Design, synthesis and evaluation of 4,5-di-substituted acridone ligands with high G-quadruplex affinity and selectivity, together with low toxicity to normal cells

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 17, 2009, Pages 5109-5113

  Cuenca, Francisco ^a   Moore, Michael J B ^a   Johnson, Karin ^a   Guyen, Bérangère ^a   De Cian, Anne ^b   Neidle, Stephen ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b CNRS   (France)

Author keywords

Acridones; DNA binding; Quadruplex ligands

Indexed keywords

4 CARBOXYL ACRIDONE; 4,5 DICARBOXYL ACRIDONE; ACRIDONE DERIVATIVE; ANTINEOPLASTIC AGENT; CARBONYL DERIVATIVE; DOUBLE STRANDED DNA; GUANINE QUADRUPLEX; LIGAND; SOLVENT; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CANCER CELL; CELL AGING; CELL CYCLE ARREST; CELL LINE; CELL PROLIFERATION; CELL STRAIN MCF 7; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG DESIGN; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; FIBROBLAST; FLUORESCENCE RESONANCE ENERGY TRANSFER; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIGAND BINDING; SUBSTITUTION REACTION; TELOMERE;

ACRIDINES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; G-QUADRUPLEXES; HUMANS; LIGANDS; TELOMERASE; TELOMERE; TRANSITION TEMPERATURE;

EID: 68349130197     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.07.033     Document Type: Article

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