Jin Qiang ^a   Tan, Jia Heng ^a   Chen, Shu Han ^a   Li, Zeng ^a   Li, Yan Ping ^a   Li, Ding ^a   Gu, Lian Quan ^a   Huang, Zhi Shu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGDONG UNIVERSITY OF TECHNOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; GUANINE; LIGAND; MYC PROTEIN; QUINOLINE DERIVATIVE; SYUIQ 05; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DNA STRUCTURE; DRUG DNA BINDING; DRUG MECHANISM; HUMAN; HUMAN CELL; HUMAN GENOME; IN VITRO STUDY; ONCOGENE C MYC; PROMOTER REGION; SENESCENCE; TELOMERE;

BASE SEQUENCE; BLOTTING, WESTERN; CELL AGING; CELL LINE, TUMOR; CELL PROLIFERATION; DIAMINES; DNA, NEOPLASM; G-QUADRUPLEXES; GENE EXPRESSION REGULATION, NEOPLASTIC; GREEN FLUORESCENT PROTEINS; HELA CELLS; HL-60 CELLS; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; MICROSCOPY, CONFOCAL; MOLECULAR STRUCTURE; NM23 NUCLEOSIDE DIPHOSPHATE KINASES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; QUINOLINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TELOMERASE; TELOMERE;

EID: 80051910937     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200062u     Document Type: Article

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