Bis-alkylamine quindolone derivatives as new antimalarial leads

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5634-5637

  Lavrado, João ^a   Gani, Kaamil ^a   Nobre, Pedro A ^a   Santos, Sofia A ^a   Figueiredo, Paula ^b   Lopes, Dinora ^b   Rosário, Virgílio Do ^b   Gut, Jiri ^c   Rosenthal, Philip J ^c   Moreira, Rui ^a   Paulo, Alexandra ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Antiplasmodial; Digestive vacuole; Hemozoin; Indoloquinoline; Malaria

Indexed keywords

2 [(10H INDOLO[3,2 B]QUINOLIN 11 YL)OXY] N,N DIETHYLETHANAMINE; 2 [11 (2 (DIETHYLAMINO)ETHOXY) 10H INDOLO[3,2 B]QUINOLIN 10 YL] N, N DIETHYLETHANAMINE; 2 [11 (2 (DIETHYLAMINO)ETHOXY) 10H INDOLO[3,2 B]QUINOLIN 10 YL] N,N DIETHYLETHANAMINE; 5,10 BIS[2 (DIETHYLAMINO)ETHYL] 5H INDOLO[3,2 B]QUINOLIN 11(10H)ONE; ALIPHATIC AMINE; ANTIMALARIAL AGENT; BIS ALKYLAMINE QUINDOLONE DERIVATIVE; CHLORINE; CHLOROQUINE; HEME; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN HEPG2; CELL VACUOLE; CHEMICAL REACTION; CYTOTOXICITY; DRUG SELECTIVITY; IC 50; NONHUMAN; PLASMODIUM FALCIPARUM;

ALKYLATION; ANTIMALARIALS; CARBOLINES; DRUG RESISTANCE; HEMEPROTEINS; HEP G2 CELLS; HUMANS; INDOLEQUINONES; PLASMODIUM FALCIPARUM; QUINOLONES;

PLASMODIUM FALCIPARUM;

EID: 77957554431     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.043     Document Type: Article

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